http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
김현준,김유진,이수진,이지연,박세훈 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.1
Objective: In the treatment of metastatic soft tissue sarcoma (STS), pazopanib is considered a standard treatment after failure of chemotherapy. We retrospectively investigated outcomes of pazopanib in patients with metastatic uterine STS. Methods: A retrospective study was performed on 35 consecutive patients with uterine STS treated with oral pazopanib 800 mg daily as salvage therapy for metastatic disease between September 2013 and December 2015. Endpoints included response rate, survival, and safety. Results: Among 35 patients, 27 (77%) had a histologic diagnosis of leiomyosarcoma (LMS) and the median age was 57 years (range, 36–70). Median number of metastatic sites was one (range, 1–5) with lung as the most frequently involved site. Pazopanib was generally well-tolerated: the major hematologic toxicity was grade 1/2 anemia (14%). Among the non-hematologic toxicities, grade 1/2 stomatitis was most commonly observed (22%), followed by fatigue and hypertension. Objective response and stable disease were observed in 10 (29%) and 11 (31%) patients, respectively. However, most cases of clinical response were observed in patients with LMS: 33% for LMS, 20% for undifferentiated pleomorphic sarcoma, and 0% for endometrial stromal sarcoma. Median progression-free and overall survivals were 5.8 months (95% confidence interval [CI]=3.6–8.1) and 20.0 months (95% CI=11.6–28.4), respectively. Conclusion: In this “real-world” retrospective study, salvage therapy with pazopanib demonstrated clinically relevant efficacy and tolerability in unselected patients with uterine STS. Although it is encouraging that outcomes for Korean patients with uterine STS were similar to those reported in the phase III trial, the clinical benefit was limited to LMS.
초경량 블록 암호 CHAM에 대한 CPA 공격과 대응기법 제안
김현준,김경호,권혁동,서화정 한국정보처리학회 2020 정보처리학회논문지. 컴퓨터 및 통신시스템 Vol.9 No.5
Ultra-lightweight password CHAM is an algorithm with efficient addition, rotation and XOR operations on resource constrained devices. CHAM shows high computational performance, especially on IoT platforms. However, lightweight block encryption algorithms used on the Internet of Things may be vulnerable to side channel analysis. In this paper, we demonstrate the vulnerability to side channel attack by attempting a first power analysis attack against CHAM. In addition, a safe algorithm was proposed and implemented by applying a masking technique to safely defend the attack. This implementation implements an efficient and secure CHAM block cipher using the instruction set of an 8-bit AVR processor. 초 경량암호 CHAM은 자원이 제한된 장치 상에서 효율성이 뛰어난 덧셈, 회전연산, 그리고 XOR 연산으로 이루어진 알고리즘이다. CHAM은 특히 사물인터넷 플랫폼에서 높은 연산 성능을 보인다. 하지만 사물 인터넷 상에서 사용되는 경량 블록 암호화 알고리즘은 부채널 분석에 취약할 수 있다. 본 논문에서는 CHAM에 대한 1차 전력 분석 공격을 시도하여 부채널 공격에 대한 취약성을 증명한다. 이와 더불어 해당 공격을 안전하게 방어할 수 있도록 마스킹 기법을 적용하여 안전한 알고리즘을 제안하고 구현 하였다. 해당 구현은 8-비트 AVR 프로세서의 명령어셋을 활용하여 효율적이며 안전한 CHAM 블록암호를 구현하였다.
김현준,남명식,추헌구,김수한 대한안과학회 2019 대한안과학회지 Vol.60 No.12
Purpose: To report a case of recurrent intraocular hemorrhage due to type A hemophilia in a female patient without any previous medical history. Case summary: A 51-year-old female patient without any previous medical history was referred to our clinic due to blurred vision in her left eye. Slit lamp microscopy of the anterior segment was nonspecific. Fundus examination revealed vitreous hemorrhage with retinal tear in her left eye. Vitrectomy and cataract surgery were performed. One day after surgery, hyphema and vitreous hemorrhage recurred. A coagulation disorder was suspected and further serological evaluation was conducted. Coagulation factor analyses showed that the activity of coagulation factors 8 and 12 decreased to 25% and 47%, respectively. Genetic sequence analyses were conducted, and a missense mutation of C6724G> A] was found in exon 25, and type A hemophilia was confirmed. Conclusions: In patients who tend to show persistent bleeding even after proper treatment, hematological evaluation including coagulation factor assays, and the possibility of rare diseases such as hemophilia should be considered. 목적: 저자들은 특이 과거력이 없는 여성에서 A형 혈우병에 의하여 발생한 반복적인 안구내 출혈 1예를 경험하였기에 이를 보고하고자 한다. 증례요약: 이전 내과적 과거력이 없는 51세 여자가 4일 전부터 발생한 좌안의 시력저하 소견으로 본원 안과에 의뢰되었다. 세극등현미경검사에서 전안부의 특이 소견은 관찰되지 않았다. 안저검사에서 좌안 유리체출혈 소견이 관찰되어 유리체절제술 및 백내장수술을 시행하였다. 수술 후 1일 전방출혈 및 유리체출혈이 재발하였다. 이에 혈액응고장애를 의심하여 시행한 검사에서 Factor 8 및 Factor 12가 각각 25%, 47%로 저하되어 있는 소견을 보였다. 유전자 서열 변이 분석 결과상 Exon25에 c.6742G<A인 missense mutation 소견을 보여 A형 혈우병이 확진되었다. 결론: 출혈경향을 보이는 여자 환자에서 적절한 치료 후에도 bleeding tendency가 지속되는 경우 혈액내과 진료 및 Coagulation Factor Assay가 필요하며, Hemophilia 등의 드문 질환들도 고려해야 하겠다.
피부건강 웰니스 프로그램이 웰니스지수 및 피부건강지표에 미치는 영향
김현준 대한통합의학회 2019 대한통합의학회지 Vol.7 No.4
Purpose : The purpose of this study is to investigate the wellness and skin health effects of skin health programs to develop high-value health care services. Methods : The subjects were 15 middle-aged women who understood the research and volunteered and participated in the two-day skin health wellness program. Participants were measured the wellness index and skin health twice before and after participating in the program and wellness index measures include comprehensive wellness, physical wellness, mental wellness, emotional wellness, social / cultural wellness, financial wellness, and environmental wellness and skin health measurement items are skin oil, skin water, skin pore, skin elasticity, skin wrinkle and skin pigment. The skin wellness program included aerobic exercise, endurance exercise, functional food, cosmetics, herbal tea, massage, spa, meditation and marine leisure sports. Results : Among the wellness index items, comprehensive wellness index (p<.05), mental wellness index (p<.05) and environmental wellness index (p<.05) showed statistically significant differences. Among skin health items, skin oil (p<.05), skin elasticity (p<.01) and skin wrinkle (p<.01) showed statistically significant differences. Conclusion : This study confirmed that the two-day complex wellness program is an effective program for some items of wellness index and skin health.