물의 종류를 달리한 동치미의 경도 변화 및 세포벽 관찰

심영현,안기정,김지은 한국조리과학회 2004 한국식품조리과학회지 Vol.20 No.1

The purpose of this study was to investigate the changes of hardness and microstructure of Dongchimi cooked with various source of water(distilled water, purified water, Cho Jung Carbonated Natureal water). This study was conducted to observe the change of pH, total acidity, salt content, turbidity, texture and microstructure. Dongchimi cooked with source of water of water was fermented at 10℃ for 46 days. The changes of pH on Dongchimi cooked with various source of water decreased in all samples during fermentation period, and then showed a slowly decrease after 12 days of fermentation. The total acidity of Dongchimi cooked with Cho Jung Carbonated Natural water was arrived slowly at best tasting condition 0.3~0.4 point compared with other conditions. So Dongchimi cooked with Cho Jung Carbonated Natural water was continued to the best tasting condition for end of fermentation. At early stage of fermentation, the changes of turbidity of Dongchimi used Cho Jung Carbonated Natural water showed highly as compared with other test condition for 12th days of fermentation. The maximum cutting force of chinese radish of Dongchimi showed the highest value among all at the 25th day of ripening and then decreased gradually. The maximum cutting force of chinese radish of Dongchimi used Cho Jung Carbonated Natural water was the highest compared with other conditions at 25th day of fermentation. The calcium content of Dongchimi juice used Cho Jung Carbonated Natural water was observed high at the early stage of fermentation and showed the highest value at 25th day of ripening. The calcium content of chinese radish and Dongchimi juice of Dongchimi cooked with water purifier was lower than that of Dongchimi cooked with Cho Jung Carbonated Natural water, and was higher than that of Dongchimi cooked with Distilled water at the early stage of fermentation. The magnesium content in all samples increased gradually from the early stage of fermentation. The microstructure showed disintegration appearance of middle lamella and cell wall during fermentation period.

정신분열병 환자의 우울증에서 Paroxetine과 삼환계 항우울제 병용치료

심주철,공보금,박정환,윤영란,신재국,김정익,안동성,김용관,차인준,김영훈 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.4

저자들은 마산동서병원에 입원중인 우울증이 동반된 정신분열증 환자 10명을 대상으로 사용중인 항정신병약물에 paroxetine과 저용량의 삼환계 항우울제를 6주간 병용투여한 후 우울증상에 대한 효과와 치료의 안전성 및 약물상호작용을 알아보았다. Paroxetine은 고정량의 항정신병약물과 삼환계 항우울제에 부가하여 일일 20㎎을 6주간 병용하게 하였으며, 임상상태는 HDRS, HARS, UKU Side Effect Rating Scale등의 평가척도를 사용하여 평가하였다. 또한 약동학적 약물상호작용은 삼환계 항우울제들의 혈장농도를 HPLC로 측정하여 분석하였다. 결과는 다음과 같다. 1) 10명의 전체 대상환자에서의 HDRS 평균점수는 TCA와 paroxetine 병용투여 6주후에 통계적으로 유의하게 감소되었다. 이중 40%의 환자에서는 병용투여 6주후에 HDRS 점수상 50% 이상의 감소를 보여, 일부의 환자들에서는 정신분열병에 동반된 우울증상의 치료에 소량의 삼환계 항우울제와 paroxetine의 병용치료가 효과가 있음을 확인하였다. 2) 두 명의 환자에게서 심각한 약물독성이 발생하였다. 이중 한 명은 삼환계 항우울제의 높은 혈중농도로 인한 항콜린성 위기(anticholinergic crisis) 소견을 보였으며, 다른 한 명은 인지기능 및 의식수준은 명료하였으나 망상과 환각증상이 약화되는 소견을 보였다. 따라서 본 연구에서 시도된 복합적 약물치료의 경우, 삼환계 항우울제의 혈중농도의 측정을 포함한 세심한 임상적 추적이 필요하다고 생각된다. 3) 기저치의 amitriptyline과 그 대사물인 nortriptyline의 농도합. imipramine과 대사물인 desipramine의 농도합은 각각 47.8-226.5ng/㎖. 80.5-395.6ng/㎖였으며 일반적으로 이들 약물들의 단독사용시에 문헌에 보고된 혈중농도를 훨씬 상회하고 있었다. 이는 병용투여된 항정신병 약물 약시 강력한 CYP2D6 효소억제제로서 기저치의 삼환계 항우울제들의 혈장농도를 이미 상당히 증가시켰던 것으로 판단되며, 그러한 결과로 인해 본 연구에서는 paroxetine이 이전의 문헌보고들과는 달리 뚜렷하게 삼환계 항우울제들의 혈장농도를 증가시키지 못하였다. 본 연구는 SSRI와 삼환계 항우울제의 병합 투여가 우울증의 개선 효과를 빠르게 하고, 치료역을 넓히고, 약물상호작용의 결과 paroxetine이 삼환계 항우울제의 혈중농도를 증가시킨다는 기존의 연구결과를 이용하여 정신분열병 우울증상의 치료에 parotextine과 소량의 삼환계 항우울제를 병용하는 방법을 시도해 본 연구이다. 저자들은 이러한 약물치료가 일부의 환자들에게서 효과가 있음을 관찰하였으나, 항정신병약물과 삼환계 항우울제를 병용투여 할 경우는 물론 이에 paroxetine과 같은 선택적 세로토닌 재흡수 억제제를 병용할 경우 복합약물상호작용의 결과로 약물독성의 위험성이 크며 세심한 주의가 필요함을 경험하였다. Depression is well-known to comorbid with several psychiatric disorders. Many schizophrenics also suffer from depression in the course of their illness. Combined therapy of SSRI and tricyclic antidepressants were reported to have benefits in some depressed patients. Paroxetine, a potent CYP2D6 inhibitor, increases the blood levels of tricyclic antidepressant markedly. Using paroxetine, we tried this combined therapy in the treatment of depressive symptoms in 10 chronic schizophrenic inpatients and evaluated its efficacy and drug interactions between paroxetine and tricyclic antidepressants. The following results were obtained : 1) The mean score of Hamilton's Depression Rating Scale(HDRS) was reduced significantly after 6 weeks-trials of this combined therapy for the mild depressive symptoms in 10 chronic schizophrenics. In four patients, 50% or more reductions in the scores of HDRS were noticed at final evaluation. 2) Two among our 10 subjects experienced severe toxic behavioral problems. Anticholinergic crisis with toxic confusion due to high blood levels of tricyclics was found in one patient and the other showed rapid clinical deterioration in his psychotic symptoms such as delusion and hallucination without any consciousness alternation. 3) Baseline plasma levels of tricyclics before adding paroxetine were higher than expected in our chronic schizophrenic subjects maintained with their antipsychotic medications. Several antipsychotics were also known as a potent CYP2D6 inhibitors and to increase the blood levels of tricyclics. Because the blood levels of tricyclics had already increased significantly by the use of antipsychotics, adding paroxetine to antipsychotics and tricyclic antidepressant in our subjects could increase the blood levels of tricyclics not so much as previously reported in the literatures.

택시 운전기사들의 유병상태에 관한 조사 연구

심운택,이종연,오장균,조영채 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.1

A questionnaire survey was conducted on 572 taxi drivers in Taejeon City to investigate the prevalence rate which was derived from the subjective symptoms of respondents according to the working condition and daily life effected on health. The disease were classified the cardiovascular disease, gastrointestinal disease, neurotic disease and musculoskeletal disease according to the subjetive symptoms. The results obtained were as follows : 1. Among the subjective symptoms. the complaint rate of latigability, eye strain, loss of appetite, irritability, dizziness on standing, stiffness on shoulder. and low back pain became decreased in that order. 2. The prevalence rates of cardiopulmonary and gastrointestinal disease were low in the old aged group, and the prevalence rates of all disease was proportional to the frequencies of accident experience. but no evident trend in job conditions. 3. The groups having regular meal time and rest after meal showed low prevalence rate in all disease. The sleeping time and smoking habit were related to the neurotic and cardiopulmonary disease. 4. The group of usual drug intake occupied 68% of all studied subjects, the age group of 40 or more and the group of having G-1 disease showed high rats of usual drug intake.

가상현실 기법의 활용이 지식 성취도 향상에 미치는 효과 : 눈의 구조와 기능 내용을 중심으로 The Structure and Function of Eye

심규철,류수정,김현섭,김희수,박영철 한국과학교육학회 2003 한국과학교육학회지 Vol.23 No.1

The purpose of present study was to develop teaching-learning materials based virtual reality technology(VRT), and to examine the effect of it on the knowledge achievement of biology. Authoring tool of virtual reality(VR) was 3D Webmaster made in Superscape Ltd., United Kingdom. Educational materials was developed for the structure and function of eye of life field in the 10th science. It was learner-directed and interactive educational material using the Web-based and desktop VR. The result showed a meaningful improvement on the achievement. Using 3D VR shows the potential of available education media in the next generation as science teaching-aided material, which especially was efficient in the understanding and perception of abstract or difficult to direct experience learning contents.

대학의 추진전략 및 촉진 성과 지각이 대학 이미지에 미치는 영향에 관한 연구

정형식,김영심,이재석 조선대학교 경영경제연구소 2002 經營經濟硏究 = Management and economics research Vol.25 No.1

산복도로에서 보는 釜山港 景觀의 構圖的 特徵 에 관한 硏究

심은경,강영조,김승환,남정칠,박승범,이기철,박한우 동아대학교 건설기술연구소 2000 硏究報告 Vol.24 No.1

This study is to clarify the characteristics of the type of view on a prospect from the road view, approach to the purpose of the maintenance plan of the road view. First, in the viewpoint of view is understanding meaning of the road, the method come into contact with a road view. Second, in the view appear an object land is grouping to the road view and presentation to a point in dispute and a settlement. This study have the keynote to different a form of view depend on viewpoint in a point view of prospect of road view, it will be presentation of practice method to the maintenance plan of the road view of the future.

모터 제어ㆍ감시를 위한 Monitoring Device 개발

정도영,박영록,심낙순,박종국,허규환 삼척대학교 산업과학기술연구소 2001 産業科學技術硏究論文集 Vol.6 No.1

A motor used as power source by factory has a relay panels up to recently. But they have the problems of operating and maintenance, such as mechanical contracts, etc. They also need some additional relays to check the over load, over currents and ground faults. But in the development of computers the relay panels to control motor are changed by electrical motor controllers with microprocessor or DSP. They can check the event, the over load, over currents and ground faults and also supervise the trend and state of operating. In this paper, a monitoring devices for the control and supervision of motor has been presented and developed.

브랜드이미지와 店鋪이미지가 賣場內 感精 및 消費感情과 滿足에 미치는 影響

정형식,김영심 조선대학교 경영경제연구소 2001 經營經濟硏究 = Management and economics research Vol.24 No.1

미용산업에 있어 상업적 우정이 고객 충성도에 미치는 영향

정형식,모정희,김영심 朝鮮大學校 經營經濟硏究所 2003 經營經濟硏究 = Management and economics research Vol.26 No.2

하악 고정성 임프란트를 이용한 퇴축된 하악골의 수복

정영진,박원희,안원준,이명렬,이영수,유광희,심광섭 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.2

Transmandibular implants are used limitedly such as on remaining symphyseal basal bone of atrophic mandible, on the bony defect of symphyseal area due to trauma or tumor as surgical implants. Among the more recent advances in oral implantology are the Fixed Mandibular Implant (FMI)based on the pioneering studies and clinical applications by Irwin Small of the USA and the development very high success rates for providing attachments and abutments in areas of the oral cavity severely compromised by either atrophy or surgical loss of osseous tissues. We will present a case report of regabilitation of totally edentulous mandible with advanced alveolar atrophy using Fixed Mandibular implant (F.M.I).