진행성 비소세포폐암의 이차항암화학요법으로서 Docetaxel 단독요법의 성적

강현모,이정은,장필순,이연선,권선중,안진영,정성수,김주옥,김선영 충남대학교 암연구소 2006 암연구소 업적집 Vol.5 No.-

Background : The survival benefit associated with first-line chemotherapy in lung cancer has led to the need for second -line chemotherapy, for which Docetaxel (Taxotere^(?)) has proven efficacy in both settings. This study evaluated the safety and efficacy of docetaxel in patients with non-small cell lung cancer who had failed first-line platinum-based chemotherapy. Methods : Thirty one patients with non-small-cell lung cancer, who had failed first line platinum-based chemotherapy, between March 1999 and August 2003, were enrolled in this study. Patients received intravenous docetaxel, either 75 mg/㎡ or 100 mg/㎡, with routine premedication every three weeks. Results : Fourteen patients (45.2%) had a partial response. The median survival and progression- free survival times were 12.5 months (95% CI 7.3-17.6) and 3.0 months (95% CI 1.6-4.5), respectively. This study showed 2 factors gave different survival benefits; the age (< 60 years: 20.1 months vs. > 60 years: 6.6 months, p=0.0105) and the histological type (adenocarcinoma: 25.6 months vs. others: 7.9 months, p=0.0055). The predominant toxicity was neutropenia, which occurred as WHO grade 3 or 4 in 38.7 % of patients. One treatment related death was also reported. Non-hematological toxicity was minor and easily controlled. There were no significant statistical differences in the survival benefit and toxicity between the two doses. Conclusion : Docetaxel, as second-line monotherapy, was well tolerated and effective in patients with non-small-cell lung cancer who failed first line platinum -based chemotherapy. (Tuberc Respir DiS 2005: 58: 465-472)

진행성 비소세포폐암의 이차항암화학요법으로서 Docetaxel 단독요법의 성적

강현모,이정은,장필순,이연선,권선중,안진영,정성수,김주옥,김선영 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Background : The survival benefit associated with first-line chemotherapy in lung cancer has led to the need for second -line chemotherapy, for which Docetaxel (Taxotere^(?)) has proven efficacy in both settings. This study evaluated the safety and efficacy of docetaxel in patients with non-small cell lung cancer who had failed first-line platinum-based chemotherapy. Methods : Thirty one patients with non-small-cell lung cancer, who had failed first line platinum-based chemotherapy, between March 1999 and August 2003, were enrolled in this study. Patients received intravenous docetaxel, either 75 mg/㎡ or 100 mg/㎡, with routine premedication every three weeks. Results : Fourteen patients (45.2%) had a partial response. The median survival and progression- free survival times were 12.5 months (95% CI 7.3-17.6) and 3.0 months (95% CI 1.6-4.5), respectively. This study showed 2 factors gave different survival benefits; the age (< 60 years: 20.1 months vs. > 60 years: 6.6 months, p=0.0105) and the histological type (adenocarcinoma: 25.6 months vs. others: 7.9 months, p=0.0055). The predominant toxicity was neutropenia, which occurred as WHO grade 3 or 4 in 38.7 % of patients. One treatment related death was also reported. Non-hematological toxicity was minor and easily controlled. There were no significant statistical differences in the survival benefit and toxicity between the two doses. Conclusion : Docetaxel, as second-line monotherapy, was well tolerated and effective in patients with non-small-cell lung cancer who failed first line platinum -based chemotherapy. (Tuberc Respir DiS 2005: 58: 465-472) 연구배경 : 일차항암화학요법 후에 생존의 이득을 얻었음에도 불구하고 비소세포폐암 환자들의 대다수가 결국은 재발하거나 진행성 병변을 보인다. 이에 저자들은 기존의 여러 연구에서 보고 된 구제요법으로서 docetaxel의 항암효과와 비교적 적은 독성의 결과를 바탕으로,platinum을 근거로 한 항암화학요법을 시행 밖았으나 개발되거나 진행된 비소세포폐암 환자들을 대상으로 docetaxel 단독요법의 치료효과와 부작용에 대하여 알아보고자 하였다. 방법 : 조직학적으로 비소세포폐암으로 진단을 받고 platinum을 근거로 한 항암화학요법을 받았으나 재발 또는 진행성 병변을 보인 31명의 환자들을 대상으로 docetaxel 75 mg/m² 또는 100 mg/m²을 3주마다 정주하였다. 임상기록을 통한 후향적인 방법으로 분석하였다. 결과 : 1) 재발 또는 진행성 병변을 보인 31명중 남녀 비는 24:7이고 중앙연령은 60세였다. 2) 반응평가로 완전 관해는 없었고 부분관해는 14명(45.2%), 불변이 10명(32.3%), 진행이 7명(22.6%)으로 전체적인 반응율은 45.2%이었다. 3)중앙생존기간은 12.5개월(95% 신뢰구간: 7.3개월 17.6개월) 이었고, 1년 생존율은 52%였다. 무진행생존기간의 중앙값은 3.0개월(95%신뢰구간: 1.6개월 -4.5개월)이며, 반응군에서의 중앙반응지속피간은 3.7개월(95% 신뢰구간: 3.0개월 - 4.4개월)이었다. 4) 60세 미만인 경우(20.1 months vs 6.6 months. p=0,0105), 조직학적 아형이 선암일 경우(25.6 months vs 7.9 months, 0=0.0055) 통계적으로 유의한 생존기간의 증가가 있었다. 5) 부작용으로 3도 이상의 백혈구 감소증은 12명(38.7%),호중구 감소증에 동반된 발열은 6명(19.3%),감염이 동반된 호중구 감소증은 4명(12.9%)에서 발생했다. 치료와 관련되어 1명이 사망하였다. 6) Docetaxel 용량에 따른 생존기간의 차이나 독성의 차이는 없었다. 결론 : Platinum을 근거로 하는 항암화학요법으로 치료받은 후 재발 또는 진행성 병변을 보이는 비소세포폐암환자들에게 docetaxel을 투여하는 것은 비교적 안전하고 효과적인 항암치료법으로 사료된다.

附着位置가 다른 單一平板핀을 가진 水平圓筒에서의 自然對流 熱傳達

權純錫,金善政 東亞大學校 大學院 1986 大學院論文集 Vol.11 No.-

This interferometric study on the natural convection has been studied experimentaly for the heat transfer characteristics of the horizontol cylinder with a vertical plate fin in air according to the various positions of fin and the various Rayleigh numbers. 1. Heat Transfer rate from the cylinder surface with a vertical plate fin at the same position is increased by increasing Rayleigh number. 2. As Rayleigh number is constant, the mean cylinder Nusselt number has the highest value at ?= 0˚ and the lowest value at ?=90˚ 3. As As Rayleigh number is constant, the mean fin Nusselt number has the highest value at ?=180˚ and the lowest value at ?=90˚ 4. As Rayleigh number is constant, the mean total Nusselt number has the highest value at ?=0˚ and lowest value at ?=90˚ 5. Local fin Nusselt number distribution on dimensionless fin lengths is increased by increasing Rayleigh number.

국내 혈액질환 환자에서 침습성 아스페르길루스증의 구제치료로서 Voriconazole의 효과와 안전성

권재철,김시현,최수미,최재기,이동건,박선희,최정현,유진홍,신완식 대한감염학회 2010 감염과 화학요법 Vol.42 No.1

Background: Invasive aspergillosis (IA) is associated with significant morbidity and mortality in patients with hematologic malignancies. We investigated the efficacy and safety of voriconazole (VCZ) when used as salvage therapy for IA in Korean adults with hematologic malignancies who had not responded to prior antifungal therapy. Materials and Methods: We retrospectively reviewed data, collected from January 2007 to October 2008, from patients with proven or probable cases of IA. All were probable IA cases, except for one proven case. All cases were refractory or intolerant to antifungal therapy prior to administration of VCZ. Efficacy and safety were assessed in patients treated with VCZ for more than 3 days and for more than one dose, respectively. A favorable response [complete (CR) or partial (PR)] was defined by significant improvement of all clinical symptoms, signs, and radiologic abnormalities. Results: Fifty patients who met the inclusion criteria were enrolled. There were 27 male and 23 female patients with mean age of 44.4 years (range, 15-65 years). Underlying diseases were acute leukemia (35 cases), chronic myelogenous leukemia (4 cases), myelodysplastic syndrome (3 cases), lymphoma (3 cases) and other hematologic diseases (5 cases). Twenty-two patients had received chemotherapy and 13 patients had undergone hematopoietic stem cell transplantation. The lung was the main infection site (94%) followed by the sinus (6%). Amphotericin B deoxycholate alone was the most frequent previous antifungal therapy. The mean duration of antifungal therapy prior to VCZ therapy was 13.9±8.8 days (2-44 days). The median duration of VCZ therapy was 19 days (interquartile range, 49 days). Sixteen patients (32.0%) showed favorable responses (CR:PR=8:8) at the end of VCZ therapy. The numbers of patients with stable disease, progression and death were, 6 (12%), 6 (12%) and 22 (44%) respectively. Most of those with unfavorable responses had relapsed underlying malignancies or refractory graft versus host diseases. Twelve patients developed drug-related adverse events but only one patient stopped VCZ treatment prematurely. Conclusions: VCZ demonstrated an acceptable level of toxicity in patients with hematologic malignancies but further studies are required to prove its efficacy as salvage therapy.

수직상향핀이 부착된 등온수평평판에서의 자연대류

권순석,권용일,김선정 東亞大學校 大學院 1990 大學院論文集 Vol.15 No.-

This study has been carried out to investigate the natural convection heat transfer from the isothermal horizontal plate with upward projecting fins numerically. The governing equations for the system are solved by the finite difference analysis and successive over relaxation method at Ra=4000-7000, Pr=0.71, C?=7.75. Mean Nusselt numbers, velocities, temperatures and stream functions are obtained for various dimensionless fin lengths The results are as follows ; 1. The local fin Nusselt number is increased rapidly near the fin tip and that of the fin tip is decreased rapidly by increasing the dimensionlesss fin lengths. 2. The mean plate Nusslt number is decreased by increasing the dimensionless fin lengths and the mean fin Nusselt number shows the maximum value at H/S=2.0 3. The mean total Nusselt number shows the optimum fin length for the maximum heat transfer at H/S=2.0 4. The mean plate, fin and total Nusselt number are increased by increasing the dimensionless fin lengths at H/S=1.0

Helicobacter pyloir 양성 소화성 궤양에서 lansoprazole 포함 삼제요법의 제균율 및 제균판정에 있어서 요소호기검사의 유용성

정혜경,곽재진,유민아,배기선,권정미,이종수,김도영,문일환 대한감염학회 2003 감염과 화학요법 Vol.35 No.3

목적 : 본 연구는 Helicobacter pylori (이하 H. polyri) 양성인 소화성 궤양 환자에서 lansoprazole 포함 삼제요법의 제균율을 알아보고, 제균 치료 후 제균 판정에 있어서 요소 호기 검사(Urea breath test, 이하 UBT) 및 신속요소분해(rapid urease test, 이하 RUT test)와의 일치율에 대하여 알아보고자 하였다. 방법 : 상부위장관내시경 검사에서 H. polyri 양성인 소화성 궤양환자에서 lansoprazole 60㎎+amoxicillin 2g+clarithromycin 1g의 약제를 2회 분복하여 1주간 복용하는 삼제요법을 실시하였다. 최소 4주후 추적 상부위장관내시경을 실시하였고, 전정부와 체부에서 각각 RUT를 실시하였으며 UBT(5분, 20분)를 시행하였다. 결과 : 대상환자는 총 46명으로 남자 34명(48±13세), 여자 12명(53±14세)이었다. LAC 삼제요법의 제균율은 40/46명(87.0%)이었고, 궤양의 치유율도 42/46명(91.3%)이었다. RUT와 20분 UBT 결과가 모두 음성이었던 경우는 41예, 모두 양성이었던 경우는 4예로 RUT와 UBT는 97.8% (45/46)의 일치율을 보였고, 1예는 UBT는 음성이었으나 체부에서 시행한 RUT가 양성이었다. 5분 UBT 검사가 양성이었던 예는 14/34 (41.2%) 이었고, 이 14예 중 12예(85.7%)는 20분 UBT 검사 음성, RUT 음성이었다. 결론 : Lansoprazole과 amoxicillin, clarithromycin 1주일 병합요법은 H. polyri 양성인 소화성 궤양 환자에서 87.0%의 제균율을 나타내어 우수한 효과를 보였고, 요소호기검사는 제균 치료 후 제균 판정에 유용한 비침습적인 방법임을 확인할 수 있었다. Background : There are only a few studies on Helicobacter pylori (H. pylori) for its eradication rates of lansoprazole-based triple therapy in Korea, and the results are controversial. Therefore, we undertook to investigate the eradication rate of lansoprazole-based triple therapy, and compare the concordance rate of urea breath test (UBT) and rapid urease test (RUT) in evaluating H. pylori eradication. Methods : Patients with acute peptic ulcer who were H. pylori-positive were recruited by prospective, consecutive manner. They received lansoprazole 30 ㎎ b.d., amoxicillin 1 g b.d. and clarithromycin 500 ㎎ b.d. for 1 week. Upper endoscopy was performed after 4 weeks to check for ulcer healing, and UBT and RUT were performed to evaluate H. pylori eradication status. Results : A total of 46 patients were recruited, and they were all compliant. H. pylori eradication rate was 87.0% (40/46) and ulcer healing rate was 91.3% (42/46). Forty one patients showed negative in both UBT and RUT, and 4 patients revealed positive in both tests, therefore, the concordance rate of UBT and RUT was 97.8% (45/46). Conclusion : Our study showed that 1-week lansoprazole-based triple therapy was effective in H. pylori eradication and ulcer healing. UBT can be an effective, noninvasive method for evaluating H. pylori status after H. pylori eradication.

垂直上向핀이 附着된 水平平板에서의 自然對流 熱傳達

權純錫,金善政,全永煜 동아대학교 공과대학 부설 한국자원개발연구소 1987 硏究報告 Vol.11 No.2

This study on the natural convection has been conducted experimentally for the heat transfer characteristics of the horizontal flat plate with three aluminium fins in air according to the various heights of fin and the various Rayleigh numbers. The experimental results are as follows; 1. The mean fin, mean plate and total Nusselt number are increased by increasing dimensionless fin height. 2. The mean fin, mean plate and total Nusselt number are increased by increasing Rayleigh number. 3. The mean fin Nusselt number is the highest at the outside surface where there is no interference from each other. 4. The mean plate Nusselt number at H/S =0.67 and 1.67 for Ra_(s) =7.31×10³ are 53% and 52% less than the mean fin Nusselt number owing to the interference of fins. 5. The distribution of mean total Nusselt number shows similar tendency as compared with the experimental results of Jones and Smith (2).

水平과 垂直平板이 結合된 直角모서리에서의 自然對流

權線錫,金善政,柳秉郁 동아대학교 공과대학 부설 한국자원개발연구소 1989 硏究報告 Vol.13 No.2

A study has been conducted experimentally on natural convection heat transfer characteristics for various Rayleigh number at horizontal and vertical plates with the rectangular corner. The results are as follows : 1) In case of constant Rayleigh number, the mean Nusselt number of the vertical plate is 32.9% more than that of the horizontal plate at Ra=1.680×10⁴. 2) Local Nusselt number is maximum at the leading edge of the vertical plate and is minimum at the end edge of the horizontal palte. 3) The mean Nusselt number of the horizontal plate has 27.6% less than the result of reference 9 at Ra=1.185×10⁴ 4) The mean Nusselt number of the plate combined in horizontal and vertical plates has 24.9% less than the result of reference 9 at Ra=1.185×10⁴

소집단 협력학습을 통한 방정식 지도에 관한 연구

권정환,이재돈,이향순 대구대학교 기초과학연구소 1997 基礎科學硏究 Vol.14 No.1

The important goal of mathematics education is to help students develop the ability to solve problems rationally and to think mathematically. In this case study it is concluded that the active and positive participation on the part of students could be achieved in the small group cooperative learning rather than the teacher-centered classroom activity. As such desirable attitude of the student largely depends on the teacher's will, his continuous interest and effort are urgently demanded. We hope that this study will contribute to the development of the teaching-learning methods of mathematics.

主觀的인 評價에 의한 靑少年의 肥滿傾向 分析

權善鈺,金基學,李東洙,鄭鎭國 慶北大學校 師範大學 體育學硏究會 1992 體育學會誌 Vol.20 No.-

This study was conducted to analyze the tendency of obesity by subjective evaluation method in measuring the skinfold thickness in adolescents. The validity norms were height, weight, the sum of skinfold thickness, Db1, %Fat1, %Fat2, and BMI. The subjects surveyed were 2,442 boy and girl students of middle and high school in medium and small city and big city. The results are summarized as follows; 1. Weight of adolescents evaluated as obesity was over 76㎏ in boy's middle, over 67㎏ in gril's middle school, over 79㎏ in boy's high school, and over 68㎏ in girl's high school, the sum of skinfold thickness was over 40㎜, over 39㎜, over 54㎜, and over 41㎜ respectively. 2. Except the case of height in girl's middle, boy's high and girl's high school, in height in boy's middle, weight, the skinfold thickness, Db1, %Fat1, %Fat2, and BMI, difference among the degree of obesity evaluated subjectively was significant(p<.05). 3. Except heigh in girl's middle, boy's and girl's high school, correlation between the degree of obesity evaluated subjectively and height in girl's middle school, weight, the sum of skinfold thickness, Db1, %Fat1, %Fat2, BMI respectively was high and significant(p<.01 or p<.001) Therefore, on the basis of above results, I think we can evaluate the tendency of obesity in adolescents validly by subjective evaluation method as well.