바터 팽대부에 생긴 유암종 1예

강명주,지삼룡,박석주,이재익,조영완,김준영,박성재,박은택,이연재,이상혁,설상영,배상균 인제대학교 2006 仁濟醫學 Vol.27 No.-

Carcinoid tumors have been reported in a wide range of organs but most commonly involve the lungs, bronchi and gastrointestinal tract. Within the gastrointestinal tract, appendix is the most common location for carcinoid, followed by the distal small intestine, the rectum, and the stomach. Among these, primary involvement of the ampulla of Vater is extremely rare. We report a case of carcinoid tumor of ampulla of Vater. A 62-year-old man presented with epigastric soreness. Gastroduodenal endoscopy showed hyperemic bulging mass on ampulla of Vater and diagnosed as carcinoid tumor by histologic finding, with immunohistochemical study. In ^(111)In-octreoscan, tumor had regional lymph node metastasis, but no evidence of distant metastasis. Pancreatoduodenectomy with lymph node dissection was performed.

우심방을 침범한 거대 비호지킨씨 림프종 1예

강상범,진승원,이은경,박용현,최용호,김용주,박준철,김재형,홍순조,최규보,권종범,원용순,박건,이은희 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

최대하 운동부하검사가 노인 허혈성 뇌졸중환자의 혈관탄성·운동유발성 고혈압 및 허혈성 심장질환진단에 미치는 영향 : 사례연구

강동연,차재관,허재택,박정준,양점홍 釜山大學校 附設 體育科學硏究所 2009 體育科學硏究所 論文集 Vol.25 No.2

Purpose: The purpose of this study was to observe the blood pressure response during exercise test and to investigate baPWV and ABI and potentiality of the cardiovascular disease of three ischemic stroke elderly in submaximal exercise test. Method: It measured the blood pressure, ECG during submaximal exercise test and baPWV, ABI before and after exercise test. Results: It discovered low blood vessel elasticity, exercise induced hypertension, ST segment depression ≥ 1 mm through exercise test. Conclusion: Exercise test have a diagnosis valuable to decide a cardiac disorders. Moreover, It increases a sensibility of baPWV and ABI test and heighten a reliability of potential diagnosis of high blood pressure by submaximal exercise test. 뇌졸중(stroke)은 가령(加齡)과 함께 증가하며 크게 허혈성과 출혈성 형태로 니누고 근래에는 허혈성 뇌졸중의 발생빈도가 증가하고 있는 추세로 뇌졸중 환자의 혈류역학에 대한 연구는 순환기학 분야에서 뿐만 아니라 운동이 고혈압의 주요 개선 중재방법의 하나라는 관점에서 운동처방 분야에서도 심도 있는 연구가 요구된다. 그러므로 이 연구에서는 60세 이상의 허혈성 뇌졸중환자 3명에게 최대하 운동부하검사를 실시하여 각각의 사례에서 안정시에는 발견되지 않았던 혈관폐색의 높은 가능성, 운동유발성 고혈압 및 허혈성 심장질환의 정후인 ST분절≥1.0 mm 하강을 발견하였다. 이러한 점에서 운동부하검사는 심장질환을 판단하는 진단적 가치뿐만 아니라 baPWV와 ABI검사의 민감성을 증가시키며 고혈압 잠재성 진단에 유용하게 활용될 수 있다.

黃芩 抽出物이 DNCB로 誘導된 생쥐의 Allergy性 接觸皮膚炎에 미치는 影響

全宰弘,姜允皓 동국대학교 한의학연구소 1998 東國韓醫學硏究所論文集 Vol.7 No.1

본 실험은 황금이 Allergy性 접촉피부염의 면역과민반응 및 염증반응에 미치는 영향을 조사하기 위해서 시행되었다. 실험을 위해 BALB/C계 생쥐를 DNCB 처리군과 DNCB 처리 후 황금추출액을 경구 투여한 황금추출물투여군(HGET군)으로 나누어 2,4-dinitrochlorobenzene(DNCB)를 도포하여 Allergy性 접촉피부염을 유발한 뒤, 시간의 경과에 따라 contact hypersensitivity assay, 피부의 일반적인 구조 혈관생성, 림프구를 비롯한 염증세포, sulfated acid mucosubstance, 비만세포, IL-2 R, ICAM-1 그리고 CD11b의 변화를 관찰하였다. Contact hypersensitivity assay에서 HEGT군은 DNCB처리군에 비해 有意性있는 ear swelling의 감소를 보였다. 피부표피의 변화에서 HEGT군에서 DNCB처리군에 비해 감소된 것으로 나타났다. 또한 혈관생성, 림프구의 침투 및 표피 기저층과 가시층 세포치 손상은 HEGT군에서 DNCB처리군에 비해 감소된 것으로 나타났다. 또한 혈관생성, 림프구를 비롯한 염증세포, sulfated acid mucosubstance와 비만세포, IL-2 R 양성반응세포, ICAM-1 양성반응세포 그리고 CD11b 양성반응은 Allergy性 접촉피부염의 면역과민반응억제와 항염증작용에 효과가 있는 것으로 사료된다. This study was performed to investigated the effects of an immunosuppression and a mitigation of inflammation of Scutellaria baicalensis GEORGI on Allergic contact dermatitis. In order to study, after oral administration of Scutellaria baicalensis GEORGI extract, contact hypersensitivity assay, general morphologic change of skin, suIfated acid mucosubstance, mast cell, lL-2R, ICAM-1 and CD11b were observed in BALB/C mouse induced allergic contact dermatitis by the contact sensitizing DNCB. Ear swelling in contact hypersensitivity assay was decreased in the Scutellaria baicalensis GEORGI extracts administered(HEGT) group, compared with DNCB painted group. In the general morphologic change of skin, hyperplasia of keratinocytes, increase of lymphocytes and inflammatory cell, increase of vasculogenesis and epidermal lymphocytes infiltration, increase of cell damage in epidermal basal layer and prickle layer were decreased in the HEGT group, compared with DNCB painted group. Increase of sulfated acid mucosubstance, mast cell, lL-2R positive cell, ICAM-1 positive cell, CD11b positive cell were decreased in the HEGT group, compared with DNCB painted group.

回轉圓板法에 의한 下水處理에 관한 硏究

姜龍太,全裕燦,柳在益 東亞大學校 大學院 1986 大學院論文集 Vol.11 No.-

This study has been investigated about the actual applicational propriety for the theoretical equation which have been proposed, the relationship between h/a and factors, and the determination of disc area with h/a. The results carried out the experiment are the following: 1. When the final settlement tank was used, in the case of r=0.1 optimum submerged rate was 45% and Optimum Disc interval was 1cm. 2. Bod removal efficiency was inversely proportional to the submerged rate and the Disc interval. 3. Saturation constant, Area capacity constant, Microbial maximum growth rate, Yield constant, Attached active biomass:36 ㎎/ℓ, 90.3g/㎡·d, 3,9, 0.79, 19.06g/㎡, respectiverly. 4. The experiment value well corresponded to the Korneegay equation. 5. There was nearly no the substrate utilization by suspended microorganism because the experimental value well corresponded to the korneegay equation.

PDA를 이용한 건설 현장업무의 효율 제고를 위한 연구

강민수,신규철,김재준 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

Information Technology is making rapid progress in other industries. However, construction industry is composed of various teams spreaded out to work in their place, so supply and demand on construction information within the appropriate time and the right place are becoming more important and control a successful completion of the construction project. Many researches have been conducted and operated in various construction work scope such as productivity management, logistics management, and so on. However the research concerned work scope that can be efficiently managed by using IT devices are insufficient. This study investigates how this technology especially PDA can be used to improve efficiency and effectiveness of construction management process. It classifies work scope into 9 catalogs based on PMBOK, and subdivides into 28 catalogs. This study propose the future works on PDA application in construction industry from the improvement effect's and applicability's point of view.

밀링가공에서의 온도분포와 절삭력 예측을 위한 연구

강재훈,송준엽,박종권 한국공작기계학회 2004 한국공작기계학회 춘계학술대회논문집 Vol.2004 No.-

This paper presents a simple analytic method using 2D simulation program for predications of cutting force and machining temperature in dry type milling process. And also, comparison of cutting force and machining temperature obtained from experiment and simulation work is accomplished to distinguish of suitability.

독성물질의 세포사 기전 및 세포사 유발물질의 검색법 개발에 관한 연구(Ⅰ) : 독성물질로 인한 파킨슨병 모델에서의 세포사 기전 연구 Study on the cell-death mechanisms of toxin-induced parkinsonism

강태석,김종민,서경원,김영옥,김준규,오재호,이윤동,김규봉,오정자,송연정,임종준,전범석,문전옥,최광식 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

MPTP 독성물질이 도파민성 신경세포에 선택적으로 작용하여 산화성 손상에 의한 신경세포사를 일으키는 것을 이용하여 파킨슨병의 동물모델을 만들고, 이를 통해서 아폼토시스를 비롯한 포사의 기전에 대한 연구 및 너코틴의 신경세포 보호효과 여부를 판정하는 실험을 병행하고자 하였다. 파킨슨꾐의 동물모델을 MPTf 독성 물질을 이용하여 확립하였으며, MPTP(30mgag, i.p.)를 투여한 후 1, 2,3, 4, 5일째 흑질 조직을 채춰하여 tarm로 박걸하여 tyrosine hydroxylase 면역조직화학염색을 수행하여 cell countif우한 결과, control은 57.635ce11s, 1일째 친.OfDells,2일째 57.9±6cells,3일릴 없.3±죠ells, 4일째 49.0츠3cells, 5일째 39.4±Scells료 4, 3일째 뚜렷한 신경세포 수의 감소를 보였다. 신경세포사 기전 규명을 위한 아폼토시스 분걱에서는 벼PTP 투여 후 1, 2, 3, 4, 5일째 조직을 채취하여 Hoechst staining, TUNEL staining을 수곡하였는데 양성 반응을 보인 신경세포는 관찰되지 않아. 아폼토시스로 인한 세포사가 관찰되지 않았다. bIPTP 파킨슨병 동물모델에서 nicotine 보호효과 탐색에 관한 실험은 nicat푸e 0.2mgAg을 5일 퐁안 투여 후 리『fP(30mgag)를 CS7Bt/6 마은스에 복강 내주사로 nicotine과 병용 투여한 후 1, 2, 3, 4, 5일째 뇌를 적출하땄다. 신경세포사가 뚜렷이 관찰되기 시작하는 4, 5일째의 신경세포 수의 감소 정도를 20. 30% 정도 약화시키는 경향을 보였으나, nicotine 보호효과에 대한 추가 실헝이 현재 수행 중에 있다. The cause of Parkinson's disease (PD) is largely unknown. However, free radical toxicit? may plaf a role ip. the degeneration of substantia nigra, which is the Hajorfocus of pathological damages in PD. Recently, a neuroprotective effect of nicotine in PD has been suggested. Therefore, the mechanism of neurodegenerafion and protective potential o( nicotine in PD were investigated in the experimental modeB of Pll using a neurotoxin, C57BL/6mice were administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30 mg/kg,j.p.). The degree of neurodegenerafion was determined by immunohistochemical stainiHB oftyrosine hydroxylase (TH). TH-positive cells on nigral sections were found 56.0 ±4, 57.9 ±6,52.315ce11s, 49.0±3cells, and 39,4±Scells at days 1, 2, 3, 4, 5, respectively (controls : 57.6±Scells). Hoechst and TUNEL staining showed no evidence of apoptosis. The exandnation on themice co-adrunistered with nicotine(0.2mgAg) and MPTP(30mgag) revealed a tendency ofnicotine protective effects. At days 4 and 5, the degree of TH-positive cells was decreased by20-30%, In corclusiffn, the role of apoptosis was not evidenced in this MPTP modeB of PB.The possible proteccon by nicotine should be elucidated with further studies.

공작 기계의 신뢰성 평가를 위한 웹 기반 해석 프로그램 개발

강태한,김봉석,이수훈,송준엽,강재훈 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-

Web-based analysis programs for reliability assessment of machine tools were developed in this study. First, the reliability data analysis program was developed to search for failure rate using failure data and reliability test data of mechanical part. Second, failure mode analysis was developed through performance tests like circular movement test vibration test for machine tools. This analysis program shows correlation between failure mode and performance test result. Third, tool life was predicted by correlation between flank wear and cutting time, using the extended Taylor tool life equation in turning data and the equivalently converted equation in order to apply ball endmill data to Taylor tool life equation in milling data. All the information related to input and result data can be stored in theses programs.

용융염 전해정련 계에서 초 우라늄 대용물질로서 cerium dysprosium의 적용

강영호,황성찬,심준보,유재형 한국공업화학회 2003 공업화학 Vol.14 No.3

회토류원소 중 cerium과 dysprosium은 악틴족 원소와 염화물 생성 자유에너지의 차이가 크지 않기 때문에 분리하기가 매우 어렵다. 즉, 용융염을 사용 하는 전해정련 공정에서는 이들 회토류 원소가 악틴족 원소와 함께 석출되는 특성을 나타낸다. 이러한 성질을 이용하여 본 연구는 용융염을 전해질로 이용하는 전해정련실험에 cerium과 dysprosium금속을 초 우라늄원소의 대용 물질로 사용하여 그들의 모사 특성을 고찰하었다. 실험 결과 용융염 중 낮은 염화우라늄농도에서는 이 두 회토류 원소가 초 우라늄과 유사한 전해 특성을 나타냈으나, 높은 염화우라늄 농도에서는 회토류 원소의 거동을 보여주었다. The rare earth elements, especiaily cerium and dysprosium are very difficult to be separated from actinide elements due to their narrow differences in the Gibbs free energy of formation of chloride. That is, they are codeposited with actinide elements in electrorefining process with molten salt. Using this characteristics, present study discusses the feasibility for use of cerium and dysprosium metals to simulate the electrorefining characteristics of the transuranium. The experimental results show that the electrolytic behaviors of these two rare earth elements are similar with the transuranium in low concentration range of uranium chloride in molten salt. However, in high concentration range of uranium chloride they behave as the rare earth elements.