플라즈마 표지소자의 제작

이상윤,라병욱,박동수,황인헌,이덕동,신영남,박성배,이동욱,박용석,박형근,손상호,권태근,채경락,정경득 慶北大學校 自然科學大學 1986 自然科學論文集 Vol.4 No.-

An Ac-type Plasma Display Panel (PDP) operating with Ne-Ar(0.1%) Penning mixture gas is fabicated. The characterics of the panel with electrodes covered with thin and thick dielectric layers are studied. The brightness of the Neon-orange light emitted by the panel measured as function of applied voltage and frequency. As an application, a graphic display system equipped with PDP showing still and moving pictures is made.

동종 골수이식 후 만성 이식편대숙주반응 환자에서 발생한 폐렴구균에 의한 수막뇌염 1예

신완식,김병욱,유진홍,김동집,김춘추,박종원,이종욱,김동욱,강문원,김양리 대한감염학회 1993 감염 Vol.25 No.3

Graft-versus-host disease (GVHD) is a frequent complication after bone marrow transplantation. Infectious complications are common in GVHD patients due to defect in cell-mediated immunity. A rare case of S. pneumoniae meningoencephalitis occured in a patient with extensive form of chronic GVHD after allogeneic bone marrow transplantation. He was immediately treated with full dosage of ceftriaxone and ampicillin. He suffered from various complications such as sepsis, acute renal failure, atelectasis, and seizure. Despite of aggressive treatment, he died probably due to renal shutdown and massive subacute cerebral infarction of left cerebral hemisphere. This report showed two unusual and rare features. First, the infection site was CNS rather than respiratory system. Second, the causative organism was S. pneumoniae, which is rare cause of CNS infection in immunocompromised patients.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

CD34+ 조혈 모세포 이식 2례

김정아,정현식,김원석,윤성수,이홍기,박찬형,박성규,김동욱,이종욱,한치화,민우성,김춘추,김동집 대한조혈모세포이식학회 1996 대한조혈모세포이식학회지 Vol.1 No.1

Background: In most solid tumors, the CD34 antigen has not been detected, so positive selection of CD34+ cells may reduce tumor cell contamination and the CD34+ cells are capable of reconstituting hematopoiesis. We tried CD34+ cell transplantation in two patients. Method: CD34+ cells from chemotherapy + G-CSF mobilized PBPCs or bone marrow were positively selected with an avidin-biotin immunoadsorption column (CEPRATE SC system). Case 1. One course of chemotherapy using cyclophosphamide(200㎎/㎡) and etoposide (4.2g/㎡), combined with G-CSF(5㎍/㎏) S.C. was used in a relapsed lymphoma patient. This patient responded to the induction chemotherapy. CD34+ cells from harvested bone marrow were selected by the CellPro immunoadsorption column. The total number of mononuclear cells loaded onto the CellPro was 2.4×10^(8)/㎏, with 1.1% CD34+ cells. After column separation, the total number of positively selected cells was 5.16×10^(6)/㎏. The number of CFU-GM was 76.8×10⁴/㎏. This patient was treated with melphalan (140㎎/㎡) and TBI (1200cGy) and the positively selected CD34+ cells were infused. The time to neutrophil recovery greater than 0.5×10^(9)/L was 19 days and the time to platelet recovery greater than 50×10^(9)/L was 21 days. Case 2. Two courses of mobilizing chemotherapy were given 4 weeks apart using taxol(210㎎/m2) and adriamycin(60㎎/m2), combined with G-CSF(5㎍/㎏) S.C. in a breast cancer patients with 7 axillary node metastasis. CD34+ cells from each single leukapheresis product were selected by the CellPro immunoadsorption column. In the first collection, the total number of nucleated cells was 4.4×10^(8)/kg, with 0.42% CD34+ cells. In the second collection, the total number of nucleated cell was 2.8× 10^(8)/㎏ with 0.43% CD34+ cells. After colum separation, the total numbers of collected cells were 4.0×106/kg and 4.8×10^(6)/kg, the total number of CD34+ cells were 1.2×10^(6)/㎏ and 0.82×10^(6)/㎏. Colonogenic assays of positively selected CD34+ cells gave rise to myeloid erythroid, and multilineage colonies, with a median of 190 CFU-GM, 190 BFU-E, and 164 CFU-GEMM per 1×10³ adsorbed cells, respectively. High-dose chemotherapy with cumulative doses of 40mg/㎡ mitoxantrone, 750mg/㎡ thioptepa, and 1000mg/㎡ carboplatin was administered. Positively selected CD34+ cells were rapidly infused 24 hours after the end of high-dose chemotherapy. The time to neutrophil recovery greater than 0.5×10^(9)/L was 16 days and the time to platelet recovery greater than 50×10^(9)/L was 20 days.

Detergent가 NAD의존성 α-glycerophosphate 탈수소효소에 미치는 영향

박수언,이동욱,이희성 중앙대학교 의과대학 의과학연구소 1984 中央醫大誌 Vol.9 No.3

The physical properties and the effects of detergent on the activities of purified NAD-linked a-glycerophosphate dehydrogenase(EC 1.1.1.8, GPDH) from kidney, liver and skeletal muscle of the rat were studied. The activity of this enzyme was measured by the method of White and Kaplan. The enzyme activity of liver (9.65 units/g tissue) was higher than those of other organs, but the highest value of the specific activity was shown in skeletal muscle as 0.058 unit/㎎ protein. These enzymes were purified approximately 167, 286 and 216-fold from kidney, liver and skeletal muscle, respectively, by ammonium sulfate saturation and blue dextran Sepharose column chromatography. These enzymes were composed of two isozymes which have different isoelectric points. Isoelectric points of the two isozymes were 6.5 and 6.7, and the molecular weights were 62,000 and 60,000 daltons. The UV spectrums of the purified enzymes from three organs of the rat showed very simillar pattern. But the representative compounds from three classes of detergents showed different effects on these enzymes. The enzyme of the skeletal muscle was activated by all of the detergents which were studied expect for Triton X-100, whereas the enzymes of the kidney and the liver were not activated or strongly inhibited by all of the detergents. In conclusion, the purified a-glycerophosphate dehydrogenases from the three organs of the rat were the homogeneous proteins out of consideration for physical properties. But the differences in the interaction between enzymes and detergents revealed that there are unsimilarities in the three dimentional structure between the skeletal muscle and those of other two organs inspite of similarities between the enzyme of kidney and that of liver.

Modelling and Analysis of DFB SE Semiconductor Lasers

朴東旭 弘益大學校 科學技術硏究所 1994 科學技術硏究論文集 Vol.5 No.-

본 논문에서는 2차 격자를 이용한 표면 발광 레이저의 레이징 모우드에 관한 연구 결과를 제시하였다. 결합 모우드 기법을 적용하여 종 모우드와 이에 관련된 space harmonic 횡 모우드를 분석하였고 상용되는 반도체 레이저의 실제 값을 수치 해석에 이용하여 모우드 스펙트럼 근거리 및 원거리 복사필드 패턴, 그리고 복사 효율 등의 결과를 구하였다. 기판층의 반사율, 격자의 깊이 및 모양 등의 영향도 분석하였다.

군 훈련병의 스트레스, 성인 주의력결핍 과잉행동장애 증상과 자살사고의 연관성에 관한 연구

이동윤,이철순,박철수,손진욱,김봉조,차보석,이소진 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:This study is conducted to investigate the effect of Attention Deficit and Hyperactivity Disorder(ADHD) symptoms on stress and suicide idea among 224 conscripts. Methods:Total number of subject is 224 conscripts. We evaluate symptoms of adult ADHD with Korean-Wender Utah rating scale(K-WURS) and Korean adult attention-deficit/hyperactivity disorder scale(K-AADHDS), stress with Brief Encounter Psychosocial Instrument-K(BEPSI-K), suicide idea with Scale for suicide ideation(SSI) after basic military training. Multivariate logistic analysis with backward stepwise selection is performed to evaluate risk factors of stress. Multiple linear regression analysis with stepwise selection is performed to evaluate association of suicide idea with adult ADHD symptoms. Results:Stress is significantly associated with K-WURS score, K-AADHDS score and SSI score(p<0.01, p<0.05, p<0.01). K-WURS score are significant risk factor of stress after basic military training(p<0.05, O.R : 1.034, 95% CI : 1.005-1.065). And K-WURS score influence suicide idea after basic military training(p<0.05, β : 0.031). Conclusion:The result suggests that K-WURS score might be a risk factor of stress and could affect suicide idea.

베체트병에서 보이는 혈관질환

박우일,김동익,조진현,이병붕,신성욱,도영수 대한혈관외과학회 2003 Vascular Specialist International Vol.19 No.2

Ceramic-Modified된 폴리이미드의 기계적 및 열적 물성

박영욱,이동성 경상대학교 생산기술연구소 2002 工學硏究院論文集 Vol.2 No.-

Polyimide-epoxysilane (coupling agent) composites were reacted with silica, a condensation product of TEOS, by a sol-gel process and were then cast into films. After this procedure, the chemical characteristics, mechanical and thermal properties were measured. The study showed that silica existed in the polyimide matrix by the use of FT-IR. As a proper amount of silica was added in the polyimide matrix, the tensile strength, elongation, and toughness increased greatly. In this experiment, polyimide-30 wt% epoxysilane composite with 20 wt% TEOS had the best mechanical properties. TGA results in the nitrogen and oxygen atmosphere indicated that the char contents increased with the amount of silica. The each glass transition temperature of the polyimide-silica nanocomposites was observed at about 170-180 ℃ by the use of DSC. This approach can be a new method for low temperature thermal curing of polyimide.

AZO 투명전도막의 전기 광학적 특성에 미치는 PET 기판 표면처리 효과

박병욱,김지훈,성열문,추영배,곽동주 경성대학교 공학기술연구소 2008 공학기술연구지 Vol.15 No.-

In this paper aluminium-doped zinc oxide(ZnO:Al) conducting layer was deposited on polyethylene terephthalate(PET) substrate by r. f. magnetron sputtering method PET substrate was modified by a DBD(dielectric barrier discharge) plasma before sputtering to improve the electric and optical properties of ZnO:Al film and to increase also the deposition rate The effect of heat treatment time on the dectrical, optical, chemical and structural properties of ZnO:Al thin film were investigated experimentally The PET films modified with the DBD plasma showed a significant decrease in water contact angle The deposition rate of ZnO:Al film in the case of the plasma-treated substrate was also increased by around 2 times compared to the untreated substrate The minimum resistivity of about 28×10-3 Ω-cm and transmittance of about 83.3% were obtained under the experimental condition of 6min of heat treatment time.