기니픽 와우에서 전압 의존성 K^+ channels의 발현

강성호,김보형 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Ion channels or pumps in the membrane of eukaryotic cell respond to difference between the intracellular and the extracellular ion concentrations. They induce the electrical potential necessary develop the flow of solutes and ions. Ion channel is one of the basic structures maintaining the homeostasis to control the excitation, secretion, motility, growth and volume of cell. In particular, K^+ channel has a wide variety of sub-types and participates in signal transmission and signal spreading within the hair cells and the supporting cells. In cochlea, K^+ channel is responsible for the creation of positive endolymphatic potential and it is necessary for the sensory transduction of hair cell. However, there has been few research on the involvement of K^+ channel for the homeostasis of hair cell, due to the anatomical and physiological characteristic of stria vascularis. In this study, the expression and the distribution of voltage-dependent K^+ channels(I_K, I_A) were examined in albino guinea pigs. Results are summarized below. 1.Immunoblot analysis using antibodies against the delayed outward rectifiers(I_K) - K_V 1.1, 1.2, and 2.1 and the transient outward rectifier(I_A)-K_V 1.4 revealed the expression of theses channels in the lateral wall of the guinea pig cochlea. 2.Immunohistochemical staining with these antibodies in cochlear lateral wall revealed a strong positive response in the intermediate cells and a weak positive response of stria vascularis that lacks intermediate cells. These results suggest a role of K_V channels in the voltage-dependent flow of K^+ in intermediate cells, supporting the 'two-cell model' theory.

마라톤후 발생한 열사병 1례

강보승,이정훈,송형곤,송근정,정연권 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Heat stroke, a medical emergency, occurs when the body's thermal regulation is upset and unable to dissipate adequate amounts of heat with a rise in body temperature. It is characterized by hyperpyrexia, with a core temperature of 40˚C or more. hot dry skin, and central nervous system disturbance and usually results in rhabdomyolysis and multiorgan failure. Our case, a 43-year-old healthy male, was caused by a marathon, half course, on a sunny day in late summer. He suddenly fell down on the road and was delivered to a nearby hospital, where a seizure developed. He was transfered to our hospital and then displayed Central Nervous System disturbance, hot dry skin, acute liver failure, rhabdomyolysis, anurlc acute renal failure, and disseminated intravasculular coagulopathy. He was treated with general supportive care and hemofiltration. Despite the aggressive management, he died of shock on the fifth day after admission.

천측두 동맥류 1예

강성호,임대준,김동욱,김보형 건국대학교 의과학연구소 1998 건국의과학학술지 Vol.8 No.-

Superficial temporal artery aneurysm is a rare entity, which is related to blunt trauma. It was diagnosed with history, physical examination and CT or angiography. Aneurysm is simply treated with excision and ligation. We report a case with review of literature.

악성 갑상선 우연종의 임상상 및 초음파 소견의 진단적 가치

강한욱,김광원,이병완,강보현,김형훈,김범진,정재훈,민용기,이명식,이문규 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.5

연구배경: 최근 갑상선 초음파 검사의 빈번한 시행으로 갑상선 우연종의 발견이 증가하고 있다. 이러한 갑상선 우연종은 임상적으로 어떻게 접근하고 치료를 해야 하는지 적지 않은 문제가 되고 있다. 본 연구에서는 직경 1.5㎝ 이하의 갑상선 우연종의 유병률, 입상적 특징 및 초음파 특성, 그리고 가장 효율적인 진단적 접근에 대해 알아 봤다. 방법: 1999년 1월부터 2000년 12월까지 삼성서울병원 내과 및 일반외과로 갑상선 결절을 주소로 내원한 1457명을 대상으로 후향적 연구를 시행하였다. 우연히 발견된 직경 1.5㎝ 이하의 갑상선 결절을 가지는 환자들에서 갑상선 결절의 촉지 유무, 갑상선 기능검사, 항갑상선 항체, 갑상선 초음파 및 미세침 흡인세포검사, 99m^Tc 갑상선 스켄, 수술 조직검사 및 병기를 검토하였다. 결과: 분석한 갑상선 결절 1475예 중 갑상선 우연종의 유병률은 13.4%(198예)였다. 갑상선 우연종에서 악성률은 28.8%(57예)으로 나왔다. 양성 및 악성 갑상선 우연종에서 나이, 성별, 갑상선 기능검사, 결절 크기에는 의미 있는 차이는 없었다. 갑상선 스켄은 갑상선 우연종의 감별에 적합하지 않았다. 갑상선 결절의 초음파 지표 점수만이 양성 및 악석 갑상선 우연종의 감별에서 초음파 지표 점수의 민감도는 88.9%, 특이도는 74.4%, 양성 예측률은 92.4%로 나왔고 진단적 정환도는 85.5%였다. 갑상선암으로 수술을 받은 50명중 stage 1은 34명, stage 2는 6명, stage 3은 10명으로 대부분의 악성 갑상선 우연종은 낮은 TNM 병기로 나타났으나, 상당수에서는 국소 침범의 소견을 보였다. TNM 병기의 3기 환자 전부는 45세 이상이였고, 주로 갑상선암의 피막 침범에 의한 것이었다. 임파절 전이는 6명의 환자에서 나왔다. 결론: 악성 갑상선 우연종은 비교적 흔히 접할 수 있는 질환이며 양성 우연종과는 임상적으로 구별이 안 된다. 악성 갑상선 우연종은 발견 당시 대부분 낮은 병기이나, 갑상선의 피막 침범 및 임파절 전이가 상당수에서 발견되었다. 갑상선 우연종의 초음파 소견은 향후의 진단 방향을 제시하는 중요한 길잡이가 될 수 있다. 초음파 지표 점수 2점 이상의 갑상선 우연종에서만 초음파 유도 미세침 흡입검사를 권장한다. Background: High-resolution ultrasonography has made the detection of asymptomatic small thyroid possible. Recent increases in the detection of incidentalomas have created a clinical dilemma on how to properly manage such incidental nodules. We investigated the prevalence, clinical and ultrasonographic characteristics, and optimal diagnostic approach toward incidentally detected benign and malignant thyroid nodules of less than 1.5㎝ in size. Methods: A retrospective review was undertaken on the 1,475 patients who had visited Samsung Medical Center, Seoul Korea between January 1999 and December 2000. The review consisted of a physical examination of the thyroid gland, thyroid function test, antithyroid antibodies, thyroid ultrasonography, fine-needle aspiration biopsy, pathology and TNA staging of the incidentally detected thyroid nodules of less than 1.5㎝ in size. Results: The prevalence of thyroid incidentalomas was 13.4% and the malignancy rate within them was 28.8%. There were no significant differences in age, sex, thyroid function test and size between the benign and malignant incidentalomas. Ultrasonographic characteristics showed meaningful diagnostic value for the detection of malignancy in incidentalomas. Most malignant incidentalomas were of a low stage. Conclusion: Occult thyroid cancers are fairly common finding. There are no clinical difference between benign and malignant thyroid nodules less than 1.5㎝; however, ultrasonographic findings can be used to decision of optimal management strategies (J Kor Soc Endocrinol 17:649∼656, 2002).

안와내벽외향골절의 비내시경적 정복술

김보형,강성호,임대준 건국대학교 의과학연구소 2003 건국의과학학술지 Vol.13 No.-

Background and objectives: High-resolution endoscopes and the advent of endoscopic instruments for sinus surgery currently provide surgeons with excellent endonasal visualization and access to the medial orbital walls. The purpose of this study was to demonstrate the reduction of medial orbital wall fractures through an endonasal endoscopic approach that allows the repair of the medial orbital wall fractures without an external incision. Materials and Method : This study was a retrospective analysis of 16 patients who underwent surgical repair of medial orbital wall fractures from March of 2000 to June of 2002. The 11 male and five female patients ranged in age from 15 to 54 years (mean, 28.8 years). These patients had undergone primary reduction of medial orbital wall fractures and were observed for at least 2 months after surgery. Result: All of 16 patients showed a complete improvement of their preoperative symptoms. There were no intraoperative or postoperative complications. Conclusion: Endoscopic reduction of medial orbit wall fracture using an endonasal approach seems to produce good results and definite cosmetic advantages.

Ehrlich 암세포에 대한 Acriflavine-Guanosine 복합제 (AG60)의 항암효과 -광학현미경적, 자기방사법적 및 전자현미경적 연구-

안의태,고정식,김형진,김상건,이경영,강종구,유보림,정영신,홍은경,한영복 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.2

급성 심근경색 후 심인성쇽의 발생에 관여하는 위험인자

전두수(Doo Soo Jeon),정해억(Hae Uk Chung),승기배(Ki Bae Seung),강동헌(Dong Hun Kang),김상우(Sang Wo Kim),김용주(Young Ju Kim),채장성(Jang Sung Chae),김재형(Jae Hyung Kim),홍순조(Soon Jo Hong),최규보(Kyu Bo Choi) 대한내과학회 1996 대한내과학회지 Vol.50 No.6

N/A Objectives: Cardiogenic shock resulting from acute myocardial infarction is a serious complication with high mortality. The early identification of patients at high risk of developing post-infarction cardiogenic shock might allow early intervention in an attempt to prevent cardiogenic shock and to reduce the mortality due to cardiogenic shock. The aim of the present study was to examine the risk factors of inhospital development of cardiogenic shock among patients with acute myocardial infarction. Methods: We studied 152patients with acute myocardial infarction who were admitted to Kang-Nam St. Mary's hospital within 24hours after the onset of chest pain and did not have cardiogenic shack on admission between March 1991 and May 1994. Clinical data of these patients were analyzed. Results: Of 152patients, 17(11.1%) developed cardiogenic shock during their hospital stay. Cardiogenic shock developed in 53% of cases more than 24hours after admission. 82.4% of patients with cardiogenic shock died whereas a 6.7% in-hospital mortality was found among patients without cardiogenic shock. Multivariate regression analysis that controlled for variables affecting incidence of postinfarction cardiogenic shock showed that independent risk factors for in-hospital cardiogenic shock were history of myocardial infarction (adjusted relative odds[RO]=5.294, 95% confidence interval[CI]=2.149 to 13.041); heart failure on admission (RO=3.344, 95% CI=1.738 to 6.432); hyperglycemia (>180mg/dl) in non-diabetic patients (RO=3.270, 95% CI=1,590 to 6.727); age over 70 year old (RO=2.912, 95% CI= 1.816 to 4.668); ST deviation over 4mm (RO=2.417, 95% CI=1.225 to 4.767); peak LDH level greater than 1600U/ml (RO=1.154, 95% CI=1.080 to 1.233). Patients with one independent risk factor had an estimated probability of 10.5% for developing inhospital cardiogenic shock; patients with two independent risk factors, 48.5%, patients with three risk factors, 65.0% patients with four risk factors, 65.7% patients with five risk factors, 67.2%. Conclusion: Of post-infarction cardiogenic shock during admission, 53% developed more than 24hours after admission. The more independent risk factors on admission for inhospital cardiogenic shock patients with acute myocardial infarction had, the more likely in-hospital cardiogenic shock developed.

The Accuracy of Radiologic Usual Interstitial Pneumonia Pattern in Rheumatoid Arthritis Associated Interstitial Lung Disease

( Bo Hyung Kang ),( Joyce S Lee ),( Brett M Elicker ),( Thomas Urbania ),( Jay H Ryu ),( Talmadge E King ),( Harold R Collard ),( Dong Soon Kim ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

Introduction: Definite usual interstitial pneumonia (UIP) pattern on high-resolution computed tomography (HRCT) is very specific, but not sensitive, for UIP pattern on surgical lung biopsy in patients suspected of having idiopathic pulmonary fibrosis (IPF). We investigated whether definite UIP pattern on HRCT was specific for UIP pattern on histopathology in patients with rheumatoid arthritis associated interstitial lung disease (RA-ILD). Methods: Two radiologists reviewed HRCT scans patients with biopsy proven RA-ILD. The radiologists categorized the HRCT scans as definite, possible or inconsistent with UIP pattern using the ATS/ERS/JRS/ALAT criteria. We also determined the sensitivity and specificity of definite UIP pattern on HRCT to UIP pattern onhistopathology. Results: There were 69 patients with RA-ILD included in this study and were collected from 3 tertiary care centers: University of California San Francisco, Mayo Clinic, and Asan Medical Center. The frequency of histopathologic UIP pattern in this cohort was 61%. Men were more likely than women to have a UIP pattern on histopathology (p 0.02). The agreement between the 2 radiologists for definite UIP pattern was 87% (kappa 0.67, p value <0.0001). The specificity of UIP pattern on HRCT for histopathologic UIP pattern was 96% (95% CI 81%-100%), with a positive predictive value of 95%. The sensitivity of UIP pattern on HRCT for histopathologic UIP pattern was 45% (95% CI 30%-61%), with a negative predictive value of 53%. Conclusion: Definite UIP pattern on HRCT in patients with RA-ILD is highly specific, but not sensitive, to UIP pattern on histopathology. This is consistent with the literature in IPF.

말단비대증 환자의 혈중 프롤락틴 수치와 면역조직화학염색과의 상관관계

강보현 ( Bo Hyun Kang ),정인경 ( In Kyung Jeong ),조덕신 ( Duck Shin Cho ),강한욱 ( Han Wook Kang ),김형훈 ( Hyung Hoon Kim ),김범진 ( Beom Jin Kim ),민태훈 ( Tae Hoon Min ),손준성 ( Jun Seong Son ),홍성노 ( Sung No Hong ),이춘영 대한내과학회 2003 대한내과학회지 Vol.64 No.2

목적: 말단비대증은 대부분 성장호르몬 분비 뇌하수체 선종에 의한 것으로 35%에서 고프롤락틴혈증이 동반된다고 알려져 있다. 저자들은 말단비대증 환자의 뇌하수체 조직의 면역조직화학염색 소견과 혈중 호르몬 수치를 비교하여 이들간에 어떠한 관계가 있는지 알아보고자 하였다. 방법: 1998년 8월부터 2001년 5월까지 말단비대증 진단 하에 뇌하수체 종양 제거수술을 받은 환자 28명(남자:여자=18:10, 평균연령: 41세)을 대상으로 하였다. 혈중 기저 성장 Background: Acromegaly occurs by excessive secretion of growth hormone and more than 99% of cases are caused by a growth hormone-secreting pituitary adenoma. Pituitary adenomas expressing multiple immunoreactivities are common. We assumed that the pituita

Two Dimensional Chloride Ion Diffusion in Reinforced Concrete Structures for Railway

Kang, Bo-Soon,Shim, Hyung-Seop The Korean Society for Railway 2011 International Journal of Railway Vol.4 No.4

Chloride ion diffusion at the corner of rectangular-shaped concrete structures is presented. At the corner of rectangular-shaped concrete, chloride ion diffusion is in two-dimensional process. Chloride ions accumulate from two orthogonal directions, so that corrosion-free life of concrete structures is significantly reduced. A numerical procedure based on finite element method is used to solve the two-dimensional diffusion process. Orthotropic property of diffusion coefficient of concrete is considered and chloride ion profile obtained from numerical analysis is used to produce transformed diffusion coefficient. Comparisons of experimental data are also carried out to show the reliability of proposed numerical analysis. As a result of two-dimensional chloride diffusion, corrosion-free life of concrete structure for railway is estimated using probability of corrosion initiation. In addition, monographs that produces transformed diffusion coefficient and corrosion-free life of concrete structure are made for maintenance purpose.