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유보림,최진욱 대한의료정보학회 2012 Healthcare Informatics Research Vol.18 No.1
Objectives: The purpose of this study is to validate a method that uses multiple queries to create a set of relevance judgments used to indicate which documents are pertinent to each query when forming a biomedical test collection. Methods: The aspect query is the major concept of this research; it can represent every aspect of the original query with the same informational need. Manually generated aspect queries created by 15 recruited participants where run using the BM25 retrieval model in order to create aspect query based relevance sets (QRELS). In order to demonstrate the feasibility of these QRELSs, The results from a 2004 genomics track run supported by the National Institute of Standards and Technology (NIST) were used to compute the mean average precision (MAP) based on Text Retrieval Conference (TREC) QRELSs and aspect-QRELSs. The rank correlation was calculated using both Kendall’s and Spearman’s rank correlation methods. Results: We experimentally verified the utility of the aspect query method by combining the top ranked documents retrieved by a number of multiple queries which ranked the order of the information. The retrieval system correlated highly with rankings based on human relevance judgments. Conclusions: Substantial results were shown with high correlations of up to 0.863 (p < 0.01) between the judgment-free gold standard based on the aspect queries and the human-judged gold standard supported by NIST. The results also demonstrate that the aspect query method can contribute in building test collections used for medical literature retrieval.
광산란법 미세먼지 계측기의 현장 적용성 평가에 관한 연구
유보림 ( Liu Bao-lin ),이충원 ( Lee Chung-won ),임효진 ( Lim Hyo-jin ),태성호 ( Tae Sung-ho ) 한국건축시공학회 2023 한국건축시공학회 학술발표대회 논문집 Vol.23 No.2
Now, there are many cases where materials are maintained at construction sites or standard construction prices are not in accordance with the applicable regulations, resulting in a lot of fine dust. Therefore, a particulate matter measurement system is applied not only to manage particulate matter at construction sites but also to reduce particulate matter .This study aims to evaluate the applicability of this particulate matter measurement system to the construction site through long-term measurement experiments using a light scattering method particulate matter measurement instrument at the construction site.
마우스 Macrophage의 IL-1 및 TNF-${\alpha}$의 분비유도에 있어서 한국산 겨우살이 추출물이 미치는 영향
윤택준,유영춘,홍은경,조영호,이석원,유보림,김종배,Yoon, Taek-Joon,Yoo, Yung-Choon,Hong, Eun-Kyung,Cho, Young-Ho,Lee, Suk-Won,Azuma, I.,Yoo, Bo-Im,Kim, Jong-Bae 한국생약학회 1994 생약학회지 Vol.25 No.2
To investigate the effect of Korean mistletoe on stimulation of macrophage, the activity to induce interleukine-1(IL-1) and tumor necrosis factors-${\alpha}(TNF-{\alpha})$ from murine peritoneal macrophage by its extracts originated from oak was examined. From in vitro analysis of the cytokines using the culture supernatants of macrophages stimulated with its extracts for 1hr, it was found that Korean mistletoe induces IL-1 and $TNF-{\alpha}$ from murine macrophage. Furthermore, both extracts of Korean mistletoes that were extracted with distilled water and 2% acetic acid exhibited a significant activity to induce two cytokines. In the stimulation for 30 min, Korean mistletoe at concentration of $1{\sim}100\;\mu/ml$ showed a significant induction of IL-1 from macrophage until 24 hrs after stimulation, showing maximal activity on $5{\sim}10\;hrs\;at\;10{\sim}100\;\mu/ml$. On the other hand, $TNF-{\alpha}$ was induced on the early period, 2 hrs, after stimulation at a wide range of concentration, $1{\sim}500\;\mu/ml$. In addition, the fraction of Korean mistletoe from 80% saturated ammonium sulphate precipitation showed a significant activity to induce both cytokines from macrophage. The present study demonstrates that Korean mistletoe contains immunoregulatory factors responsible for stimulating murine macrophage to secrete IL-1 and $TNF-{\alpha}$ which play an important role in immune responses, and suggests that the activity of Korean mistletoe to induce two cytokines is functioned by a possible independent stimulation manner.
독거 취약층 통풍 환자들의 요산강하 요법 치료지속성 연구
장유미 ( Yu Mi Jang ),김민정 ( Min Jung Kim ),유보림 ( Borim Ryu ),선지유 ( Ji Yu Sun ),문기원 ( Ki Won Moon ),신기철 ( Kichul Shin ) 대한내과학회 2023 대한내과학회지 Vol.98 No.3
Background/Aims: Irrespective of socioeconomic status, urate lowering therapy (ULT) is crucial for all chronic gout patients. We investigated the presence of missed opportunities for ULT among underprivileged patients treated at a major public hospital in Korea after a severe gout flare. Methods: We first collected information on patients admitted under the diagnosis of gout (International Classification of Diseases 10th Revision code M10) at a major public hospital from March 2011 to February 2022. De-identified patient data, including sociodemographic status, uric acid levels, list of medications, and outpatient follow-up data, were extracted. The patients were grouped into frail patients, who were living alone and were admitted to the specialized ward (SPE), and those who were admitted to the general ward (GEN). Primary endpoints were the outpatient visit rate immediately after discharge and the rate of ULT maintenance after a year. Results: Acute gouty arthritis was the chief event during admission in 136 cases. The mean (± standard deviation) age was 60.1 (± 16.1) years, and 95% of the patients were male. Only 18% of the patients were on ULT before admission. The patients were divided into the SPE (n = 25) and GEN (n = 111) groups. Body mass index in the SPE group was lower than in the GEN group (23.4 [± 4.4] and 25.1 [± 3.7], respectively, p = 0.082). The uric acid levels at admissio in the SPE and GEN groups were 9.6 (± 2.7) and 7.6 (± 2.3), respectively (p = 0.0023). After discharge, 80% and 95.5% of the SPE and GEN group participants presented to the outpatient department within 1 month, respectively (p = 0.019). ULT was continued or initiated in 85% of the patients. However, fewer patients continued colchicine for at least 3 months in the SPE group compared to the GEN group (25.0% and 43.4%, respectively). After 1 year, the SPE group had a higher rate of loss to follow-up (32.0% vs. 23.4%), higher uric acid levels (7.4 [± 3.8] vs. 6.2 [± 2.1]), and fewer ULT users (41.2% vs. 50.6%) compared to the GEN group, but the differences were not statistically significant. Conclusions: Frail patients who lived alone, even in the metropolitan area, missed opportunities for ULT and long-term gout care. Joint efforts on the part of health authorities and social workers are necessary to devise a strategy for better access and management among underprivileged gout patients. (Korean J Med 2023;98:137-143)