범불안장애 혹은 공황장애 환자에서 Mindfulness에 기반한 인지치료의 장기치료 효과 : 1년 추적관찰

윤지원,이상혁,김용우,김묘정,육근영,류미,최태규,김근향 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.1

Objectives Mindfulness-base cognitive therapy (MBCT) has been used to treat patients with depression to prevent relapse. The purpose of this study was to examine the effectiveness of Mindfulness-Base Cognitive Therapy for patients who suffer with generalized anxiety disorder or panic disorder for 1 year. Methods 19 patients with generalized anxiety disorder or panic disorder were assigned to receive MBCT for a period of 8 weeks. The Hamiltion Anxiety Rating Scale (HAM-A), the Hamilton Depression Rating Scale (HAM-D), the Beck Anxiety Inventory (BAI) and the Beck Depression inventory (BDI) were used at 0 weeks, 8 weeks and 1 year to assess the results. Results MBCT demonstrated significantly decreases on all the anxiety scale scores (HAM-A, p=0.00 ; BAI, p=0.00) and depressive scale scores (HAM-D, p=0.99 ; BDI, p=0.00). The patients who received 8-week of MBCT showed a higher remission rate (15/19, 78%) during the 1-year follow-up period. Conclusion MBCT may be effective at relieving the anxiety and depressive symptoms of patients who suffer with generalzed anxiety disorder or panic disorder for 1 year. However, further well-designed controlled trials are needed to assess the value of MBCT.

마우스에서 조합시험법에 의한 고려홍삼의 생식발생독성 평가

김미라, 박동선, 장자영, 신선희, 이예은, 백인정, 연정민, 이세라 , 남상섭, 황방연, 노재섭, 김순선, 조대현, 남상윤, 이범준, 김윤배, 윤영원 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.1

본문참조

임플란트의 collar design이 변연골과 연조직에 미치는 영향

유현상,강선녀,정창모,윤미정,허중보,전영찬 대한치과보철학회 2012 대한치과보철학회지 Vol.50 No.1

연구 목적: 임플란트 경부가 잘 설계된 경우 양호한 연조직 반응을 통해 변연골을 보존하는데 도움이 된다. 본 실험에서는 연, 경조직 경계부에 가장 가까이 위치하는 임플란트의 collar design이 변연골 변화와 연조직 반응에 미치는 영향을 동물실험을 통해 알아보고자 하였다. 연구 재료 및 방법: 2마리의 건강한 Beagle dog에 임플란트 collar design만 다른 두 종류의 임플란트(Neobiotech Co. Seoul, Korea)를 식립하였다. Collar에 bevel 을 부여한 군(Bevel 군)과 "S"자 형태를 부여한 군(Bioseal 군)으로 나누어 마리 당 7개, 군당 7개, 총 14개의 임플란트를 무작위로 식립한 후 Healing abutment를 즉시 체결하였다. 디지털 표준구내 방사선사진을 이용해 4주 간격으로 총 12주간 근원심 변연골 변화를 관찰하였고, 12주에 희생하여 조직학적 분석을 통해 협설 변연골 흡수 및 임플란트 주변 연조직 반응을 평가하였다. Mann-Whitney test를 통해 동일한 방사선 사진 촬영 시점에서 근원심 변연골 변화량 및 조직계측치를 군 간 비교하였고, Kruskal-Wallis test를 통해 방사선 사진상 근원심 변연골 변화량이 시간에 따른 차이가 있는지 군 내 분석 한 후 Duncan test를 통해 사후 검증하였다(α=.05). 결과: 방사선학적 분석 결과 각 촬영 시점에서 두 군간 근원심 변연골 변화량의 차이를 보이지 않았다(P>.05). 군 내에서 시간에 따른 근원심 변연골의 흡수량을 분석한 결과 Bevel 군에서는 시간에 따른 차이를 보이지 않았으나 (P>.05), Bioseal 군에서는 시간에 따른 차이를 보였으며, 4주및8주와 비교했을 때 12주에서 변연골의 증가를 보였다(P<.05). 조직학적 분석 결과 협설측 변연골 흡수량에서 두 군간 차이를 보이지 않았으나 (P>.05), Bevel 군에 비해 Bioseal 군에서 더 견고한 결합조직부착을 관찰할 수 있었으며, 생물학적 폭경의 값은 두 집단 간 차이를 보이지 않은 반면에 (P>.05), 접합상피부착은 Bevel 군에서 유의하게 길었고, 결합조직부착은 Bioseal 군에서 더 길게 나타났다(P<.05). 결론: Bevel 군에 비해 Bioseal 군에서 결합조직부착은 길게 형성된 반면에 접합상피부착은 더 짧게 나타났으며, 생물학적 폭경과 초기 변연골 흡수에는 차이가 없음을 알 수 있었다. 연조직 반응의 차이가 실제 기능하중 하에서 변연골 변화에 미치는 영향에 대해서 향후 연구가 필요할 것으로 생각된다. PURPOSE. The purpose of this study was to investigate the effects of implant collar design on marginal bone change and soft tissue response by an animal test. MATERIALS AND METHODS. Two types of Implant (Neobiotech Co. Seoul, Korea) that only differs in collar design were planted on two healthy Beagle dogs. The implants were divided into two groups, the first group with a beveled collar (Bevel Group) and the second group with "S" shaped collar (Bioseal group). Standardized intraoral radiographs were used to investigate the mesio-distal change of the marginal bone. Histological analysis was done to evaluate the bucco-lingual marginal bone resorption and the soft tissue response adjacent to the implant. Mann-Whitney test was done to compare the mesio-distal marginal bone change at equivalent time for taking the radiographs and the tissue measurements between the groups. RESULTS. Radiographic and histological analysis showed that there was no difference in marginal bone change between the two groups (P>.05). Histological analysis showed Bioseal group had more rigid connective tissue attachment than the Bevel group. There was no difference in biological width (P>.05). Bevel group showed significantly longer junctional epithelium attachment and Bioseal group showed longer connective tissue attachment (P<.05). CONCLUSION. For three months there were no differences in marginal bone change between the Bevel group and the Bioseal group. As for the soft tissue adjacent to the implant, Bioseal group showed longer connective tissue attachment while showing shorter junctional epithelium attachment. There were no differences in biologic width.

일부 大學敎授와 敎職員의 心血關係疾患 危險要因 및 健康行態에 關한 硏究

윤의성,천병철,박미숙,김순덕,염용태 고려대학교 의과대학 1997 고려대 의대 잡지 Vol.34 No.3

We reviewed the health screening record(1996) of a university to compare cardiovascular risk factors and major health behavior of teaching staffs with those of other staffs. The reviewed cardiovascular risk factors were body mass index (BMI), blood pressure (BP), total cholesterol (TCH) and fasting blood sugar (FBS). Smoking, drinking, exercise and diet habits were cheked as major risk factors. We defined the obesty (BMI>25), hypertension (systolic BP 140 or diastolic BP 90 mmHg), hypercholesterolemia (TCH 230mg/dl), and hyperglucosemia (FBS 110mg/dl) , drinking group (alcohol intake 3-4 times a week and over 1 bottle of soju a time), smoking group (smoking over 10 cigarettes a day), non-exercising group(do excercise below 3-4 times a week, and below 30 min a times), unbalanced diet group(do favor salty and spicy food or do favor flesh food). The 1,341(81.7%) of 1,640 staffs were screened in 1996, the teaching staffs were 614(69.3% of 886 teaching staffs) and other staffs (mainly clerks and administrators) were 737(97.7% of 754). 41 (6.7%) of teaching staffs were female and 166(22.4%) of the other staffs were. Among the teaching staffs, there were no below age 30 but 11.5% of them were over 60; in case of the other staffs 11.3% and 2.0% were in each age group. We divided the teaching staffs into medical staffs and non-medical staffs and compare the risk factors of each group. The total number of screened medical staffs were 92(36.2%) of 254, and non-medical staffs were 522 (82.6%) of 632. The results were follows; 1) The frequency of hypertension of each group were significantly different (7.2% in teaching staff, 11.8% in other staffs) after adjusting sex, age, smoking, drinking, exercise, and diet habits by multiple logistic regression (p<0.001). Hyperglucosemia were founded 10.5% and 12.4% in each staffs and the difference were significant after adjusting age, sex and health habits(p=0.005). Teaching staffs had more hypercholesterolemic persons than other staffs(24.3%, 16.3% in each staffs, p=0.019). Obesity frequency was not significantly different. 2) The number of drinking group were 114(18.6%), 208(28.3%) in each staffs, and this difference were significantly different (CMH=38.295, p=0.001). The number of smoker were 140(22.8%) and 274(37.2%) (CMH=58.109, p=0.001). The frequency of non-exercising group and the frequency of unbalanced diet group were not significantly different. 3) The frequency of obesity were 39.1% and 30.9% in each medical and non-medical staffs (CMH=4.414, p=0.036), but this difference remains non-significant after adjusting by the health habits. The frequency of hyperglucosemia of medical staffs (17.4%) were significantly higher than non-medical staffs (9.2%) after adjusting age, sex and the health habits (p=0.0005). Other risk factors were not significantly different. 4) Medical staffs had more smoker(29.4%) than non-medical staffs(21.5%) (CMH=6.401, p=0.011) and more non-exercising persons (27.2%) then non-medical staffs(11.1%) (CMH=12.446, p=0.001). Other health behaviors are not significantly different.

냉기 치료에 따른 둔근에서의 피부 및 근육내 온도 변화

정우성,김미정,박시복,이상건,김영호,양길태,장윤희 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.2

저체중 또는 과체중 청소년에서 캠프 프로그램을 이용한 영양 교육효과에 관한 연구

성미경,승정자,류화춘,박재년,박동연,최미경,조경옥,최선혜,이윤신,김유경,이은주 대한지역사회영양학회 2003 대한지역사회영양학회지 Vol.8 No.4

This study was performed to evaluate the effectiveness of a nutrition education program developed for nutritionally imbalanced adolescents. A summer nutrition camp was held for 23 overweight and 16 underweight subjects. Its effectiveness with regard to was evaluated at the end of the camp and 6 months later. Nutrition knowledge, nutritional attitude, food behavior, nutrient intake, exercise habit and ideal body figures desired by the subjects. The results showed significantly higher nutrition knowledge scores at the end of the camp as compared to those obtained prior to the camp program, and these scores were maintained for at least six months. Nutrition attitude scores also improved after the education program, and these improved scores also lasted for 6 months. However, the food behavior scores measured 6 months after the education program were not significantly different from those obtained prior to the camp. Also, the exercise habit, the ideal body figures and the body figures desired by the subjects remained unchanged. When nutrient intakes of subjects were assessed before the program and 6 months later, the mean daily vitamin C intake was significantly increased after the education program. Also, the intake of iron from plant food sources increased in the overweight subjects, while less iron from animal source were consumed by the underweight subjects. Both groups tended to consume more vegetables and fruits 6 months after the education program which may have contribute to the higher vitamin C and plant-based iron intakes. These results indicate that a 4-day nutrition education camp program sustained changes in nutrition knowledge and nutrition attitude for 6 months. The increased intake of vegetables and fruits was also achieved through this education program. However, changes in dietary behavior in adolescents may require repeated education.

돼지 신장세포(PK15)의 이종이식 거부반응에 대한 재조합 IL-18의 영향

최연실,김은미,김영관,박상연,심정현,윤도영,강형식,명평근 충남대학교 생물공학연구소 2004 생물공학연구지 Vol.10 No.1

Various cytokines including IL-1β, IL-2, IL-4, IL-10, IL-12p40, IFN-γ, and TNF-α have been recently reported to play important roles in both host and donor cell activations during xenotransplantation. Interleukin (IL)-18, a proinflammatory cytokine, can induce IL-4 and IL-13 production in T cells, NK cells, B cells, mast cells, and basophils. IL-18 has the capacity to stimulate innate immunity and both Th1-and Th2- mediated responses, but little is known to involve in the xenograft rejection. In order to investigate the role of IL-18 in xenograft rejection, we transplanted the pig kidney (PK15) cells to C57BL/6 mouse with or without intraperitoneal injection of mouse recombinatant IL-18. It was analyzed the population of T cell, B cell and NK cell in the mice transplanted with PK 15 cells and recombinant IL-18 by flow cytometry. We found that splenic CD3+ T cells were increased in mice injected PK15 cells with recombinant IL-18. These results suggest that recombinant IL-18 is critical in the xenograft rejection by increasing T cell population of the recipients.

유기용제 사용 소규모사업장의 체계적 건강관리 프로그램 개발에 관한 연구1) : 신경행동학적 검사법의 적용 가능성 Application of Neurobehavioral Core Test Battery(NCTB)

한상환,하미나,권호장,윤덕로,조수헌 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.2

It is known that there appear some nonspecific and delicate changes in neuropsychiatric aspect on the workers when they are exposed for a long period to low concentrated organic solvents in the work places. Therefore, it gives rise to the necessity of developing a program for the health supervisor stationed in the work place to supervise these neurobehavioral health affection. In addition to the questionnaire posed to the workers exposed to organic solvents, the study team conducted NCTB(Neurobehavioral Core Test Battery) respectively on an exposed group and a non-exposed group to organic solvents. The study team compared the results and decided whether or not to apply the results to the evaluation program of health affection. The study team divided 132 workers in 6 car repairing factories and 2 textile printing factories into exposed group and non-exposed group, pairing them off into 66 research objects according to their age, sex, and job. Neurobehavioral test was conducted on 6 items, except the POMS test, of NCTB developed by the World Health Organization(WHO). The study team conducted examinations of working environment on the exposed and non-exposed groups of each work place. The analysis of the collected materials for examinations were conducted with GC-MS. The concentration of the mixture in the air, relative to their respective threshold limit values(TLV) was calculated according to the formula of the ACGIH and the Korean threshold limits. The results indicated that for two of eight factories samples the recommended concentration limits for mixtures was exceeded. Of the six tests, the 'digit span forward', 'digit span backward' and 'digit symbol' produced conspicuous statistical differences between the two groups(p<0.1) as a result of compairing the test values by means of paired t-test. The results of respective analysis of the car repairing factories and textile printing factories revealed that the textile printing factories had greater differences between the exposed and the non-exposed than in the car repairing factories. It is presumably because the textile printing workers are continuously exposed to the organic solvents during working hours, whereas the car repairing workers are exposed only when they are doing painting works, The NCTB is assessed very useful in examining the neurobehavioral health affection under the exposure to organic solvents, and, therefore, the study team expects that the NCTB will play an important part in the course of developing a health program for the workers exposed to organic solvents.

거주자 평가를 통해 본 담장 허물기 사업 : 성동구, 관악구, 구로구의 사례를 중심으로

노윤미;신경주;장상옥 한양대학교 2010 韓國 生活 科學 硏究 Vol.30 No.2

The wall removal campaign was being held to exam its impact on living quality for tenants. From this study we tried to prove what are achievements and positive effects from the campaign through out the surveys and opinions from tenants. It will guide the campaign to the better direction to support housing plan. The conclusions from the study are as follows. (1) The level of satisfaction had been increased on safety sanitation, convenience, amenity aesthetics and sociability after the campaign.. (2) The high level of satisfaction refers positives changes on light dust, ventilation, clean environment, larger space on street, parking lots, and car accessibility to house. But they did not satisfy on security, privacy, noise, vibration, indoor air pollution, use of yard space, inconvenience of laundry space, disvalued of property, pre-facilities, independent operation, and reflection of their response when it planed. (3) Survey shows that the percentage of agreement on the campaign was low before it executed, but the percentage gets doubled after it. (4) About fifty percent of total tenants disagreed on this campaign. Although the percentage of disagreements got lower after the campaign.

콩 미이라병의 유전적 분리

엄상미,윤홍태,김용호 순천향대학교 기초과학연구소 2003 순천향자연과학연구 논문집 Vol.9 No.2

Phomopsis seed decay (PSD) is a major fungal disease found in most soybean production areas of the world. PSD significantly reduces soybean yield and seed quailty, particularly when soybean plants are exposed to high humidity and high temperature during maturation. To certificate genetic segregation ratio for PSD, PI 417479 line(resistant) and Hwaeomputkong(susceptible) were crossed and examined their inheritance mode. Experiment was conducted at glasshouse of Soonchunhyang Univ., in Korea. Different PSD seed infection levels were induced in soybean seeds by artificially infected plants exposing to above 95% relative humidity and 30˚C. A sample of seeds harvested from inoculated plants was analyzed to determine percent PSD incidence. The patterns of resistant response between Hwaeomputkong and PI 417479 were different in their seed and pod shape. The F₁plants of the resistance is governed by the two dominant genes. This results indicate that a resistance to PSD is controlled by complementary genes.