한국인 관상동맥의 변화양상에 대한 형태학적 연구

권태정,이상용,이한영,고영창,권기석,조재홍,김태공,김유훈,조갑래,서중석,이원태 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

매크로/마이크로 레벨 볼트 결합 구조물에서의 실험적/해석적 방법을 통한 시스템 특성 비교

김봉석,이성민,이문구,이수훈,Jun Ni,송준엽,이창우,하태호 한국공작기계학회 2006 한국공작기계학회 추계학술대회논문집 Vol.2006 No.-

As the micro technology and miniaturization of a structure and component in the last couple of decades have been concretely realized, the understanding of structural and dynamic characteristics and prediction of dynamic behavior are indispensable to the miniaturized structures and micro machines. This paper shows the effect of dynamic characteristics in bolt-jointed structures by comparing natural frequencies and mode shapes between macro and micro-scale beams through experimental modal analysis and finite element analysis with a1 8 test models by materials, by size, and by joining condition; that is, SS41 and A16061-T651, micro and macro, and monolithic beam and bolt-jointed beam.

Toluene, Xylene, Trichloroethylene 투여가 흰쥐의 시상하부와 뇌하수체의 GnRH, GnRH Receptor, Pit-1 유전자 발현에 미치는 영향

기노석,이종태,강대성,김대환,이채관,이헌,전진호,김정호,이채언 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.2

The workplace exposure of chemicals has steadily increased, therefore the concern for subsequent effect on reproductive outcome has been an important issue in occupational medicine. In previous studies, higher rates of spontaneous abortion, reduced fertility and menstrual disorder among women, and an impairement of sperm quantity and quality among men have been associated with a wide variety of chemical agents. This study was conducted to evaluate the effects of toluene, xylene and trichloroethylene(TCE) injection on the mRNA levels of GnRH, GnRH receptor and Pit-1 genes in male rats hypothalamus and pituitary and the effects on the plasma levels of FSH, LH, prolactin and testosterone. Sprague-Dawley male rats were divided into five groups of five each according to concentration of toluene, xylene and TCE. The rats were injected subcutaneously to 0, 50, 100, 200, 400 mg/kg body weight/day of toluene, xylene and TCE, respectively for 6 days. Rat brains were excised and hypothalamus and pituitary were separated. Reverse transcription-polymerase chain reaction (RT-PCR) and RNase protection assay(RPA) were used to evaluate the GnRH, GnRH receptor and Pit-1 mRNA levels. Plasma concentrations of FSH, LH, prolactin and testosterone were assayed by radioimmunoassay(RIA). The results were as follows; 1. GnRH, GnRH receptor and Pit-1 mRNA levels in toluene and xylene injected groups, and GnRH receptor mRNA levels in TCE injected group were lowered dose-dependently. Especially, GnRH receptor and Pit-1 mRNA levels in 200mg/kg of toluene injected group, and GnRH, GnRH receptor and Pit-1 mRNA levels in 400mg/kg of toluene injected group were significantly lower than control group (p<0.05). GnRH receptor and Pit-1 mRNA levels in 400mg/kg of xylene injected group, and GnRH receptor mRNA levels in 400mg/kg of TCE injected group were significantly lower than control group(p<0.05). 2. The plasma levels of prolactin and testosterone in 400mg/kg of toluene injected group, and LH in 100, 200 and 400mg/kg of xylene injected group, and testosterone in 400 mg/kg of TCE injected group were significantly lower than control group(p<0.05). In conclusion, we speculated that toluene and xylene affected reproductive system secondarily through hypothalamus-pituitary axis, and TCE affected directly through steroidogenesis. And we recommended that further study for assessment of the reproductive toxicity of mixed organic solvent exposures should be conducted.

일 간호대학의 간호환경시스템 통합실습방안 적용 : 간호관리학과 지역사회간호학의 통합

김광숙,이경자,김의숙,이정렬,김인숙,이태화,조윤희,정제인,이현정,배선형,김은현 대한간호학회 간호행정학회 2008 간호행정학회지 Vol.14 No.1

Purpose: Integrated curriculum has been considered as a desirable method in health related school course. The present study was conducted to develop practice curriculum which integrates nursing management and community health nursing and measure the education effect. Method: Literature review and scores of professional meeting were carried out to generate main educational goals, contents, operating principle, and evaluation item. Student evaluation was done by survey and in-dept interview in right after practicum and three months respectively. Results: Six concepts were derived as main component of the integrated curriculum. From 2 to 3 sub-categories were matched to each main component as well. Subsequently, practice contents were suggested on the basis of sub-categories. Attainment of practicum goal scores ranged from 2.82 to 3.54 in four points index. Students expressed that they found nursing manager's role in the community setting. Conclusion: This new approach encouraged students to ascertain relationship between hospital oriented and community based practice. Additionally, they can be prepared to comprehend diverse health care environment.

Monocyte Chemoattractant Protein-1[MCP1] -2518 유전자 다형성과 주요 우울장애

배치운,이지현,신윤경,김태석,김정진,이창욱,이수정,전태연,이철,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Object : This study was designed to examine the association between monocyte chemoattractant protein-l (MCPl) -2518poly morphism and major depressive disorder (MDD). Methods : Ninety patients with MDD and 114 healthy controls participated in this study. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method. Results : Genotype and allele distributions in patients with MDD were significantly different from those of the controls, In particular, subjects with the allele A were found to have an increased risk of MDD. Conclusion : The present study suggests that the MCPl -2518 polymorphism may have a potential role for susceptibility to MDD in the Korean population and thus calls for consecutive studies in order to pile up the data with larger different ethnic background.

양극성 장애와 Monocyte Chemoattractant Protein-1 유전자 다형성

배치운,김태석,장우영,김정진,이창욱,이수정,전태연,이철,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5

Objectives : Several studies suggested that cytokines could be involved in the pathogenesis of mood disorders, while data for bipolar disorder is relatively deficient (BD). BD, Knowned to have a inherited tendency, has been considered to be related with T-helper cell system. This study was designed to investigate the association between polymorphism of monocyte chemoattractant protein-1 (MCP1) gene at promoter-2518 and BD. Methods : Patients with BD (n=92) in accordance with DSM-FV criteria and control subjects (n=114) participated in this study. DNA was extracted from whole blood and the MCP-1 gene promoter region was amplified by polymerase chain reaction-based method. Results : Genotype and allele distributions in patients with BD were not different from those of control subjects (p=0.587 ; p=0.384). Genotype and allele distributions in accordance to presence or absence of suicide attempt (p=0.423), family history (p=0.733) and psychotic feature (p=0.436) were not different between the two groups. Conclusion : Present study suggests that the MCP1 promoter -2518 polymorphism may not affect the susceptibility and clinical diversity of the development of BD.

치과 기공사들에게서 나타나는 호흡기 증상과 이의 관련 요인

김웅철,오세윤,김지환,김진완,이준석,이가영,이세훈,유진호,김태석 高麗大學校 倂設 保健大學 保健科學硏究所 2001 保健科學論集 Vol.27 No.1

This study was carried out to investigate subjective respiratory symptoms and their attributable factors in Korean dental laboratory technicians. A questionnaire was mailed to randomly selected 1,900 dental laboratory technicians. Among them, 1,344 dental technicians completed the questionnaires and returmned them. Validity and reliability tests on the questionnaires were carried out before the main survey. To investigate risk factors on respiratory subjective symptoms, we performed analysis on distribution of characteristics, and then investigated univariate analysis and multiple logistic regression analysis. The prevalence rate of wheezing, cough and phlegm, and dyspnea was 4.8%, 33.9%, 54.9%, respectively. Statistically significant factors inducing subjective respiratory symptoms by multiple logistic regression analysis were sex, smoking, exercise, health examination, work hours a day, investment gas, investment dust, metal fume, resin vapor, and asbestos dust. Considering the results above, it seems that most subjective respiratory symptoms are related with health habits and occupational environmental-related factors. The result, consideration in mind, suggest that health promotion programs for smoking cessation, regular health examination, and physical exercise in health habit, and improvement on casting and resin work in dental technological environment be necessary.

중국 연변지역의 조선족과 한족의 의식구조 비교

李將鎬,朴泰洙,魯錫練 서울대학교 사회과학연구소 1996 社會科學과政策硏究 Vol.18 No.2

PbZrO₃첨가에 의한 PZT의 입계이동

이호용,김재석,허태무,이종봉 선문대학교 1998 공과대학논문집 Vol.1 No.1

미세연마된 Pb(Zr_(0.52),Ti_(0.48))O_(3)(PZT) 소결체에 PbZrO_(3) 입자들을 뿌리고 900℃에서 1200℃ 사이에서 각각 3시간씩 열처리 하였을 때, 뿌려진 PbZrO_(3) 입자 주위에서 빠른 입자성장과 화학불안정에 의한 입계이동이 일어났다. 1100℃에서는 물결모양의 입자들이 관찰되었고, 1200℃에서는 1100℃?비하여 길쭉하고 큰 입자들이 관찰되었다. 물결모양의 입자들 중에서 입계이동 부위를 조성 분석한 결과 입계이동부위에서 Zr/Ti 비가 약 1.35 정도로 입자 내부보다 높게 나타났다. 이 결과로 PbZrO_(3)가 PZT의 입계를 통하여 확산되면서 입자성장과 화학불안정에 의한 입계이동을 유발하였다는 것을 알 수 있었다. When PbZrO_(3) particles were scattered on polished surfaces of sintered Pb(Zr_(0.52),Ti_(0.48))O_(3) and annealed at temperatures between 900℃ and 1200℃, fast growth of PZT grains and chemically induced grain boundary migration (CIGM) occurred near scattered PbZrO_(3) particles. At 1100℃, corrugated grain boundaries were the most offer observed. In the region swept by a moving grain boundary, Zr/Ti ratio was about 1.35 which is higher than inside PZT grains. This shows that Zr ions diffused along grain boundaries from scattered PbZrO_(3) grains and then CIGM was induced by alloying of Zr in PZT grains

FENCING선수 SABRE, FOIL의 공격에 대한 연결성 및 포인트 정확성에 관한 비교 연구

李根培,崔太錫 韓國體育大學校 1985 論文集 Vol.8 No.-

The result of our investigation about fencing player's (Sabre, Foil) comparative chart of Offensive extension, point accuracy, accuracy of moving point, 14M distance measurement, and 8M time measurement, are as follows. A. The fente times of sabre was 17.9 and the point was 129.3. And the fente times of foil was 18.2 and the point was 148.6. So, Foil players were more excellent than Sabre players in accuracy. B. In moving point accuracy measurement, sabre players marked 11.8 times 85 point after 20 sec. marches fente. and foil players marked 12.6 times and 96.2 point. As a result, Foil players were more excellent than sabre players in both times and point. C. In 14M distance measurement (offensive extension), Sabre players marked 157.7M and foil players marked 155.7m. And so, Sabre players were better than foil players. D. In 8M speed measurement (sec), sabre players marked 48.27 sec. and foil players 47.8 sec. As a result, foil players were a little better than sabre players. Considering above result, new development of technique and improvement of physical strength and needed urgently.