위절제술 환자의 표준진료지침 개발 및 적용 효과

김은희,김철규,이순교,김순덕,이혜옥,권정순,이경미,이민미,심순미,유용만,신종식,강은희,이상일,김병식,오성태,육정환,박수길 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.2

Background : Gastric cancer is the most common malignant tumor in Korea. surgical operation is one of the major treatment modalities for gastric cancer patients. Therefore, gastrectomy is one of the most common procedures in General Surgery. There were variation in length of hospital stay and medical treatment for gastrectomy between three surgeons at Asan Medical Center. Clinical pathways have received considerable attention as a tool for recucing the medical practice variation, increasing the efficiency of care process, and improving the quality of care. The aim of this study was to evaluate the effect of a clinical pathway for gastrectomy in gastric cancer patients. Methods : The clinical pathway for gastrectomy was developed and implemented by a multidisciplinary group in Asan Medical Center. A computerized clinical pathway program was developed and revised after a pilot test. A total of 145 patients underwent gastrectomy by three surgeons at Asan Medical Center. We compared the length of hospital stay, patient satisfaction, and unplanned readmission rate between the pre-pathway group(n=67) and the post-pathway group(n=78). We also investigated the degree of satisfaction among the physicians and nurses who were main end-users of the clinical pathway. Results : The clinical pathway was applied to all target patients. The average length of hospital stay was shortened from 12.7days to 10.6days(p<0.01). The degree of patient satisfaction with the care process changed from 90.3% to 89.2% after the implementation of the clinical pathway, but the difference was of satistically significant(p=0.761). Unplanned readmission rate was 2.9% in the pre-pathway group. More than 90% of physicians and nurses answered that the clinical pathway had been a useful tool in their medical practice. Conclusions : The findings of the study demonstrated that implementation of the clinical pathway for gastrectomy produced substantial reduction in the length of hospital stay while improving the quality of patient outcomes. The computerized clinical pathway program can be used as one of the powerful patient management tools for reducing the practice variations and increasing the efficiency of care process in Korea hospital settings.

A Plant Breeder’s View on H5N1

Soon‐Kwon Kim 한국육종학회 2008 한국육종학회지 Vol.40 No.2

International conferences to block the spread of Avian bird flu occurred in Beijing, 2006 and others warned of the seriousness of the H5N1 strain. The meetings succeeded in generating billions of dollars from USA, EU and World Bank. Migratory birds seem to play a major role in the spread of the aggressive strain globally from Asia to Europe and Africa. Experiences of tolerance breeding of maize (Zea mays L.) for four decades against 20 biotic stresses suggest that the prime cause of the occurrence of H5N1 strain was due to the human beings’counter‐efforts against nature. Excessive use of chemicals (spray and injection) in the commercial poultry farms had created high selection pressure on virus. The new strain had mutated for survival. Attempting to eliminate the virus by chemicals for 100% control is a dangerous way to control biotic stresses. This can create more aggressive strains. A solution would be to build up tolerability of the commercial animals against the virus. Improvement of poultry cage environments and respect for nature must be integrated. Potential foes must be watched.

Increased Urinary KIM-1 and Tubular KIM-1 Expression in IgA Nephroapathy (초)

( Mi Seon Seo ),( Soon Hyo Kwon ),( Moo Young Park ),( Soo Jung Choi ),( Jin Seok Jeon ),( Hyun Jin Noh ),( Jin Gook Kim ),( Dong Cheol Han ),( Seung Duk Hwang ) 대한내과학회 2010 대한내과학회 추계학술발표논문집 Vol.2010 No.-

저해음의 비음화 : 음운론 및 음성학적 접근 Its Phonology and Phonetics

안현기,권순석,김기열 대한언어학회 2000 언어학 Vol.8 No.1

Ahn, Hyunkee, Soon-Suk Kwon, and Ki-Yeol Kim. 2000. Obstruent Nasalization: Its Phonology and Phonetics. Linguistics 8-1, 27-38. This paper discusses a Korean phonological rule, Obstruent Nasalization--i.e., an obstruent is phonologically nasalized when followed by a nasal. As is well known, this rule is productively prevalent in Korean, but not in English. Within the Optimality Theoretic framework, the difference in this phonological pattern between the two languages is well captured by means of adjusting the dominance relationship between two constraints (markedness and faithfulness constraints). This constraint-based explanation, however, doesn't suffice our question of why the phenomenon is phonetically natural in Korean, but cross-linguistically rare. To this question, we will provide one possible answer by suggesting that the markedness constraint is phonetically oriented due to a phonetic constraint on laryngeal feature juxtapositions. (Kyung Hee University)

Multiple Markers of Contrast Induced Nephropathy after the Percutaneous Coronary Intervention

Byoung-won Park,Seong Soon Kwon,Min Ho Lee,Do Hoi Kim,Min Su Hyon,Duk Won Bang 순천향대학교 순천향의학연구소 2018 Journal of Soonchunhyang Medical Science Vol.24 No.1

Objective: Contrast-induced nephropathy (CIN) frequently occurs after percutaneous intervention. Objective of this study was to investigate the usefulness of serum cystatin C, neutrophil gelatinase-associated lipocalcin (NGAL), urinary kidney injury molecule-1 (KIM-1), and interleukin-18 (IL-18) as early predictors for CIN after percutaneous coronary intervention (PCI). Methods: In 53 patients who underwent PCI were enrolled. Serum creatinine and cystatin C level were measured immediately before, and 24 hours and 48 hours after catheterization. Serum NGAL, urinary KIM-1, and IL-18 were measured immediately before, and 4 hours, 24 hours, and 48 hours after catheterization. CIN was defined as a rise in creatinine 0.5 mg/dL or 25% above baseline. Results: CIN occurred in four patients (7.5%). Serum cystatin C levels were higher at 24 hours and 48 hours in CIN patients than in those without CIN (P<0.05). Serum NGAL levels were higher at 48 hours in CIN patients than in those without CIN. Urinary KIM-1 levels were higher at 48 hours in CIN patients than in those without CIN. There were no significant markers of CIN on multi-variate analysis. Conclusion: In this study, the occurrence of CIN after PCI was 7.5%. Although there were some time-course changes in serum cystatin C and urinary KIM-1 after PCI, there was no significant predictor for CIN after PCI.

인삼 선발계통의 지역적응성 검정

Bong Jae Seong,Sun Ick Kim,Ka Soon Lee,Moo Geun Jee,Su Dong Kim,A Reum Kwon,Hyun Ho Kim1,Young Chang Kim 한국약용작물학회 2017 한국약용작물학술대회 발표집 Vol.2017 No.05

Background : For cultivation of varieties of ginseng, the pure line selection method, which is to select the best among those cultivated in farms for pedigree breeding, replicated yield trials and regional adaptation trials before registering as a new variety, is widely used. Although there are 25 registered varieties of ginseng in Korea, the quality of ginseng is declining together with the amount of harvest being decreased by 15 - 20% due to the heat injuries and diseases from the warming & abnormal climate. Thus, the needs for development of disaster-resistant varieties with better chances of surviving through high temperature, salts and disease are increasing. Therefore, this study is to cultivate disaster-resistant varieties among those selected for their disaster tolerance and salt tolerance through regional adaptation trials. Methods and Results : As a result of examining the growth characteristics of the selected 2 - 5 year old varieties used in the study, among the 5-year old crops, Goryeo 4 and Eumseong 5 showed superior growth in both above and below aerial parts, and among the 4-year old crops, Eumseong 11 and Cheonryang showed superior growth while the growth in the below aerial parts were satisfactory in the order of Cheonryang > Eumseong 10 > Eumseong 11 > Eumseong 9. Among the 3-year old crops, the most superior growth in both above and below aerial parts was observed in Eumseong 14 with the weight of the below aerial part, root diameter and taproot length at 13.8 g, 11.8 ㎝ and 6.2 ㎝ respectively. Among the 2-year old crops, Eumseong 10 showed the most superior growth in both above and below aerial parts. Conclusion : Based on the above results, Goryeo 4 and Eumseong 5 among the 5-year old crops, Eumseong 11 among the 4-year old crops, Eumseong 14 among the 3-year old crops and Eumseon 10 among the 2-year old crops showed the most superior growth among the selected varieties. The growth characteristics of both above and below aerial parts in each year will continuously be monitored.

해마 theta리듬과 pyramidal neuron의 세포내 특성과의 상관관계

권오흥,조진화,남순현,김현정,최병주,김영진,이만기 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.4

Eledctrophysiological phenomena of pyramidal cells in the CAI area of the dorsal hippocampus were recorded from and filled with neurobiotin in anesthetized rats. The electropharmacological properties of membrane as well as the cellular-synaptic generation of rhythmic slow activity (theta)were examined. The intracellular response characteristics of these pyramidal cells were distinctly different from responses of inteneurons. Pyramidal cells had a high resting membrane potential, a low input resistance, and a large amplitude action potential. A afterhyperpolarization was followed a single action potential. Most of pyramidal cells did not display a spontaneous firing. Pyramidal cells displayed weak inward rectification and anodal break excitation. The slope of the frequency-current relation was 53.4 Hz/nA for the first interspike interval and 15.9 Hz/nA for the last intervals, suggesting the presence of spike frequency adaptation. Neurobiotin-filled neurons showed pyramidal morphology. Cells were generally bipolar dendritc processes ramifying in stratum lacunosum-moleculare, radiatum, and oriens. Commissural stimulation discharged pyramidal cells, followed by excitatory and inhibitory postsynaptic potentials (EPSPs and IPSPs). The frequency of theat-related membrane potential oscillation was voltage-independent in pyramidal neurons. At strong depolarization levels (less than 30 mV) pyramidal cells emitted sodium spike oscillation, phase-locked to theta. The observations provide direct evidence that theta-related rhythmic hyperpolarization of principal cells is brought by the rhythmically discharging interneurons. Furthermore, the findings in which interneurons were also paced by rhythmic inhibitory postsynaptic potentials during theta suggest that they were periodically hyperpolarized by their GABAergic septal afferents.

PC를 이용한 2축 구동시스템개발

권순호,김교형 嶺南大學校 工業技術硏究所 1997 工業技術硏究所論文集 Vol.25 No.1

본 연구는 X-Y테이블을 스테핑 모터로 구동하여 시일드를 파렛에 적재하기 위한 시스템을 구성하는 것으로서 X-Y테이블에 조립된 파렛의 움직임을 여러경로의 시일드적재에 적용할 수 있도록 하였다. 본 연구를 통해 차분에 의한 직선제어 방식의 알고리즘을 제안하였으며, 이 알고리즘에 의해 제어되는 복잡다양한 경로를 PC에서 다운로드 받아 처리할 수 있는 시스템을 구성하여 시일드적재장치에 적용함으로써 유연생산시스템을 구현하였다. Tow axis driving system was developed to establish flexible loading system of shield which is a part of electronic equipment, on pallet. Driving of two stepping motors is accomplished by Z-80 single board microprocessors. Moving trajectories of x-y atble are developed by personal computer and downloaded to single boad through RS232C serial communication port. Developed system has shown flexible movement as expected to laad shield on pallet automatically.

전이 금속 촉매에 의한 히드록시 관능성기를 갖는 전도성 고분자의 합성

김윤희,권순기 慶尙大學校生産技術硏究所 1989 生産技術硏究所論文集 Vol.5 No.-

단량체인 4-hydroxy-4-isopropyl-1,6-heptadiyne 은 3-브로모프로핀과 마그네슘으로부터 제조된 Grignard 시약과 이소부탄산 메틸과의 반응에 의해 합성되었으며 IR 및 H-NMR 등의 분광학적 방법으로 확인하였다. 히드록시 관능성기를 갖는 단량체는 ?? 또는 ?? 계 촉매와 여러가지 조촉매에 의해 환상 중합되었으며 ??를 단독 촉매로 하여 벤젠에서 중합시켰을 때 64% 의 중합 수율을 보였다. 중합체의 구조는 분광학적 방법에 의해 확인되었으며, 고분자는 톨루엔, 클로로벤젠, 에테르, 아세톤 등 대부분의 유기 용매에 잘 용해되었고 pellet 상태에서 요오드로 도핑하였을 때 ??의 전기 전도도를 보였으며 분자량은 폴리스티렌을 표준 시료로 하여 보정하였을 때 GPC 상에서 8500 ~ 11000 의 범위에 있었다.

평판램프의 주파수 특성

김명녕,권순석,이정환 大田産業大學校 2002 한밭대학교 논문집 Vol.19 No.-

In this paper, the frequency characteristics of flat fluorescent lamp(FFL) using ultra-violet generated from gas discharge are studied. The lamp is constructed of a simple structure with insulator layer, phosphor layer, and gas gap(1.1 [㎜]). The firing voltage is decreased as the frequency is increased. It is considered that this tendency is resulted from the space charge effect due to Xe and Ar positive ions trapped in gas gap. Decreasing of uniform voltage at the region of higher drive frequency is due to the remaining space charges which are produced by preceding period. Increasing the drive frequency, the luminance is also increased because ultraviolet generated in gas gap is increased. The luminance in FFL using Xe of discharge gas is shown 2700[cd/㎡] at the operation point of 700[V_rms], 80[㎑]. Uniformity is obtained 96[%] over the entire lamp surface. Hence, the maximum luminous efficiency is obtained 5[㏐/W].