랫드에서 인체 재조합 적혈구 조혈인자, rHuEPO의 13주 정맥투여 아만성독성에 관한 연구

김형식,곽승준,천선아,박현선,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500 IU/㎏/day for a period of 13 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,500 IU/㎏ group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose-dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500 IU/㎏ groups. The spleen weight was also increased in both sexes of 500 and 2,500 IU/㎏ groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500 IU/㎏ groups. From these results, it is concluded that the no-observed adverse effect level(NOAEL) of rHuEPO is 100 IU/㎏ in rats in the present study.

남자대학생의 흡연태도와 행동에 관한 연구

강경진,김정미,민혜영,안소진,오경숙,은경희,이현,이희선,홍주미,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37

There have been so many researches about problems of cigarettes and relation of smoking and heath since 1950's and generally known that smoking is one of the worst factor of increasing disease and mortality. No matter what such many proofs about various problems of smoking have been researched, smoking rate of current male collage students has not been decreased. Besides, most of the researches about cigarette use and its addiction have been focused on the adolescent or adult women smokers or adult male, not male collage student. Therefore, the subject of this study is about smoking attitude and smoking behavior of male collage students by general features. Smoking attitude was analyzed by modifying 'Guidelines for the content of tobacco smoking surveys of the general population'(WHO, 1982). Two hundred of male collage students participated to the distributed questionnaire for one week in May. The smoking attitude was categorized into duration of smoking and number of cigarette per day(CPD), and nicotine dependency, investigated by Fagerstrom Tolerance Questionnaire(FTQ) (Fagerstorm & Schneider, 1989). All statistics were performed by procedure of SAS according to number, percentage, mean, standard deviation, and ANOVA. The results are as follows: 1. Smoking attitude level was mean 25.73±5.15 marks, ranging from 13 to 39 marks of the total 40 marks. 2. Duration of cigarettes, number of cigarette per day, and nicotine dependency were mean 5.14±2.84 years, 12.88±6.85 pieces, and 4.78±1.69, respectively. 3. Smoking attitude showed significance according to general features such as marital state and allowance, but the significance according to marital state is not valuable because the numerical difference is so big between married one and single that they cannot be compared with each other. 4. Duration of smoking was significant according to general features such as age and allowance. 5. Smoking amount showed significance the factors of age only. 6. ll1ere was no significance in nicotine dependency according to general features. As a result, smoking attitude of male collage student in this study shows moderate level. Smoking attitude and duration is significant according to allowance, and smoking amount is significant according to age. Nicotine dependency according to general features is not significant but comparing with the preceding study about adult male, male collage students in this study are respectively more nicotine-dependent than adult male smokers. In conclusion, the right allowance usage strategies and effective heath education focused on the young are needed. In addition, helpful programs and information spreading strategies are necessary for establishing higher level of smoking attitude. At last, systemic regulations in daily living for ""anti-nico-dependent"" and perspective reforming of male university student are needed for reducing nicotine dependency.

성인간호학회지 논문(1989-2000)의 내용과 경향 분석

서문자,김소선,송미순,이명선,오의금,신경림,김옥수,이숙자,이영자,오효숙,정재심,김철규 성인간호학회 2001 성인간호학회지 Vol.13 No.4

"Journal of Korean Academy of Adult Nursing" has been published since 1989 and more than 330 articles have been published up 2000. We reviewed all the articles published in this journal to analyze the contents and trend of published articles and to find out the way of improvement both in quantity and quality of studies in this area. The results are as follows : 1) Ninety percent of articles were quantitative studies. Experimental design was used in 16.1% and quasi-experimental design was adapted in 73.6% of articles. Qualitative research were 10.3% of total articles reviewed. 2) Only 5.1% of articles described theoretical framework and 73.6% of experimentally designed articles included research hypotheses. 3) Among experimental studies, only one was true experimental studie design. Eighty nine point three persent had descriptive survey method among non-experimental studies. Amog the thirty four qualitative studies, phenomenologic(73.5%), grounded theory(14.7%), and ethnographic (11.8%) design were used. 4) Most of research subject were patients and few healthy people, healthcare worker, and patient family. 5) Psychosocial data collection method which used questionnaire were 53.7% and interview. physical measurement, observation were used in 22.8%. 8.2% 5.4% of articles respectively. 6) Total number of keywords were 692, and average number of key words per article was 2.2. Health-related keyword was the most frequently used according to four metaparadigm of nursing (human, health, nursing, and environment). Environment related keyword was rarely appeared. The number and quality of nursing research in "Journal of Korean Academy of Adult Nursing" have been improved continuously. It is difficult to find out special trend or characteristics which is unique in this journal because of relatively short history of adult nursing studies. This review study was performed to analyze adult nursing studies only in the view of quantitative aspect, but it is needed to analyse qualitatively to find philosophical or theoretical trend in nursing.

Chemical Properties and Nutrient Loadings of Rainwater during Farming Season

Min-Kyeong Kim,Seong-Chang Hong,Jong-Sik Lee,Goo-Buk Jung,Soon-Ik Kwon,Mi-Jin Chae,Sun-Gang Yun,Kyu-Ho So 한국토양비료학회 2013 한국토양비료학회지 Vol.46 No.5

Recently, special attention has been given to acid rain and its problem to environment such as acid precipitation and air pollution in East Asia. In the present study, rainwater samples were collected from Apr to Nov in 2012. The samples were chemically characterized for the assessment of emission sources. Suwon and Yeoju regions, typical agricultural areas in South Korea, were chosen for study sites. Ion composition and cation-affected neutralization were determined to evaluate the contribution of cations to the acidity of rainwater. Ion and electrical conductivity between the measured and the estimated showed high correlation. The cations observed in Suwon and Yeoju were Na<SUP>+</SUP> > NH4<SUP>+</SUP> > K<SUP>+</SUP> > Ca<SUP>2+</SUP> > Mg<SUP>2+</SUP> > H<SUP>+</SUP> and Na<SUP>+</SUP> > K<SUP>+</SUP> > NH4<SUP>+</SUP> > Ca<SUP>2+</SUP> > Mg<SUP>2+</SUP> = H<SUP>+</SUP>, respectively. The anions of all sites were SO4<SUP>2-</SUP> > NO3- > Cl<SUP>-</SUP>. While the amounts of sulfate, one of the major dissolved components of rainwater, were 77.6 and 75.6 ueq L<SUP>-1</SUP> in Suwon and Yeoju, the ones of NSS-SO4<SUP>2-</SUP> (Non-Sea Salt sulfate) were 83 and 82% in Suwon and Yeoju, respectively. The comparison of observed pH values (pHobs) with the theoretical pH values (pHthe) showed that the neutralization of rain water considerably went along during the study periods. The highest amounts of rainfall throughout the year in Suwon and Yeoju were 572.3 and 484.6 mm in July, and its corresponding nitrogen loadings in Suwon and Yeoju were 5.28 and 3.50 kg ha-1, respectively. The major ion contents for crop growth with SO4<SUP>2-</SUP>, Ca<SUP>2+</SUP>, K<SUP>+</SUP> and Mg<SUP>2+</SUP> were 51.7, 5.2, 11.8 and 1.8 kg ha<SUP>-1</SUP> in Suwon and 34.2, 4.0, 4.2 and 1.1 kg ha<SUP>-1</SUP> in Yeoju.

암환자에게 제공된 다빈도 간호중재 분석 : 5개 종합병원을 중심으로

문경희,안미정,김필자,박정연,김명애,박인숙,배수현,이소정,권인각,김소선 병원간호사회 2009 임상간호연구 Vol.15 No.1

Purpose: The purpose of this study was to identify nursing interventions frequently used with cancer patients. Nursing records from 5 general hospitals for patients with stomach, liver, lung or colon cancer were analyzed. Method: A descriptive study methodology was used and nursing records for 15 patients in each disease category at each hospital, who were admitted and discharged during June 2007 were analyzed. Results: Five domains of NIC were found and the physiological(basic) domain was most frequent (31.52%). Twenty two classes of NIC were identified with risk management for safety being most frequent (22.49%). For the 119 nursing interventions identified, the most frequent was pain management with 7,827 (12.31%), followed by prevention of falls (11.76%), surveillance (6.79%) and wound care (5.12%). Nursing activities of pain management and prevention of falls were comparable to activities listed in literature on guidelines for evidence based and best practices in nursing care. Eight of the 17 nursing activities for pain management, and 9 of 14 for fall prevention were consistent with these guidelines. Conclusion: In this study, nursing interventions were found to be focused on physical care, monitoring patients' condition and education. We have to develop diverse nursing interventions and a convenient recording process.

사업장(事業場) 근로자(勤勞者)의 사상체질(四象體質)에 따른 생활습관(生活習慣), 자각증상(自覺症狀), 건강인식(健康認識)에 관(關)한 연구(硏究)

서명효,강홍구,장두섭,왕명자,차남현,김삼태,권소희,정해경,송용선,이기남,Seo Muoung-Hoy,Kang Hong-Goo,Jahng Doo-Sub,Wang Myoung-Ja,Cha Nam-Hyun,Kim Sam-Tae,Kwon So-Hee,Jung Hae-Kyoung,Song Yung-Sun,Lee Ki-Nam 대한예방한의학회 2003 대한예방한의학회지 Vol.7 No.2

The study was conducted to evaluate the difference of life style, subjective symptoms and health cognition depending on the Sasang Constitution in the industrial workers. The results were as follows ; Constitutional distribution among exposed group were Tae-eum In(38.4%), So-eum In(35.2%), and So-yang In(26.4%) and it was turned out that Tae-eum In took a higher portion of Sasang constitution than other constitutions in technician workers. 'Exercise' and 'Obesity' were found most in Tae-eum In, In So-eum In there were many 'Normal' weight and 'Having digestive disorders' were found most in So-eum In. There were no significant difference in the health cognition among the constitutions. The closer to 'normal' weight, the higher prevalence in 'having' concern about health condition and the more 'normal' condition in sleeping, the higher prevalence of 'having' self-confident in present health.

電子商去來와 各國法의 抵觸

金選二,蘇在選 법무부 2003 선진상사법률연구 Vol.- No.18

최근 인터넷의 폭발적인 보급과 함께 그것을 이용한 상거래가 급증되고 있으며 네트워크가 국경을 넘어가 세계적인 규모로 결부되고 있다. 이러한 네트워크를 이용한 거래에는 국제거래가 상당히 많은 비율을 포함하고 있다. 이러한 국제적 측면을 동반한 전자상거래를 둘러싸고 분쟁이 발생하는 경우에 국제재판관할이나 준거법의 선택 등 필연적으로 저촉법상의 다양한 문제가 발생하게 된다. 본고에서는 전자상거래에 관한 저촉법상의 여러 문제에 대하여 우리법과 일본법을 비교, 고찰하였다. 국제재판관할과 준거법에 관하여 계약과 불법행위로 나누어 양국의 제도를 살펴보았다. 우리 경우는 현행국제사법 제2조에서 국제재판관할에 대하여 - 법원은 당사자 또는 분쟁이 된 사안이 대한민국과 실질적 관련이 있는 경우에 국제재판관할을 가진다는 규정을 두고 있으나 해당 일본 법례에는 규정하고 있지 아니하다. 일본은 의무이행지의 국제재판관할에 관하여 인터넷상의 국제거래의 관계에 있어서도 당사자간에 명시 또는 묵시의 합의가 있으면 그에 따르고 합의가 없을 때에는 당사자간의 계약준거법에 의해 의무이행지의 관할이 결정된다고 하고 있다. 한국의 경우도 현실공간의 계약에 관하여 의무이행지관할을 긍정한다면 인터넷상의 계약에 관하여도 원칙적으로 의무이행지의 관할을 긍정할 수 있다고 한다. 한국의 경우 인터넷상의 전자상거래에서 불법행위가 있는 경우 불법행위지와 불법행위 결과 발생지 모두를 불법행위지로 보아 불법행위지법이 준거법이 된다. 일본의 경우도 예컨대 타인의 명예를 훼손하는 내용을 인터넷에 올리는 경우 그 손해가 생기는 것은 현실의 세계이기 때문에 그 정보가 제공된 모든 장소가 손해발생지이고 그 장소의 법이 불법행위의 준거법이 된다. 그 밖에 학설, 판례 등에 대하여서도 고찰하였다. Mit der jüngsten explosivartigen Verbreitung des Internets nehmen dieses gebrauchende Händel ebenfalls rapide zu und die Landesgrenzen überschreitende Netzwerk breitet sich in einem weltweiten Auschuß aus. Einen derartigen Netzwerk gebrauchender Handel besteht zum grossten Teil aus dem internationalem Handel. Falls ein Elektrohandel durch solch eine internationale Sicht umgeben wird und es zu einem Konflikt führt, entwickeln sich, aus der Wahl der internationalen Jurisdiktion oder des massgebenden Recht usw. unvermeidlich nach dem Widerspruchsgesetz verschiedene Probleme. Dieser vorliegende Text zieht verschiedene Probleme des Widerspruchsgesetz, den Elektrohandel betreffend und das koreanische und japanische Gesetz vergleichend, in Betracht. Nach der internationalen Jurisdiktion und dem massgebenden Recht wird es in Vertrag und unerlaubte Handlung geteilt und die Systeme beider Länder werden verglichen. Nach dem jetzigen internationalen Privatrecht mit Artikel 2 in Korea ist der Internationale Gerichtsstand bestimmt. Danach, die Faelle, in den die streitenden Parteien in einem realen Zusammenhang mit Korea steht. ist das koreanische Gericht fuer die Jurisdiktion zustaendig. Aber gibt es keine Bestimmung darueber in dem japanischen internationalen Privatrecht. In Japan, wenn eine Partei mit anderer Partei ueber den internatoinalen Gerichtsstand fuer Erfuellungsort einer Verpflichtung beim Elektrohandel vereinbart, richten die Parteien danach. Im Fall keiner betreffenden Vereinbarung wird der Gerichtsstand fuer den Erfuellungsort einer Verpflichtung nach dem massgebenden Recht zum Vertrag festgesetzt. In Korea ist es dasselbe. Wenn der Gerichtsstand fuer den Erfuellungsort einer Verpflichtung beim gegenwaertigen Vertrag anerkannt wird, wird es beim Elektrohandel anerkannt. Im Fall dass, in Korea, unerlaubte Handlung beim Elektrohandel sich ereignet, werden beide (der eine ist der Ursachenort zur unerlaubten Handlung, der andere ist der Wirkungsorts zur unerlaubten Handlung) als den Ort zur unerlaubten Handlung angesehen. Das im unerlaubten Handlung ereigneten Ort in Kraft gesetzten Gesetz ist das massgebende Gesetz. Auf dem Fall eines Elektrohandels ist dasselbe anwendbar. In Japan ist es auch gleich. z.B. wenn jemand die Ehr der anderer beim Netzwerk verletzt, bringt das Schaden bei der Ehrverletzung der anderer in der gegenwaertigen Welt. Deswegen ist es der alle Schadensort, die Ehrverletzung erlitten zu weren. Das Gesetz dieses Orts ist das massgebende Recht. Daneben werden die betreffenden Rehtssprechungen und Lehre betrachtet.

2-[(4-Cyanophenyl)amino]-3-chloro-1,4-naphthalenedione (NQ-Y15)의 돌연변이원성

김봉희,정기화,유충규,창동신,이기선,전선덕,소동수,채상호,문창규 德成女子大學校 藥學硏究所 2001 藥學論文誌 Vol.12 No.1

2-[(4-Cyanophenyl)amino]-3-chloro-1, 4-naphthalenedione (NQ-Y15) was asssayed for its genotoxic potential by using Salmonella typhimurium reversion assay and in vitro chromosome aberration test on Chinese hamster lung cells. In the Ames test, NQ-Y15 induced his+revertants of Salmonella typhimurium TA 98 and TA 1537, reaching levels twice the negative control values. But, NQ-Y15 induced only his+revertants of Salmonella typhimurium TA 1537 more than twice the control values under the condition with metabolic activation system. In the cytogenetic test on chinese hamster lung cells. NQ-Y15 showed significant chromosomal aberrations, but the incidence was significantly reduced in the presence of metabolic activation.

아미노 말단 영역 돌연변이 루마진 단백질들의 제조, 정제 및 특성 비교

김소영,최지선,우영은,이찬용 충남대학교 생물공학연구소 2009 생물공학연구지 Vol.15 No.-

The lux regulon from Photobecterium leiognathi contains the genes for bacterial bioluminescence reaction as well as the lumazine protein (lumP) and for riboflavin synthase (ribE) that are transcribed opposite direction. The fluorescent protein of lumazine protein is a riboflavin synthase superfamily and shows considerable amino acid identity with the enzyme. To characterize the amino acid in binding site of N-terminal domain of lumazine protein, the mutant proteins containing 6X-His tag system were constructed and purified. The mutated N-terminal domain of lumazine proteins containing one Trp amino acid at the different position show peculiar maximum wavelength peak in fluorescence emission.

서울 단일 지역의 Helicobacter pylori 1차 제균율과 2차 제균율의 변화

김미연,심기남,김혜인,강현주,류민선,안소영,정혜경,정성애 Ewha Womans University School of Medicine 2014 EMJ (Ewha medical journal) Vol.37 No.1

Objectives: To investigate the rate of first-line eradication and the rate of second-line eradication of Helicobacter pylori (H. pylori) from 2001 to 2010 in a single institute in Seoul. Methods: Among the 2,717 patients who received H. pylori eradication treatment from 2001 to 2010 at Ewha Womans University Mokdong Hospital, the medical records of 1,466 patients who satisfied the condition of execution of upper gastrointestinal endoscopy, positive H. pylori eradication results at 6~8 weeks after eradication therapy were reviewed retrospectively. Then the first-line and second-line eradication rates and the eradication rates according to endoscopy findings were also compared. Results: The first-line eradication rate was 77% H. pylori eradication rate for the last 5 years was continuously increasing and no sign of decline was observed even for the whole 10 years. The rates of eradication related to endoscopic findings showed statistical significance (P<0.001) of 79.8% and 70.1% each for peptic ulcer and non-ulcerative gastric diseases, respectively. Conclusion: In this study, no decrease in tendency of first-line eradication rate could be found. In addition, the patients with the non-ulcerative gastric disease seemed to show significantly lower eradication rate. This finding suggests eradication treatment may be affected by the category of gastric diseases, and careful considerations should be taken assessing the effects and needs for the H. pylori eradication treatment.