항암화학요법 관련 오심과 구토 완화를 위한 비약물요법에 관한 연구동향

소향숙,최자윤,조인숙,김영재,김지영,김애숙,김옥미,김춘심,김현오,설영애,안정옥,이애리,이영자 성인간호학회 2003 성인간호학회지 Vol.15 No.3

Purpose: Purposes of this study were to understand the current trends on complementary therapy in relieving chemotherapy-induced nausea and vomiting and to suggest the future research direction. Method: Subjects were selected on CINAHL, MEDLINE, Korean Academy Data Base from 1980 to 2001 which used nausea, vomiting, chemotherapy and complementary therapy as key words in experimental studies. Eight korean articles and twenty-one international articles were analyzed in terms of general characteristics, research methods, and types of complementary therapy. Data were analyzed by using descriptive statistical methods. Result: Since 2000, researchers have more actively used complementary therapy. In subject characteristics, mean age was 35.5 years old, 45% of the researchers were performed with high level of incidence of chemotherapy induced vomiting, 14% of them set limit of consecutive cycle during research, and 65% of them did not comment the selecting criteria of sample. About 60% of them were designed post-test only control group: 35% used INV by Rhodes, 31% used Likert scale, and 24% used VAS for dependent variable. Muscle relaxation therapy was mostly applied for relief of nausea and vomiting. Conclusion: Further studies will be needed to control extrinsic variables affecting nausea and vomiting in research design and to accumulate evidence with studies applying various complementary therapies.

신증후출혈열에 의한 신자연파열

전상준,소영석,노준,김철성,장대수 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

Spontaneous renal rupture is relatively rare. It is usually associated with benign and malignant renal tumors, vascular diseases and inflammatory disorders. however, a few patients in whom there is no apparent underlying disease are described. Recently we experienced a case of spontaneous renal rupture secondary to HFRS (Hemorrhagic Fever with Renal Syndrom) and report with a brief literature review.

HPLC를 사용한 쌀 중 잔류농약 동시분석법

최재천,이영자,김소희,최수영,최희주,정성욱,박흥재,김우성 한국환경과학회 2005 한국환경과학회지 Vol.14 No.4

A simple and sensitive analytical method based on RP-HPLC with UV detector(225 nm) and mobile phases using 0.1% phosphoric acid and acetonitrile was developed for simultaneous determination of quinclorac, bentazone, 2,4-D, bensulfuron-methyl, dymuron, capropamide, pencycuron, ethofenprox. This method was resulted in recovery of 78~ 96% with RSD 3.3~7.5%. LODs 0.12~0.84 and LOQs 0.34~1.20 ㎎/L. Calibration curves were linear with r of 0.9995~ 0.9999.

가설재해의 원인 분석과 안전성 개선방안에 관한 연구

김용수,소용성,김천학 중앙대학교 건설환경연구소 2001 環境科學硏究 Vol.12 No.2

본 연구는 통계자료를 통해 건설재해 및 가설재해에 관한 현황을 조사하고, 가설재 제조 및 임대 · 유통업체와 가설재 사용업체를 중심으로 가설재 사용실태에 대한 설문조사 및 사례조사를 실시하여 가설재 사용실태에 관한 가설재해의 원인을 파악하고 가설재해 예방에 관한 개선방안을 제시하였고, 그 결과는 다음과 같다. 1.가설재 제조 및 임대 · 유통업체의 경우 가설재 제조 및 임대 · 유통업체의 문제점은 불량 가설재의 불법유통으로 인한 가설재 제조업체의 경영악화와 영세 가설재 임대 · 유통업체의 난립으로 인한 유통과정에서의 가설재 품질저하 그리고, 가설재 성능 검정제도의 미흡으로 나타났다. 그에 대한 개선방안으로는 가설재 제조업체의 제도적인 육성, 임대 · 유통업체에 대한 허가기준 강화, 그리고 가설재 성능 검정제도의 보완과 재사용가설재의 명확한 사용기준 마련을 들 수 있다 2.가설재 사용업체의 경우 가설재 사용업체의 문제점은 원청업체의 가설재에 대한 하도급업체로의 비용전가와 가설재 반입 및 사용시 형식적인 품질검사로 나타났다. 그에 대한 개선방안으로는 가설재에 대한 비용을 설계이전 단계에서부터 계획에 포함, 전 공정에 대한 품질검사 절차의 모델화, 그리고 현재 유통되고 있는 기존의 불량 가설재에 대한 자발적인 폐기의 유도를 들 수 있다. This study aims to find the cause of temporary work accidents and suggests a improvement plan for the prevention of accidents in temporary works. For this purpose, the following research methods were used: statistical analysis of construction accidents, questionnaire survey, and a case study. As conclusions, causes of temporary work accidents were showed and a improvement plan for the prevention of the accidents in temporary works was suggested for the 2 groups: (1) temporary material manufacturers, lease and sales companies, (2) construction companies which use those temporary materials

자발성 뇌지주막하출혈 환자에서 Cardiac Troponin Ⅰ를 이용한 심근손상의 발생율

김용권,류진호,소정일,문원식,전병조,허탁,민용일 대한응급의학회 1999 대한응급의학회지 Vol.10 No.4

Background : More than 90% of acute stroke patients have measurable cardiovascular sequelae, but we have been often overlooked in formal discussions of treatment. If we estimate the incidence of myocardial injury in patients with spontaneous SAH, we may figure the possibility of cardiac dysfunction in such patients. This study was designed to investigate the incidence of myocardial injury in patients with spontaneous SAH using cardiac troponin I(cTnI). Methods : A prospective single emergency center study was performed to determined preoperative incidence of unrecognized cardiac injury in patients suffering spontaneous SAH. We include the spontaneous SAH patients who underwent serum measurements of the cardic troponin I immediately upon admission last six month period. ECG, CK, CK-MB and myoglobin were also performed at admission. We excluded the spontaneous SAH patients who had past history of myocardial ischemia and ECG abnormality. Results : Fifty-two patients(34 females, 18 males) with spontaneous SAH were studied prospectively. 18 patients(34.6% of the total study population) had cTnI level above 0.5ng/ml. ECG was performed in 52 patients and was abnormal in 15 of the 52 patients(28.8%). Conclusion : The measurement of cTnI has provided physicians with a myocardial marker that has a cardiac sensitivity for cardiac injury equal to that of CK-MB yet with greater specificity. So, cardiac troponin I is useful to estimate the incidence of myocardial injury in patients with spontaneous SAH. And we may estimate the possibility of cardiac dysfunction in such patients. This knowledge will hopefully aid in the care and improve the outcome.

입원환자 교육활동에 관한 조사 연구 : 임상간호원을 중심으로

홍춘실,소희영,김태숙 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.1

This study was made on Nurses working at the medical and surgical department at the hospitals of local National university and General hospital in Chungnam province from 1st August 1986 to 15th September 1986. We researched for knowledge and attention of the patient teaching to the variables such as level of education, length of service, level of position, working place, educational experience of the patient teaching. Results 1. Questions about knowledge of nurses' concepts for patient teaching was given in four items. The results is very significant to the variables such as level of education, level of position and working place in three items (p<0.01, Table 2-1). 2. Questions about attention of nurses' concepts for patient teaching was given in three items. The results is very significant to the level of education in three items (p<O.01, Table 2-2). 3. Questions about knowledge of nurses' concepts of plans for patient teaching was given in three items. The results is very significant to the length of service and level of position in each. two items (p<0.01) and significant in one item (p<0.05, Table 3-1). 4. Questions about attention of nurses' concepts of plans for patient teaching was given in two items. The results is very significant to the level of position (p<0.01, Table 3-2). 5. Nurses' knowledge of proper time for patient teaching is very significant to the level of education and educational experience of the patient teaching in each two items (p<0.01, Table 4-1). 6. Questions about attention of proper time for patient teaching was given in two items. The results is very significant to the level of education and length of service (p<0.01, Table 4-2). 7. Questions about knowledge of the methods for the patient teaching was given in four items. The result is very significant to the length of service and educational experience of the patient teaching in three items (p<0.01, Table 5-1). 8. Questions about attention of the methods for the patient teaching was given in two items. The results is very significant to the :length of service and working place (p<0.01, Table 5-2). 9. Questions about knowledge of content for the patient teaching was given in three items. The results is very significant to the level of education in all items (p<0. 01, Table 6-1). 10. Questions about attention of content for the patient teaching was given in three items. The results is very significant to the level of education and level of position in all items (p<0. 01, Table 6-2). 11. Questions about knowledge of the evaluation of patient response after performing patient teaching was given in three items. The results is very significant to the level of position (p<0.01, Table 7-1). 12. Questions about knowledge of the evaluation of nurses' feeling after performing patient teaching was given in three items. The results is very significant to the level of education and working place (p<0.01, Table 7-2). 13. Questions about attention of the evaluation of patient response after performing patient teaching was given in three items. The results is very significant to the level of position and level of education in two items (p<0.01), and is significant in one item (p<0. 05, Table 7-3). 14. Questions about attention of the evaluation of nurses' feeling after performing patient teaching was given in three items. The results is very significant to the level of education and level of position in two items (p<,0.01, Table 7-4).

대장암의 예후와 Apoptosis 활성

김종봉,배옥석,전소영 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 1998 Journal of biomedical laboratory sciences Vol.4 No.2

본 연구에서는 genomic DNA 전기영동과 TUNEL labeling법을 이용하여 정상대장조직, 대장암조직, 대장암인접림프절조직과 대장암환자 혈액에서 apoptosis 발현을 분석하였다. 정상대장조직 37례중 4례에서, DNA ladder가 확인되었고, 암조직은 47례중 20례에서, 림프절조직은 15례중 5례에서 나타났으며 대장암환자혈액은 7례 모두에서 발현되지 않았다. TUNEL labeling법을 이용한 조직상의 in situ apoptosis 발현은 암조직과 림프절조직에서 확인되었다. 따라서 본 연구에서는 대장암이 진행됨에 따라 apoptosis 발현비가 증가되었으므로 apoptotic index가 대장암 발현과 관련되어 있는 듯 하며 예후예측지표자로서 이용될 가능성이 있다고 사료된다. We studied on the expression of apoptosis in colorectal cancer, lymph node, their corresponding normal mucosa and colorectal cancer patient's blood by genomic DNA electrophoresis and TUNEL labeling method. From 7 cases among 37, 20 cases among 47 and 5 cases among 15, DNA ladders were expressed in normal tissues, colorectal tissues and lymph node tissues, respectively. A DNA ladder was not observed in 7 cases of colorectal cancer patients blood. In case of TUNELlabeling, we could observe TUNEL color espression in colorectal cancer and lymph node tissues. As these result suggest that apoptotic index may be associated with the colorectal cancer development, and mat be used as a prognostic indicator but further evaluations will be needed.

랫드에서 인체 재조합 적혈구 조혈인자, rHuEPO의 13주 정맥투여 아만성독성에 관한 연구

김형식,곽승준,천선아,박현선,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500 IU/㎏/day for a period of 13 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,500 IU/㎏ group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose-dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500 IU/㎏ groups. The spleen weight was also increased in both sexes of 500 and 2,500 IU/㎏ groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500 IU/㎏ groups. From these results, it is concluded that the no-observed adverse effect level(NOAEL) of rHuEPO is 100 IU/㎏ in rats in the present study.

미세절제술과 비교 유전자 보합법에 의한 각종 종양에서의 유전자 변화에 관한 연구

구선회,신소영,임춘화,전영미,이윤이,김진만 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.2

For the evaluation of oncogenesis, progression and prognosis of cancer, CGH is an important technique, because this technique is economic due to utilization of only one probe and lack of culture, screening mathod of whole genome and possibility of retrospective and prospective study. By the CGH, genornic variation of 20 breast cancer tissues, 23 stomach cancer tissues and 16 bladder cancer tissues were analyzed. The results were as followes ; 1. breast cancers The CGH results showed gains on chromosomes 8q(40%), lq(30%), 17q(15%), 20q(15%), 18q (15%), 5p(15%), and 13q(15%). The Deletions were on chromosomes 17p(45%) and 22q(20%). High-level amplifications(green/red ratio >1.5) were noted on chromosomes 1p31, iq, 3q25-qter, 5p, 7q31-qter, 8q, 9q22-qter, 10p, l1p, 11q22-qter, 12p, 12q24, 14g21-qter, 15q23-qter, 17q, 18p, 18q12-qter, 20p, and 20q. By comparison with infiltrating ductal carcinoma, the two medullary carcinomas showed high-level amplification on chromosomes iq3l, lq, 8q, 10p, 11p and 12p. 2. stomach cancers 1) Usual amplification sites of genome were lq, 13q, 17q, 20p,q. 2) 17p was the most common deletion site. The other sites of the deletion were lq, 4q. 3) In intestinal type of stomach cancer, genomic variation is more common than diffuse type. 4) In the cases of no evidence of lymph node metastasis, deletion of 17p is absent but amplification of 8q is obvious in the case of lymph node metastasis. 3. bladder cancers Common amplification of copy numbers of DNA sequences by CGH were seen at 1q, 3q, 4q, 5p, 6pq, 7p, 8q, 11q, 12q, 13q, 17q, 18q and 20pq(more than 20% of cases). High level amplification was noted at 1p32, 3p2l, 3q24, 4q26, 8q21-ter, 11q14-22, 12q15-21, 12q21-24, 13q 21-31, 17q22, and 18q22. Deletions were noted at 2q21-qter, 4q13-23, 5q, 8p12-22, 9pq, 11p13-15 (more than 20% of cases).

강원도 원주지역 초·중·고등학생의 식습관 및 섭식행동에 관한 단면연구

허혜경,박소미,김기연,김춘배,안정숙,송희영,김기경 韓國保健敎育.健康增進學會 2003 보건교육건강증진학회지 Vol.20 No.1

Purpose : The purpose of this study was to investigate the dietary habits of students in order to identify risk groups according to their Body Mass Index (BMI), and to compare the eating behavior of students in the normal range (19<I≤24) and those in risk groups (BMI≤19, 24<I≤27, BMI>). Method : 1176 elementary school students, 850 middle school students and 672 high school City, were the participants The instrument for this study was a structured questionnaire that included demographic data as well as dietary habits, and the eating behavior instrument developed by Stunkard &essick(1985) and revised by Kim &im (1997). Result : 1) As students moved up in grade level their dietary habits became more irregular and the degree that students chewed food was reduced 2) As students moved up in grade level, a greater number of the students did not eat breakfast. The reasons given were that there were not enough time before classes started(40.4%) and a lack of appetite in the morning(10.6%) in high school students. 3) As for supper, from 67.8 to 81.9% of subjects reported having regular supper. However the rest of the subjects did not eat supper because of anorexia and fear of weight gain. 4) The results identified risk groups according to their BMI showed that for elementary school students, 55.9% were in the low weight group, 5.5% in the overweight group, and 0.9% in the obese group. For middle and high school students, 40.6% and 35.5% respectively were in the low weight group, 7.4% and 6.3% in the overweight group, and 4.1% and 2.5% the obese group. 5) Comparisons of the eating behavior of students in the normal weight group with that of those in the three risk groups showed that there were significant differences in 'hunger' and 'cognitive restraint of eating' in elementary school students, and significant differences in 'cognitive restraint of eating' in middle and high school students. Conclusion : The results of this study show that management of diet in school health sholud be addressed from both the aspect of lack of nutrition and that of excess nutrition. In other words, good diet is as important for students in the low weight group as it is f3r those in the overweight and obese groups. The estatblishment of good dietary habits and eating behavior in students, by nurses and dieticians should be done by providing repeated diet education and involvement in diet counseling.