Urapidil, Labetalol의 투여가 기관내 삽관시 심혈관계에 미치는 영향

신용섭,윤석화,손수창,이원형,이정은,황원재,김만수,김영주,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

We have examined the comparative efficacy of small doses of intravenous urapidil and labetalol in blunting hemodynamic response to endotracheal intubation and surgical incision in 30 patients without cardiovascular diseases. After intravenous urapidil 0.2 mg/kg or labetalol 0.2 mg/kg anesthesia was induced with thiopental 5mg/kg. Endotracheal intubation was facilitated by vecuronium 0.15 mg/kg with priming principle and anesthesia was maintained with enflurane and nitrous oxide in oxygen. Systolic, diastolic and mean arterial pressure and heart rate were measured before administration of the drugs, 5 minute after administration, just prior to endotracheal intubation and 1, 3, 5, 10 minute after intubatin. Also the peak blood pressures and heart rate within 10 minutes after surgical incision were measured. Endotracheal intubation and surgical stimulation were associated with significant increases in blood pressures and heart rate in both urapidil and labetalol group. Comparison of the changes in systolic, diastolic, and mean artrial pressures and heart rate between urapidil and labetalol group showed no significant difference except peak systolic pressure after surgical incision. It is concluded that the pressor response to endotracheal intubation and surgical stimulation are not influenced significantly by urapidil 0.2 mg/kg or labetalol 0.2 mg/kg. However, urapidil and labetalol preloading may be similarly effective in the blunting of the increases in blood pressures with larger doses of the durgs during anesthetic induction.

퇴행성 요추질환에 대한 편측성 후방 추체간 유합술(1개의 cage를 이용한) 및 척추경 나사못 고정술

신호,김석원,이승명,주창일 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.3

Objective: The puspose of this study was to determine the efficacy of unilateral posterior lumbar interbody fusion (Hemi-PLIF) by using one cage for the patients with focal type of degenerative lumbar diseases. Materials and Methods: The authors reviewed clinical and radiologic data of 43 patients with focal type of degenerative lumbar diseases who were performed unilateral Hemi-PLIF during the period between November 2000 and June 2003. The operation procedure was unilateral hemi-PLIF using titanium cages with transpedicular screw fixation. Results: The mean follow-up period was 11.2 months. The mean operation time was 197 minutes and the average estimated blood loss was 285mL. The clinical success rate according to Prolo's scale was achieved in 89.3%. of patients and the solid bony fusion was occurred in 96.4%. There were 2 patients of postoperative complications such as superficial infection and screw malposition. Conclusion: This procedure has been found to be an effective and safe procedure with rare complication. To compared with bilateral PLIF, less operation time, less blood loss, more fusion rate is noted.

진행파를 이용한 디지탈 거리 계전기법의 고장발생각에 따른 고장거리 산출 보정에 관한 연구

정주환,서희석,김철환,신명철 成均館大學校 科學技術硏究所 1992 論文集 Vol.43 No.1

For many years digital protective methods have employed for the calculation of transient phenomena on power system networks caused by faults. This paper presents a travelling wave digital protection scheme to be used as an ultra high speed EHV/UHV transmission line relay. A detection of fault is made by a highly reliable relaying algorithm which makes use of the modal components of the voltage and currents which are caused to be superimposed on the steady state prefault power frequency components following the fault inception. Some of the potential problems and limitations associated with fault angles are achieved using correction factor. Varification of the algoithm is presented through digital computer numerical simulation using electromagnetic transients program(EMTP).

PCR을 이용한 Rat 기관지 세척액에서의 Pneumocystis carinii DNA의 검출 : 기초실험 A pilot study

김주옥,홍석철,한표성,이종진,김선영,이영하,신대환 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.1

Background: Pneumocystis carinii (PC) is a opportunistic pathogen causing serious pneumonia (Pneumocystis carinii pneumonia : PCP) in immunosuppressed patients including AIDS. Laboratory diagnosis of PCP is dependent on microscopic demonstration of the PC by using cytochemical staining or by immunocytochemical staining with monoclonal antibodies. However, these staining methods are not highly sensitive. The development of the polymerase chain reaction (PCR) has made it possible to detect very small numbers of pathogens in clinical specimens. To establish the usefulness of PCR for detection of PC DNA, We performed PCR as a pilot study. Methods: PCP was induced on Spraque-Dawley rats with prednisolone 5mg IM twice a week. Bronchial lavages, impression smears, and permanent sections were performed from the 3rd week to 7th week of cortisonized rats. PC DNA was extracted with bead beater / 10% CTAB method. Results: Impression smears showed PC cyst after the 4th week (100%, 28/28 rats), and permanent sections showed 27/28 rats. Control rats showed some PC cysts (2/7). PCR result was positive only one case among the 6th week rats (1/7), But positive 6 cases at the 7th week rats, (6/7). Among control rats. 2 cases were positive (2/7). ??This data is a pilot study for the PC DNA detection using a PCR. PCP were successfully cortisonized rats. If adequate bronchial washing technique will be used, PCR can be a sensitive for PC DNA detection.

한국인 성인형 치주염의 실험실 표식자 개발에 관한 연구

임석중,신형식,김강주,정종평 대한구강생물학회 1992 International Journal of Oral Biology Vol.16 No.2

The significance of plaque bacteria and its toxin in the etiology of various periodontal diseases has been well established. The purpose of this study is to develop laboratory marker in adult periodontitis. Five patients with adult periodontitis were examined. Bacterial morphotype was observed by phase contrast microscope. Microflora was isolated by selective and nonselective media. Data was analysed between healthy sites and disease sites by paired T-test. Wolinella recta in the disease sites was isolated more frequently than that of healthy sites and the proportion of Actinomyces in the healthy sites were higher than that in the disease sites. These results suggested that Wolinella recta in the disease sites and Actinomyces in the healthy sites might be the marker of adult periodontitis in Koreans. Further study is needed to clarify the in vitro virulence of Wolinella recta.

Bleomycin에 의한 채찍양(flagellate) 피부 색소 침착 1예

김주섭,신성욱,박석돈 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.2

Bleomycin is one of the widely-used chemotherapeutic agents. It may cause non-specific changes in the skin including stomatitis, hair loss, nail changes, inflammatory nodules, multiform erythema and vesicobullous eruptions. Cutaneous flagellate pigmentation on pressure or trauma sites is known as specific cutaneous reaction to bleomycin, although its pathomechanism is not clearly elucidated. We experienced a rare flagellate pigmentation due to bleomycin injection in a patient with metastatic testicular tumor. A 25-year-old male showed linear brown flagellate pigmentations on the trunk, axillae, dorsa of hands, which were developed after BEP(bleomycin. etoposide, cisplatin) combination chemotherapy. He underwent left radical orchiectomy and artificial testicular replacement because of metastatic testicular endodermal sinus tomor(stage D_2). Gentle rubbing or scratching on the skin caused linear brownish edema and residual pigmentation. Histopathologic finding of the pigmented sites revealed melanin pigmentation of basal cell layer and patchy pigmentation of low prickle cells. The flagellate pigmentation became paler during 7 months follow-up period. Authors report a cutaneous flagellate pigmentation after bleomycin chemotherapy.

곁순의 화학적 방제가 연초식물의 생장량에 미치는 영향

이재흥,석영선,신주식,정찬문 충북대학교 엽연초연구소 2001 煙草硏究 Vol.18 No.-

This study was carried out to compare the effects of suckercides - Fatty alcohol(FA), Maleic hydrazide(MH) and Butralin - on the sucker control and growing characters of flue-cured tobacco leaves. Among the three suckercides, Butralin was treated at three different times, one day before topping, topping day and one day after topping, and at two different concentration, 1/30 and 1/60 water solution. The results are summarized as follows. Suckercide treated plot showed higher growth and weight of upper leaves than not-treated plots did. MH treated plot decreased numbers, fresh weight and dry weight of suckers compared to the other treated plots, and made the leaves shape narrow. The effect of Butralin on sucker control was lower than that of MH, but higher than that of FA. The yields when treated Butralin decreased compared to the yields when treated MH. Though there were no significant differences of yields and growing characters of leaves among the plots of three concentrations and two times of treating Butralin, it is recommended to apply 1/60 water solution of Butralin at topping time.

스티렌 현탁 중합반응에서 폭주반응 해석

박형일,신석주,이헌창,장서일,김태옥 한국산업안전학회 2002 한국안전학회지 Vol.17 No.3

The runaway reaction was analyzed experimently and theoretically at the batch styrene suspension polymerization process. In the experiments, the reaction temperature with time was measured at various experimental conditions. According to the experimental results, the risk of the runaway reaction was increased with increasing the ratio of the monomer(styrene, M) to the dispersion medium(water, W), the concentration of the initiator(BPO), and the monomer mass, respectively. And simulation results showed that the runaway reaction was significantly affected by the reaction rate constant of the propagation and that the phenomena of the runaway reaction occurred at about 70% conversion. Also, we found that the runaway reaction did not occur under the operation condition of below 0.5 for M/W, approximate 3 wt% BPO, and below 75℃ for the cooling temperature.

젤라틴에 메틸메타크릴레이트로 유화중합시킨 그라프트 폴리머의 열분해에 관한 연구

설수덕,박찬헌,신은주,왕석주 동아대학교 공과대학 부설 한국자원개발연구소 1994 硏究報告 Vol.18 No.2

Emulsion graft copolymerization with sodium lauryl sulfate(SLS) of methyl methacrylate(MMA) onto gelatin was carried out in aqueous solution by potassium persulfate(KPS) as an initiator and thermal degradation of graft copolymer was stuied using a dynamic and isothermal thermogravimetry in the stream of nitrogen gas with 60㎖/min at various heating rate from 4 to 20℃/min, and various time at 200℃ The optimun concentration on emulsion graft copolymerization of KPS, gelatin, MMA, reaction temperature and time were 12×10^(-4)㏖/ℓ, 6g, 6.3×10^(-1)㏖/ℓ, 65℃ and 4hours, respectively. The activation energy of polymerization was 17.8 ㎉/㏖. The range of activation energies of decomposition obtained using Friedman's method was between49~57 ㎉/㏖ and using Ozawa's method was between 44~52㎉/㏖. The thermal degradation of gelatin-g-PMMA is likely due to decomposition of PMMA branches dominantely.

고립성 폐결절의 조직학적 진단에 있어서 경기관지폐생검의 진단적 가치

김치훈,김정주,왕준호,연규민,김형수,리원연,용석중,신계철 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-

Transbronchial lung biopsy(TBLB) is a relatively simple and convenient diagnostic tool in solitary pulmonary nodule(SPN) on chest radiograph, which is cannot be diagnosed through routine tests. To investigate the diagnostic value and diagnostic rate of TBLB according to the variable factor, we analyzed 69 patients with radiologically SPN lesion on chest radiograph which was confirmed histologically. A histologic diagnosis of TBLB was made in 47 of 69 patients(68.1%), in which 26 of 37(70.3%) with malignancy and 21 of 32(65.6%) with benign lesion. There were no significant differences in diagnostic yield according to age, sex and location of the lesion. The diagnostic rate tended to increase with the more than 5 pieces to acquired by TBLB. When the size of SPN was less than 3 ㎝, it cannot be diagnosed. In conclusion, TBLB is a diagnostic procedure with good yield and safety, but percutaneous needle aspiration, transbronchial needle aspiration, and bronchial washing fluid cytology may be a complementary procedure to overcome the limitation of TBLB and get higher diagnostic yield for SPN.