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Flurbiprofen 함유 키토산 제제가 치은 섬유아세포에 미치는 영향
정종평,박윤정,이승진,유인철,최상묵 梨花女子大學校 藥學硏究所 1997 藥學硏究論文集 Vol.- No.6
The main goal of periodontal regeneration is to be achieved by epithelial exclusion, periodontal ligament cell activation or alveolar bone regeneration. The purpose of this study was to investigate on the physico-chemical and biological characteristics of biodegradable chitosan beads. Chitosan beads were fabricated by ionic gelation with sodium tripolyphosphate and they had the size in 300㎛ diameter. As therapeutic agent, flurbiprofen was incorporated into the beads by 10, 20% loading contents. The release of drugs from the chitosan beads was measured in vitro. Also, biological activity tests of flurbiprofen loaded chitosan beads including cytotoxicity test, ihhibition of IL-1β production, suppression to PGE_2 production, collagenase inhibition test, the ability of total protein synthesis, and tissue response were evaluated. The amount of flurbiprofen released from chitosan was 33-50% during 7 days. Minimal cytotoxicity was observed in chitosan beads. Flurbiprofen released from chitosan beads significantly suppressed the IL-1β production of monocyte, PGE_2 production and markedly inhibited collagenase activity. Meanwhile, flurbiprofen released from this system showed increased ability for protein synthesis. Throughout 4-week implantation period, no significant inflammatory cell infiltrated around chitosan bead and also fibroblast like cell types at the beads-tissue interface were revealed with gradual degradation of implanted chitosan beads. From these results, it was suggested that flurbiprofen loaded chitosan beads can be effectively useful for biocompatible local delivery system in periodontal regeneration.
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황금(Scutellariae Radix)의 에타놀추출물과 플라보노이드 성분들의 독성평가
정종평,구영,배기환 충남대학교 약학대학 의약품개발연구소 1995 藥學論文集 Vol.11 No.-
Flavonoids from Scutellariae Radix possessed a dual function both as an anti-inflammatory agent and an enhancer of cel1ular activity in gingival fibroblast. The purpose of this study was to evaluate on the toxicity of ethanolic extract from the root of Scutellariae Radix Georgi and its flavonoids, Wogonin, Baicalein, and Baicalin were isolated and purified by the following method. The crude drug was extracted with ethyl acetate and the residue was dissolved in ethyl alcohol. The ethyl a1cohol soluble fraction was separated, concentrated, and men chromatogaphed on a silica gel column. The acute oral LD 50 in rats was determined for EtOH ex. of Scutellariae Radix and three compounds were evaluated with a single oral gavage at three graded dosage levels. The acute intravenous LD 50 was determined with a single intravenous injection via the jugular vein at three graded dosage levels. Groups of 5 male and 5 female rats, 6 week of age at the start of the study, were fed diets containing 3 graded dosage leve1s for 14 days. Groups of 5 male and 5 female hamster received 0.5㎖ of the test article at once in a day for 5 days to the buccal cheek pouch for two minutes each. The acute ora1 LD50 for EtOH ex. of Scutellariae Radix is 1430㎎/㎏, and for Wogonin 1320㎎/㎏, or Baicalein 1250㎎/㎏, for Baicalin 1330㎎/㎏. The acute intravenous toxicity of EtOH ex. of Scutellariae Radix and its extracts was found to be 27㎎/㎏ body weight No toxic effects were observed in rats fed up to 200㎎/㎏ of EtOH ex.of ScutelIariae Radix, Wogonin, Baicalein and Baicalin in the diet for 14 days. The acute Mucouse Membrane LD 50 in hamsters was found to be greater than 100㎎/㎏. These resu1ts suggested that EtOH ex. of Scutellariae Radix and its flavonoids are safe for oral care products using limited amount of extract.
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