노인의 기능저하예방을 위한 표준운동프로그램 개발 및 효과검증 연구

원영신(Won young Shin),도기현(Do ki hyun),홍미화(Hong Mi Hwa),조은영(Cho Eun Young),정문미(Jung Moon Mi) 글로벌시니어건강증진개발원 2012 글로벌시니어건강증진개발원 논문집 Vol.2 No.1

본 연구의 목적은 일상생활 속에서도 누구나 쉽고 편하게 따라 할 수 있는 노인의 신체기능 저하예방 및 개선에 적합한 표준운동프로그램을 개발한 후, 그 효과를 검증하는 것이다. 연구대상은 서울시 마포구 화신경로당에 등록되어 있고, 본 프로그램에 참여한 총 36명(남성노인 10명, 여성노인 26명)의 노인으로 선정하였으며, 평균연령은 77세이다. 프로그램은 2011년 8월 19일부터 10월 18일까지 총 3개월 동안 주 2회씩 12주간, 총 18회를 실시하였으며, 안무가 1명과 보조연구원 1명이 프로그램을 진행하였다. 조사도구는 설문지로 SFT(Senior Fitness Test)를 사용하였으며, 노인 체력 테스트로 본 프로그램의 효과분석을 실시하였고 세부적으로는 상·하체 유연성, 상·하체 근력, 평형성, 민첩성 에 관한 테스트를 실시하였다. 사후검사는 프로그램 18회를 모두 진행하고 10월 18일 프로그램이 종료된 후, 사전검사와 동일한 방법으로 실시하였다. 자료처리는 SPSS Windows 15.0 version 을 이용하여 빈도분석, 대응표본 t-test를 실시하였으며, 그 결과는 다음과 같다. 첫째, 참여노인의 체력 요인에 대한 차이분석 결과, 평형성을 제외한 하체유연성, 상체유연성, 하체근력, 상체근력, 평형성, 민첩성 모든 요인에서 통계적으로 유의하게 증가하였다. 둘째, 참여노인의 신체구성비에 대한 차이 분석 결과, 체지방율과 BMI는 통계적으로 유의하게 감소하였고, 기초대사량과 근육량은 유의하게 증가하였다. 또한 체지방량은 감소하여 프로그램에 따른 긍정적인 효과가 검증되었다. The purpose of this study was to verify the effect of poor physical function of the elderly in everyday life that anyone can easily and comfortably suitable for the prevention and improvement to develop a standard exercise program after. Distribution of Hwa-Sin-dong, Mapo-gu, Seoul incarnation is registered in the senior center, was selected and a total of 36 patients (10 patients, elderly men and elderly women, n = 26) participated in this program for the elderly, the age range from 61 years to 91-year-old and the average age 77-year-old. Program for three months from August 19, 2011 10 18 in 12 weeks, a total of 18 times, twice a week was conducted by research assistant choreographer with 1 program. Research tool, a detailed questionnaire to the elderly as a fitness test this program was carried out to analyze the effects of SFT (Senior Fitness Test), the upper and lower body flexibility (right, left), upper and lower body strength, balance (right, left), agility test was conducted. Post-inspection program 18 times in the same way as the pre-test and after the program ends Oct. 18, and all proceeds were conducted. Data processing were analyzed using SPSS Windows 15.0 version to the corresponding sample t-test was conducted, and the results are as follows. First, the analysis for differences in participation in physical factors of the elderly, lower body flexibility, balance, except for lower body strength, upper body flexibility, upper body strength, balance, and agility in all factors statistically significantly increased. Second, the difference analysis results for the participation of the elderly in the Composition of the body, was a statistically significant reduction in the percentage of body fat and BMI, basal metabolic rate, muscle mass increased significantly increased. Also reduced body fat, according to the program has a positive effect was verified.

대동맥 협착증과 동반된 출혈성 위장관 동정맥 기형에서 Estrogen-Progesterone 치료 1예

김도연,김화정,김효정,남준식,박수영,박영미,신정은,주미순,황민규,정혜경,손혜영,이선영,이한주 大韓消化器內視鏡學會 1999 Clinical Endoscopy Vol.19 No.부록2

타목시펜이 간세포암 세포주의 성장과 Transforming Growth Factor-β 1의 발현에 미치는 영향

신정우,정영화,박무인,김정아,최민희,이윤정,류수형,박능화,이한주,이영상,서동진,유은실 대한간학회 2003 Clinical and Molecular Hepatology(대한간학회지) Vol.9 No.1

목적: 타목시펜을 진행성 간세포암 환자에게 투여한 결과 일부에서 효과가 있었다는 보고가 있으나 타목시펜이 간세포암의 성장을 억제하는 기전은 밝혀져 있지 않다. TGF-β1은 간세포암의 성장과 분화에 관여하는 중요한 성장인자로 알려져 있으며 최근 타목시펜이 TGF-β1의 분비조절에도 관여한다는 보고들이 있었다. 따라서 본 연구에서는 타목시펜이 간세포암의 성장과 TGF-β1의 발현에 미치는 영향을 알아보고 궁극적으로 타목시펜이 간세포암 환자에게 항암제로 사용될 수 있는지를 알아보고자 하였다. 대상과 방법: 인간 간세포암 세포주인 Hep 3B세포를 에스트로겐이 없는 RPMI 1640과 dextran coated charcoal로 처리한 5% fetal bovine serum을 혼합한 배지에서 3일 배양 후 2×10^4 세포/well로 분주하여 2일간 배양한 후 0.1 μM, 0.5 μM, 1 μM, 5 μM, 10 μM 농도의 타목시펜으로 처치하고 6일간 배양하였다. 매일 세포를 수집하여 trypan blue로 염색한 후 생존 세포수를 산출하였으며 상층액내 TGF-β1 농도는 ELISA법으로 측정하였다. 결과: 비교적 저 농도인 0.1 μM 타목시펜 처치군은 배양 6일째 생존 세포수가 대조군에 비해 의미 있게 증가하였다(2.59×10^6 vs 1.97×10^6, p<0.05). 생존 세포수는 타목시펜농도가 증가할수록 감소하여 10 μM 처치군은 대조군에 비해 의미있는 감소를 보였다(1.4×10^6 vs 1.97×10^6., p<0.05). 상층액내의 TGF-β1dml 분비량은 타목시펜 처치 농도와 상관없이 전 군에서 대조군에 비해 의미있게 감소하였으며 타목시펜 농도에 따른 각 군간에 차이는 없었다. 결론: 타목시펜은 실험실내에서 처치 농도에 따라 간세포암 세포주의 성장에 미치는 영향이 다양했으나, 처치 농도와 관계없이 일정한 정도로 TGF-β1의 발현을 억제하였다. 타목시펜의 이러한 효과는 생체에서 TGF-β1이 과발현된 간세포암의 성장과 진행을 억제할 것으로 생각된다. 또한 타목시펜은 TGF-β1의 발현을 조절하는 기전 이외의 다른 기전을 통해서는 간세포암의 성장을 억제하는 것으로 사료된다. Background/Aims: Tamoxifen has been tried in patients with hepatocellular carcinoma (HCC), however, its inhibitory mechanism remains unknown. In this study, we evaluated the effects of tamoxifen on HCC cell growth and the expression of transforming growth factor-β1 (TGF-β1) which had been known as an important cytokine in growth of HCC. Methods: Hep 3B cells were cultivated in estrogen free media with 0.1 μM, 0.5 μM, 1 μM, 5 μM, and 10μM of tamoxifen for 6 days. Viable cells were counted daily and the TGF-β1 concentrations in supernatant were measured by ELISA method. Results: The number of viable HCC cells increased rather significantly after the treatment of tamoxifen of lower concentration (0.1 μM) compared with that of the control (2.57×10^7 us. 1.97×10^7; p<0.05). As the concentration of treated tamoxifen was higher, the number of viable HCC cells became gradually less, resulting in the significant decrease of it at the highest concentration (10 μM) compared with that of the control (1.40×10^7 us. 1.97×10^7; p<0.05). TGF-β1 concentration in supernatant of tamoxifen-treated samples was significantly decreased compared with those of controls, regardless of the amount of treated tamoxifen. Conclusions: These results suggest that tamoxifen may suppress TGF-β1 expression to an extent, although it has different effects on the proliferation of HCC cells, at the various concentrations of this agent in vitro. Such effects of tamoxifen on TGF-β expression may inhibit the growth and progression of HCCs over-expressing TGF-β1 in vivo.

CSB^(+)-Tree 기반의 DTD 통합 그래프를 이용한 XML 문서 저장 시스템 설계 기법

신성현,송화선,김진호,정영준 강원대학교 정보통신연구소 2004 정보통신논문지 Vol.8 No.-

As information processing recently increases over Internet. there have been many researches about designing an efficient storage system to process a huge amount of information, which is based upon DTD in XML However, most of them have some difficulties in meaningful and structural presentation of XML documents and some restrictions in integration of many heterogeneous documents. In other word, we need a storage system which well-defines the structure of heterogeneous XML documents and integrates them. In this paper, we proposed a technique of an XML documentation storage system using DTD integration graphs based on CSB+-tree. This technique retrieves structural information from elements of XML documents, creates a CSB+-tree based DTD integrated graphs of the man storage system, and generates an integrated storage system by using element mappings. The proposed technique utilizes the man storage system more efficiently in space and provides more faster response time.

섬유강화형 포스트를 이용한 치관-치근 파절의 치료: 증례 보고

임화신,라지영,이광희,안소연,김윤희,금기석,이상봉 大韓小兒齒科學會 2012 大韓小兒齒科學會誌 Vol.39 No.1

The crown-root fracture is defined as a fracture of tooth that contains enamel, dentin and cementum with or without pulp exposure. Generally the fracture lines place obliquely from labial surface, between incisal edge of the crown and marginal gingiva, to palatal surface subgingivally. If the fracture line is located supragingivally, the removal of tooth fragment and supragingival restoration can be performed. In subgingival fracture line, the surgical exposure, orthodontic eruption or surgical eruption can be considered. If the fracture line is too deep to restorate, extraction or decoronation can be selected. In children and adolescents, the extraction should be the last option. Another option to select before extraction is the restoration using fiber-reinforced post and the reattachment of tooth fragment. The fiber-rainforced post enhances the retention and the durability of tooth fragment. The reattachment of crown fragment using resin adhesive system is considered minimal invasive treatment biologically. This case reports the treatment of crown-root fracture using the reattachment of crown fragment and the insertion of fiber-reinforced post. 치관-치근 파절은 법랑질, 상아질, 백악질이 모두 포함된 치아의 파절로, 파절선이 대부분 절단연이나 순측의 변연부 치은 에서 구개측 치은열구 하방으로 사선으로 진행된다. 파절선의 위치가 치은 연상이라면 파절편의 제거 및 치은연상 수복을 시 행하고, 치은 연하라면 파절면의 외과적 노출술, 교정적 정출술, 외과적 정출술을 이용한 치아의 수복이 이루어진다. 그 외에 섬유 강화형 포스트를 삽입하여 치관 수복물의 유지력을 높이고, 레진 접착 시스템을 사용하여 치관 파절편을 재부착함으로 써 생물학적으로 최소한으로 침습적인 치료를 하는 방법도 있다. 만약 파절의 정도가 치은 연하로 깊은 경우 발치나 치관절제 술을 이용한 치근의 유지 등을 고려할 수 있다. 본 증례는 치관-치근파절로 내원한 12세 환아로 섬유강화형 포스트를 사용하여 치관 파절편 재부착을 시행하였으며 양호 한 경과를 보여 이를 보고하는 바이다.

척수 경막에 발생한 Sarcoidosis

김영신,양기화,김병기,김선무 대한병리학회 1991 Journal of Pathology and Translational Medicine Vol.25 No.2

응급실을 내원한 구강악안면외과 안면골 골절 환자의 변화에 대한 비교 연구

신상훈,성화식,강영훈,황대석,김용덕,김욱규,김종렬,정인교 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.24

Although there have been many clinical studies about the facial trauma in the recent as well as in the past, severity and frequency of facial trauma are reported multifarious. It seemed to be because of variety of social, cultural, and environmental factors, and the view point of investigators. In this study, we investigated about the patients visiting emergency room during recent 4 years(2004-2007), and compared with retrospective study during former 10 years(1992-1996, 1999-2003) in Dept. OMS Pusan National University Hospital. We assessed the cause, type, demographic, etc, and analyzed alterations of facial bone fractures during past 3 periods. The results were as follows. The total number of patients was increased. 429 patients treated for maxillofacial fractures between January 1992 and December 1996, 466 patients treated between January 1992 and December 1996 and 764 patients treated between January 2004 and December 2007. The male-to-female ratio were 4.6:1, 3.9:1, and 4.16:1, respectively. Patient in the age groups of 10-19 years and 20-29 years increased in the latter two periods. Assaults and falls are decreased gradually, but slip down s are increased. Traffic accidents are still major cause of facial trauma. The mandibular fractures showed the highest incidence thorought three periods. Symphysis fractures of mandible was increased and condyle fractures of mandible was drecreased in the third period.

韓國 寺刹의 景觀과 植物相에 關한 硏究

申永澈,郭炳華 培材大學校 1982 論文集 Vol.3 No.-

To investigate the traditional garden style of Korean temples, 22 renown Buddhist temples diversely located throughout Korea were chosen to survey the environmental landscape and vegetation along the entering way to the gate of these temples, inner and outer garden landscape and studied with special reference to the location and function of the garden, function of the landscaping plants, tree species planted an d landscaping facilities in site. The results are summarized as follow: 1. The present Korean Buddhist temples are built and chosen proper locations as space of Asceticism in the existing landscape and nature, with a traditional influence of the orient geographical theory called "Pungsu Giri Seol" forming philosophy of Taoism, Buddhism and Korean native Shamanism. 2. Buddhism-garden concept represents the highest natural resources-topography, trees: as it stands, with special reference to philosophy of Buddhism which has the real aim of spiritual awakening and deliverance as manifested by coexistence and harmony between nature and human being with the intention of forming space Asceticism. 3. Pinus densiflora and Quercus mongolica are the most frequently found tree species and remains of the natural vegetation around the temple site, while Quercus mongolica are regarded tree species as the substituted vegetation for pinus densiflora. Zelkova serreta are also frequently seen as mixed trees with some-other species in the vegetational stand, showing a sign of major artificial vegetation. Abies hollophylla as an evergreen species, flowering Prunus yedoensis, Acer formosum var. coreannum, and few other kinds of specific deciduous tree species are also found to consist of a minor artificial vegetation. Some Chamaecyparis obtusa, Cryptomeria japonica and Sasamorpha borealis are observed only in the southern region of Korea, but Betule latifolia and Paulownia coreana in the north that is usually called the central zone, indicating the man-made stand of tree species which are specifically well adapted to the given environmental conditions. No particular design of planting arrangement is found for the establishment of the entering way to these temples. The largest trees are more·obvious along edge of the road than the outer sides, again indicating tar fact that the trees art remains of an old vegetation and planted tree which have Bong beers protected by human existence nearby. The entering way to the gate of temples, "lljumoon" shows a typical of the canopied landscape with these tree stands and always accompainies valley stream by side. These represents the natural beauty of Buddhist temple at the natural vegetation partially substituted by artificial plantings and direct use of a simplicity of the great nature without certain modifications. 4. Composition of inner garden is formed by stone pagoda, stone lantern, stone lotus table and Daeung - jeon Hall. Samgharama arrangement has changed to single towered style →double towered style →free style. In Yi-dynasty it had been free style farther by succeeding to style of Zen Samgharama of Koryo dynasty. 5. Founded years and topography about woody vegetation planted in the inner garden is not able to find typical characteristics, and plants were planted in the inner garden for the following purposes. Fruit tress (Diospyroskaki, Ginkgo biloba, Juglans sinensis. Castanea crenata, etc.), ornamental plants (Viburnum pubinerve f. hydrangeoides, Prunus serrulata var. spontanea, Lagerstroemia indica, Cercis chinensis, Magnoliadenudata, etc.), and green shade trees(Diospyros kaki, Ginkgo biloba, Prunus serrulata var. spontanea, Acer formosum var, coreanum, etc.) are also found here. Temple gardens have simple, neat, well - organized beauty, whereas some Zen(禪) principle applied to the garden design and its ornamental purpose. 6. Outer gardens are seen as mixed planting with Quercus mongolica, Acer formosum var. coreanum, Zelkova serreta, and Pinus densifloru etc. in the vegetatiort stand. These are well conserved natural vegetation, whereas show that tree species are not homogeneous it an area. and it does not seem to have characteristic design of plant arrangement in man- made stand of tree species for the area. Above species (Quercus mongolia, Acer formosum var, coreanum, Zelkova serreta, Pinus densiflora, etc.) were showed landscape which was formed decorative hedge to given geograpical condition and ,satisfied with architectural function. 7. Streams in the temples permit landscape for an environmental creation and serve either as water surrounding and belting the temple site, and show a striking view of the enclosed landscape with Zelko serreta, Acer formosum var. coreanum, Styrax japonicus, etc. 8. Through the present studies of landscape and vegetation at the site of the Buddhist temples, one visualizes a firm necessity for protection and preservation of dignity of the temples, ancient appearance and landscape of the surrounding temples, which can be easily deteriorated by the gradual development and an increase in the number of people enjoying leisure there.

GIS를 이용한 자연자원관리체계 구축 및 활용 : 소백산 국립공원의 일부지역을 중심으로

申永澈,金善和 충북대학교 농업과학기술연구소 1997 農業科學硏究 Vol.14 No.-

GIS-based management information system including graphic and attribute data was studied on selected 4 tree and 8 herbs in Mt. Sobaek. G.I.S. with IDRISI software was applicated. The results were as followed ; 1.The use of G.I.S. system made easy to store, manage and update data. It would save time and effort as well as prevent the data lost. Therefore it would make easy to hand over the duty between natural park manager. 2.Overlay method and three- dimensional spatial analysis by DTM would give the better chance to grasp the location of natural resources and to understand environmental information in Mt. So-baek. 3.This method would give necessary information for establishment of management plan. The user would easily understand spatial details by output of overall analysis. 4.Overlay and DTM's analysis could be utilized for management of natural resources and establi-shment of developmental plan in the Mt. Sobaek National Park.

수술적으로 치료한 통증을 동반한 흉추부의 후외상성 Schmorl씨 결절 : 2례 보고 Report of Two Cases

신병준,이재철,송화용,정석봉,권계원,조영일,김연일 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Study Design : Two patients who had painful Schmorl's node at thoracic level from acute trauma were adopted and taken operation for its treatment Objectives : To document the effect of operation for the treatment of painful Schmorl's node at thoracic level summary of background data : Schrmorl's nodes are common spinal lesion generally believed to be asymptomatic, but in some cases there were painful symptom by Schmorl's node. This case report is to explain the effect of operative treatment for the painful Schmorl's node. Methods : Two patients were adopted who had traumatic painful Schmorl's node at thoracic level for our case report. They were treated conservative methods at first but it's effect were poor, so they were taken anterior decompression and fusion, and checked back pain symptom. Result : In all two patients, the symptom of back pain by Schmorl's nodes at thoracic level was almost subsided. conclusion : For the treatment of traumatic painful Schmorl's node, most of surgeon says that conservative treatments were treatment of choice, but operative treatments are also benefit to subsidence of back pain by Schmorl's node.