서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

Isolated Cortical Vein Thrombosis with Long Cord Sign

Ban, Seung Pil,Chung, Young Seob,Park, Sung Bae,Son, Young-Je The Korean Neurosurgical Society 2015 Journal of Korean neurosurgical society Vol.58 No.5

Isolated cortical vein thrombosis (ICVT) is a rare disease, accounting for less than 1% of strokes. A 46-year-old woman presented with progressive left side weakness. Magnetic resonance (MR) imaging with $T2^*$-gradient echo ($T2^*$-GE) sequence showed long cord sign at the right frontal cortex. The patient was treated with low molecular weight heparin, followed by oral warfarin for 6 months. The 3-month follow-up MR imaging showed recanalization of the previously thrombosed cortical vein. She was completely recovered without neurological deficits after 6 months. This provides that MR imaging with $T2^*$-GE sequence can help to diagnosis the ICVT and outcomes of the ICVT are generally favorable.

Optimal Duration of Dual Antiplatelet Therapy after Stent-Assisted Coil Embolization of Unruptured Intracranial Aneurysms : A Prospective Randomized Multicenter Trial

Ban, Seung Pil,Kwon, O-Ki,Kim, Young Deok,Kim, Bum-Tae,Oh, Jae Sang,Kim, Kang Min,Kim, Chang Hyeun,Kim, Chang-Hyun,Choi, Jai Ho,Kim, Young Woo,Lim, Yong Cheol,Byoun, Hyoung Soo,Park, Sukh Que,Chung, J The Korean Neurosurgical Society 2022 Journal of Korean neurosurgical society Vol.65 No.6

Objective : Stent-assisted coil embolization (SAC) has been increasingly used to treat various types of intracranial aneurysms. Delayed thromboembolic complications are major concerns regarding this procedure, so dual antiplatelet therapy with aspirin and clopidogrel is needed. However, clinicians vary the duration of dual antiplatelet therapy after SAC, and no randomized study has been performed. This study aims to compare the safety and efficacy of long-term (12 months) dual antiplatelet therapy and short-term dual antiplatelet therapy (6 months) after SAC for patients with unruptured intracranial aneurysms (UIAs). Methods : This is a prospective, randomized and multicenter trial to investigate the optimal duration of dual antiplatelet therapy after SAC in patients with UIAs. Subjects will receive dual antiplatelet therapy for 6 months (short-term group) or 12 months (long-term group) after SAC. The primary endpoint is the assessment of thromboembolic complications between 1 and 18 months after SAC. We will enroll 528 subjects (264 subjects in each group) and perform 1 : 1 randomization. This study will involve 14 top-performing, high-volume Korean institutions specializing in coil embolization. Results : The trial will begin enrollment in 2022, and clinical data will be available after enrollment and follow-up. Conclusion : This article describes that the aim of this prospective randomized multicenter trial is to compare the effect of short-term (6 months) and long-term (12 months) dual antiplatelet therapy on UIAs in patients undergoing SAC, and to find the optimal duration.

Analysis of Complications Following Decompressive Craniectomy for Traumatic Brain Injury

Ban, Seung-Pil,Son, Young-Je,Yang, Hee-Jin,Chung, Yeong-Seob,Lee, Sang-Hyung,Han, Dae-Hee The Korean Neurosurgical Society 2010 Journal of Korean neurosurgical society Vol.48 No.3

Objective : Adequate management of increased intracranial pressure (ICP) is critical in patients with traumatic brain injury (TBI), and decompressive craniectomy is widely used to treat refractory increased ICP. The authors reviewed and analyzed complications following decompressive craniectomy for the management of TBI. Methods : A total of 89 consecutive patients who underwent decompressive craniectomy for TBI between February 2004 and February 2009 were reviewed retrospectively. Incidence rates of complications secondary to decompressive craniectomy were determined, and analyses were performed to identify clinical factors associated with the development of complications and the poor outcome. Results : Complications secondary to decompressive craniectomy occurred in 48 of the 89 (53.9%) patients. Furthermore, these complications occurred in a sequential fashion at specific times after surgical intervention; cerebral contusion expansion ($2.2{\pm}1.2$ days), newly appearing subdural or epidural hematoma contralateral to the craniectomy defect ($1.5{\pm}0.9$ days), epilepsy ($2.7{\pm}1.5$ days), cerebrospinal fluid leakage through the scalp incision ($7.0{\pm}4.2$ days), and external cerebral herniation ($5.5{\pm}3.3$ days). Subdural effusion ($10.8{\pm}5.2$ days) and postoperative infection ($9.8{\pm}3.1$ days) developed between one and four weeks postoperatively. Trephined and post-traumatic hydrocephalus syndromes developed after one month postoperatively (at $79.5{\pm}23.6$ and $49.2{\pm}14.1$ days, respectively). Conclusion : A poor GCS score ($\leq$ 8) and an age of $\geq$ 65 were found to be related to the occurrence of one of the above-mentioned complications. These results should help neurosurgeons anticipate these complications, to adopt management strategies that reduce the risks of complications, and to improve clinical outcomes.

가스발생기 사이클 액체로켓엔진 성능 평가

김승한(Seung-Han Kim),김성룡(Seung-Ryong Kim),김성혁(Sung-Hyuk Kim),김채형(Chae-Hyung Kim),서대반(Dae-Ban Seo),우성필(Seong-Pil Woo),유병일(Byung-Il Yu),소윤석(Yoon-Seok So),이광진(Kwang-Jin Lee),이승재(Seung-Jae Lee),이정호(Jung-Ho 한국추진공학회 2016 한국추진공학회 학술대회논문집 Vol.2016 No.12

한국형발사체용 엔진 개발을 위한 엔진시스템 개발 시험이 진행되고 있다. 본 논문에서는 현재 진행되고 있는 액체산소/케로신을 추진제로 하는 가스발생기 사이클 엔진의 성능 평가 방법에 대해 소개하였다. 엔진 개발 시험에서의 주요 측정 변수와 이를 이용한 엔진시스템 및 엔진 구성품의 주요 성능변수를 기술하였다. Development tests of the LOx/Kerosene liquid rocket engine for KSLV-II are going on. This paper introduces the performance evaluation techniques for the firing test of LOx/Kerosene gas generator cycle liquid rocket engine system under the KSLV-II program. Major measurement parameters and major performance parameters based on the parameters measured during engine development tests are described.

Effect of Various Factors on the Brazed Joint Properties in Al Brazing Technology

Ashutosh Sharma,Seung Hyun Lee,Hyung Oh Ban,Young Sik Shin,Jae-Pil Jung 대한용접·접합학회 2016 대한용접·접합학회지 Vol.34 No.2

Last few decades have seen a rapid increase in the fabrication and characterization of Al alloys for automobiles, heat exchangers and aerospace industries. Aluminium alloys are popular because of their high specific strength, light weight, excellent wear and high oxidation resistance. The development of aluminium alloys in these applications makes their study and research of utmost importance. Brazing is applied to the aluminium alloys for joining various aluminium parts together in most of the industrial applications. Various parameters affect the joining process of these aluminium alloys. In this article, various types of processing parameters have been discussed, and special attention has been given to the category of aluminium brazing alloys. The article reviews on the various parameters that affect the brazing property in various scientific and technological applications.

Effects of hyperin, isoquercitrin and quercetin on lipopolysaccharide-induced nitrite production in rat peritoneal macrophages

Lee, Sanghyun,Park, Hee-Seung,Notsu, Yohko,Ban, Hyun Seung,Kim, Yong Pil,Ishihara, Kenji,Hirasawa, Noriyasu,Jung, Sang Hoon,Lee, Yeon Sil,Lim, Soon Sung,Park, Eun-Hee,Shin, Kuk Hyun,Seyama, Toshio,Hon John Wiley Sons, Ltd. 2008 Phytotherapy research Vol.22 No.11

<P>The extract of the root of Acanthopanax chiisanensis Nakai is used for the treatment of inflammation. To analyse the action mechanism of this extract, the effect of hyperin (quercetin-3-O-&bgr;-d-galactose) isolated from the ethyl acetate fraction of the root of A. chiisanensis on nitrite production and induction of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS, 1 µg/mL)-stimulated rat peritoneal macrophages were examined. The effect of the structurally related compounds, isoquercitrin (quercetin-3-O-&bgr;-d-glucose) and quercetin (an aglycone of the two compounds) isolated from the extract of the leaves of Vaccinium koreanum Nakai was also examined to compare the effect. It was shown that hyperin inhibited the LPS-induced iNOS expression and nitrite production. Of the three compounds, quercetin showed the most potent inhibitory activity. The phosphorylation of p44/42 mitogen activated protein kinase (MAPK), p38 MAPK and c-Jun N-terminal kinase (JNK) were also inhibited by these compounds. These findings suggested that hyperin in the extract of the root of A. chiisanensis inhibits nitric oxide (NO) production through inhibition of the expression of iNOS by attenuation of p44/p42 MAPK, p38 MAPK and JNK, and thus participates in the antiinflammatory activity of the extract. Copyright © 2008 John Wiley & Sons, Ltd.</P>

Effect of Various Factors on the Brazed Joint Properties in Al Brazing Technology

Sharma, Ashutosh,Lee, Seung Hyun,Ban, Hyung Oh,Shin, Young Sik,Jung, Jae-Pil The Korean Welding and Joining Society 2016 대한용접·접합학회지 Vol.34 No.2

Last few decades have seen a rapid increase in the fabrication and characterization of Al alloys for automobiles, heat exchangers and aerospace industries. Aluminium alloys are popular because of their high specific strength, light weight, excellent wear and high oxidation resistance. The development of aluminium alloys in these applications makes their study and research of utmost importance. Brazing is applied to the aluminium alloys for joining various aluminium parts together in most of the industrial applications. Various parameters affect the joining process of these aluminium alloys. In this article, various types of processing parameters have been discussed, and special attention has been given to the category of aluminium brazing alloys. The article reviews on the various parameters that affect the brazing property in various scientific and technological applications.

Endovascular Treatment for Acute Ischemic Stroke Patients over 80 Years of Age

황기환,Gyojun Hwang,권오기,Chang Hyeun Kim,Seung Pil Ban,한문구,배희준,Beom Joon Kim,Jae Seung Bang,오창완,Boram Lee,Eun-A Jeong 대한뇌혈관외과학회 2015 Journal of Cerebrovascular and Endovascular Neuros Vol.17 No.3

Objective:We evaluated the effect of endovascular treatment (EVT) for acute ischemic stroke in patients over 80 years of age. Materials and Methods:The records of 156 acute stroke patients aged over 80 years who were considered as candidates for EVT were analyzed. Fifty-six patients (35.9%, EVT group) underwent EVT and 100 patients (64.1%, non-EVT group) did not. Outcomes, in terms of functional outcomes and rates of symptomatic hemorrhage, in-hospital morbidity and mortality, were compared between groups. Each comparison was adjusted for age, time from onset, initial National Institute of Health Stroke Scale, and pre-stroke modified Rankin Scale (mRS). Results:More patients in the EVT group achieved good outcomes (mRS score of 0-2) at 3 months (35.7% vs. 11.0%, adjusted odds ratio [OR] 4.779 [95% confidence interval 1.972-11.579], p = 0.001) and 12 months (35.7% vs. 14.0%, adjusted OR 3.705 [1.574-8.722], p = 0.003) after stroke. During admission, rates of hospital-acquired infection including pneumonia (12.5% vs. 29.0%, adjusted OR 0.262 [0.098-0.703], p = 0.008) and urinary tract infection (16.0% vs. 34.0%, adjusted OR 0.256 [0.099-0.657], p = 0.005) were significantly lower in the EVT group. More symptomatic hemorrhages (10.7% vs. 2.0%, adjusted OR 6.859 [1.139-41.317], p = 0.036) occurred in the EVT group, but no significant difference was observed in in-hospital mortality rate (12.5% vs. 8.0%, adjusted OR 1.380 [0.408-4.664], p = 0.604). Conclusion:EVT improved functional outcome and reduced the risk of hospital-acquired infections in acute stroke patients over 80 years of age without increasing the risk of in-hospital mortality, although symptomatic hemorrhage occurred more frequently after EVT.

Trends in the Incidence and Treatment of Cerebrovascular Diseases in Korea : Part I. Intracranial Aneurysm, Intracerebral Hemorrhage, and Arteriovenous Malformation

Lee, Si Un,Kim, Tackeun,Kwon, O-Ki,Bang, Jae Seung,Ban, Seung Pil,Byoun, Hyoung Soo,Oh, Chang Wan The Korean Neurosurgical Society 2020 Journal of Korean neurosurgical society Vol.63 No.1

Objective : To analyze the incidence and treatment trends of hemorrhagic stroke (HS), according to HS subtypes, using nationwide data in Korea from January 2008 to December 2016. Methods : We used data from the national health-claim database provided by the National Health Insurance Service for 2008-2016 using the International Classification of Diseases. The crude incidence and age-standardized incidence of each disease associated with HS, which included intracranial aneurysm (IA), hypertensive intracerebral hemorrhage (ICH), and arteriovenous malformation (AVM), were calculated and additional analysis was conducted according to age and sex. Changes in trends in treatment methods and number of treatments were analyzed for each cerebrovascular disease using the Korean Classification of Diseases procedure codes. Results : In 2016, the total number of newly diagnosed adult patients with HS was 24169, showing a decrease by 7.0% since 2008; the age-standardized incidence of HS was 46.2 per 100000 person-years. The age-standardized incidence of unruptured IA (UIA) in adults was 71.4 per 100000 person-years-increased by 2.6-fold since 2008-while that of ruptured IA (RIA) was 12.6 per 100000 person-years, which had decreased at a rate of 20.3% since 2008. The number of coil embolization (CE) for UIA increased by 3.4-fold over 9 years and exceeded that of clipping since 2008. With respect to RIA, CE increased by 2.0-fold over 9 years and exceeded that of clipping from 2014. As for spontaneous ICH in adults, the age-standardized incidence was 31.3 per 100000 person-years in 2016-decreased by 34.7% since 2008-and 14.6% of patients diagnosed with ICH were treated in 2016, which was not significantly different from the proportion of patients treated since 2008. The age-standardized incidence of unruptured AVM (UAVM) was 2.0 per 100000 person-year in 2016, while that of ruptured AVM (RAVM) was 2.4 per 100000 person-years in 2016, showing a decreasing rate of 17.2% from 2008. The total number of treated patients with AVM declined since 2014. Conclusion : In Korea, age-related cerebral vascular diseases, such as RIA, ICH, and RAVM, demonstrated a declining trend in age-standardized incidence; meanwhile, UIA and UAVM demonstrated an increased trend in both crude incidence and age-standardized incidence for 9 years. The increase in the elderly population, management of hypertension, and development of diagnostic and endovascular techniques appear to have influenced this trend.