백혈병과 과립구 감소증에서의 감시배양(surveillance culture) : 예방적항균제 사용에 따른 균총의 변화

최강원,김성민,오명돈,김병국,김의종 대한화학요법학회 1991 대한화학요법학회지 Vol.9 No.1

A surveillance culture was to monitor the changes in flora during prophylactic antibiotics(PA) in patients whith granulocytopenia. Twenty patients with granulocytopenia were included: divided into 3 PA groups. Terimthoprim-sulfamethoxazole(TS) group consisted of 7 patients who underwent induction chemotherapy, Cipprofloxacin plus nystatin(CN) group consisting of 7 patients and Gentamicin plus Nystain(GN) group consisting of 7 patients. All of the latter 2 group underwent bone marrow transplantation and were put in protected environment (laminar air flow, sterile food) in addition to PA. Normal flora and other colonizing microorganisms were replaced with antibiotic resistant bacteria and fungus : MRSA, methicillin resistant CNS, P. aeruginosa, Enterobacter spp. and candida spp. and truolopsis. Entreobacteriaceae were diminished markedly, expecially with CN. Two episodes of bacteremia were preceded by the colonization with the same organisms in the skin, throat, and stool. Surveillance culture seems useful in the helping to design prdventive measures, select antibiotics n selected cases.

염처리에 따른 벼 遊離 Proline 축적과 생육반응

정진일,김기영,최돈향,오명규,이승엽,이동진 한국국제농업개발학회 2003 韓國國際農業開發學會誌 Vol.15 No.4

염처리에 따른 무기성분 흡수 및 Proline 축적등을 비교하여 수도의 내염성 품종육성의 기초자료를 얻고자 Annapurna를 대비품종으로 일반계 6품종, 통일계 5품종을 공시하여 얻은 결과는 다음과 같다. 1. 초장, 건물중 및 고사율은 염처리시 감소하였으며, 시간이 경과될수록 감소율이 증가하였다. 2. K/Na비와 건물중 감소율 및 고엽율과는 부의 상관을 보였다. 3.proline 축적은 염농도가 증가함에 따라 증가하였으며 일반계품종들이 통일계품종들보다 축적량이 높았다. 4. Proline 함량과 건물중비율과는 정의 상관을 보였다. In other to find out the basic information on cultivation and breeding for salt tolerance in rice, these studies were conducted in treatment hydroponics added in NaCl using 6 Japonica type varieties and 5 Tongil type varieties compared to the salt tolerance variety, namely Annapurna. The following results were obtained. Plant height, ratio of dry weight and ratio of dead leaf were decreased with increasing periods of salt treatment. Negatively significant correlation was observed between Rario of K/Na were highly negative correlated with the rate of dead leaf and rate of dry weight. The accumulation of proline increased as the salt content higher. The content of proline was positively correlated with the ratio of dry weight after salt treatment.

인간 면역부전 바이러스(HIV) 감염자 사이에서의 1기 및 2기 매독의 유행

장희창,조재현,박완범,이기덕,이창섭,김홍빈,오명돈,최강원 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

목적 : 국내 HIV 감염자 사이에서 발생한 매독의 유행을 보고하고, 그 역학적 특성을 규명하고자 하였다. 재료 및 방법 : 1999년 7월부터 2003년 9월까지 서울대학교 병원에서 추적 관찰을 받아온 HIV 감염자를 대상으로 하여 1기 및 2기 매독의 발생을 조사하였다. 발생률을 정확히 구하기 위해 추적 관찰을 받은 모든 HIV 감염자의 인년을 6개월 간격으로 구하였다. 결과 : 51개월 동안, 465명의 HIV 감염자가 서울대학교 병원에서 추적 관찰을 받았다. 이중 38명이 1기 및 2기 매독으로 진단되었다. 1기 및 2기 매독의 발생률은 이기간 동안 100인년 당 4.1명이었다. 1999년 7월부터 2001년 12월 사이에는 발생자가 없었으나, 이후 발생률은 꾸준히 증가하여 2003년 9월에는 100인년 당 18.8명이 되었다. 1기 및 2기 매독의 발생률은 동성애자 및 양성애자에서 이성애자에서보다 4.3배 높았고, HAART로 치료를 받지 않은 환자에서 HAART로 치료를 받고 있던 환자에서 보다 10.9배 높았다. 결론 : 2002년부터 국내 HIV 감염자 사이에서 1기 및 2기 매독이 유행하기 시작하였고, 이러한 유행은 동성애자와 양성애자 및 HAART로 치료를 받고 있지 않던 사람 사이에서 발생하였다. Background : This study was performed to characterize the epidemiologic and clinical features of outbreak of syphilis among HIV sero-positive patients in Korea. Materials and Methods : A retrospective case review of patients diagnosed with primary and secondary syphilis from July 1999 to September 2003 was carried out at Seoul National University Hospital in Korea. To estimate the incidence, person-years (PYs) of all HIV sero-positive patients, who visited the hospital in the same period, were calculated every 6 months. Results : In a 51 month period, 465 HIV-positive patients were followed up at Seoul National University Hospital. 38 cases of primary and secondary syphilis were diagnosed. The incidence of primary and secondary syphilis was 4.1 per 100 PYs during the study period. There was no case from July 1999 to December 2001, and then the incidence rose until September 2003 from 5.5 per 100 PYs in 1999 to 18.8 per 100 PYs in 2003. The rate of primary and secondary syphilis was 4.3 times higher among homosexual and bisexual men than heterosexual men (95% CI 1.87 to 11.17), and 10.9 times higher among patients who did not receive HAART than patients who were receiving HAART (95% CI 5.47 to 21.79). Conclusion : The outbreak of primary and secondary syphilis among HIV-positive patients started in 2002 and has been escalating, especially among homosexual/bisexual men and in patients who did not receive HAART.

AIDS의 증상 진단 및 치료

오명돈,최강원 한국의학사 1986 診斷과治療 Vol.6 No.2

In vitro antiviral activity of ribavirin against severe fever with thrombocytopenia syndrome virus

( Myung Jin Lee ),( Kye-hyung Kim ),( Jongyoun Yi ),( Su Jin Choi ),( Pyoeng Gyun Choe ),( Wan Beom Park ),( Nam Joong Kim ),( Myoung-don Oh ) 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.4

Background/Aims: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV), a novel bunyavirus. As yet, there is no effective antiviral therapy for SFTS. Ribavirin is a broad-spectrum antiviral agent, which has been tried for treatment of SFTS. In this study, antiviral activity of ribavirin against SFTSV has been investigated. Methods: Vero cell-grown SFTSV strain Gangwon/Korea/2012 was treated with ribavirin at various concentrations. Antiviral activity of ribavirin was evaluated by inhibition of the SFTSV cytopathic effect in Vero cells and quantification of viral RNA load in culture supernatant using one-step real-time reverse transcription polymerase chain reaction. Cytotoxicity of ribavirin was determined by a tetrazolium- based colorimetric method. Results: Ribavirin reduced SFTSV titers in a dose-dependent manner, with a half-maximal inhibitory concentration ranged from 3.69 to 8.72 μg/mL. Cytopathic effects were reduced as ribavirin concentration increased. No significant cytotoxicity was detected at ribavirin concentrations of ≤ 31.3 μg/mL. Conclusions: Ribavirin exhibited inhibitory activity against SFTSV replication in vitro, which suggests that ribavirin can be used as a potential antiviral agent for SFTS.

Infections in Acute Leukemia: A Retrospective study of 148 Patients

Myung Shik Lee,Myoung Don Oh,Kang Won Choe,Byoung Kook Kim,Noe Kyeong Kim,Mun Ho Lee 대한내과학회 1986 The Korean Journal of Internal Medicine Vol.1 No.2

Cardiac Amyloidosis Diagnosed by Endomyocardial Biopsy

Myung A Kim,Cheol Ho Kim,Byung Hee Oh,Young Bae Park,Yun Shik Choi,Jung Don Seo,Young Woo Lee 대한내과학회 1988 The Korean Journal of Internal Medicine Vol.3 No.2

질의 평활근종 1례

라명재(Myung Jae Ra),김광진(Kwang Jin Kim),오영돈(Young Don Oh) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.12

Leiomyomas of the vagina is a rare tumor, with 300 cases reported in the world literature. We experienced a case of leiomyoma of the vagina, and present it with a brief review of the literatures.

AIDS 연관형 Kaposi 육종 1예

권오상,최강원,서대헌,조광현,김철우,은희철,오명돈,윤재일,박병순,임정구 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.5

We report a case of AIDS-related Kaposi's sarcoma in a 47-year-old male. He was diagnosed as HIV-positive 3 years ago. He developed two asymptomatic purple-colored papules on the nose and right elbow. The histopathological finding showed abnormally proIiferated and dilated vessels, vascular slits, spindle shaped cells, and extravasated erythrocytes. In immunohistochemical studies, the cryptic vessels was positive with CD34, but negative with factor XIIIa and factor VIII-related antigen, Human herpesvirus-8 was found by PCR. We think that this is the first reported case of AIDS-related Kaposi's sarcoma in Korean dermatologic literature.

급성 관동맥증후군과 만성 안정형협심증 사이에서 보이는 전환효소와 안지오텐시노젠 유전자 다형성의 차이

이명묵(Myung Mook Lee),오명돈(Myoung Don Oh),최강원(Kang Won Choi),오병희(Byung Hee Oh),김효수(Hyo Soo Kim),김광일(Kwang Il Kim),채인호(In Ho Chae),손대원(Dae Won Sohn),박영배(Young Bae Park),최윤식(Yun Shik Choi),이영우(Young Woo Le 대한내과학회 1999 대한내과학회지 Vol.56 No.5

Objectives : The renin-angiotensin system(RAS) had an important role in the pathogenesis of ischemic heart disease(IHD). Angiotensinogen(ATG), angiotensin-converting enzyme(ACE), and angiotensin II receptor are key components of RAS and reported to have polymorphisms. We studied to investigate the separate and interactive effects of ACE (I/D) and ATG (M235T) gene polymorphisms on the pathogenesis of IHD, and to compare the genetic influences between on the chronic stable angina(CSA) and on the acute coronary syndrome(ACS). Methods : We studied total 468 patients who underwent CAG. Control group comprised 159 patients who did not have a significant coronary lesion. IHD group was subgrouped according to clinical manifestation into CSA group(n=90) and ACS group(n=219). To determine the frequency of ACE and ATG genotype, polymerase chain reaction (PCR) and enzyme digestion was done. Results : 1) In ACS group, genotype frequency of ACE(II:ID:DD) was 0.27:0.48:0.25 and ATG (MM:MT:TT) was 0.31:0.59:0.10, which was significantly different from control group (ACE II:ID:DD =0.38:0.45:0.17 and ATG MM:MT:TT =0.51:0.40:0.09) (p<0.05). 2) There was no significant difference in genotype frequency of ACE, ATG gene between CSA group and control. 3) In multiple logistic regression analysis, sex, age, ATG and ACE genotype were independent risk factors for ACS. The relative risk for ACS in ACE DD compared to II genotype was 3.52 (95% CI: 1.52-8.13) and that in ACE ID compared to ACE II genotype was 1.55 (95% CI: 0.82-2.94), which showed that the risk increased with the number of ACE D-allele. In contrast, sex, age, and DM were independent risk factors for CSA, whereas ATG and ACE genotype were not. 4) In combined analysis including both ACE and ATG gene polymorphism, the relative risk for ACS associated with ATG genotype increased with the number of ACE D-allele. Conclusion : ACE and ATG gene polymorphism are associated with the development of ACS but not CSA, which suggests that ACE and ATG genes may be involved in the plaque unstabilization or thrombosis rather than the chronic progression of coronary atherosclerosis.