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1
멀티센서 기반 수면장애 개선 시스템 설계 및 구현

이영우,박석천,Le, Young-Woo,Park, Seok-Cheon 한국정보통신학회 2013 한국정보통신학회논문지 Vol.17 No.11
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대표적인 수면장애로 수면 무호흡증과 코골이가 있다. 하지만 기존에는 수면장애 측정과 진단만 이루어지고 그 원인을 파악하는 연구는 미비하였다. 따라서 본 논문에서는 이를 보완하기 위해 멀티센서를 기반으로 한 수면장애 개선 시스템을 제안한다. 본 논문에서는 제안한 시스템을 설계하기 위해 전체 시스템의 구성을 파악하고 데이터의 흐름을 설계하였다. 설계한 시스템을 구현하기 위해 사용자 인터페이스 및 모바일 애플리케이션은 안드로이드 기반으로 구현하였다. 본 논문에서 설계 및 구현한 시스템의 결과의 정확도를 테스트하기 위해 테스트 시나리오를 작성하였다. 테스트 시나리오에 따른 수면 장애 요인 값을 변화시키며 추론 결과의 정확도를 테스트 한 결과 제안한 수면장애 개선 시스템이 정확하게 동작함을 확인하였다. Representative sleep disorders represent sleep apnea and snoring. Although researches to diagnose sleep disorders as solutions for these problems are going on, the original researches only diagnose and measure sleep disorders but ones to find out the reasons are not activated much. Therefore, to reinforce this, this paper suggests sleep disorder improvement system based on multi-sensor. To design the system proposed in this paper, the entire system's structure was found and data's flow was planned. To ensure that the system works, mobile application and user interface was built based on Android. To test the results on accuracy of sleep disorders improvement system based on ontology using multi sensor built and planned in this paper, a scenario was written. As a result of testing inference results' accuracy changing factor values of sleep disorders following test scenario, proposed sleep disorders improvement system's accuracy was checked.
2
급성 관동맥증후군과 만성 안정형협심증 사이에서 보이는 전환효소와 안지오텐시노젠 유전자 다형성의 차이

이명묵(Myung Mook Lee),오명돈(Myoung Don Oh),최강원(Kang Won Choi),오병희(Byung Hee Oh),김효수(Hyo Soo Kim),김광일(Kwang Il Kim),채인호(In Ho Chae),손대원(Dae Won Sohn),박영배(Young Bae Park),최윤식(Yun Shik Choi),이영우(Young Woo Le 대한내과학회 1999 대한내과학회지 Vol.56 No.5
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N/A Objectives : The renin-angiotensin system(RAS) had an important role in the pathogenesis of ischemic heart disease(IHD). Angiotensinogen(ATG), angiotensin-converting enzyme(ACE), and angiotensin II receptor are key components of RAS and reported to have polymorphisms. We studied to investigate the separate and interactive effects of ACE (I/D) and ATG (M235T) gene polymorphisms on the pathogenesis of IHD, and to compare the genetic influences between on the chronic stable angina(CSA) and on the acute coronary syndrome(ACS). Methods : We studied total 468 patients who underwent CAG. Control group comprised 159 patients who did not have a significant coronary lesion. IHD group was subgrouped according to clinical manifestation into CSA group(n=90) and ACS group(n=219). To determine the frequency of ACE and ATG genotype, polymerase chain reaction (PCR) and enzyme digestion was done. Results : 1) In ACS group, genotype frequency of ACE(II:ID:DD) was 0.27:0.48:0.25 and ATG (MM:MT:TT) was 0.31:0.59:0.10, which was significantly different from control group (ACE II:ID:DD =0.38:0.45:0.17 and ATG MM:MT:TT =0.51:0.40:0.09) (p<0.05). 2) There was no significant difference in genotype frequency of ACE, ATG gene between CSA group and control. 3) In multiple logistic regression analysis, sex, age, ATG and ACE genotype were independent risk factors for ACS. The relative risk for ACS in ACE DD compared to II genotype was 3.52 (95% CI: 1.52-8.13) and that in ACE ID compared to ACE II genotype was 1.55 (95% CI: 0.82-2.94), which showed that the risk increased with the number of ACE D-allele. In contrast, sex, age, and DM were independent risk factors for CSA, whereas ATG and ACE genotype were not. 4) In combined analysis including both ACE and ATG gene polymorphism, the relative risk for ACS associated with ATG genotype increased with the number of ACE D-allele. Conclusion : ACE and ATG gene polymorphism are associated with the development of ACS but not CSA, which suggests that ACE and ATG genes may be involved in the plaque unstabilization or thrombosis rather than the chronic progression of coronary atherosclerosis.

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