Duplication 9p Syndrome 1례

이미경,노영래,김영훈,백청순,신미경,이진,장필상,김진택,이권행,황경태 대한소아과학회 2002 小兒科 Vol.45 No.9

배 주스 슬러리로 제조한 배 페이스트의 품질 특성과 생리기능성

김영헌, 장인택, 나광출, 이종수 배재대학교 자연과학연구소 2012 自然科學論文集 Vol.23 No.1

In order to reduce environmental pollution by pear slurry from pear juice processing and further, develop new valuable sauces, pear pastes was prepared using pear slurry and its quality characteristics was investigated with physiological functionality. Pear paste contained 29.1% of carbohydrate, 1.0% of crude protein and 0.25% of crude fat, and also fructose content and edible fiber content were 16.42mg/100ml and 0.5g/100ml, respectively. Anti-obesity α-glucosidase inhibitory activity of the pear pastes was 20.0% and antihypertensive angiotensin I-converting enzyme inhibitory was increased to 17.9% from 4.0% during storage at 20℃ for 2 weeks.

마산만 퇴적물의 중금속 및 유기염화합물 오염에 관한 연구

이찬원,민병윤,권영택,양운진,이규환 경남대학교 환경문제연구소 1990 환경연구 Vol.12 No.-

마산내만 및 마산만 유임 주요하천의 오염퇴적물을 1988년 7월부터 1989년 8월에 걸쳐 채취하여 중금속 및 유기염소화합물을 분석하였다. 오염퇴적충의 뚜께는 10㎝에서 169㎝의 넓은 분포를 보였으며 조사지점의 중금속농도는 지점에 따라 많은 차이를 나타내었다. 특히 인근에 마산수출자유지역 및 조선산업이 위치한 조사 지점에서는 모든 중금속의 농도가 가장 높게 나타났다. 마산만 퇴적오염물 중금속 농도를 오염된 일본의 자료와 비교하였을때 Osaka만의 수온을 제외하고 모든 평균농도가 높게 나타났다. 유기염소화합물(PCB 및 DDE)의 농도는 주거지역 및 공장지대가 함께 위치한 산호천 및 마산시 연안지역에서 높게 검출되었다. 본 연구결과에 의하면 마산만과 같은 폐쇄성 해역에서 중금속 오염원으로 공장폐수가 고려될때는 퇴적된 오염물질의 중금속 분석이 좋은 척도가 철 수 있음을 시사하고 있다. Sediments were collected from Masan bay and two main waterways into Masan Bay in the period of July 1988 to August 1989 for the analysis of heavy metals and Organochlorine compounds. The polluted layer of black sludge had a wide range between 10㎝ to 169㎝ and the content of heavy motels was widely distributed from site to site. One site near the Masan free-export area and a shipmaking company was extremely contaminated by heavy metals. All the average concentration of heavy metals in the sediments from Masan Bay were higher than those from Japanese bays compared except Hg from Osaka Bay. Higher levels of PCBs and DDE were found in sediments from Sanho stream and along the coastal area of Masan city. The results obtained in this study imply that the heavy metal analysis of sediments may be a useful to reveal the pollution sources in a closed bay fuck as Masan Bay.

회생용 4분할 2상 쵸퍼에 의한 회생영역의 확대

이승환,김용주,한경희,정연택,강승욱 明知大學校 産業技術硏究所 1993 産業技術硏究所論文集 Vol.12 No.-

In this paper, we proposes two phase chopper system with flour. separate groups of D.C motor for regenerative braking. The main circuit consists of four sets of chopping parts, eight diodes and four separate groups of D.C motor. Although the proposed chopper circuit requires more circuit elements than the conventional two phase chopper system with, combined output, it has the following advantages: (1) The region of regenerative braking becomes twice as that of the conventional two phase chopper system. (2)Current division of load becomes equalized. Therefore. it is possible to drive not only series motor but also shunt and separately excited motor (3) The harmonic component of the source current is greatly diminished.

국산밀 제분부산물을 첨가한 고식이섬유빵의 품질 특성

이영택 한국응용생명화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.4

국산밀의 제분시 생성되는 밀기울(총 식이섬유 42%)을 밀가루에 0-30% 첨가함에 따라 반죽과 yeast 발효빵의 품질에 미치는 영향을 조사하여 고식이섬유빵의 소재로 활용하였다. 밀가루에 첨가하는 국내산 밀기울의 양이 증가함에 따라 amylograph 최고점도와 set back은 감소하였으며, mixograph에 의한 반죽의 리올로지 특성에서 peak height는 증가한 반면에 mixing time은 감소하는 경향이었다. 밀기울의 참가는 빵의 부피를 현저히 낮추고 crumb grain, 텍스쳐 등 관능특석에서 빵의 품질을 떨어뜨리는 것으로 나타났다. 밀기울의 첨가에 의해 빵은 L값이 감소하여 어두워졌으며, crumb의 a와 b값은 증가하여 적색과 황색의 색조를 부여하였다. 빵의 부피와 관능검사 측정 결과에 따라 국내산 밀기울의 적정 첨가수준은 약 15%까지인 것으로 판단되었다. 15% 밀기울 첨가빵은 대조구 빵에 비해 경도가 2배 이상 높았으며 5℃와 25℃에 5일간 저장실험에서 저장 2-3일에 급격한 경도의 증가를 보여주었다. Wheat bran, a milling by-product of domestic wheat grains, containing approximately 42% of the total dietary fiber, was tested for the effects on bread-making properties. The amylograph peak viscosity and set back values considerably decreased with increasing levels (0~30%) of wheat bran. Adding wheat bran somewhat increased water absorption and showed no consistent effect on mixing time. Yeast-leavened breads were baked with wheat flour with up to 30% of the flour substituted with domestic wheat bran. Adding domestic wheat bran exerted detrimental effect on loaf volume and decreased sensory acceptability such as crust and crumb color, crumb grain, texture, and flavor. Wheat bran decreased lightness and imparted red and yellow tint. It was suggested that domestic wheat bran could be substituted for wheat flour at levels up to 15% without significantly depressing bread quality in the preparation of high-fiber bread. Crumb firmness of bread containing 15% wheat bran was significantly higher than that of the control bread (100% wheat flour) and increased rapidly at 2~3 days during storage.

Quality Characteristics of Reconstituted Multi-Grain by Extrusion Process

이영택 선문대학교 첨단과학기술연구소 1996 첨단과학기술연구소 논문집 Vol.1 No.1

현미, 보리, 밀, 조, 수수, 콩, 팔 등의 원료를 일차 분쇄하고 혼합한 후 쌍축압출성형키를 사용하여 쌀알 형태로 성형하였다. 기본배합비를 현미 30%, 보리 3O%, 밀 20%, 조 5%, 수수 5%, 콩 7%, 팥 3%로 결정하였으며 원료의 배합비율에 따른 압출성형조건으로 스크류 속도는 430 rpm, 가수율은 24-30%, 배럴온도는 50-60℃로 설정하여 성형물의 팽화를 억제함과 동시에 5 x 0.8 mm 직사각형의 토출구를 사용하고 절단칼의 회전속도등을 조절하여 재성형 혼합곡립을 제조하였다. 재성형 혼합곡립의 크기와 형태는 단립종 백미와 유사하였고 체적은 백미에 비해 약간 높았으며 침지에 의한 수화속도가 빨라 수분흡수율이 백미에 비해 높게 나타났다. 혼합곡립의 취반후 경도는 백미에 비해 약간 낮았고 부착성은 높았다. 압출성형기법을 이용하여 제조한 재성형 혼합곡은 쌀밥에 영양성, 간편성, 기호성을 보충시킬 수 있는 주식개념의 혼합곡으로서의 가치가 매우 크다고 사료되었다. Raw materials including brown rice, barley, wheat, millet, sorghum, soybean, and red bean were ground/mixed and extruded with a twin-screw extruder to form a reconstituted grain type. The extruded multi-grain was air-dried and compared for quality characteristics with milled rice. Grain size and shape of reconstituted grain were similar to short-grain milled rice. Stacking volume of reconstitued multi-grain was a little higher than that of milled rice, and rapid water absorption was observed in reconstituted multi-grain. As a result of texture measurements determined by rheometer, hardness of cooked reconstituted grain was slightly lower and adhesiveness was appeared to be higher.

자궁경부종양에서 Cathepsin-D 표현의 의의

이춘희,김세진,전상식,이택후,조영래,채종민 경북대학교 병원 1997 경북대학교병원의학연구소논문집 Vol.1 No.1

Various clinical and histopathologic characteristics are currently used to obtain prognostic information about cervical carcinoma, but they do not predict the outcome for any individual patients. Thus, there is a need to identify additional tumor characteristics that are able to predict more accurately the outcome for an individual patient with cervical cancer. In this study, we explored the relationship between cathepsin-D expression and progression of the cervical neoplasia, the correlation between response to neoadjuvant chemotherapy and cathepsin-D expression, and we investigated if tumor cell cathepsin-D expression could serve as a prognostic factor in cervical carcinoma. Tumor tissues were obtained from 14 patients with cervical intraepithelial neoplasia and 52 patients with squamous cell carcinoma of the cervix. Cathepsin-S expression was identified by immunohistochemical methods using monoclonal antibody cathepsin-D (BioGene). Positive cathepsin-D immunoreaction in greater than 30% of carcinoma cells was scored as high expression. High cathepsin-D expression was seen in 15 of 52 invasive cancer but was absent in cervical intraepithelial neoplasia. It was shown that cathepsin-D expression was independent of the rumor grade, tumor size, lymph node involvement, depth of invasion, parametrial invasion, and response to chemotherapy. In disease free survival analysis by log-rank test, cathepsin-D expression was not significantly associated with survival. These results show that cathepsin-D expression is not a clinically useful adjunct to assessment of prognosis in invasive squamous cell carcinoma of the cervix.

黃柏에서 抽出한 多糖類의 抗癌作用에 대한 硏究

최영철,홍희탁,홍영욱,이태균,박원환,김철호 동국대학교 경주대학 1997 東國論集 Vol.16 No.1

In order to investigate antitumor activities of the extracted polysaccharides from Phellodendron chinense SCHNEID, the following studies were carried out. Phellodendron chinense SCHNEID was extracted with hot water and alkali, and the extracted polysaccharides showed antitumor activities against mice Sarcoma-180 solid tumors in parameters of tumor weight, inhibition ratio, thymidilate synthetase(TS) and thymidine kinase(TK) activities. The results were as follows : 1. Delipidated extracts from Phellodendron chinense SCHNEID, were systematically fractionated, the heteropolysaccharide contains D-N-acetylglucosamine, D-galactose, D-mannose, D-glucose. The molecular weight distribution of the sample was found to be nearly homogeneous (about from 200 to 1000 kDa) in gel permeation analysis. 2. Among the polysaccharide fractions, the water extracted fractions, particularly Fr.-2, showed a potent growth-inhibitory activity against implanted in mice Sarcoma 180 solid tumor (inhibition, 95.3%, at 2 ㎎/100g), but the cold alkali extract (Fr.-4) showed a very low activity (inhibition; 4.7%). Fr.-7 and Fr.-8 showed the highest tumor inhibitory activity (inhibition; 96.4 and 98.2%, respectively). 3. TS activity in the Fr.-2 given oral administration of propolis was markedly suppresed to 73.7% of that in the control (p<0.01 by Student's t-test). However, there was little difference in TK activity with a slight decrease in Fr.-2 only.

단독 전이성 척추 종양의 일괄 전척추 절제술

김기택,한정수,석경수,이영호,이상훈 대한척추외과학회 2003 대한척추외과학회지 Vol.10 No.3

집단 정신치료에서 신환자의 동화과정에 대한 관찰

권영탁,이시형 大韓神經精神醫學會 1983 신경정신의학 Vol.22 No.3

1982년 7월부터 서울대학교 병원 61병동에서 입·퇴원 환자들로 이루어진 혼합집단을 정신 치료하던 중 네 번째 session에서 두 명의 입원환자들이 처음으로 참가하였다. 신환자들이 참가하게 되면 여러가지 집단의 저항이 나타날 수도 있겠는데 오히려 첫 시간에 동화 과정이 잘 이루어져서 이를 분석하고 그 요인을 살펴본 바 다음과 같은 점들을 들 수 있다. 1. 구환자들은 구성원 탈락에 따라 집단을 유지시켜야 한다는 불안으로 신환자들을 따뜻하게 환영했다. 2. 구환자들 입장에선 신환자들을 도와주고 하는 충고가 곧 자기 치료적이란 점도 작용했을 것이다. 3. 대부분의 구성원들이 입원을 통해서 어느 정도 서로를 알고 있었다. 4. 구환자들도 전원 입원한 병력이 있어서 신환자들이 보기에 병원 동창회같은 분위기를 느꼈다. 5. 구성원 모두가 본 병원이라는 기구에 긍정적인 감정이 있었다. 6. 전 환자들의 주치의가 본 치료자여서 환자들의 소속감이 증대되었다. 이런 혼합집단 형태의 집단 정신치료를 임상에서 도입해 볼 만한 것이 아닌가 한다. From July 1982, the author has conducted a group psychotherapy at the department of Neuropsychiatry in Seoul National University Hospital. It was a mixed group that consisted of in and out patients. In the fourth session, two new in-patients were introduced into the group to fill the vacancies. The successful assimiolatin of new patients into the group during this session was so impressive that the dynamics of this event was discussed as follows: 1. Old members were anxious because two members dropped out of the group so that the old ones had to welcome the new ones to preserve the group. 2. Helping new patients was an 「ego-booster」 for the old patient. 3. Most of the members knew one another prior to the group through concomitant admission. 4. New patients viewed the group as an alumnimeeting as the old ones had been also ex-patients in this group. 5. All of the members had a positive transference to this institution, thus group feeling was easily promoted. 6. All of the members were also under the individual psychotherapy by the author, thus their loyalty toward the therapist played a considerable role on group feeling. The author concluded that a mixed group of in and out patients was worth trying in clinical practice.