Plenary Session 2 : PS-2-1 ; Outcomes of hepatitis B virus recurrence after liver transplantation: a multicenter analysis in Korea

( Hee Yeon Kim ),( Jong Young Choi ),( Dong Goo Kim ),( Myoung Soo Kim ),( Soon Il Kim ),( Shin Hwang ),( Sung Gyu Lee ),( Kwang Woong Lee ),( Kyung Suk Suh ),( Young Seok Han ),( Dong Lak Choi ),( Se 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: The outcome of hepatitis B virus (HBV) infection after liver transplantation (LT) was improved by hepatitis B immunoglobulin (HBIG) and nucles(t)ide analogue (NUA). However, HBV recurrence after LT is critical because the recurrence is occasionally accompanied by a progressive destruction of graft and poor survival. The aims of this study were to investigate the significance HBV recurrence and identity factors associated with HBV recurrence. Methods: From October 1999 to February 2011, a total of 2684 consecutive LT recipients who underwent HBV-associated LT were retrospectively enrolled from 7 transplantation centers in Korea. Results: Prophylaxis regimens were HBIG monotherapy (67.7%) or a combination of HBIG with NUA (22.3%). The recurrence rate of HBV was 6.1% (164 recipients) during mean follow-up duration of 10.9 years. The median time from transplantation to recurrence was 2.1 years (0.1-7.9 years). Of the 1,071 patients with hepatocellular carcinoma (HCC) prior to LT, 155 patients (14.5%) had HCC recurrence after transplantation, and 48 patients (31.0%) had HBV recurrence. Of the 48 patients with recurrence of both HBV and HCC, 25 patients (52.1%) experienced HBV recurrence after HCC recurrence. In the multivariate analysis, pretransplant HCC, pretransplant HBV DNA above 5.5 log copies/mL was independent clinical factors influencing HBV recurrence after LT. The mortality rate among the recipients with HBV recurrence was 34.1% (56 recipients). Mean overall survival was 6.4 years in the HBV-recurrence group and 9.9 years in the HBV-nonrecurrence group (p<0.001). HBV recurrence was not an independent prognostic factor for overall survival. HCC recurrence was the most important factor for overall survival. Conclusions: The overall outcome of LT in HBV-related liver disease was excellent with the current prophylaxis regimen Choon Hyuck David Kwon,8 Suk-Koo Lee8 Pretransplant HBV DNA and HCC were important factors for HBV recurrence. HBV recurrence after LT did not significantly influence on the overall survival without combining of HCC recurrence.

하루 콩단백질 25g 섭취를 위한 메뉴작성 및 영양성분 분석

한재숙,김정애,서봉순,이연정,서향순,조연숙,한경필,이신정,오옥희,우경자,조은자,구성자,김수진,李承彦,南出隆久 동아시아식생활학회 2002 동아시아식생활학회지 Vol.12 No.2

The purpose of this study was to develop menus for daily intake of 25g soybean protein and to analyse nutrients of these foods. Analytical values were compared to the theoretical one using the food composition table and recommended dietary allowances for Koreans (7th revision). The results are as follows. 1. Soybean curd residue stew, Soybean curd, Kimchi saute, and hard boiled soybean and lotus root were selected for the menu for January, of which the content of soy bean protein(SBP) was 33.1g, soybean stew, soybean curd and soybean sprout saute, and Italian deep fried soybean curd were for February, of which the content of SBP was 35.0g. The content of SBP in soybean paste soup with soybean curd, fried soybean curd and fried soybean curd roll, the menu for March, was 24.9g. That of April were soybean curd gratin with soymilk, soybean curd and ham with garlic dressing and the content of SBP was 26.3g. That of May were soybean porridge, soybean flour cake with honey (Dasik), soybean sprout soup and the content of SBP was 26.7g. That of June were soymilk, pan-fried soybean curd, steamed soybean curd with chicken and the content of SBP was 28.4g. That of July were noodle with soymilk, mapatofu, soybean curd salad and the content of SBP was 24.7g. That of August were soybean sprout with mustard dressing, Tossed green pepper with raw soybean flour, Tofu and Kimchi stew, soybean curd steak and the content of SBP was 26.2g. That of September were Chinese cabbage soup with raw soybean flour, sweet and sour tofu and the content of SBP was 23.2g. That of Oct. were Fermented soybean stew, soybean pan cake and the content of SBP was 24.3g. That of November were not-pressed soybean curd casserole, pan-fried mashed soybean curd with egg, stir frying deep-fried soybean curd with vegetables and the content of SBP was 22.4g. That of December were soybean curd and mushroom casserole, fried soybean curd and vegetables, hard boiled soybean curd and the content of SBP was 28.9g. 2. The ratio of the analytical value over theoretical value (A/B%) of one serving in kcal, carbohydrate, protein, fat, ash and dietary fiber were 57.7~107.7%, 42.9~131.9%, 79.2~118.3%, 54.5~100%, 40.7~80.8% and 42.1~113.2%, respectively. 3. The ratio of A/B% of one serving in Ca, K, Na, P and Fe were 44.1~93.6%, 59.0~153.1%, 53.1~117.7% 64.6%~138.8 and 33.8~77.3%, respectively. That in Fe was the lowest among minerals. 4. The ratio of analytical value over Korean R.D.A(A/C%) in Ca was relatively higher (22.0~85.9%) than that in kcal(18~63%). 5. The ratio of A/C% in Fe was 25.1~64.3% and lower than that in Ca and protein in general.

Ito 저색소증

이근수,장홍준,서연림,안규중,김종민,이종주 ( Geun Soo Lee,Hong Zoon Jang,Yeon Lim Suh,Kyu Joong Ahn,Jong Min Kim,Chong Ju Lee ) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.5

A Case of Hypomelanosis of lto Geun Soo Lee, M.D., Hong Zoon Jang, M.D., Yeon Lim Suh*, M.D., Kyu Joong Ahn, M.Dl., Jong Min Kim, M.D., Chong Ju Lee, M.D. Departments of Dermatology and Pathology*, Clooege of Medicine, Hallym University Seoul, Korea We report a case of hypomelansis of Ito developed in a 6-year-old male patient. He had numberous bizarre, hypopigmented streaky macules on the left side of the chest, and upper arm. The histopathologi findings demonstrated that hypopigmented areas contained slightly decreased basal pigmentation with decreased content of intracellualr melanin in keratinocytes and melanocytes and revealed neither inflammatory changes nor dropping of melanin granule into the dermis. The electron microscopic finding showed decreased number of melanosomes, incomplete melaniztion, and cytoplasmic vacuoles in keratinocytes and melanocytes. Extra-cutaneous alterations were not found.

靑少年期 子女가 父母의 行動에 미치는 影響

李在然,金舒英 淑明女子大學校 生活科學硏究所 1988 論文集 Vol.2 No.1

세포사에 미치는 산화·환원 민감성칼슘통로의 역할

서연원,이용수 덕성여자대학교 약학연구소 2005 藥學論文誌 Vol.16 No.1

Calcium signal plays an essential role in both apoptotic and necrotic cell death. Intracellular calcium release through emptying of calcium stores and/or change in intracellular calcium concentrations appear to modulated cell death in almost all cell types. These calcium fluxes are only regulated by the activity of membrane channels normally under tight control. These calcium channels may be ligand activated or voltage dependent as well as being under the control of affector molecules such as calmodulin. Many calcium channels have been recently shown to be affected by reactive oxygen or reactive nitrogen species; ROS/RNS. This mechanism may be evoked by normal signaling pathways in the cell or by the actions of exogenously applied toxins. This review covers the recent literature on the role of these redox sensitive calcium channels associated with cell death.

하악전돌증의 악교정수술후의 회귀성향에 관한 연구

서연호,서혜경,문선혜,박노부,이용오 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.2

저자등은 악교정수술후에 발생하는 희귀성향에 관한 연구를 위하여 계명대학교 의과대학 치과학교실에 내원하여 하악전돌증으로 진단되어 하악후퇴술을 받은 7명의 환자를 대상으로 하여 수술전, 후의 경조직의 변화를 계측, 분석하여 다음과 같은 결과를 얻었다. 수술직후 Gn(H)는 평균 8.2mm 후방이동되었고 SNB는 평균 4.4 감소하였다. SNB는 장기간 경과후 수술직후보다 평균 0.9 증가되었으며 21.1%의 희귀율을 나타내었다. Gn(H)는 장기간 경과후 수술직후보다 6례에서 평균 1.3mm 전방희귀되었으며 나머지 1례에서 4mm 후방이동되었다. SN-MP 및 gonial angle 은 장기간 경과후 수술 직후보다 각각 평균 2.2 ,5.8 증가되었다. Gn(V)는 장기간 경과후 수술직후와 비교하여 변화가 없는 경우가 4례, 증가 2례, 감소 1례로 나타났다. 상하악 중절치는 장기간 경과후 수술직후보다 각각 순측 혹은 설측으로 경사되었다. This study was undertaken to examine relapse tendency after mandibular setback. Seven cases were selected from patients who underwent orthodontic treatment and mandibular setback surgery in our department. The serial lateral cephalogram of each patient were obtained and analyzed: The result were as follows; 1. By operation, Gn(H) moved backward (average 8.2mm), SNB angle decreased(average 4.4˚). 2. When the long term follow-up measurements were compared with the immediate postop, mesurements. ·SNB angle increased on average by 0.9˚and relapse tate was 21.1%. ·GN(H) returned foward on average by 1.3mm in 6 cases, moved backward by 4mm in 1 case. ·SN-MP and gonial angle increased on average by 2.2˚, 5.8˚respectively. ·Gn(V) stayed unchanged in 4 cases, increased in 2 cases, decreased in 1 case. ·Upper and lower incisors slightly moved labially or lingually.

교아종 1례의 양자방사선 단층촬영(Positron Emission Tomography)과 CT/MRI 소견의 비교 및 병리조직학적 소견과의 연관성 : 증례보고 Case Report

김기준,이정일,김상은,서연림,김종현 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.12

Computed tomography(CT) and magnetic resonance imaging(MRI) facillitated detection and accurate localization of brain tumors, however, have limitation in predicting the physiologic nature of tumors or the extent of tumor cell infiltration. The PET with [¹?F] fiuorodeoxyglucose(FDG) can give complementary information by measuring glucose consumption It was reported that PET was useful for differentiation between recurrent tumor and necrosis, detection of early recurrence. and prediction of the degree of malignancy. Also it can evaluate the metabolic status of different areas in a lesion with heterogeneous components, and be useful for optimal targeting in stereotactic biopsy. We performed stereotactic biopsy of a glioblastoma obtained multiple specimens from different sites, and investigated correlation between histopathological findings and the findings in CT MRI, and PET The histopathological findings such as cell density and presence of microscopic necrosis were well correlated with the metabolic status measured by PET The extent of the area involved by infiltrating tumor cells was estimated more approximately by PET than by CT or MRI. These findings suggest that PET may give additional information which may be useful for diagnosis and evaluation of the disease.

Budd-Chiari 증후군 : 1례 보고 A Case Report

김승현,오연희,이현경,이성우,서정욱 동국대학교 경주대학 1997 東國論集 Vol.16 No.1

하대정맥의 막성폐쇄로 인한 Budd-Chiari 증후군은 비교적 드문 질환으로 알려져 있다. 저자들은 우상복부 동통을 주소로 내원한 환자에게 방사선학적 검사와 임상적으로 확진된 하대정맥의 막성폐쇄에 의한 Budd-Chiari 증후군 1례를 경험하였기에 문헌고찰과 함께 보고 하고자한다. The Budd-Chiari syndrome is a rare, often fatal illness resulting from hepatic venous outflow occlusion. It occurs secondary to intrinsic vascular thrombosis, tumor invasion, or rarely a congenital web. We report a case of primary Budd-Chiari syndrome with membranous obstruction of inferior vena cava, with a brief review of literature.

Rasmussen 뇌염 : 1예 보고 A Case Report

김나래,한재준,서연림,이문향 대한병리학회 2001 Journal of Pathology and Translational Medicine Vol.35 No.4

사망 진단서(시체 검안서) 작성의 문제점

김규석,임용수,이중의,서길준,윤여규,어은경,염석란,정연권,이윤성 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: This study was conducted to analyze the current problems in completing death certificates and to identify the correct method for completing death certificates Methods: We reviewed 262 death certificates in three hospitals from March 1 to April 30, 2000, and 119 death certificates in one hospital from March 1 to 31, 2000. We identified major and minor errors and analyzed and compared them retrospectively. Results: A total of 381 death certificates were reviewed: 59 in Seoul National University Hospital,101 in Ewha Woman's University Hospital, and 102 in Gachon Medical College Hospital, which has no education program for completing death certificates in postgraduate training, and 119 in Samsung Medical Center which has an education program for completing death certificates. 358 certificates(94.0%) had at least one error. There were only 23 death certificates(6.0%) without an error. In 182 cases(47.8%), there was one major error. In 321 death certificates(84.3%), there were more than two errors. A comparison of Samsung Medical Center with the other hospitals showed that the number of total errors was statistically different(p=0.001). Conclusion: There were few death certificates without an error in this study. In a hospital which has postgraduate training in completing death certificates, there are fewer errors than in other hospitals which have no training course. Emergency physicians actually certify many deaths, so they must know the correct method of completing death certificates for statistics on morbidity and mortality.