실험실 내에서 배양된 편평상피암 세포주에 대한 염화불소의 효과

박노부 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.2

The effects of Sodium Fluoride on squamous cell carcinoma cell line(SCC-cells) cultured in vitro have been studied with respect to cytotoxicity and induction of chromosome aberrations. Cytotoxicity of NaF on SCC-cells, as determined by a decrease in colony-forming ability, linearly increased with dose of NaF(150-300 ug/ml) or exposure time (3-24h). SCC-cells treated with 30-60ug/ml NaF for 24h were analyzed for chromosome aberrations. A significant increase in the frequency of chromosome aberration at the chromatid level was induced by NaF in a dose-dependent manner. These results suggest that NaF is a toxic substance which inhibit cell proliferation and causes DNA damage in SCC-cells cultured in Vitro.

안면골 골절과 동반된 경동맥해면동루의 증례보고

박노부,서연호,문선혜,이용오,Park, No-Bu,Seo, Yeon-Ho,Moon, Seon-Hye,Lee, Yong-Oh 대한악안면성형재건외과학회 1993 Maxillofacial Plastic Reconstructive Surgery Vol.15 No.2

저자들은 두개저 골절을 동반하지 않은 단순 안면골 골절환자에서 본과에서 안면골 정복 수술후 발현한 외상성 경동맥해변동루 환자를 신경외과에 의뢰하여 분리풍선술식으로 처치한 후 현저한 임상적 증상의 개선을 가져왔고 12개월간 관찰시 다른 합병증도 유발되지 않았다. 외상성 경동맥해면동루는 두경부 손상시 매우 드물게 발생되는 심각한 합병증으로 임상증상의 복잡성 때문에 혼동하기 쉬으므로 Neurosurgeon과 협조하여 조기에 정확한 진단과 적절한 치료가 이루어지는 것이 바람직하다. Carotid-cavernous sinus fistula(CCSF) is an abnormal arterio-venous communication between the cavernous sinus and the internal carotid artery. It is usually caused by craniofacial trauma and a very rarely encountered complication, but it may also occur spontaneously. The most common cause of traumatic CCSF is blunt trauma, which usually associated with a skull base, frontal or midfacial fracture. The common clinical feature of CCSF are orbital bruit, headache, exophthalmos, chemosis, diplopia, visual disturbance and others. This dramatic ocular-orbital symptoms are principally due to orbital venous hypertension. The symptoms occured within a few hours to a maximum of a year after injury, usually within several weeks. The patient, 33-year-old female, developed a carotid-cavernous sinus fistula after only minimal closed trauma We present a rare case of CCSF associated facial bone fracture that was successfully treated by detachable balloon embolization with a review of the literature.

하악과두 골절의 임상통계학적 연구

박노부 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.1

This is a retrospective study on mandibular condyle fractures. This study was based on a series of 139 inpatients with mandibular condyle fracture treated in our department from Jan, 1984 to Oct, 1993. The results obtained are as follows : In 340patients of mandibular fracture, 139 patients suffered from condylar fracture(36.1%). Peak age incidence was 3rd decade(28.2%) and the rate of male to female was 3.3 : 1. In regard of seasonal variation, there were two peaks in May and Oct. The most frequent etiologic factor was traffic accident(42.4%), followed by falls(39.5%) and violence(13.0%). The most common fracture site was subcondyle(46.6%). Compound fracture with symphysis was more frequent(56.0%) than simple fracture(31.2%). In respect of treatment, closed reduction was 50.4% and remainder was open reduction(49.6%). In children, closed reduction was done in 89.5%. Complications ensued such as limitation of mouth opening and mandibular movements, TMJ dysfunctioin, TMJ ankylosis, deviation of mandible, and infection.

임상소견에 따른 법랑모세포종의 방사선학적 특징에 관한 임상통계학적 분석

박노부 慶北大學校 齒科大學 1995 慶北齒大論文集 Vol.12 No.1

법랑모세포종 115 증례 (원발성 82 증례, 재발성 33증례)의 병상일지, 방사선사진, 생검보고서 등을 참고하여 임상소견 (성별, 연령, 부위, 주소, 병력기간, 치료방법, 병소크기, 재발성여부, 매복치 유무)과 방사선 소견과의 관련성을 연구한 결과 다음과 같다. 1. 성별에서 남자에서는 단방성 소견이 55.2%, 여자에서는 다방성 소견이 67.4%였다(P>0.05). 2. 연령별에서 30세 미만에서는 단방성 소견이 52.5%, 30세 이상에서는 다방성 소견이 64.8%로 나타났다(P>0.05). 3. 부위별에서 상하악 모두에서 다방성 소견이 61.5%,54.9%로 나타났으며, 하악 우각부에서는 다방성 소견이 54.4%, 하악우각 부위를 제외한 다른 부위에서는 다방성 소견이 57.4%로 나타났다(P<0.05). 4. 동통이 없는 경우에는 단방성 및 다방성 공히 50%로 나타났으며, 동통이 있는 경우에느 다방성 소견이 65.9%로 나타났다(P>0.05). 5. 평균병력기간 30.45개월 이하인 경우에는 단방성 소견이 54.4%, 30.45개월 이상인 경우에는 다방성 소견이 77.8%였다(P<0.05). 6. 보존적 외과술을 시행한 경우는 단방성 소견이 65.2%였으며, 근치적 외과술을 시행한 경우는 다방성 소견이 69.6% 였다(P<0.05). 7. 평균크기 6.19cm 이하인 증례에서는 단방성 소견이 56.8%로 나타났으며, 6.19cm 이상인 증례에서는 다방성 소견이 78.0%로 나타났다(P<0.05). 8. 원발성인 경우에는 다방성 소견이 53.7%, 재발성인 경우에는 다방성 소견이 60.6%로 나타났다.(P>0.05). 9. 매복치가 없는 경우에는 다방성 소견이 60.0% 였으며, 매복치가 있는 경우에는 단방성 소견이 54.3% 였다(P>0.05). 이상의 성적을 Chi-square test를 이용하여 통계처리 하여 보면 연령, 부위, 주소, 재발성 여부 및 매복치 유무는 방사선 소견과 통계학적인 관련성이 없었으나, 여성, 평균병력기간(30.45 개월)이상, 평균크기 (6.19cm)이상 및 근치적 외과술을 시행한 증례에서는 다방성 소견이 많은 것으로 나타났다 (P<0.05). The author studied on the 115 cases of the ameloblastoma which had been diagnosed with biopsy during the period of 1962 to 1994 at the Kyungpook National University Hospital, Keimyung University Hospital, Youngnam University Hospital, Catholic Medical School Hospital, Pusan National University Hospital and Maryknol Hospital. This study contains the statistical analysis of the clinico-pathological findings such as sex, age, location, chief complaint, duration, treatment method, size, recurrence and impacted teeth in relation to radiographic findings. The results were as follows: . The incidence rate was 60% in male and 40% in female. . At the time of diagnosis, the age of the patients ranged from 9 to 69 years old (average 31.4 years old). The cases of 73% were in the 2nd, 3rd and 4th decades of life. . The majority of cases, 88.7% occurred in the mandible, especially 59% in the mandibular angle area. . The most prevalent chief complaint of swelling was 56.5%. . As regards duration, the cases less than 12 months appeared 49.5%, and average duration is 30.45months. . Unilocular radiographic findings showed 43.5%, Multilocular radiographic findings appeared 56.5%. . Conservative treatment was performed 40.0%, and radical treatment was employed 60.0% . There was the variation of lesional sizes between 2.0cm and 15cm, average size 6.19cm . Recurrent cases were 28.7%, and impacted teeth were shown 30.43%. . The radiographic finding has no relationship with the factors of age, location, chief complaint, recurrence and impacted teeth, however there is slight indication that the below 30-year-old patient tend to be related to the multilocular type. . But the multicular radiographic findings were shown more frequentily in the roupes of female, over average of 30.45 months, over average size of 6.19cm and radical treatment.

상악골과 하악골에 각각 발병한 섬유성이형성증 치험 2례

박노부,문선혜,남동석,이용오,서연호,김우철 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.4

The fibrous dysplasia of bone is a benign, slow growing, perplexing tumor of bone that replace the normal bone by the fibrous tissue composed of collagen fibers, fibroblasts and containing variable amount of mineralization. A fibrous dysplasia tends to occur more frequently in women than men and to be seen more in maxilla than mandible. This tumor may obliterate maxillary sinus and extend to the infraorbital area, zygoma but may not obliterate the nasal cavity. And this tumor may expand the cortical plate of the mandible, mandibular cannal and may involve to the condylar head so that facial asymmetry is provoked. Ideal treatment of the fibrous dysplasia is the surgical intervention. Because it is a diffuse lesion the complete excision is difficult, so the conservative osseous contouring is recommended. We treated two patients, one was a 18-year-old female with fibrous dysplasia in maxilla involving zygoma, infraorbital rim and maxillary sinus, the other was a 32-year-old female with fibrous dysplasia in mandibular posterior area. We operated the former by conservative surgery with osseous contouring and the latter by reconstructive surgery with titanium mesh and plate after mandibular resection under general anesthesia. We obtained successful functional and esthetic results and no recurrence was seen in two years postoperative follow up.

백서 좌골신경의 압좌상과 절제에 따른 말초신경 재생의 비교

박노부,김진수,김호석 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.1

The purpose of this experimental study was to examine and compare the regeneration capacity between crushed nerve & transected nerve. For this study, 20 Sprague-Dawley female albino rats were used as experimental animals and divided into two groups. In group 1, the sciatic nerves were crushed 6mm. in length for 1 min. using maximum force with a needle holder. In group 2, the sciatic nerves were resected 6mm. in length and the gaps were encased by inserting the proximal and distal stumps into each end of silicone tubes. The animals were sacrificed 1 month & 2 months after the experiment. All specimens were fixed in 2.5% glutaraldehyde and 1% Osmium tetroxide solution then embedded in epon 812 and were cross-sectioned at 1 ㎛. After these procedures, specimens were observed under Light microscope. The results obtained were as follows. 1. Group 1 showed greter diameters of regenerating nerves than group 2. 2. Group 1 showed greater number of axons than group 2.

임상소견에 따른 법랑모세포종의 방사선학적 특징에 관한 임상통계학적 분석

김진수,신상욱,박노부 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.4

The author studied on the 115 cases of the ameloblastoma which had been diagnosed with biopsy during the period of 1962 to 1994 at the Kyungpook National University Hospital, Pusan National University Hospital, Youngnam University Hospital, Keimyung University Hospital, Catholic Medical School Hospital, and Maryknol Hospital. This study contains the statistical analysis of the clinico-pathological findings such as sex, age, location, chief complaint, duration, treatment method, size, recurrence and impacted teeth in relation to radiographic findings. The results were as follows : 1. The incidence rate was 60% in .male and 40% in female. 2. At the time of diagnosis, the age of the patients ranged from 9 to 69 years old (average 31.4 years old). The cases of 73% were in the 2nd, 3rd and 4th decades of life. 3. The majority of cases, 88.7% occurred in the mandible, especially 59% in the mandibular angle area. 4. The most prevalent chief complaint of swelling was 56.5%. 5. As regards duration, the cases less than 12 months appeared 49.5%, and average duration is 30.45months. 6. Unilocular radiographic findings showed 43.5%, Multilocular radiographic findings appeared 56.5%. 7. Conservative treatment was performed 40.0%, and radical treatment was employed 60.0%. 8. There was the variation of lesional sizes between 2.0cm and 15cm, average size 6.19cm. 9. Recurrent cases were 28.7%, and impacted teeth were shown 30.43%. 10. The ratiographic finding has no relationship with the factors of age, location, chief complaint, recurrence and impacted teeth, however there is slight indication that the below 30-year-old patient tend to be related to the multilocular type. 11. The multilocular radiographic findings were shown more frequently in the groups of females, over average of 30.45 months, over average size of 6.19cm and radical treatment.

국내 미술교과교육 연구 실태조사 연구: 1977-1995

노부자,박은덕,김혜숙 한국미술교육학회 1997 美術敎育論叢 Vol.6 No.-

SILICONE TUBE에 삽입된 신경절편이 말초신경 결손부의 재생에 미치는 효과

장현중,박노부,홍창수 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.4

The purpose of this study is to observe the stimulant effect of the isolated nerve segment on the peripheral nerve regeneration using silicone tube in rats. Srague-Dawley female albino rats were used as experimental animals and nerve defects were made by resection of 14 mm-long segment of right sciatic nerves. In control group, the defects were bridged with the silicone tubes. In experimental group, the defects were bridged with the same manner and additionally, 2mm-long nerve segments were inserted at the center of the silicone tubes. 3 months later, the regenerated nerve tissue within the silicone tubes were examined by histologic study. Axonal diameters and numbers of axons were measured and all data were analyzed by using SAS package program. The results obtained were as follows : 1. The experimental group was increased than the control group in general diameters of the regenerated nerve fiber.(P<0.05) 2. The diameters of axons were increased int he experimental group compare to the control group. (P<0.05) 3. The numbers of axons were increased int he experimental group compare to the control group. (P<0.05)

3차원 CT을 이용한 안면 비대칭의 치험 1례

최봉주,박노부,박효상 啓明大學校 醫科大學 1996 계명의대학술지 Vol.15 No.3

It is very difficult to diagnose the facial asymmetry, that is, difficult to determine what part of problem is major cause to treatment. The three dimensional CT developed recently can provide excellent three dimensional image of soft and hard tissue, thus authors decided to determine the possibility of three dimensional CT for the diagnostic means for facial asymmetry. The patient, 19 year old female, had anterior edgebite with deviated dental midline and mild concave profile and was diagnosed as facial asymmetry with skeletal asymmetry and functional displacement of mandible by using three dimensional CT. The orthodontic and orthognathic procedure were performed. The following results were obtained. The facial asymmetry was favorably corrected. The favorable facial profile was achieved. The harmonious occlusion was obtained. The three dimensional CT will provide useful guide for skeletal abnormality and will be good diagnostic means for facial asymmetry. However, the appropriate analysis method is not established, it will be further needed.