성인에서 장기간 Furosemide오용과 연관된 신수질 석회화

김윤구,이윤하,이규백,장세호,김대중,오하영,김보현,김미경,조윤숙 대한신장학회 1996 대한신장학회잡지 Vol.15 No.4

비만을 동반한 위암 환자에서 두 병을 같이 수술 치료한 경험(증례)

최경현,윤기영,문형환,신연명,서경원,안수미,송윤미,석정희,정경연,이은하 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Obesity is growing problem in Korea. We had a case of bariatric surgery during gastric cancer operation. Patient was 29 year old Korean lady with early gastric cancer located in the lesser curvature side of the middle 1/3 of the stomach. Her body weight was 89 kg, height 163 cm, and thus body mass index was 33.5 kg/m2. Preoperative blood pressure was 130/90 mmHg, hemoglobin 12.9 g/dL, total lymphocyte count 3,280/mL, serum albumin 4.3 g/dL, CEA 1.1 ng/mL, CA 19-9 9.1 ng/mL, and alpha fetoprotein 2 ng/mL. Another associated disease was right thyroid follicular neoplasm. The chest X-ray was normal. After IM injection of 2,500 units of heparin 30 minutes before the induction of general anesthesia, she received curative subtotal gastrectomy and Roux en Y gastrojejunostomy when a malabsorption loop of 120 cm jejunum was incorporated between the Treitz ligament and the end to side jejuno-jejunostmy site at May 29th 2006. Her postoperative course was uneventful except a minor wound seroma and the elevations of serum amylase(up to 4 folds) and lipase(up to 2 folds). She lost her body weight 9 kg in 5th, 21 kg in 7th, and 27 kg in 10th postoperative months to became 61.5 kg. On follow up exams in July 2008, she gained 4 kg to overcome her weakness and fatigue. From the above result, the incorporation of a malabsorption loop during reconstruction phase of gastric cancer operation was a good option for obese gastric cancer patients especially in cases of early gastric cancer.

의사소통능력 신장의 관점에서 본 초등학교 3학년 영어 교과서 삽화 분석

윤희백,하경옥,손순익 부산교육대학교 교육대학원 1999 논문집 Vol.1 No.-

The purpose of this study was to analyze the illustrations of Elementary English textbooks for the third grade students focusing on helping students improver communicative competence. Sixteen sorts of Elementary English textbooks, teacher's guides and visual aids were analyzed. The illustrations were found to be good to some degree, but not good enough to improve student's communicative competence. Many of them had some problems. These findings are presented in order to contribute to the development of the illustrations of English course materials which will be made in the future.

쇄목펄프폐수를 이용한 Bacillus thuringiensis var. israelensis 의 Spore-Crystal 복합체 생산에 관하여

윤경하,김영돈,김태전 서울保健大學 1991 論文集 Vol.11 No.1

Benzo(a)pyrene에 의해 유도된 간기능 장해에 미치는 당귀의 효과

윤수홍,조수열,이윤경,하두현 한국환경독성학회 1992 환경독성보건학회지 Vol.7 No.1

This study was performed to investigate the effect of Angelicae gigantis Radix extract on the hepatic detoxifying enzyme activities and lipids. Male sprague-dawley rats were administrated the extracts with benzo(a)pyrene, a hepatotoxic agent, inducing liver damages. Results obtained from this study were as follows: 1. The markedly increased enzyme activities (AST, ALT, LDH, ALP, γ-GTP, GSH -Px) in B(a)P induced groups tended to be decreased by the treatment of the Angelicae gigantis Radix extract. 2. Liver GSH content and lipid peroxide activity were decreased by the administration of the extracts. 3. It tended that the curative effects were better than the protective effects of the extracts.

일 농촌지역의 우울 증상에 관한 역학연구 -위험요인 및 요인구조분석

하양숙,홍진표,김한규,이군희,한경자,조맹제,김용익,송미순,박성애,김창윤 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.2

연구목적 : 세계적으로 널리 사용되는 우울증 척도인 the Center for Epidemiologic Studies Depression Scale(CES-D)을 이용하여 지역사회 주민의 우울증상의 정도를 평가하고, 우울증상의 위험요인을 분석하고, 한국인에서 우울증상의 요인구조를 알기 위해 본 연구를 실시하였다. 방 법 : 경기도 일 농촌 지역의 30세 이상 주민에 대해 무작위 군집 집락 추출을 실시하였고, 훈련된 면담원들이 가정 방문을 통하여 면접 및 자기보고 검사인 CES-D를 실시하였다. 총 1,315명에서 응답을 하였고 응답율은 59.3%이었다. 결 과 : CES-D에 의한 우울증 점수는 0∼5점이 57%정도를 차지하였고, 평균 점수는 남자 7.8점 여자 9.5점으로 비교적 낮은 편이었다. ANCOVA 분석 결과 비결혼, 저학력, 여성이라는 위험요인은 독립적으로 우울증상을 악화시키는 요인이었으나 연령은 통계적으로 유의하지 않았다. CES-D 결과를 요인분석을 시행한 결과 4가지 요인이 추출되었는데 우울증상 및 신체증상이 한 개의 요인으로, 다른 나라에서 보고되지 않는 정서적 고통이 별도의 요인으로 추출되었다. 결 론 : 국내 역학 조사에서도 외국과 유사한 우울점수 및 위험요인이 확인되었으나 우울증의 요인에서는 특이한 요인이 추출되었다. 한국인에 독특한 우울 반응에 관한 추가 연구가 필요하다. Objectives :The rates, correlates, and factor structure of depressive symptoms in a Korean rural sample were examined using Korean version of the Center for Epidemiologic Studies Depression Scale(CES-D). Methods : Door to door visiting survey was conducted by trained interviewers. A random cluster sample of 1,315 respondents, aged 30 and over completed the CES-D scale along with additional sociodemographic questionnaire. Results : In this sample, mean CES-D score of male and female were 7.8 and 9.5, respectively which were lower than those reported previously. Symptoms of depression were most common among the less educated, non-married and female according to ANCOVA. Age was not a significant risk factor for depressive symptoms. Different factor structures emerged from this sample as compared to other studies using this approach. Somatic symptoms and affective symptoms were combined as one factor and emotional hardship emerged as a separate factor. Conclusion : Symptoms scores and risk factors were similar to the results reported in other countries but unique factor structures were found in this study. Further research is needed about the Korean depressive symptomatology and related areas.

동국대학경주병원에서 분리된 각종 병원성 세균 및 항생제 감수성 양상

하경임,고은하,전창호,정병욱,안우섭,김우택,배정수,어경윤 동국대학교 경주대학 1993 東國論集 Vol.12 No.-

We investigated characteristics of bacterial infection and antimicrobial suscerptibility patterns of clinical specimens in Dong Guk University Kyong Ju Hospital from october 1991 to december 1992. The types of clinical specimens requested for culture were as follows ; pus(34.2%), urine(29.6%), sputum(25.2%), blood(9.2%), etc. The most frequently isolated organisms were E. coli(17.6%), Pseudomonas(12.7%), S. aureus(12.2%), and CNS(11.2%), orderly. Predominant organisms from pus, urine and sputum were S.aureus, E. coli and Pseudomonas. Blood culture was requested 1,244 samples from 614 patients, 91 pathogeni organisms were isolated(14.8% from patient and 7.3% from requested clinical samples). E. coli was most frequently isolated(29.7%) and Salmonella typhi was noted 8.8% from the requested samples. The patterns of isolated organisms according to departments were as follows ; E.coli and Klebsiella were frequently isolated in internal medicine and general surgery, E.coli and Pseudomas in Neurosurgery, S. aureus and Pseudomonas in orthopedic surgery. In ICU, Pseudomonas was predominatly isolated and the rate of mixed infection was also high(16.4%). Most of gram-negative bacilli revealed relatively high susceptibility to Chlorampenicol, Amikacin, Tobramycin and Carbenicillin, but Acinetobacter were only susceptible to Carbenicillin and Tetrecyclin, and Serratia were to Carbenicillin and Amikacin while Salmonella were susceptible to all tested first drugs. The proportions of multi-drug resistant bacteria were 34.9% of Acinetobacter, 21.1% of Serratia, 20.0% of Pseudomonas and 15.4% of Citrobacter but Aztreonam was highly susceptible(84∼100%) except Acinetobacter. S. aureus and CNS were susceptible to Chlorampenicol, Oxacillin, Cephalothin and Vancomycin, especially, 100% susceptible to Vancomycin. But Methicillin reistant Staphylococcus aureus were very high(49%) inspite of new constructed hospital. Pneumococcus and Streptococcus species were relatively high susceptible to all tested drugs.

천마의 GABA-benzodiazepine 수용체 복합체에 대한 조절작용

하정희,이동웅,어경윤,하정상,김현주,용철순,허근 영남대학교 약품개발연구소 1998 영남대학교 약품개발연구소 연구업적집 Vol.8 No.-

Methanol extract of G. elata inhibited the binding of [³H]Ro15-1788, a selective benzodiazepine receptor antagonist, to benzodiazepine receptor of rat cortices. Saturation experiments followed by Scatchard analysis of the results showed that the inhibition of [³H]Ro15-1788 binding by G. elata. appeared to be competitive. These competitive inhibiton of the butanol fraction was observed to be higher than the methanol extract. Methanol extract of G. elata inhibited a [³H]flunitrazepam, a selective benzodiazepine receptor agonist, binding to benzodiazepine receptor. GABA significantly enhanced the inhibition of [³H]flunitrazepam binding by G. elata, and these "positive GABA shift" supported the strong possibility of agonistic activity to benzodiazepine receptor. Butanol fraction was observed to be higher than crude extract by methanol in an agonistic activity to benzodiazepine receptor, furthermore enhanced the binding of [³H]SR95531 to GABA_(A) receptor. Butanol fraction of G. elata significantly diminished the pentylenetetrazole-induced lethality of mice. From these results, it can be concluded that substance or substances with neurochemical properties characteristic of a benzodiazepine receptor agonist may be important components, and contribute to the anticonvulsant property of G. elata.

한국산 고온성 방선균의 Protease 생산에 관한 연구

윤경하 순천향 대학교 1984 논문집 Vol.7 No.2

우리 나라 중부 이남에서 수집한 180여개의 표품으로부터 90주의 고온성 방선균을 분리하고 이들의 단백질 분해효소의 활성을 측정 비교하여 효소생산능력이 우수한 균주를 선정함과 동시에 그의 단백질분해효소의 생산을 위한 몇가지 배양조건을 조사하였다. (1) 단백질분해효소의 생산능에 있어서 우수균주로 선정된 S68-2는 산성, 중성 및 알카리성 단백질분해효소의 활성을 11.0, 17.4, 그리고 17.3으로 각각 나타냈다. (2) 알카리성 단백질분해효소의 생산은 배지의 조성이 3.0% soluble starch, 1.0% peptone, 0.05% MgSO₄·0.15% K₂HPO₄, 0.002% FeSO₄·7H₂O 0.01% CaCl₂·일 때 가장 양호하였다. (3) 효소생산의 최적배양조건하에서 24시간 진탕배양 했을 때 단백질분해효소의 활성(21.5㎍ /ml)이 가장 높았다. Protease activities of thermophilic Actinomycetes which were isolated from various habitat substrates collected througout South Korea were measured. The cultural conditions of the best strain in protease production were investigated. 1. Among the 90 strains of thermophilic Actinomycetes isolated, strain number S68-2 was selected as the predominant strain in acidic, neutral and alkaline protease activity. 2. The composition of effective medium for alkaline protease production by S68-2 strain was 3.0% soluble starch, 1.0% peptone, 0.05% MgSO₄·7H₂O, 0.15% K₂HPO₄, 0.01% CaCl₂·2H₂O and 0.002% FeSO₄·7H₂O. 3. S68-2 strain exhibited the most remarkable protease activity when it was grown at 50℃ for 24 hours with rotatory shaking.

실시간 렌더링을 위한 다각형 감소 기법 연구

하정호,윤경현 중앙대학교 기술과학연구소 1997 기술과학연구소 논문집 Vol.27 No.-

현재 컴퓨터 그래픽스 기술을 이용하여 물체를 표현하기 위한 작업들은 물체의 복잡도에 따라 많은 시간을 요구한다. 따라서, 실시간 렌더링을 요구하는 응용분야에서는 다른 기술을 요구한다. 이러한 요구에 따라 본 연구에서는 실시간 렌더링을 지원하기 위해서 물체의 원형을 유지하면서 단순화시키는 다각형 감소 기술을 다루고 있다. 다각형 감소를 위해서 물체의 지형정보 분석, 면합성, 재삼각형화 같은 기술들이 필요하다. 본 연구를 통하여 기대되는 효과는 현재 많이 연구되고 있는 가상현실 공간에서나 지형저보시스템등에서 더욱 빠른 시간내에 현실감있는 영상을 만들 수 있을 것으로 기대된다. In present, the jobs which express objects with computer graphics need execution time as much as object complexity. So, real-time application needs other techniques. In this research, we studied the polygon reduction technique which maintain the object frame and reduce the object. This technique require the geometric analysis of object, face merge and re-triangulation. In this research, the applied region which we hope are VR(Virtual Reality) and GIS(Geographical Information System).