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      • KCI등재SCOPUS
      • SCOPUSKCI등재

        특발성 부종과 연관된 전신성 홍반성 낭창 1예

        이규백,김대중,장세호,김윤구,오하영 대한신장학회 1996 Kidney Research and Clinical Practice Vol.15 No.1

        We report a 31-year-old woman admitted to our hospital with the cornplaints of generalized edema and 6 kg weight gain, which was unresponsive to conventional treatment, such as bed rest and diuretics. There was no evidence of cardiac, hepatic, or renal diseases and initial diagnosis was idiopathic edema. Futher laboratory studies, however, disclosed positive Coombs' test, lymphopenia, hypocomplemen- temia, increased anti-ds DNA level, and results of fluorescent antinuclear antibody(FAiVA) and LE cell tests were positive. A kidney and a skin biopsy were performed and the diagnosis of SLE was then made, based on laboratory tests including immunologic test, skin and kidney biopsy. Therapy with systernic corticosteroids resulted in disappearence of edema which has not recurred for seven months after discharge. The diagnosis of SLE should be considered in menstruating women who has no evidence of cardiac, hepatic, or renal diseases.

      • 지방자치단체에 민원실의 실내디자인에 관한 연구 : 울산광역시 자치단체 민원실을 중심으로

        이규백 울산대학교 1998 조형논총 Vol.2 No.2

        The civil affairs office of local self-governing body has the object which offers the direct service to the civilian. Likewise the interior environment of civil affairs office becomes the important factor that control images of self-governing group with standard of service to the people who utilize the room. This study analyzes present inside-room based on civil affairs office of the city hall and the district office of ULSAN. And it has the aim which establishes the basic information that can serve better direction. The indoor room of civil affairs office of ULSAN has the inferior situation when we view the subject from angle of interior design. So the civil affairs office has a negative effect on the subject from angle of interior design. so the civil affairs office has a negative effect on the image of local-government, pride inspiration of citizen and formation of integration between people and government. Therefore the interior environment of the civil affairs office in ULSAN must be improved promptly. Also the program for realization of inside room of civil affairs office which presents unique character of self-government group must be studied with serious attitude constantly.

      • KCI등재후보
      • 3차원 애니메이션을 이용한 가상쇼핑공간의 인터페이스 디자인에 관한 연구

        이규백,김돈한,이명재 울산대학교 2000 조형논총 Vol.3 No.1

        최근 인터넷의 급격한 보급에 따라 가상 환경하에서의 전자상거래 시장이 급격한 신장세를 보이고 있다. 이에 따라 각 기업에서도 마케팅 수단으로서의 사이버 스페이스의 중요성을 인식하여, 가상공간 상에서의 제품구매 과정과 소비패턴의 분석 및 상품 시뮬레이션 기법의 개발에 집중적인 투자를 하고 있다. 이와 같이 가상공간 상에서의 사이버쇼핑을 위한 잠재 소비자의 수효가 급증함에 따라 보다 많은 소비자들에게 개개인의 감성적 취향에 적합한 제품환경을 제공하기 위한 웹기반하에서의 쇼핑공간의 계획과 인터페이스의 구축이 무엇보다 필요하다. 전자상거래는 실물을 손으로 만져보고 눈으로 확인하는 과정을 통해 이루어지던 기존의 상거래 방식이 아닌 가상의 공간 속에서의 제공되는 인터페이스를 통해서 이루어지는 형식이기 때문에 현실감이 현저히 떨어지는 것이 제약 조건이다. 이러한 제약을 극복하기 위한 지원시스템의 개발여부가 전자상거래의 성공여부를 가름하는 중요한 요인으로 되고 있다. 따라서 본 연구에서는 2차원 컴퓨터 그래픽스와 애니메이션 기술을 이용하여 컴퓨터 안에 가상의 쇼핑공간을 구축하고 이 공간을 Walkthrough하는 것에 의해 실제의 쇼핑공간에 보다 근접한 현실감을 느낄 수 있는 전자상거래 지원 시스템을 제안하였다. 연구는 인터넷상에서의 소비자 구매행동을 분석하고, 실제 웹사이트에 구축하기 위해, 디자인 개념 설정, 타겟 설정, 디자인 적용, 업로드 등의 프로세스 구축과 3차원 인터넷 쇼핑몰을 개발하는 순으로 진행하였다.

      • SCOPUSKCI등재

        출혈 위험성이 높은 만성신부전증 환자에서 헤파린으로 전처치한 Hemophan 투석기를 사용한 혈액투석

        이규백,김대중,김범,장세호,김윤구,이윤하,오하영 대한신장학회 1997 Kidney Research and Clinical Practice Vol.16 No.2

        Systemic anticoagulation in routine hemodialysis is not desirable in patients with high risk of bleed- ing. Since heparin can bind to Hemophan, we evaluated the risk of bleeding and efficiency of hemodialysis using heparin bound Hemophan membranes in patients with high risk of bleeding. Heparin solution (lliter, 20IU/ml saline) was recirculated through the Hemophan(Gambro dialyzer, GFS Plus 11) for 1hour while removing saline solution(700ml/hr) by application of transmembrane pressure gradient, followed by a single pass rinse with 1 liter of saline solution. As a pilot study, we performed 17 hemodialyses on 15 chronic dialysis patients with contraindication to systemic anticoagulation. The duration of each dialysis was standardized to 4 hours at blood flow of 200 to 250ml/min. Blood samples were obtained to measure activated partial thromboplastin time (aPTT), and heparin concentrations (HC) before dialysis, at 15min, 60min, 120min after initiation of dialysis and at the end (240min) of dialysis. Dialysis efficiency was assessed by measuring Kt/V and urea clearance of dialyzer (K) by the direct quantification of dialysate urea and then compared with the 25 control dialyses with systemic anticoagulation. We successfully completed all 17 hemodialyses without severe clotting defined as, requiring replacement of the dialyzer and/or the extracorporeal blood lines. There was a slight increase in the aPTT (meanSD, 42.9±4.4sec) and HC (0.15±0.03IU/ml) taken at 15min from predialysis levels of 36.3±6.3sec and 0.11±0.03U/ml, respectively. But no increase in aPTT, HC was observed in measurements taken at 60min, 120min, and at the end of dialyses. The value (mean±SD) of Kt/V and K was 1.27±0.25 and 134±19ml/min respectively, which did not differ from those of the control dialyses which was 1.24?0.21 and 13613ml/min respectively. We performed 82 hemodialyses using such treated Hemophan on 27 patients for 4 hours basing the result of the pilot study. Clotting of dialyzer necessitating termination of dialyrred in 1 dialysis(1.2%) at 150min and clotting in the venous blood lines requiring change of blood lines occurred in 6 dialyses(7.3%) on 4 patients from 180min to 230min after initiation of dialysis. We conclude that the use of heparin bound Hemophan can be a safe and effective technique of hemodialysis with careful monitoring of extracorporeal clotting in patients with high risk of bleeding.

      • KCI등재

        Angiotensinogen and Angiotensin II Type 1 Receptor Gene Polymorphism in Patients with Autosomal Dominant Polycystic Kidney Disease: Effect on Hypertension and ESRD

        이규백,김언경 연세대학교의과대학 2003 Yonsei medical journal Vol.44 No.4

        Autosomal dominant polycystic kidney disease (ADPKD), a common genetic disease, is characterized by the development of hypertension and end stage renal disease. An increase in the activity of the renin-angiotensin system, due to a renal ischemia caused by cyst expansion, contributes to the development of hypertension and renal failure in ADPKD. Recently, the angiotensinogen (AGT) gene, M235T, and angiotensin II type 1 receptor (ATR) gene, A1166C, polymorphisms have been associated with the susceptibility to develop hypertension and renal disease. We hypothesized that the AGT M235T and ATR A1166C polymorphisms could account for some of the variability in the progression of ADPKD. Genotyping was performed in 108 adult patients with ADPKD, and 105 normotensive healthy controls, using PCR and restriction digestion. We analyzed the effects of the AGT M235T and ATR A1166C polymorphisms on hypertension and age at the end stage renal disease (ESRD). Of the 108 patients with ADPKD, 64 (59%) had hypertension and 24 (22%) reached the ESRD. The prevalence of hypertension were; [MM+MT], [TT] genotypes, 60%, 59% (p=1.00); [AA], [AC+CC] genotypes, 60%, 50% respectively (p=0.54). The ages at the onset of ESRD were; [MM+MT], [TT] genotypes, 50±9 years, 56±8 years (p=0.07); [AA], [AC+CC] genotypes, 54±8 years, 52±14 years, respectively (p=0.07). There were no differences in the prevalence of hypertension and the ages at the ESRD in relation to the AGT M235T and ATR A1166C polymorphisms. We suggest that the AGT and ATR gene polymorphisms would not have an effect on hypertension or the ESRD in ADPKD.

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