용융동및 Speiss와 Calcium Ferrite Slag사이에서 As의 분배평형에 관해서

강헌찬,황용길 동아대학교 공과대학 부설 한국자원개발연구소 1987 硏究報告 Vol.11 No.2

The distribution of arsenic between calcium ferrite slag and liquid copper was measured at 1473 K under controlled CO-CO₂ atmospheres. The distribution ratios defined by % X in slag/%X in metal, were plotted against the oxygen potential. The distribution ratios of arsenic between speiss and calcium ferrite slag were also investigated. From the above experiments, the results obtained are as follows : 1. The liquidus and solidus lines divide the equilibrium diagram into Fe-Cu-As system at 1150℃. 2. In general arsenic has a greater affinity fir Fe-As systems than for Cu-As systems. 3. The distribution ratios of arsenic between speiss or liquid copper and slag increase with the increased content of the CaO in calcium ferrite slag or oxygen potential.

내시경적 점막절제술로 치험한 식도 과립상 세포종 1례

강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.

알데히드탈수소효소 2(ALDH2) 및 CYP2E1 유전자 다형성에 따른 요중 뮤콘산 농도와 요중 8-hydroxydeoxyguanosine과의 관련성

김용대,강종원,엄상용,장연위,김성훈,김은영,이철호,문재동,김헌 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.2

직업과 생활 습관, 그리고 CYP1A1, GSTM1, GSTT1 유전자 다형성이 요중 1-hydroxypyrene과 2-naphthol 농도에 미치는 영향

김헌,강종원,임현술,이호익,김용대,남홍매,이철호 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.4

Objectives : This study was performed to describe the distribution patterns of urinary 1-hydroxypyrene (1-OHP) and 2-naphthol concentration in coke oven workers and workers not occupationally exposed to polycyclic aromatic hydrocarbons (PAH), and to determine the effects of occupation, life style, and genetic polymorphism of cytochrome P450 1A1(CYP1A1), glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) on urinary 1-OHP and 2-naphthol concentration. Methods : The study subjects were 19 coke oven workers and 156 shipyard workers. A questionnaire was used to obtain data about detailed smoking and food intake history. Urinary 1-OHP and 2-naphthol concentration and genetic polymorphism of CYP1A1, GSTM1, and GSTT1 were analyzed. Results : The urinary 1-OHP and 2-naphthol concentration was higher in the coke oven workers and in smokers. Urinary 1-OHP concentration was significantly correlated with time after last intake of roasted in non-smoking coke oven workers, whereas urinary 2-naphthol concentration was with amount of cigarette smoking at the sampling day in smoking shipyard workers. Urinary 1-OHP, but not 2-naphthol, concentration of the shipyard workers with Ile/Ile type of CYP1A1 was significantly lower than that of the shipyard workers with other CYP1A1 genotype. Conclusions : Urinary 1-OHP would be a better marker for occupational exposure to PAH in coke oven workers, and urinary 2-naphthol might be better for non-occupational inhalation exposure to PAH. CYP1A1 would not play an important role in the metabolism of naphthalene but in the metabolism of pyrene.

뇌졸중후 연하곤란 환자의 식이 상태 비교

신용일,양충용,김헌수,강문규,주민철,길은영,권영미 圓光大學校 醫科學硏究所 2004 圓光醫科學 Vol.19 No.2

만성 간질환에 대한 DDB(Biphenyl Dimethyl Dicaboxylate)의 임상적 효과

이헌영,임의혁,김성걸,김진희,육은주,성자원,김병호,정형용,강대영,김영건 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

To investigate the effects of short-term administration of DDB(Biphenyl Dimethyl Dicarboxylate) for decreasing elevated serum aminotransferase levels in chronic liver diseases, authors applied 3 capsules of DDB per day at each meal time for 35 patients and compared with 35 patients treated with other conservative management. The following results were obtained. 1. Serum alanine aminotransferase (ALT) levels significantly decreased from 247.1± 180.0 IU/L of pretreatment level to 96.6±126.0 IU/L, 61.1±62.7 IU/L and 38.0±26.8 IU/L after 1, 3 and 6 months of treatment(p<0.05) and effective rates were observed in 60.0%, 71.4% and 88.6% of patients after 1, 3 and 6 months of treatment. 2. Serum aspartate aminotransferase (AST) levels decreased also significantly from 167.8±96.9 IU/L of pretreatment levels to 124.4±155.0 IU/L, 77.9±49.6 IU/L, 60.6± 46.9 IU/L after 1, 3 and 6 months of treatment(p<0.05), but decreasing pattern of serum AST was less significant than that of serum ALT. 3. No significant difference were observed in the serum ALT and AST changes according to the cause and duration of hepatitis. 4. No significant adverse effects were observed in whole patients treated with DDB. It is suggested that small dose administration of DDB is effective for decreasing serum aminotrans ferase levels in chronic liver disease in which other conservative management was not effective.

수중 가청음에 의한 쏨벵이의 청각능력 : 2. 청각 임계비

이창헌,박용석,문종욱,강창익,김고환,서두옥 제주대학교 해양연구소 1999 해양자원연구소연구보고 Vol.23 No.-

수중 가청음은 어군의 행동 제어와 해양목장화에서 음향 순치에 많이 이용되고 있다. 수중 가청음에 의한 어류반응 해석을 하기 위해서는 물고기의 청각능력을 정확히 파악할 필요가 있으며,오래전부터 여러물고기의 청각능력을 관련된 연구가 수행되었다.

급성심근경색증의 조기진단에 있어서 Myoglobin의 진단적 의의

이정헌,김종근,정병천,서강석,박정배,조용근,류재근,전재은,채성철,박의현 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

Background: Exact and early diagnosis of acute myocardial infarction (AMI) is essential for the subsequent routine management of this frequent cardiovascular disease. Currently, AMI has been diagnosed using the combination of the history, electrocardiogram(ECG), and biochemical markers of myocardial necrosis. At present, many biochemical markers are used to diagnose AMI. In this study, the predictive values of serum myoglobin and creatine kinase-MB(CK-MB) were compared in the emergency department. Methods: Fifty-four consecutive patients who presented within 12 hours from onset of chest pain of presumed cardiac origin were enrolled into the study. Patients with trauma or renal failure were excluded. The serial serum myoglobin and CK-MB levels were obtained prospectively at admission and 2, 4, 6, 12, 24 and 48 hours after admission. We compare the levels of serum myoglobin and CK-MB within 2, 4, 6, 8, 10, 12, 24, and 48 hours after symptom onset respectively. And we compare the sensitivity, specificity, positive predictive value, and negative predictive value of myoglobin and CK-MB. Results: using World Health Organization criteria, 28 AMI patients were identified. Mean time from symptom onset to presentation was 4.1±1.3 hours. The predictive values of serum myoglobin were better than those of CK-MB within 6 hours after symptom onset. But, 6 hours after symptom onset, the predictive values of CK-MB were better than those of serum myoglobin. The false positive cases of serum myoglobin were 3-one was lung cancer with pleural effusion and the others were unstable angina. The false positive cases of CK-MB were 6-one case was viral myocarditis and the ohters were unstable angina. Conclusion: To compare the serum myoglobin and CK-MB in the diagnosis of AMI, serum myoglobin had better predictive values than CK-MB within 6 hours after symptom onset and useful in the early diagnosis of AMI. But, 6 hours after symptom onset, CK-MB had better predictive values than serum myoglobin and useful in following up.

만성 간질환에서 혈청 Type Ⅳ Collagen 측정의 의의

이헌영,김성걸,정현용,구선회,박종우,강대영 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

To evaluate the clinical significance of serum type N collagen levels in patients with various liver diseases, serum type IV collagen levels were measured by one-step sandwich enzyme immunoassay using monoclonal antibodies in 80 patients from December 1993 to December 1994 at Chung Nam National University Hospital. The results were as follows : 1. Mean age of patients was 45 years. Men was 2.1 times more than women. 2. Compared to 15 normal controls(159.9±34.0 ng/ml), serum type IV collagens were significantly elevated in patients with chronic hepatitis (254.5±158.0 ng/ml), liver cirrhosis(281.0±195.7 ng/ml) and hepatocellular carcinoma(420.5±241.4 ng/ml) (p<0.005). 3. Serum type IV collagen levels were increased without significance in patients with alcholic liver cirrhosis(331.6±244.5 ng/ml) compared to non-alcholic cirrhosis(230.4±117.8 ng/ml. p>0.05). 4. The serum levels of type IV collagen were not correlated with the levels of alanine amino-trnasferase(ALT), aspartate aminotransferase(AST) and alkaline phosphatase(ALP). The results suggest that the serum type IV collagen levels correlate well with the degree of progression of chronic liver diseases. Therefore the measurement of serum type IV collagen is relatively simple and useful method to reflect the progression of chronic liver diseases.

Fe-Cu-As 3원계의 비소 활량에 관해서

黃龍吉,姜憲贊 동아대학교 공과대학 부설 한국자원개발연구소 1985 硏究報告 Vol.9 No.2

Fundamental studies of the behaviour of arsenic in copper smelting as well as the phase relations and arsenic activity in liquid Fe-Cu-As systems were undertaken. The arsenic activity in the liquid Fe-As stystems, Cu-As systems and Fe-Cu-As systems was determined at 1150℃ by the use of an isopiestic method. 1. The value of arsenic activity coefficient, γ°_(As)(1), was calculated to be 2×10^(-3) from the experimetal data by the solute arsenic at infinite dilution in Fe-As system at 1150℃. 2. In the genral case of arsenic has a greater affinity for Fe-As systems than for Cu-As systems. 3. The arsenic activity of Fe-Cu-As systems increases drastically in the high concentration range. 4. The liquidus and Solidus lines divide the equilbrium diagram into Fe-Cu-As system at 1150℃.