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서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)
김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2
Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.
Clinicopathologic factors influencing the accuracy of EUS for superficial esophageal carcinoma.
Jung, Jung Im,Kim, Gwang Ha,I, Hoseok,Park, Do Youn,Kim, Tae Kyun,Cho, Young Hwa,Sung, Yong Wan,Choi, Mun Ki,Lee, Bong Eun,Song, Geun Am WJG Press 2014 WORLD JOURNAL OF GASTROENTEROLOGY Vol.20 No.20
<P>To identify clinicopathologic factors influencing the accuracy of a high-frequency catheter probe endoscopic ultrasonography (EUS) for superficial esophageal carcinomas (SECs).</P>
Im, Jung-Kyun,Biswas, Goutam,Kim, Wan-Il,Kim, Kyong-Tai,Chung, Sung-Kee Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.3
5-Fluorouracil (5-FU), an anticancer agent was covalently attached to the recently developed sorbitol-based G8 transporter, and the conjugate (7) with FITC was found to have an affinity toward mitochondria and to readily cross BBB to gain an entry into mouse brain. Measured by $IC_{50}$, the conjugate (9) without the fluorophore showed enhanced cytotoxic activity toward two types of multidrug-resistant cell lines. These results strongly suggest that the sorbitol-based G8 transporter can be utilized as a good CNS delivery vector.
Cellular Uptake Properties of the Complex Derived from Quantum Dots and G8 Molecular Transporter
Im, Jung-Kyun,Maiti, Kaustabh K.,Kim, Wan-Il,Kim, Kyong-Tai,Chung, Sung-Kee Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.4
The biotin-attached G8 molecular transporter (5) was synthesized and used together with quantum dots in preparing the complexes (QD-MT). The QD-MT complexes were studied in terms of the cellular uptake and the internalization mechanism in live HeLa cells with the aid of various known endocytosis inhibitors. It has been concluded that the QD-MT complex is internalized largely by macropinocytosis. The mouse tissue distribution of the QD-MT complex by i.p. and i.v. routes showed some organ selectivity and a good ability to cross the BBB.
Im, Won Bin,Kim, Yong-Il,Kang, Jong Hyuk,Jeon, Duk Young,Jung, Ha Kyun,Jung, Kyeong Youl Cambridge University Press (Materials Research Soc 2005 Journal of materials research Vol.20 No.8
<P>We optimized synthesis conditions of blue-emitting CaMgSi2O6:Eu<SUP>2+</SUP> (CMS:Eu<SUP>2+</SUP>) with conventional solid-state reaction and successfully determined structure parameters by Rietveld refinement method with neutron powder diffraction data. The final weighted <I>R</I>-factor <I>R</I>wp was 6.42% and the goodness-of-fit indicator <I>S</I> (= <I>R</I>wp/<I>R</I>e) was 1.34. The refined lattice parameters of CMS:Eu<SUP>2+</SUP> were <I>a</I> = 9.7472(3) Å, <I>b</I> = 8.9394(2) Å, and <I>c</I> = 5.2484(1) Å. The β angle was 105.87(1)°. The concentration quenching process was observed, and the critical quenching concentration of Eu<SUP>2+</SUP> in CMS:Eu<SUP>2+</SUP> was about 0.01 mol and critical transfer distance was calculated as 12 Å. With the help of the Rietveld refinement and Dexter theory, the critical transfer distance was also calculated as 27 Å. In addition, the dominant multipolar interaction of CMS:Eu<SUP>2+</SUP> was investigated from the relationship between the emission intensity per activator concentration and activator concentration. The dipole-dipole interaction was a dominant energy transfer mechanism of electric multipolar character of CMS:Eu<SUP>2+</SUP>.</P>
Jung Rock Moon,Chang Kyun Lee,Sung Noh Hong,Jong Pil Im,Byong Duk Ye,Jae Myung Cha,Sung-Ae Jung,Kang-Moon Lee,Dong Il Park,Yoon Tae Jeen,Young Sook Park,Jae Hee Cheon,Hyesung Kim,BoJeong Seo,Youngdoe 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.4
Background/Aims: Limited data are available regarding psychosocial distress at the time of diagnosis of ulcerative colitis (UC). We investigated the psychosocial burden and factors related to poor health-related quality of life (HRQL) among patients newly diagnosed with moderate-to-severe UC who were affiliated with the nationwide prospective cohort study. Methods: Within the first 4 weeks of UC diagnosis, all patients were assessed using the Hospital Anxiety and Depression Scale (HADS), Work Productivity and Activity Impairment questionnaire, Inflammatory Bowel Disease Questionnaire (IBDQ), and 12-Item Short Form (SF-12) health survey. A multiple linear regression model was used to identify factors associated with HRQL. Results: Between August 2014 and February 2017, 355 patients completed questionnaires. Significant mood disorders requiring psychological interventions, defined by a HADS score ≥11, were identified in 16.7% (anxiety) and 20.6% (depression) of patients. Patients with severe disease were more likely to have presenteeism, loss of work productivity, and activity loss than those with moderate disease (all p<0.05). Significant mood disorders had the strongest negative relationship with total IBDQ score, which indicates disease-specific HRQL (β coefficient: –22.1 for depression and –40.0 for anxiety, p<0.001). The scores of all SF-12 dimensions, which indicate general HRQL, were remarkably decreased in the study population compared indirectly with previously reported scores in the general population. The Mayo score, C-reactive protein level, and white blood cell count showed significant negative associations with the IBDQ score (p<0.05). Conclusions: Psychosocial screening and timely interventions should be incorporated into the initial care of patients newly diagnosed with UC.
Jung, Juyoung,Lim, Jae Hyung,Kim, Se Yeon,Im, Dae-Kyun,Seok, Joo Yeon,Lee, Seung-Jae V.,Oh, Min-Kyu,Jung, Gyoo Yeol Academic Press 2016 Metabolic engineering Vol.38 No.-
<P><B>Abstract</B></P> <P>Biosynthesis of isoprenoids via the 1-deoxy-<SMALL>D</SMALL>-xylulose-5-phosphate (DXP) pathway requires equimolar glyceraldehyde 3-phosphate and pyruvate to divert carbon flux toward the products of interest. Here, we demonstrate that precursor balancing is one of the critical steps for the production of isoprenoids in <I>Escherichia coli</I>. First, the implementation of the synthetic lycopene production pathway as a model system and the amplification of the native DXP pathway were accomplished using synthetic constitutive promoters and redesigned 5′-untranslated regions (5′-UTRs). Next, fine-controlled precursor balancing was investigated by tuning phosphoenolpyruvate synthase (PpsA) or glyceraldehyde 3-phosphate dehydrogenase (GAPDH). The results showed that tuning-down of <I>gapA</I> improved the specific lycopene content by 45% compared to the overexpression of <I>ppsA</I>. The specific lycopene content in the strains with down-regulated <I>gapA</I> increased by 97% compared to that in the parental strain. Our results indicate that <I>gapA</I> is the best target for precursor balancing to increase biosynthesis of isoprenoids.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The effect of precursor balancing for the biosynthesis of isoprenoids was explored through fine-control of <I>ppsA</I> and <I>gapA</I>. </LI> <LI> Precise down-regulation of <I>gapA</I> showed a better lycopene production than up-regulation of <I>ppsA</I>. </LI> <LI> A novel target (<I>gapA</I>) to balance precursor pool for biosynthesis of isoprenoids was demonstrated for the first time. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>