조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

老齡者의 建康을 위한 生活習慣 實態調査

申東敏,長鳳愚,李揆文,金賢俊,金昌範,崔宗洙,崔鍾晥,李鍾珏,金圭碩,趙庚旭,金鍾聲,朴鍾振 平生體育硏究所 論文集 1987 平生體育硏究所 論文集 Vol.2 No.-

With a view to examining the habit and method in which old people maintain and improve their health, we consulted 551 men and 444 women who were over 65 years old, and concluded as follows: 1. Habit of eating It's been revealed that most of the old people keep a regular eating hour, control the quantity of meal or eat a little food, and prefer vegetables to meat. 2. Mental health Old people feel the necessity for mental health and most of them (about 80%) keep good mental health without becoming pessimistic. Their chief concenrs have turned out to be about their sons and daughters and their own health and finance. 3. Managing Good Health It has been revelaed that old people do not possess any special kind of secret to keep good health but taking plenty of rest, regular meal, and proper exercise, and many of them (about 60%) have been shown to eat invigorant food that they can easily get around their living area. 4. Physical Functions It has been revealed that many old people are conscious of some symptoms about their parts of body and about to percent of them suffers from neuralgia. Some measures like medical aid especially for old people need to be taken as soon as possible. As we have found that the health-keeping method of old people consists plenty of rest, proper exercise, and appropriate nutrition, we can conclude that the recreatonal and culture facilities and programs for keeping old people in good health should be developed. It is also necessary to study food that contribute to their health and develop ways to get rid of the stresses to which they are exposed in their daily life. Presides, it is natural that government found an administrative department to deal with these matters effectively.

40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

人蔘 Total Saponin, Protopanaxadiol 및 Protopanaxatriol의 消炎作用에 關한 硏究

조태순,이선미,정국현,이범구,이석용,박종대 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-

Abstract-In an attempt to elucidate the anti-inflammatory action of ginseng total saponin, protopanaxadiol and protopanaxatriol, the anti-inflammatory activity of three compounds was investigated under various acute and chronic inflammatory models. The blood vessel permeability was slightly inhibited by total saponin and protopanaxatriol treatments. Granuloma formation induced by 2% carrageenan was inhibited by total saponin and protopanaxatriol. The cotton-pellet granuloma formation was significantly inhibited by intraperitoneal injection of total saponin. Total saponin and protopanaxadiol inhibited leukocyte emigration and protein exudation in CMC-induced pouch but protopanaxatriol increased leukocyte emigration. The swelling of rat hind paw induced by 1% carrageenan was significantly inhibited by total saponin, protopanaxadiol and protopanaxatriol both single and 2 weeks treatments. Total saponin, protopanaxadiol and protopanaxatriol decreased the anti-inflammatory activity in adrenalectomized rat. Our results suggest that total saponin, protopanaxadiol and protopanaxatriol have potent anti-inflammatory activity, this may be mediated in part through stimulation of adrenal glands.

ELASTIC BAND 운동과 스트레칭 운동이 노인 당뇨환자의 혈당, 중성지질 및 근지구력에 미치는 영향

조재혁,이승훈,진종현 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

The purpose of this study s to find the effects of elastic band exercise and stretching exercise on glucose level, triglyceride and muscle endurance in elderly patient with NDDM. The subjects consisted of elderly patient(n=20) with NlDDM dstributed into resstance training group(n=10) and stretching exercise group(n=10). Both groups participated in resstance training and stretching exercise program respectively, 3times per wear during 9weeks. Repeated measures ANOVA was used for statstical analysis. The results of this study are following. 1. Glucose level of both groups decreased significantly after 9 weeks training. There was significant differences between groups in FBS and no significant differences between groups in PP2 after training. There was significant differences in PP2 at time and no significant differences in FBS at times. 2. There was significant decreases in triglyceride level of both groups after 9 weeks training, however no significant differences showed between goups. There was no significant differences between groups at time. 3. Muscle endurance of both groups increased after 9weeks training, however no significant differences showed between groups. There was no significant differences between groups at time.

신뢰성방법에 기초한 강교량의 잔존피로 수명 및 피로 위험도 평가

조효남,임종권,최현호 漢陽大學校 工學技術硏究所 1999 工學技術論文集 Vol.8 No.1

본 논문은 잔존피로수명 및 피로파괴 신뢰성해석 절차의 확립을 위해 피로신뢰성방법에 대한 기존 국내외 관련 연구에 대한 심도 깊은 고찰을 수행하였고 실온적인 평가방법을 제시하였다. 따라서 본 연구에서는 Miner 누적손상법칙에 기초한 S-N 피로해석이론 중에서 주로 확률적 S-N 방법과 Ang-Munse's방법에 대한 최근 평가 기술을 집중 고찰하였으며, 이를 실제 성수대교의 붕괴원인 규명에 적용해 봄으로써 그 타당성을 검증하였다. 또한 이를 위해서 성수대교의 붕괴 원인으로 추정되고 있는 핀연결 수직재의 피로응력범위의 보다 정확한 추정을 위하여 shell요소를 사용한 엄밀 국부 FEM해석이 수행되었다. This paper presents practical evaluation methods of the fatigue life and fatigue failure probability for the assessment based on all the available results of various field and labolatory tests. Therefore, both the probabilistic S-N approach and the well known Ang-Munse's fatigue reliability method based on linear damage-accumulation hypothesis, commonly known as Miner's rule, are used and demonstrated in order to verify it's appropriateness. A local FEM analysis using fine meshes shell elements is carried out for the more precise estimation of stress range of the vertical pin-connected hanger whose fatigue fracture triggered the collapse of the bridge.

전해 인프로세스 드레싱을 이용한 Optical glass계의 경면연삭에 관한 연구

조주현,원종호,박원규,이진오,김민수,김성수 한국공작기계학회 2003 한국공작기계학회 춘계학술대회논문집 Vol.2003 No.-

Electrolytic In-process Dressing (ELID) technique for metal bonded diamond grinding wheel has been developed for mirror surface grinding of hard and brittle materials. This study process optical glass in using Electrolytic In-process Dressing. In using to main variable wheel speed(400 rpm ~ 2000 rpm), feed rate(5 μm/min ~ 25 μm/min), depth of cut (3 μm - 15 μm), dressing and spray. we measured surface roughness by Form Talysurf series2. we finded optimum grinding condition to obtain confident surface roughness in representative brittle materials.

AE 신호의 주파수분석에 의한 Chatter진동의 감시

조대현,이상태,원종식,정윤교 韓國工作機械學會 2000 한국생산제조학회지 Vol.9 No.5

A machine tool generally has some serious stability problems in the form of tool chatter during the cutting process. Chat-ter vibration deteriorates the surface finish, reduce tool and machine life, accelerates machine tool system component wear, and may lead to an unacceptable noise sound in the working environment. In this study, the behavior of spectral density of AE signal and principal cutting force signal in order to monitor the chatter vibration in the cutting process has been investi-gated. From the results, the reliability of proposed monitoring method has been confirmed.

파킨슨씨병에서 Selegiline HCI (MAO-B^(�))의 효과 및 안전성

조기현,김명규,김태선,김병채,이승한,황인용,김준태,김종기 全南大醫大 2000 전남의대학술지 Vol.36 No.2

4WD 및 4WS이 가능한 로더 개발(Ⅱ) : 4륜 조향장치 및 로더 구성 4WS System and Construction Loader

조현덕,윤문철,김유종 한국공작기계학회 1999 한국생산제조학회지 Vol.8 No.1

In this study, the loader was completed that has the 4-wheel gear driven drivetrain of study (Ⅰ), the 4-wheel steering with power wheel type, all-wheel traction system, and joy-stick type lever for hydraulic control value. From driving test of the developed 4WD and 4WS type loader, we obtained that the minimum circling radius and the necessary width in circling motion reduced about 40% and 33% compared with 2WS type loader. Also, all-wheel traction system could keep the tires glued to the ground with greater stability, the ower steering allowed a smoother operation, and the joy-stick type lever offered easily to control. Thus, the developed loader having these functions was very fit in a small cattle shed or a rugged ground.