유방암의 위와 대장전이

유현아,김은영,서민지,정은,조민정,오현진,장지혜,박지찬,이정의,박석영 이화여자대학교 의과학연구소 2014 EMJ (Ewha medical journal) Vol.37 No.2

Gastric metastasis from breast cancer is rare and only six cases have been reported in Korea. Colon metastasis is more rare than gastric metastasis. We report a 63-year-old woman with gastric and colon metastases of invasive lobular carcinoma of breast. She was diagnosed as right breast cancer, received right modified radical mastectomy 10 years ago and has been treated with chemotherapy and hormone therapy. Investigating for melena and a small caliber of stool, we found gastric and colon metastases. The diagnosis of metastatic breast cancer was made through gross pathologic and immunohistochemistry staining. We report a case with gastric and colon metastases from breast cancer and a review of the associated six case reports in Korea.

갑상선 종양에서 thrombin receptor (PAR-1)의 발현 양상

박지영,목지오,김여주,박형규,김철희,변동원,서교일,유명희,조현득,오미혜,김상진 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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섬유보강에 의한 고강도콘크리트의 내화성능 개선

오상균,김세훈,남지현 동의대학교 산업기술개발연구소 2005 産業技術硏究誌 Vol.19 No.-

Nowadays, it is a requirement to use high strength concrete for skyscrapers. Therefore safety research for high strength concrete is necessary. A fire outbreak in a reinforcement concrete structure looses the organism by the different contraction and expansion of hardened cement pastes and aggregate, and causes crack by thermal stress, leading to the deterioration of the durability. In this study, normal and high strength mortar were exposed to a high temperature environment. And than fundamental data for the character change of concrete heated highly were resented by measuring compressive strength of concrete with PP fiber and vinylon fiber, before and after heating. As the result, it is proven that adding PP fiber and vinylon fiber in high strength concrete for prevents deterioration of durability by fire.

Sol-Gel법으로 제조된 PZT Thin Film

오지현,권근희,김남철 공주대학교 생산기술연구소 2002 論文集 Vol.10 No.-

This paper presents ferroelectric Pb(Zr_0.52Ti_0.48)O_3 (PZT) thin film by sol-gel synthesis with metal-organic precursors. Sol-gel reaction sequences with metal-organic precursors were confirmed through DTA and FT-IR measurements and perovskite phase formation was investigated by rapid thermal annealing technique. The structural and morphological properties of PZT thin film were investigated by XRD and SEM. Perovskite phase PZT single phase was appeared at temperature of 650 ℃ and the second phase, pyrochlore, was decreased as increasing the annealing temperature, which was clearly indicated by investigating the size of 'rosette structure' and pyrochlore phases at different annealing temperatures. The P-E loop measurement indicated the relation of the applied voltage vs. domain alignments in the PZT thin film system.

혈액투석 환자에게서 발생한 재생불량성 빈혈 1예

정지용,윤나라,강대웅,오종찬,장재현,선길홍,박경희,정종훈,김현리 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Aplastic anemia is a disease characterized by pancytopenia in the peripheral blood and hypocellular bone marrow with the fatty infiltration. The causes of the acquired aplastic anemia were usually related to drugs and immune-related diseases. A 34-years old man was admitted due to general weakness. He has been going hemodialysis for 2 years because of end stage renal disease (ESRD) due to chronic glomerulonephritis. At admission, laboratory tests showed hemoglobin 6.2 g/dL, hematocrit 18.0 %, WBC 5,710mm (neutrophil 71.8%, lymphocyte 19.1%, monocyte 5.9%), reticulocyte 1.9%, platelet 93,000/mm, Fe 12.8 ug/dL, TIBC 204 ug/dL, ferritin 941.47 ng /ml, haptoglobin 0.72 g/L, vitamin B12 508.17 pmol/L, folate 24 ng/mL, total protein 6.54 g/dL, albumin 3.76 g/dL, Alk. pohsphatase 79 IU/L, AST 30.0 IU/L, ALT 39.7 IU/L, total bilirubin 0.57 mg/dl, BUN 79.4 mg/dl and creatinine 10.18 mg/dl. Peripheral blood smear showed the normocytic normochromic anemia with anisocytosis. Anemia was diagnosed but it was irresponsive to the recombinant human erythropoietin (EPO) and blood transfusion. In the bone marrow aspiration smear were there the hypoplastic myeloid and erythroid precursors. The bone marrow biopsy section showed the hypoplasia of all components (10-20%) and the fatty infiltration. We have experienced one case of the idiopathic aplastic anemia in a patient going through hemodialysis and we just report it with documentary records. 저자들은 혈액 투석 중인 환자에서 약물, 면역계 이상등의 원인을 발견할 수 없었음에도 재생 불량성 빈혈이 발생한 1예를 경험하여 문헌 고찰과 함께 보고하는 바이다.

各種 喀痰消化劑가 抗酸菌死滅에 미치는 影響

權智順,權五溶,崔大卿,白太鉉 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.1

For the isolation of mycobacteria in sputum specimens, it is essential to use the most gentle procedure of digestion system for the survival of organisms. The present studies were undertaken to evaluate and compare the effect of various sputum digestants on the death of Mycobacterium fortuitum and Mycobacterium tuberculosis. The results were summarized as follows: 1. Death rates of M. tuberculosis in a solution of 2% NaOH, 3% NaOH and 4% NaOH digestants after 30 minutes of contact time were 97.1%, 97.6% and 97.9%, respectively. In the digestants of 2% NaOH, 3% NaOH and 4% NaOH solution after 1 hour of contact time, survival rates were less than 2%. 2. Death rates of M. tuberculosis in Zephiran-N-acetyl-L-cysteine digestant after 30 and 60 minutes of contact time were 28.5% and 39.5%, while those of M. fortuitum after the contact time were 74.1% and 81.2%, respectively. 3. Death rates of M. tuberculosis in Zephiran-trisodium phosphate digestant after 30 and 60 minutes of contact time were 36.1% and 40.3%, and those of M. fortuitum after the contact time were 71.6% and 74.2%, respectively. 4. Death rates of M. tuberculosis and M. fortuitum in N-acetyl-L-cysteine-NaOH (2%) digestant were similar to the digestant of 2% NaOH solution.

SH-SY5Y Human Neuroblastoma Cell에서 에스트로겐의 신경세포 보호효과에 대한 기전

염지현,김희,홍현석,방오영,허균,묵인희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.1

Apoptosis is one major mechanism underlying neuronal cell death in degenerative diseases in the central nervous system. Previous studies have shown that estrogen has neuroprotective effects in several neuronal cell death model systems. In the present study, we established a staurosporine-induced apoptotic neuronal cell death system with human SH-SY5Y cell line. 17b-estradiol(E2) blocked staurosporine-induced apoptosis of SH-SY5Y cells as revealed by MTT as well as LDH assay. The cells showed typical DNA fragmentation at 4 h and 8 h following staurosporine treatment, which was attenuated by E2 pretreatment. Staurosporine-induced chromatin condensation was also reduced by E2 treatment. Because apoptotic stimuli are known to induce caspase-3 activation and PARP cleavage, we examined whether E2 blocks these processes. E2 markedly attenuated staurosporine-induced casapase-3 activation and PARP cleavage. This study shows that E2 blocks staurosporine-induced apoptosis in SH-SY5Y human neuroblastoma cells, suggesting that E2 is a neuroprotective agent that may be used for the treatment of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

송도 웰빙센터 건립사업 타당성 조사

윤철현,오세경,강지은 東亞大學校 建設技術硏究所 2008 硏究論文集 Vol.32 No.1

본 과업의 대상지는 송도 초등학교 내에 위치한 관사부지이다. 이곳을 서구청에서 확보한 예산으로써 서구 주민의 복지를 위한 문화체육시설로 개발할 경우, 그 사업의 타당성 여부를 진단하고 분석하는데 과업의 목적을 두었다. 본 과업은 문화체육센터에 대한 주민의식 및 선호도 파악에 우선 관심을 두었고 서구청 공무원을 조사대상으로 한정하였다. 그 까닭은 공무원 집단은 지역사회 전반에 걸쳐 문제의식이 강하고 가치판단기준이 일반 주민들보다 명확하며 도시 내 주요시설에 대한 식견이 비교적 넓기 때문이다. 본 조사에서 나타난 특징은 첫째, 응답자의 약 85%가 문화체육센터의 수적 부족을 인식한 점이고, 둘째, 45%만이 송도초등학교 내 웰빙센터의 건립에 찬성한 점이다. 반대의 대부분은 일반 주민을 위한 시설이 교육기관과 쉽게 양립 할 수 없다는 것이다. 서구의 인구가 감소한다는 것은 특정시설의 시장여건이 불리해진다는 뜻이다. 이 같은 현실 하에 웰빙센터의 경제적 타당성의 진단에서 나타난 분석결과는 B/C가 1보다 낮고(0.866), 내부수익률 역시 (-)값으로 나타난 점이다. 따라서 송도 웰빙센터 건립사업의 경제적 타당성은 매우 취약하다고 판단된다. 또한 교육청 및 학교당국은 학생중심의 시설건립과 시설 건립 후 교육기관에 기부채납을 요구하고 있으므로 이점이 사업의 결정적인 제약이 되고 있다. 공무원 의식조사에서 나타난 바를 참고할 때 웰빙센터와 같은 문화체육시설은 학교 내가 아닌 인접한 다른 장소에서 적극적으로 건립하는 방안을 모색해 볼 필요가 있다.

상아질 접착제의 중합 시간 조절에 따른 복합레진의 중합 수축 방향의 변화

배지현,오명환,김창근,손호현,엄정문,조병훈,권혁춘 대한치과보존학회 2001 Restorative Dentistry & Endodontics Vol.26 No.4

The purpose of this study was to evaluate the effect of adhesive curing timing on the direction of polymerization shrinkage of light-curing composite resin. In this study, the curing times of adhesive and composite resin were measured by differential scanning calorimeter(DSC). 28 extracted human molars were embedded in clear resin and box-type cavities were prepared. Based on DSC data. the experimental teeth were divided into 4 groups. Group 1: no bond: Group 2: late curing: Group 3: Intermediate curing: Group 4: Early curing. After treating with adhesive, the buccal cavities were filled with Z-100 hybrid composite resin and the lingual ones were filled with AEliteflo flowable composite resin. The depressions at the surface were measured by surface profilometer, then the specimens were embedded in clear resin and sectioned. Impressions were obtained and used to get epoxy resin replicas. The epoxy replicas were gold-coated and observed under SEM. Average Maximum Gap(AMG), Gap Proportion(GP), Average Marginal Index(AMI) were used to compare the shrinkage gap of each group. The results were statistically analyzed using the Kruskal-Wallis One Way ANOVA, Student-Newman-Keuls method. The results of this study were as follows. 1. Average Maximum Gap. Gap Proportion, Average Marginal Index and depression at the surface of Z-100 hybride composite resin were smailer than those of AEliteflo flowable composite resin(P(0.05) 2. When the bonding between composite resin and tooth structure was strong, the shrinkage gap was small, and depression at the surface was deep(P<0.05). 3. In the well-bonded group. light-curing composite resin shrank toward bonded cavity wall. not toward light source. The result suggested that the direction of polumerization shrinkage was affected by the quality of bonding in the dentin-resin interface. The strong was the bonding between composite resin and tooth structure, the smaller was the gap and the deeper was the depression at the surface. Then the flow to compensate the polymerization shrinkage proceeded from surface to bonded cavity wall.

播種期 移動에 따른 차풀의 生育反應, 收量 및 粗成分 變化

玄京卓,趙南棋,吳恩敬,高志棅,趙英一 濟州大學校 亞熱帶農業硏究所 1999 亞熱帶農業硏究 Vol.16 No.-

ABSTRACT This study was conducted to determine influence of planting date, seeding rate and phosphate rate on main growth, characters, yield and chemical composition of senna from March 11, 1998 to December in Cheju Province. Days to flowering was lessened as planting date was delayed. The plant height of senna was the longest at 31 March planting (99cm) than at the other planting date. Stem diameter, number of leaves were increased at 31 March but number of branches was not affected by planting date. And number of withering leaves were increased as planting date was earlier. Fresh forage yield per lOa, for senna was the greatest (4,660kg) at 31 March planting, the second was 4,397kg at 1 April planting and the reduced the 3,473kg at 11 March planting. Also dry matter yield per lOa, crude protein yield and total digestable nutrient (TDN) yield was nearly the same tendency. Crude protein, crude fat percent was the greastest at 11 March planting and than decreased with further increased at planting date. Crude ash and crude fiber percent was decreased tendency as planting date was delayed. Nitrogen free extract (NFE), TDN percent was increased tendency as planting date was delayed. SPAD reading value of leaves had an efficiency increased as planting date was delayed.