에이즈 환자의 거대세포바이러스 감염증

김홍빈,박상원,김남중,최희정,신동현,오명돈,김우호,정흠,최강원 대한감염학회 1998 감염 Vol.30 No.4

배 경 : 거대세포바이러스 감염은 인간면역부전바이러스 (Human Immunodeficiency Virus, HIV) 감염자에서 발생하는 가장 중요한 기회감염증의 하나이다. 특히, 국내에서는 95%이상의 국민이 거대세포바이러스의 1차감염을 경험한 상태이므로 에이즈 환자에서 거대세포바이러스 질환의 빈도가 높을 것으로 예상된다. 대상 및 방법 : 1987년 10월부터 1996년 9월까지 서울대학교 병원에서 추적 관찰하였던 128명의 HIV 감염자를 대상으로 하였다. 이들 환자의 의무 기록에서 임상 자료를 얻었다. 거대세포바이러스 망막염은 안과 전문의의 임상적인 소견으로 진단하였으며, 위장관 등 망막이외 부위의 거대세포마이러스 질환은 조직학적으로 확인된 경우에 한하였다. 결 과 : 대상환자 128명의 추적관찰기간은 중앙값이 6(0∼59)개월 이었으며 7명 (5.4%)에서 거대세포바이러스 질환이 발생하였다. 거대세포바이러스 질환은 망막염이 6예, 식도염이 2예, 대장염이 1예, 폐렴 및 부신감염이 1예, 범발성 감염이 1예였다. 거대세포바이러스 질환의 발생빈도는 CD4+ 림프구 수가 적을수록 높았으며, CD4+ 수가 200/㎣미만인 환자 중 15% (6/33)에서 거대세포바이러스 질환이 확인되었다. 11예 중 9예를 ganciclovir로 치료하였으며 이중 7예에서 호전 또는 진행의 억제가 확인되었다. 추적관찰이 가능한 6예 중 3예 (50%)에서 재발하였다. 결 론 : 국내 에이즈 환자에서 거대세포바이러스 질환은 비교적 흔한 기회감염증이다. Background : Cytomegalovirus (CMV) infection is one of the important opportunistic infections in immunocompromised patients. In Korea, seroprevalence of IgG against CMV is over 95%. Therefore, CMV diseases are expected to be a prevalent opportunistic infection in AIDS patients. in Korea. Methods : We reviewed the medical records of 128 patients with HIV infection who visited the Seoul National University Hospital during the period from Nov. 1987 TO Sep. 1996. All the patients were examined by one ophthalmologist and the diagnosis of CMV retinitis were made by funduscopic findings. Other CMV diseases were diagnosed when histopathologic examinations showed the characteristic cytomegalic cells. Results : Median duratior, of follow-up was 8 months. Eleven CMV diseases were found in 7 patients (5.4%): 6 patients ahd retinitis, 2 esophagitis, 1 colitis, 1 pneumonitis, and one patient developed disseminated infection. Fifteen percent (6/33) of the patients whose CD4+ lymphocyte counts were less than 200/㎣ at baseline developed CMV diseases. Out of the 9 cases treated with ganciclovir, 7 improved or were stabilized. No patient received maintenance treatment and 3 had relapsed. Conclusion : CMV diseases are common opportunistic infections in AIDS patients in Korea.

대퇴동맥을 통한 경피적 관동맥 중재시술 환자의 천자부위 지혈을 위한 Angioseal^(�) 사용과 고식적 용수 압박법의 비교 : 전향적 연구

김용훈,권현철,김필호,안석진,유철웅,최진호,이상철,김준수,김덕경,전은석,이상훈,홍경표,박정의,서정돈 대한내과학회 2004 대한내과학회지 Vol.66 No.5

목적 : 경피적 관동맥 중재술은 최근 양적 및 질적으로 급격한 발전을 보였지만 시술 시 천자부위의 혈관 합병증은 아직 해결해야 할 문제점이다. 저자들은 대퇴동맥을 통한 경피적 관동맥 중재술을 환자에게 천자부위 지혈을 위한 혈관폐쇄기구인 안지오실의 안전성과 유용성을 고식적인 용수 압박법과 비교 연구하고자 하였다. 방법 : 2002년 4월부터 2003년 5월 사이에 삼성서울병원 심장혈관센터에서 대퇴동맥을 통한 경피적 관동맥 중재술을 성공적으로 시행한 200명의 환자(안지오실 사용군: A군, 100명, 고식적 용수압박법 사용군 B군, 100명)를 대상으로 시술 후 주요 합병증 및 경한 합병증, 지혈 후 환자가 자리에 앉기까지의 시간, 보행개시 가능시간, 총 재원 기간과 시술 1주 후의 합병증을 전향적으로 조사하여 비교 연구하였다. 결론 : 두 군에서 연령, 성별, 기저질환, 심혈관 질환의 위험요소, 시술의 종류, 시술 중 사용한 헤파린의 양, clopidogrel의 양, ticlopidine의 양, 지혈 시 수축기와 확장기혈압, ACT (activated clotting time)는 차이가 없었다. A군이 B군에 비해 시술 후 자리에 앉기까지의 시간 (A군: 4.3±0.3시간, B군: 13.7±0.8시간, p=0.004) 및 보행개시까지의 시간(A군: 6.8±0.5시간, B군: 18.8±2.1시간, p=0.013)이 유의하게 짧았다. 시술 후 주요 합병증은 두군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 A군에서 유의하게 적었다(A군: 28명, B군: 19명, p=0.003). 반상출혈의 경우는 A군에서 유의하게 낮았지만(A군: 3명, B군: 12명, p=0.01), 혈종, 출혈의 발생은 두군간에 차이가 없었다. 총 재원기간에는 두 군간에 차이가 없었다(p=0.239). 시술 1주 후 경과관찰에서 주요합병증은 역시 두 군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 두 군에서 차이가 없었다(A군: 15명, B군: 13명 p=0.418), 반상출혈의 빈도는 차이가 없었지만 혈종의 발생은 A군에서 더 낮았다(A군: 2명, B군:6명, p=0.004). 두 군 모두에서 출혈은 발생하지 않았다. 결론 : 대퇴동맥을 통한 경피적 관동맥 중재술을 시행한 환자에서 안지오실의 사용은 고식적 용수 압박법에 비해 환자의 침상 안정시간을 줄여 조기 활동개시가 가능하게 하였으며 국소합병증의 위험도를 일부 낮추어, 시술에 따른 환자의 불편을 현저하게 감소시킬 수 있다고 할 수 있을 것으로 기대된다. Background : Although the number and the quality of percutaneous coronary intervention have been recently increased dramatically, the vascular complication at puncture site is still the major cause of patients' morbidity. We evaluated the safety and efficacy of newly of newly-developed collagen-based arterial closure device, Angioseal after transfemoral percuatenous coronary intervention. Methods : This study was designed as a prospective single center non-randomized comparative study. A total 200 patients undergoing transfemoral percutaneous coronary intervention were enrolled between April 2002 and May 2003. They were divided into two groups; Angioseal group (group A, n=100) and manual compression group (group B, n=100). The baseline clinical and angiographic characteristics were reviewed. The time to sit up, the time to ambulation, the duration of hospital stay, major and minor vascular puncture site complications were monitored. The patients were followed-up for 1 week after procedure by telephone. Results : The baseline clinical characteriwtics, clinical diagnosis, cardiocascular risk factors, typesof procedure, doses and numbers of anticoagulants were similar between two groups. The blood pressure and activated clotting time were also similar. The time to sit up (group A: 4.3±0.3 hours, group B: 13.7±0.8 hours, p=0.004) and the time to ambulation (group A: 6.8±0.5 hours, group B: 18.8±2.1 hours, p=0.013) were shorter in group A. No major vascular complications were noted. The incidence of hematoma and bleeding were not significantly different between two groups. The incidence of ecchymosis, however, was significantly lower in group A (group A:12%, group B: 3%, p=0.001) The duration of gospital stay was similar between groups. During 7 days of follow-up period incidence of hematoma was significantly lower in group A (p=0.004). Although the incidence of ecchymosis was not significantly different between two groups. Conclusion : The angioseal may be associated with earlier ambulation and less patients' morbidity with low incidence of local complication rate compared to manual compression after transfemoral percutaneous coronary intervention.

골수이식 후 발생하는 감염증(1985∼1996)

김홍빈,박상원,김의석,김남중,신동현,오명돈,박선양,김병국,최강원 대한감염학회 1999 감염 Vol.31 No.4

CNN 기반 콘크리트 구조물 균열 분류시 신뢰도 및 계산 효율을 고려한 이미지 증강 규모 최적화 연구

장현준(Hyeon-June Jang),이호현(Ho-Hyun Lee),홍성택(Sung-Taek Hong),최영돈(Young-Don Choi),김성훈(Sung-Hoon Kim) 한국정보통신학회 2022 한국정보통신학회 종합학술대회 논문집 Vol.26 No.1

노후화된 구조물의 균열 검사는 검사원이 직접 현장에서 측량 도구를 사용하여 육안으로 검사를 하는 방식이 대부분이다. 이러한 방식은 전문 작업 인력의 주관성에 크게 의존하게 되고, 많은 시간과 비용이 소모된다. 일관성과 신뢰성 있는 판단을 하기 위해 인공지능 이미지 분류 알고리즘을 활용하고 있다. 2018년부터는 이미지 전처리 단계에서 이미지 증강 기법이 높은 성능 향상을 이끌고 있어 사용되고 있는 추세이다. 본 연구에서는 이미지 증강 기법을 활용하여 콘크리트 구조물 균열에 관한 분석 알고리즘을 개발하고 증강 비율에 따른 정확도와 속도를 비교 측정하여 최적화를 하였다. 그 결과 정확성을 향상시키고 경제성을 감안했을 경우 8배에서 적정한 것으로 나타났다. Crack inspection of aged structures is mostly conducted by inspectors using surveying tools on site and visually inspecting them. This method greatly depends on professional worker, and consumes a lot of time and money. An artificial intelligence image classification algorithm is used to make reliable and objective judgments. Since 2018, image augmentation techniques have been used in the image pre-processing stage as they lead to high performance improvement. In this study, an analysis algorithm for cracks in concrete structures was developed using image augmentation techniques, in which the accuracy and speed according to the augmentation ratio were compared and measured for optimization. As a result, it was found that 8 times of image augmentation was appropriate when the accuracy was improved and economic feasibility was taken into account.

Picomolar selective detection of mercuric ion (Hg^{2 +}) using a functionalized single plasmonic gold nanoparticle

Song, Hyeon Don,Choi, Inhee,Yang, Young In,Hong, Surin,Lee, Suseung,Kang, Taewook,Yi, Jongheop IOP Pub 2010 Nanotechnology Vol.21 No.14

<P>A highly sensitive method for the selective detection and quantification of mercuric ions (Hg<SUP>2 + </SUP>) using single plasmonic gold nanoparticle (GNP)-based dark-field microspectroscopy (DFMS) is demonstrated. The method is based on the scattering property of a single GNP that is functionalized with thiolated molecules, which is altered when analytes bind to the functionalized GNP. The spectral resolution of the system is 0.26 nm and a linear response to Hg<SUP>2 + </SUP> was found in the dynamic range of 100 pM–10 µM. The method permits Hg<SUP>2 + </SUP> to be detected at the picomolar level, which is a remarkable reduction in the detection limit, considering the currently proscribed Environmental Protection Agency regulation level (10 nM, or 2 ppb) and the detection limits of other optical methods for detecting Hg<SUP>2 + </SUP> (recently approx. 1–10 nM). In addition, Hg<SUP>2 + </SUP> can be sensitively detected in the presence of Cd<SUP>2 + </SUP>, Pb<SUP>2 + </SUP>, Cu<SUP>2 + </SUP>, Zn<SUP>2 + </SUP> and Ni<SUP>2 + </SUP>, which do not interfere with the analysis. Based on the findings reported herein, it is likely that single-nanoparticle-based metal ion sensing can be extended to the development of other chemo- and biosensors for the direct detection of specific targets in an intracellular environment as well as in environmental monitoring. </P>

Maternal and fetal outcomes of pregnancies in kidney donors: A 30-year comparative analysis of matched non-donors in a single center

( Kyung Don Yoo ),( Hajeong Lee ),( Yaerim Kim ),( Sehoon Park ),( Joong Shin Park ),( Joon Seok Hong ),( Chang Wook Jeong ),( Hyeon Hoe Kim ),( Jung Pyo Lee ),( Dong Ki Kim ),( Kook-hwan Oh ),( Kwon 대한신장학회 2018 Kidney Research and Clinical Practice Vol.37 No.4

Background: Woman kidney donors face obstetric complication risks after kidney donation, such as gestational hypertension and preeclampsia. Studies on childbirth-related complications among Asian women donors are scarce. Methods: This retrospective cohort study included woman donors aged 45 years or younger at the time of kidney donation in a single tertiary hospital between 1985 and 2014. Pregnancy associated complications were investigated using medical records and telephone questionnaires for 426 pregnancies among 225 donors. Matched non-donor controls were selected by propensity score and the maternal and fetal outcomes were compared with those of donors. Primary outcomes were differences in maternal complications, and secondary outcomes were fetal outcomes in pregnancies of the donor and control groups. Results: A total of 56 cases had post-donation pregnancies. The post-donation pregnancies group was younger at the time of donation and older at the time of delivery than the pre-donation pregnancies group, and there were no differences in primary outcomes between the groups except the proportion receiving cesarean section. Comparison of the complication risk between post-donation pregnancies and non-donor matched controls showed no significant differences in gestational hypertension, preeclampsia, or composite outcomes after propensity score matching including age at delivery, era at pregnancy, systolic blood pressure, body weight, and estimated glomerular filtration ratio (odds ratio, 0.63; 95% confidence interval, 0.19-2.14; P = 0.724). Conclusion: This study revealed that maternal and fetal outcomes between woman kidney donors and non-donor matched controls were comparable. Studies with general population pregnancy controls are warranted to compare pregnancy outcomes for donors.

Physicochemical Characteristics and Antioxidant Activities of Fractions from Green Coffee Bean Extract

Ju Hyeon Kim,Yul Ri Gu,Bo Yeon Kim,Sang don Lee,Jeong Mu Lee,Joo-Heon Hong 한국식품영양과학회 2018 한국식품영양과학회 학술대회발표집 Vol.2018 No.10

Guidelines for prescribing opioids for chronic non-cancer pain in Korea

( Eung Don Kim ),( Jin Young Lee ),( Ji Seon Son ),( Gyeong Jo Byeon ),( Jin Seok Yeo ),( Do Wan Kim ),( Sie Hyeon Yoo ),( Ji Hee Hong ),( Hue Jung Park ) 대한통증학회 2017 The Korean Journal of Pain Vol.30 No.1

As the treatment of chronic non-cancer pain gradually increases, clinicians have more opportunities to encounter opioid prescription. However, guidelines for prescribing opioids for chronic non-cancer pain have never been published in Korea. The present guidelines were prepared by reviewing various research data. In cases in which the data were insufficient, recommendations were presented following discussion among experts affiliated with the Opioids Research Group in the Korean Pain Society. The present guidelines may need to be continuously revised and amended as more clinical evidence is acquired. (Korean J Pain 2017; 30: 18-33)

급성 인간면역부전바이러스 감염증이 원인이었던 불명열 1예

신동현,김의석,박상원,김홍빈,김진욱,오명돈,최강원 대한감염학회 1998 감염 Vol.30 No.4

저자들은 불명열로 입원한 환자에서 급성 HIV 감염을 진단하였다. 우리나라에서 HIV 감염 환자가 계속 증가하고 있으므로 급성 레트로바이러스 증후군을 보이는 환자가 불명열고 진단될 가능성도 높다. 그러므로, 불명열 환자를 진료할 경우에는 반드시 급성 레트로바이러스 증후군을 감별해야 하겠다. We report a case of acute retroviral syndrome presenting as a fever of unknown origin. A 22-year-old man was admitted to the hospital because of fever. He had been well until 20 days earlier when he experienced fever and headache. Three days before damission diarrhea, vomiting sore throat and myalgia developed. Physical examination revealed skin rash, and multiple lymphadenopathy. Acute human immunodeficiency virus (HIV) infection was confirmed by seroconversion. As the number of patients with HIV infection is increasing in Korea, acute retroviral syndrome should be included in the differential diagnosis of fever of unknown origin.

유전 및 육종 : 초위성체 유전표지를 이용한 한우와 외래품종간의 유전적 변이와 유연관계 분석

오재돈 ( Jae Don Oh ),공홍식 ( Hong Sik Kong ),이제현 ( Jae Hyeon Lee ),양대용 ( Dae Yong Yang ),전광주 ( Gwang Joo Jeon ),이학교 ( Hak Kyu Lee ) 한국동물자원과학회 ( 구 한국축산학회 ) 2008 한국축산학회지 Vol.50 No.6