조혈모세포이식 후 발생한 주폐포자층 폐렴에 대한 고찰

주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4

Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)

직무 스트레스 평가를 위한 측정도구 개발 및 표준화 연구 (Ⅰ) : 신뢰도와 타당도 Reliability and Validity Study

이동수,김지혜,한우상,우종민,강동우,고영건,연병길,김이영 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.5

연구목적 : 본 연구는 우리나라 실정에 적합하게 직무 스트레스(job stress)를 측정하고자 Osipow와 Spokane(1992)의 이론적 모형에 기초한 직무 스트레스 검사를 개발하고, 그 신뢰도 및 타당도를 검증할 목적으로 실시하였다. 방 법 : Osipow와 Spokane(1992)의 이론에 근거하여 한국판 직무 스트레스 검사(The Korean Version of Occupational Stress Inventory)를 제작하였다. 문항분석을 거쳐 최종적으로 직무 역할(Occupational Role Questionnaire ; ORQ), 개인적 긴장(Personal Strain Questionnaire ; PSQ), 개인적 자원〕(Personal Resource Questionnaire ; PRQ) 등 세 가지 하위 영역의 총 140문항으로 검사를 구성하였다. 한국직업사전의 직업분류에 기초하여 총 7개 직종군의 805명(남성 76.5%, 여성 23.5%)에게 검사를 시행한 뒤 직무 스트레스 척도의 신뢰도 및 타당도에 대한 연구를 실시하였다. 결 과 : 1) 직무 스트레스 검사의 신뢰도에 대한 분석에서 직무 역할(ORQ), 개인적 긴장(PSQ), 개인적 자원(PRQ) 각 하위 영역에 대해서는 .89∼.92 14개 하위 척도에 대해서는 .70∼.88의 높은 내적 일관성 신뢰도계수 α를 얻을 수 있었다. 8주 간격으로 검사-재검사를 실시하였을 때의 신뢰도 계수는 .62∼.79였으며, 2개 언어 사용자를 대상으로 한국어판 검사와 영어판 검사를 모두 실시하였을 때의 상관 계수는 .82∼.96으로 나타나서 전반적으로 높은 수준의 신뢰도를 확인하였다. 2) 타당도 분석에서 개인이 경험하는 직무 스트레스의 수준은 대처 자원과 유의한 부적 상관관계(γ=-.29)를 나타냈고, 스트레스로 인한 긴장과는 유의한 정적 상관관계(γ=.69)를 나타냈으며, 개인의 대처 자원은 스트레스로 인한 긴장과 유의한 부적 상관관계를 나타냈다(γ=-.40). 전체 직무 스트레스 검사에 대한 요인분석 결과, 전반적인 스트레스 요인과 그에 따른 반응, 스트레스에 대한 개인의 대처기술, 스트레스에 대한 개인의 심리적, 신체적, 행동적 반응 등 세 가지 요인이 추출됨으로써, 이론적 모형에 따른 구성타당도가 입증되었다. 결 론 : 본 연구에서 개발된 검사는 그 높은 신뢰도와 타당도가 입증됨으로써, 직장인의 직무 스트레스 경험을 체계적으로 이해하는 데 유용하게 활용될 수 있는 도구임이 확인되었다. 향후 직무 스트레스의 구체적 원인과 그 대처방법을 규명하고 나아가 직무 스트레스와 각종 정신적 신체적 질환의 관련성을 과학적으로 평가함으로써, 스트레스로 인해 고통받는 일반 직장인 및 환자의 치료에 기여할 수 있으리라 기대한다. Objectives : The present study explored the reliability and the validity of our newly constructed job stress scale, the Korean version of the Occupational Stress Inventory(K-OSI). Methods : Through preliminary item-analysis, we constructed 140 items of the Korean version of Occupational Stress Inventory(K-OSI). K-OSI consists of three subscales measuring three sections, 'ORQ'(Occupational Role Questionnaire), 'PSQ'(Personal Strain Questionnaire), and 'PRQ'(Personal Resource Questionnaire), respectively. The normative group consisted of 805 adult workers who represented six major job classes in Korea. Results : The internal consistency coefficients of 'ORQ', 'PSQ', and 'PRQ' ranged from .89 to .92, and of those 14 subscales ranged from .70 to .88. The test-retest reliability coefficients of 8 week duration ranged from .62 to .79, and bilingual's consistency coefficient ranged from .82 to .96. The validity of the K-OSI was investigated by factor-analysis, yielding 3 factors of overall job stress and its responses, personal stress coping, psychological, physical, and behavioral responses of job stress. Conclusion : The present results indicate that the K-OSI is a reliable and valid measure of job stress.

직무 스트레스 평가를 위한 측정도구 개발 및 표준화 연구(Ⅱ) : 인구통계학적 변인의 영향 및 규준 수립 Demographic Variables and Norm

이동수,김지혜,한우상,우종민,강동우,고영건,연병길,김이영 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 본 연구에서는 Osipow와 Spokane(1992)의 직무 스트레스 모형에 기초한`직무 스트레스 검사(Occupational Stress Inventory)`를 표준화하고 규준을 작성하기 위해서 성별, 연령, 직업기간, 직종 등의 인구통계학적 변인에 따라서 직무 스트레스의 경험이 어떤 차이가 있는지를 확인하기 위한 분석을 실시하고, 이에 따라 규준을 작성하였다. 방 법: 한국직업사전 직업분류에 따라서 7개 직종군의 805명(남성 76.5%, 여성 23.5%)에게 직무 스트레스 검사를 실시하였다. 성별, 연령, 연봉, 직업기간, 일반직종, 직급 차이, 일반직/특수직, 사무직/근로직에 따라 직무 스트레스의 경험과 반응이 어떻게 달라지는지를 살펴보았다. 이후, 이러한 결과에 기초하여 남성, 여성 집단 각각의 규준을 작성하였다. 결 과: 1) 남성과 여성은 직무 스트레스의 경험, 스트레스에 대한 반응, 대처 행동에서 서로 차이가 있었다. 전반적으로 여성은 직무 자체의 특성에 따른 스트레스 수준이 높았는데, 남성집단에 비해 역할 불충분(RI), 역할 모호성(RA), 사회적 지지(SS), 직무 긴장(VS) 척도의 수준이 높았으며, 남성은 여성에 비해 역할 과부하(RO), 책임감(R) 척도의 수준이 높았다. 2) 다음으로 연속변인으로 측정한 연령, 연봉, 직업기간과 직무 스트레스와의 상관분석을 실시한 결과, 일반적으로 연령이 많고, 연봉이 높고, 직업에 종사한 기간이 길수록 직무로 인한 스트레스와 그에 따른 문제가 적고, 적절한 대처자원을 가지고 있었다. 3) 일반적인 직종에 따라서 직무 스트레스의 경험에 차이가 있는지를 확인하기 위해서 연령, 연봉, 직업기간을 통제한 공변량분석(ANCOVA)을 실시하였는데, 남성집단, 여성집단 모두에서 일반적인 사무직종 내에서는 직무 스트레스의 경험이 유사한 것으로 나타났으며, 동일한 직종 내에서 직급에 따른 고유한 효과는 없었다. 다음으로 일반 사무직종 이외에 경비회사 직원, 직업군인(장교)과 같은 특수 직종에 종사하는 사람들의 직무스트레스 경험이 일반 회사원과 차이가 있는지를 확인하기 위해서 공변량분석을 실시하였을 때, 직종간 유의미한 차이가 존재하였으며, 일반 사무직과 기능 근로직에 대한 비교에서도 직종에 따른 차이가 유의미하게 나타났다. 이러한 결과를 종합하여 보면, 일반 사무직종 내에서 직종에 따른 직무 스트레스 경험의 차이는 적지만, 특수직종과 기능직을 비교하였을 때는 직종에 따라서 전반적으로 유의미한 차이가 있음을 확인할 수 있었다. 마지막으로 앞선 분석결과에서 가장 의미 있는 차이가 나타난 변인인 성별을 기준으로 한국판 직무 스트레스 검사의 규준을 작성하였다. 결 론: 직무 스트레스에 대한 개인의 경험과 반응은 성별, 연령, 연봉, 직업기간, 직종, 직급 등의 여러 인구통계학적인 변인에 따라 서로 유의미한 차이가 있는 것으로 나타났다. 이러한 결과는 한 개인의 스트레스 경험과 반응을 객관적으로 이해하기 위해서는 그 개인의 인구 통계학적인 특성에 대한 폭넓은 탐색이 필요하다는 점을 시사한다. 한편, 본 연구를 통해서 개발된 규준을 이용하여, 개인의 스트레스 경험을 상대적으로 비교할 수 있으며, 검사의 결과를 적절한 임상적 개입을 위한 지표로 사용할 수 있을 것이다. Objectives: This study examined the effects of demographic variables on the job stress experience and established the norms of the Korean version of Occupational Stress Inventory. Methods: The normative group consisted of 805 adult workers who represent seven major job class in Korea. K-OSI were administered to normative group and data were analyzed by subjects demographic variables. Results: To explore the effects of demographic variables on K-OSI, we considered several factors such as age, sex, duration of employment, job class, job position and so on. The results were as follows : 1) We found significant sex difference in K-OSI. Compared with men, women showed higher scores in Role Insufficiency, Role Ambiguity, Social Support, Vocational Strain Scales and men showed higher scores in Role Overload, Responsibility Scales. 2) Generally, a person who was older, earned higher salary, more duration of employment experienced job stress and had more coping resources. 3) In general, white-collar workers, job classes and job position had little effects on job stress. But other workers such as security guards, military officers were different from general white-collar workers in K-OSI. Conclusions: Because men and women showed significant difference in K-OSI, we constructed norms according to sex. K-OSI would be an useful instrument to identify one`s job stress experience and develop intervention plan.

하수에서 분리한 합성세제 분해균의 특성

정민선,전진경,정영건,이해경,권오진,지원대,김관배 嶺南大學校 環境問題硏究所 1993 環境硏究 Vol.13 No.1

대구시와 경산시의 하수에서 음이온계 합성세제인 sodium dodecyl sulfate(SDS)와 sodium dodecylbenzene sulfonate(SDBS)를 유일한 탄소원으로 이용하는 균주 289종을 분리하고 이중 합성세제 분해력이 강한, 그람음성 간균으로 운동성인 8균주를 선정하여 그 선정균들의 특성을 조사하였다. 선정균은 40℃ 이상에서는 생육하지 못하였으며 생육 최적 pH는 균주간에 다소 차이가 있었으며 pH 4.0 이하에서는 선정균 모두 생육치 못하였다. 질소원으로는 SDS분해균의 생육에는 potassium nitrate가, SDBS 분해균의 생육에는 soytone이 좋았다. SDS 분해균인 DS-3, 6, 8, 24 및 SDBS 분해균인 BS-7, 8은 세제농도가 5.0% 이상에서도 생육이 가능하였다. 선정균들은 tetracycline에 감수성이 강한 것으로 나타났지만 penicillin에는 강한 내성을 띠는 것으로 나타났고, ??와 ??금속이온은 모든 선정균들의 생육을 억제하는 것으로 나타났다. On purpose to isolate the organisms, which would utilize detergents(sodium dodecyl sulfate, SDS and sodium dodecylbenzene sulfonate, SDBS) as a sole carbon source, from the waste water of Kyungsan and Taegu city 289 strains were isolated. Among them 8 strains, which are gram negative rods with motility and produce strong enzyme to biodegrade the synthetic detergents, were selected. The characteristics of them were investigated as follows, 8 strains were failed to grow above the temperature of 40℃ and below the pH 4.0 even though they have variable optimum pH. Potassium nitrate was very effective for the growth of SDS-biodegradable strains and soytone was effective for the growth of SDBS-biodegradable strains as a sole nitrogen source. Among 8 strains especially DS-3, DS-6, DS-8 and DS-24(SDS-biodegradation strains) and BS-7 and BS-8(SDBS-biodegradation strains) could grow above 5.0% of detergent concentration. All of 8 strains were very sensitive to tetracycline but resistant to penicillin. Selected 8 strains were inhibited by metal ions of ??(0.156mg/㎖) and ??(0.156mg/㎖).

Quality Characteristics of Tomato Packaged with Functional Film Applied to Essential Oil

Hae Lin You,Min-Sun Chang,Byung Sun Lim,Ji Gang Kim,Gun-Hee Kim 한국식품영양과학회 2015 한국식품영양과학회 학술대회발표집 Vol.2015 No.8

Antioxidants of new compounds from marine Algae prevent cell death of endothelial cells

( Ji Yoen Lee ),( Mi Hwa Lee ),( Hae Ryoun Park ),( Jae Soo Choi ),( Hong Suk Seo ),( Won Gun An ),( Won Chul Choi ) 한국어병학회 2003 한국어병학회지 Vol.16 No.1

Cytosolic oxidation by 4-hydroxy-2-nonenal (4HNE) and tert0butyl hydroperoxide (t-BHP) results in cell death of bovine aortic endothelial cells (BAEC). In this study, we have investigated the roles of antioxidants such as 2,3,6-tribromo-4.5-dihydroxy benzyl methyl ether (TDB) and phloroglucinol in preventing cell death. After treatment with oxidants for 6h, cells became compact and showed nuclear condensation, which were characteristics of early apoptosis. After 12h treatment, morphologic features including severe cytoplasm condensation, membrane blebbing, and apoptotic bodies were prominent and these findings were interpreted as characteristics of late-apoptosis. When the apoptotic cells were treated with antioxidants for 12h, both early and late apoptotic cells did show no significant change. After oxidant treated cells were incubated with antioxidant for 24h, the characteristics of early-apoptosis were eliminated but cells in late-apoptosis could not return to normal cells. These results suggest that TDB and phloroglucinol prevent the cells from dying through apoptosis induced by 4HNE and t-BHP in early stage.

Initial experiences of Laparoscopic surgery using the da Vinci robotic system for the benign and malignant gynecologic diseases

( Ji Hae Bae ),( Su Kyung Sung ),( Gun Oh Chong ),( Dae Gy Hong ),( Young Lae Cho ),( Il Su Park ),( Yoon Soon Lee ) 대한산부인과학회 2010 Journal of Womens Medicine Vol.3 No.1

Objective: To evaluate surgical outcomes, feasibility and safety of laparoscopic surgery using the da Vinci robotic system. Methods: Fifteen patients underwent various gynecologic robotic assisted laparoscopic surgery using the da Vinci robotic system between March 2008 and November 2009, and were assessed for surgical outcomes. This retrospective case series analysis was carried out in the department of obstetrics and gynecology at Kyungpook National University Hospital, Daegu, Korea. The main reasons for operation were myoma (n=5), followed by endometrial cancer (n=3), cervical cancer (n=4), endometriosis (n=2) and adenomyosis (n=1). Results: All patients successfully underwent various laparoscopic surgery using the da Vinci robotic system such as myomectomy, hysterectomy, radical hysterectomy, ovarian cystectomy, and staging operation with no conversion to laparotomy. The mean operating time was 184.5±54.6 minutes, the mean hemoglobin change and estimated blood loss were 1.9±0.8 g/dL and 36.3±27.1 mL. The mean time from incision to docking the robot was 10.1±6.1 minutes and the mean console time was 119.7±67.1 minutes. The length of hospital stay averaged 5.4±1.7 days. No complications requiring treatment occurred. Conclusion: Laparoscopic surgery using the da Vinci robotic system is a feasible and safe treatment modality in the benign and malignant gynecologic diseases.

Retroperitoneal Erdheim-Chester disease without skeletal bone involvement mimicking uterine sarcoma with multiple organ involvement

( Hae Min Kim ),( Gun Oh Chong ),( Min Ju Kim ),( Ji Young Park ),( Yoon Hee Lee ) 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.4

Erdheim-Chester disease (ECD) is a rare type of non-Langerhans cell histiocytosis and is characterized by the diffuse histiocytic infiltration of multiple organs. Retroperitoneal ECD, especially with uterine involvement, is extremely rare. We report about a 73-year-old woman who presented with vaginal spotting for a month and experienced abdominal pain along with pus-like urine. Computed tomography revealed an irregular mass-like lesion in the uterus, possibly a uterine sarcoma, invading the ureter, rectosigmoid, and bladder. A tissue biopsy of the retroperitoneal mass revealed typical morphological and immunohistochemical features of ECD. However, clinical features, especially long bone involvement, did not coincide with ECD, and BRAF V600E gene mutation was not detected. We made a diagnosis of atypical retroperitoneal ECD mimicking uterine sarcoma with multiple organ involvement.

Noninvasive prenatal test for the pregnancy with Turner syndrome mosaicism 45, X/47, XXX : A case report

Ji Hye Kim,Gun Ho Lee,Dong Hyun Cha,Eun-Hae Cho,Yong Wook Jung 대한의학유전학회 2015 대한의학유전학회지 Vol.12 No.2

Noninvasive prenatal test (NIPT) is a novel screening method for the diagnosis of fetal chromosomal aneuploidies. NIPT is based on technology that detects cell-free fetal DNA in maternal plasma and analyzes it with massively parallel sequencing technology to determine whether the fetus is at risk of trisomy 21, trisomy 18, trisomy 13 or sex chromosome abnormalities(SCAs). NIPT has been reported to have sensitivity of 99% and a false positive rate of less than 1% for detecting trisomy 21 and trisomy 18. Although extension of the application of NIPT to other SCAs has been attempted, there are concerns in extending NIPT to SCAs because of maternal or fetal mosaicism, undetected maternal SCAs, and multiple pregnancies. Recently, we assessed a pregnancy with the rare Turner syndrome mosaicism 45, X/47, XXX, which was reported as 45, X with NIPT. We present the case here and briefly review the current literatures on NIPT in testing for fetal monosomy X. To the best of our knowledge, this is the first report of the 45, X/47, XXX mosaicism in Korea to be reported as 45, X by NIPT with whole genome sequencing. This case report will provide valuable information for counseling women who want to undergo NIPT.

재발한 위장관 간질성 종양(GISTs) 환자들의 임상양상 분석

나건형(Gun Hyung Na),김영균(Young Kyun Kim),이한홍(Han Hong Lee),지성배(Sung Bae Ji),채병주(Byung Joo Chae),허훈(Hoon Hur),김욱(Wook Kim),전해명(Hae Myung Jeon) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.73 No.4

Purpose: Gastrointestinal stromal tumors (GISTs) are of a mesenchymal origin, and they arise predominantly from the gastrointestinal tract. This study aims to aid the post operative management of GIST patients by analyzing the clinical and immunopathological features of recurrent GISTs. Methods: We enrolled 98 GIST patients who had been operated on for their primary tumor from 1987 to 2001 at the Catholic Medical Center. Among them, 28 patients had clinical and radiological features that were proved to be recurrence, and the patients’ survival rates were compared according to the treatment modalities. Results: When the maximum length of tumor was shorter and the mitotic index lower, then these patients had higher disease free survival rates and lower recurrence rates. The Ki-67 negative group had lower recurrence rates than their Ki-67 positive counterparts. Recurrence was mostly observed as liver metastasis. The mean length of time to recur was 22.96 months. Fifteen patients received additional treatments such as surgery, chemotherapy and radiation therapy, but there was no significant difference in survival rates when they were compared to the 13 patients who did not receive further treatments. Conclusion: Of the patients diagnosed with GIST after surgery, those with worse prognostic factors, i.e. a bigger tumor size and higher mitotic index, require more meticulous surveillance for tumor recurrence, and especially for liver recurrence, which was the most common recurrence site, during the follow up exams. In addition, although there have not been any remarkably effective treatments for the recurrent GIST patients, further researches for new therapy such as STI-571 is mandated.