대황황련해독탕의 사염화탄소 유발 간장해 보호효과 미치 급성독성

김영석,정은아,장종철,양형길,김남재,조기호,배형섭,이경섭,김동현 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2002 東西醫學硏究所 論文集 Vol.2002 No.-

ABSTRACT - This study was performed to evaluate hepatoprotective effect of daewhang-whangryunhaedok-Tang(DWT) on liver injured rats induced by CCI_4 and the acute oral toxicity of it in mice. The activities of serum transaminase(ALT/AST), alkaline phosphatase(ALP) and lactic dehydrogenase(LDH), the levels of serum total cholesterol(TC) and triglyceride(TG), change of liver enlargement, and inhibitory activities of lipid perotidation, catalase and glutathione-S-transfrease(GST) in liver microsome were determined in hepatotoxic rats induced by CCI_4. DWT was significantly reduced the serum ALT, AST, ALP, LDH. TC and TG lecels. And, the increase of lipid peroxidation, decrease of catalase and GST activities in the liver microsome of CCI_4-intoxicated rat were significantly improved by the treatment of DWT. Male and female mice were administered maximum dosages of 5.000 mg/kg b.w. of DWT. After single oral administration of DWT to mice, we observed them daily for 2 weeks.DWT did not induce any toxic signs in the mortalitie, clinical signs, body weight changes, and gross necropsy finfings of mice. Based in these results. It is concluded that DWT may have the hepatoprotective effect on CCI_4 induced hepatotoxicity in rats. Also. DWT may have no side effect and its LD_50 value may be over 5.000mg/kg b.w. in mice.

대황황련해독탕의 항고지혈증 작용

김영석,정은아,장종철,양형길,김남재,조기호,배형섭,이경섭,김동현 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-

Whangryunhaedok-Tang (WT) is formulated with Coptidis Rhizoma, Phellodendri Cortex, Scutellariae Radix and Gardeniae Fructus, and Daewhang-whangryunhaedok-Tang (DWT) is made by the combination of Rhei Rhizoma, a wellknown anticostipation drug in WT. Therefore, DWT has been evaluated for antihyperlipidemic effects on experimental hyperlipidemic rats and mice induced by corn oil and high cholesterol-diet. Oral administration of DWT significantly inhibited the increase of serum triglyceride and LDL-cholesterol levels, and the decrease of serum HDL-cholesterol levels in hyperlipidemic rats induced by corn oil. Also, oral administration of DWT significantly prevented the increase of serum total cholesterol, triglyceride and LDL-cholesterol, and liver total cholesterol and triglyceride in 1% cholesterol-diet fed mice. These results suggest that DWT is effective for the treatment of hyperlipidemia.

Lidocaine, Thrombin, Epinephrine 의 항균효과

김진우,이동건,전혜선,김승준,김석찬,안중현,김치홍,권순석,김영균,김관형,문화식,신완식,송정섭,박성학 대한감염학회 2005 감염과 화학요법 Vol.37 No.6

목적 : 기관지내시경 검사에서 흔히 사용되는 국소마취제인 lidocaine과 내시경시 지혈목적으로 사용되는 thrombin과 epinephrine이 각종 균주에 미치는 항균효과에 대해 알아보고자 하였다. 재료 및 방법 : 균주는 가톨릭대학교 성모병원에서 2004년 3월부터 2004년 9월까지 임상검체 에서 동정된 S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa 각각 42, 42, 42, 43주를 대상으로 하였다. Lidocaine, thrombin, epinephrine 감수성 검사는 National Committee for Clinical Laboratory Standards (NCCLS, 2002)의 기준에 따랐다. 결과 : Lidocaine은 S. aureus, S. pneumoniae, P. aeruginosa에서 MIC_(50), MIC_(90) 모두 20,000 ㎍/mL 이었다. K. pneumoniae는 각각 10,000 ㎍/mL이었다. Thrombin은 S. aureus와 P. aeruginosa에서 MIC50 500 lU/mL 과 MIC_(90) 500 IU/mL 이상이었고, K. pneumoniae에서는 MIC_(50)과 MIC_(90)이 모두 500 lU/mL이상이었으나 S. pneumoniae에서는 MIC_(50)과 MIC_(90)은 125 IU/mL이었다. Epinephrine은 K. pneumoniae, S. pneumoniae에 대한 MIC_(50), MIC_(90)가 모두 >500 ㎍/mL이었고, S. aureus와 P. aeruginosa에 대한 MIC_(50), MIC_(90)가 모두 500 ㎍/mL이었다. 결론 : 기관지 내시경 검사에서 흔히 쓰이는 lidocaine, thrombin, epinephrine 등의 약제들이 호흡기 질환의 흔한 병원균인 S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa 균주들에 대해 항균 효과가 있을 수 있어 세균배양검사에 영향을 미칠 수 있겠다. Background : We performed this stody to find out about antimicrobial effect of lidocaine which is commonly used local anesthetic, and thrombin and epinephrine used for hemostasis during bronchoscopic procedures. Materials and Methods : The microorganisms that were cultured from specimens obtained during bronchoscopy were Staphylococcus aureus (n=42), Streptococcus pneumoniae (n=42), Klebsiella pneumoniae (n=42), and Pseudomonas aeruginosa (n=43) collected from St. Mary's Hospital, from March to Sep 2004 were used for susceptibity testing. Susceptibility to lidocaine, thrombin, and epinephrine were tested according to the National Committee for Clinical Laboratory Standards. Result : MIC_(50) and MIC_(90) of lidocaine for S. aureus, S. pneumoniae, P. aeruginosa were all 20,000 ㎍/mL and that for K. pneumoniae were 10,000 ㎍/mL. MIC_(50) and MIC_(90) of thrombin for both S. aureus and P. aeruginosa was 500 IU/mL and above 500 IU/mL, respectively; that for K. pneumoniae were all above 500 IU/mL and for S. pneumoniae they were 125 IU/mL, MIC_(50) and MIC_(90) of epinephrine for K. pneumoniae and S. pneumoniae were above 500 ㎍/mL; that for S. aureus and P. aeruginosa were 500 ㎍/mL. Conclusion : We observed possible antimicrobial effect of lidocaine, thrombin, and epinephrine in vitro against pathogens such as S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa, which are common respiratory microorganisms. The use of these agants could affect the result of bacterial culture.

HAZARD ANALYSIS USING MULTI-COMPONENT ANALYSIS IN CHEMICAL PROCESSES

Kim,Ku-Hwoi,Lee,Dong-Eon n,Kim,Yonhg-Ha,Yoon,En-Sup 한국화재소방학회 2001 한국화재소방학회 학술대회 논문집 Vol.2001 No.추계

두개외 경동맥 협착증에 대한 스텐트 삽입술의 추적 결과

윤영섭,홍범기,최동훈,김선호,김동익,김승민,장양수,심원흠 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.11

學敎運營의 實態와 改善方案에 관한 硏究

金鍾喆,李鍾淑,陳東燮,許柄其 덕성여자대학교 고등교육연구소 1990 敎育硏究 Vol.2 No.-

持續的 農業體系 分析

金東燮,金大熙 公州大學校 地域開發硏究所 1995 地域開發硏究論叢 Vol.3 No.1

Summary The interest of sustainable agricultural system (organic agricultural system in Korea) is getting popular because of serious environmental pollution. This paper was designed with the intention of improving the understanding levels of sustainable agricultural system by comparing the characteristics of sustainable agricultural system with chemical agricultural system. The main point of sustainable agricultural system is that current agricultural system adapts to an ecosystem for nature conservation. This it would be completed with changing of attitudes and values of agriculture and with much interest and study of sutainable agricultural system. The interest of sustainable agricultural system (organic agricultural system in Korea) is getting popular because of serious environmental pollution. This paper was designed with the intention of improving the understanding levels of sustainable agricultural system by comparing the characteristics of sustainable agricultural system with chemical agricultural system. The main point of sustainable agricultural system is that current agricultural system adapts to an ecosystem for nature conservation. Thus it would be completed with changing of attitudes and values of agriculture and with much interest and study of sustainable agricultural system.

Hypothese de l'Interlangue et l'acquisition d'une langue seconde

金東燮 水原大學校 1993 論文集 Vol.11 No.-

Comme nous I'avons etudie jusqu'a present, la langue de l'apprenant est loin d'etre appelee celle de non-systematicite et celle de non-variabilite. Bien entendu, il existe de differents points de vue sur le developpement de l'IL. Ce qui est evident tout au long de la discussion. c'est que la langue de l'apprenant, comme la langue de locuteur natif, est variable. Cette variabilite est a la fois systematique et non-systematique. La variabilit systematique est determinee par le contexte linguistique et situationnel. En ce que concerne le developpement du processus au curs de l'ALS, chaque etape de developpement constitue un rearrangement du systeme variable precedent vers le nouveau systeme variable, par consequent la variabilite joue un role determinant du processus de I'ALS.

Acetobactor xylinum endo-β-1,4-glucanase CMCax의 결정학적 연구

김동섭, 김준식, 정용제 忠北大學校部設基礎科學硏究所 2007 自然科學硏究 Vol.21 No.-

-본문참고-

공동주택조명 설비 기준 설정을 위한 조사 연구

김동관,송진원,이경섭,김병인,김창석 조선대학교 에너지.자원신기술연구소 2001 에너지·자원신기술연구소 논문지 Vol.23 No.2

Current interior lighting design way that is consisting uniformly by designer's experience or simple capacity calculation diversifies according to standard of living elevation and there is problem that do not reflect been individualising resident's change request in lighting plan, design properly. Therefore, because this resident's request, enough judgment data that is worth reflecting dissatisfaction item in design concretely or standard is not saved up in business post, had gotten into bottleneck at lighting design. Diagnose resident's consciousness and feedback degree about interior lighting to existent apartment complex in this research and examined improvement plan. As a result, in the case of illumination, wanted higher brightness and showed reason that is most Afirmativ about order way of lighting fixtures. The reason is because can select registration nine that want by oneself directly. Plan qualitative elevation of house lighting environment making lighting image which is coincided in our real condition, and is thought to reflect various resident's character, fondness in design and solved dissatis faction.