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원자층 증착법으로 성장한 HfO<sub>2</sub> 박막의 제조
김희철,김민완,김형수,김혁종,손우근,정봉교,김석환,이상우,최병호,Kim Hie-Chul,Kim Min-Wan,Kim Hyung-Su,Kim Hyug-Jong,Sohn Woo-Keun,Jeong Bong-Kyo,Kim Suk-Whan,Lee Sang-Woo,Choi Byung-Ho 한국재료학회 2005 한국재료학회지 Vol.15 No.4
The growth of hafnium oxide thin films by atomic layer deposition was investigated in the temperature range of $175-350^{\circ}C$ using $Hf[N(CH_3)_2]_4\;and\;O_2$ as precursors. A self-limiting growth of $0.6\AA/cycle$ was achieved at the substrate temperature of $240-280^{\circ}C$. The films were amorphous and very smooth (0.76-0.80 nm) as examined by X-ray diffractometer and atomic force microscopy, respectively. X-ray photoelectron spectroscopy analysis showed that the films grown at $300^{\circ}C$ was almost stoichiometric. Electrical measurements performed on $MoW/HfO_2$(20 nm)/Si MOS structures exhibited high dielectric constant$(\~17)$ and a remarkably low leakage current density of at an applied field of $1.5-6.2\times10^{-7}A/cm^2$ MV/cm, probably due to the stoichiometry of the films.
산발성 위암에서 Microsatellite Instability 빈도와 hMLH1 촉진자부위 메칠화
김희철,노선애,육정환,오성태,김병식,유창식,김진천,Kim Hee Cheol,Roh Sun Ae,Yook Jeong Hwan,Oh Sung Tae,Kim Byung Sik,Yu Chang Sik,Kim Jin Cheon 대한위암학회 2003 대한위암학회지 Vol.3 No.1
Background: An aberrant function of the mismatch repair system has been reported to underlie carcinogenesis in several tumors, including colorectal and gastric carcinomas, and to induce the typical genotype of microsatellite instability (MSI). Purpose: We aimed to determine the frequency of MSI in early-onset sporadic gastric carcinoma and elucidate the role of promoter methylation in hMLH1 as the mechanism of MSI. Materials and Methods: Thirty-six early-onset sporadic gastric carcinomas were analyzed to determine the status of MSI and the frequency of methylation of the promoter region in hMLH1. MSI was determined using five markers recommended by NCI: MSI-H (high), MSI-L (low), and MSS (Microsatellite stable). Methylation specific PCR (MSP) and direct automated genomic sequencing analysis with DNA modified by sodium bisulfite have been performed to confirm promoter region methylation. All the data were analyzed regarding characteristics of molecular changes, and clinicopathologic variables. Results: The microsatellite status was determined as MSI-H in five cases ($13.8\%$), MSI-L in 13 cases ($36.1\%$), and MSS in 18 cases ($50.0\%$). hMLH1 was methylated in seven cases ($19.4\%$). In all cases of MSI-H, promoter of hMLH1 was methylated, and in two of the 13 cases of MSI-L, hMLH1 promoter methylation was identified. Methylation was not found in any cases of MSS. Promoter methylation in hMLH1 was significantly correlated with MSI status (P<0.001). We could not find any relationship between MSI and clinicopathologic parameters. Conclusion: These results suggest that an abnormal function of the mismatch repair system may be associated with gastric carcinogenesis in more than $10\%$ of early-onset gastric carcinomas and MSI appeared to be closely related to the promoter methylation in hMLH1.
Bell's Palsy와 Ramsay Hunt Syndrome 환자군의 치료 기간에 따른 호전도의 비교 연구
김희철,김정호,김영일,Kim, Hee-Chul,Kim, Jeong-Ho,Kim, Young-Il 대한침구의학회 2008 대한침구의학회지 Vol.25 No.4
Objectives : The aim of this study is comparing the improvement of Bell's palsy and Ramsay hunt syndrome according to treatment duration. Methods : The 11cases diagnosed as Ramsay hunt syndrome and 30cases of Bell's palsy who visited Cheong-ju Oriental Medical hospital from February 2006 to June 2008 were evaluated. We used Yanagihara's unweighted Grading System to confirm the improvement. Results : In the analysis of cause, except the "none", the most common cause was "Overwork" in both two group. After 5-day treatment the score was getting worse but after 10-day treatment score was improved in both group. The improvement of Bell's palsy group was better than that of Ramsay hunt syndrome group after 5-day and 10-day treatment, but there was no significance. Conclusions : In comparison of Yanagihara's unweighted grading score checked before treatment, after 5-day, 10-day and 15-day treatment between Bell's palsy and Ramsay hunt sundrome, there was no statistical significant difference.
1 포인트 드래그 연동 스마트 터치 제어용 다이나믹 모터 개발
김희철,Kim, Hee-Chul 한국전자통신학회 2015 한국전자통신학회 논문지 Vol.10 No.3
교육용 로봇은 과학의 기초 원리를 배우고 과학적 창의성을 키우는 것에 효과적인 교육 도구로 소개되면서 방과 후 학습에 적용되어 과학 교육을 위한 교육용 키트의 구성이 바뀌고 있다. 중소기업을 중심으로 과학적 창의성을 키우는 도구로서 다양한 교육용 로봇 기술과 학생들을 위한 다양한 범주의 게임로봇기술이 개발되고 있고, 기존의 mp3 음악이나 e-Learning 콘텐츠의 제공과 같이 로봇용 전문콘텐츠를 다운받아 학습에 활용하는 기술을 개발 중에 있으나 아직 전문 커뮤니티 형성이 미흡한 편이다. 현재는 사용자가 손쉽게 제어가 가능한 인터페이스 모듈용 모터가 개발이 되어있지 않아 1포인트 드래그 연동 스마트터치 제어용 다이나믹 모터 개발이 필요하다. Educational robot was introduced as an effective educational tool is to foster scientific creativity and learn the basic principles of science are applied to change the configuration of the educational after-school learning kits for science education. SMEs as a tool to foster scientific creativity center and a variety of educational robot technology and the wide range of games for students and robotic technology development, existing e-Learning by downloading mp3 music or learning content for the robot, such as the provision of specialized content Although the technology is still being developed to take advantage of the professional community formation is insufficient side. Currently, one-point linkage drag Smart Touch control dynamic motor development does not need this motor development is possible for users to easily.
김희철,Kim, Heechul 대한심미치과학회 2014 Journal of the Korean Academy of Esthetic Dentistr Vol.23 No.1
CAD/CAM에서 사용할 수 있는 소재는 composite, ceramic, hybrid 그리고 metal이 있다. 그중에 진료실 CAD/CAM에서는 주로 monolithic ceramic 테크닉을 사용하는 데, monolithic ceramic 테크닉이란 한 가지 소재로만 제작하는 방법을 말한다. 블럭상태의 소재를 최종치아형태로 깎아 폴리싱해서 사용하거나, 열을 가해서 사용하는 방법으로, 기존의 도재 축조 작업이 필요 없다. 심미성에서는 다소 부족하지만, 1시간 안에 제작이 가능하므로 1회, 1일 방문으로 치료를 완료할 수 있고, 소재의 안정성이 높으며(녹이거나 상변화를 시키지 않음에 따라 왜곡이 생기거나 강도가 약해질 가능성이 적음), 컴퓨터 조작(CAD 작업)으로 치아를 디자인하여 제작하므로 진료실에서 쉽게 작업할 수 있다는 장점이 있다. 이 테크닉에 사용할 수 있는 소재를 임상적 관점에서 세대별로 따라 분류해 보았다. Materials that can be use in CAD/CAM are composite, ceramic, hybrid and metal. Among the available materials, monolithic ceramic technique which is the manufacturing technique using one type of the materials is mainly used in a dental office. It is the technique where final tooth-shaped prostheses are made from the material block and used after polishing or applying heat and that does not require traditional ceramic build-up process. Although shot of esthetic quality, because manufactured within 1 hour the monolithic ceramic technique has advantages such as that treatment can be completed in one day and in one time visit, that stability of the material is high because there are low possibility of distort by not melting and phase transformation, and that it can be easily worked in the office with computer assisted devices. We classified the materials that can be used in this technique based on their generations from clinical stand point.
보폐양영전(保肺養營煎)이 흰쥐의 기관지평활근(氣管支平滑筋) 장력(張力)과 면역에 미치는 영향(影響)
김희철,이강녕,Kim, Hee-Chul,Lee, Kang-Nyoung 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.3
It has been reported that Bopheyangyoungjeon(BYJ) has an effect on deficiency asthma(喘虛) clinically. The aim of this study was to determine an appropriate dosage of BYJ to treat asthma. In order to study the effects of orally administered BYJ on allergic asthma, mice were pretreated with three oral doses of the herbal solution of BYJ before antigen sensitization. 2 days later Mice were actively sensitized with a subcutaneous injection of ovalbumin and 13 day later ovalbumin aerosols were used to provoke asthmatic reaction. Serum level of IgE, IL-4, WBC, RBC, HGB, cell numbers in bronchoalveolar lavage fluid(BALF), and in vitro isometric contractile responses of the isolated tracheal smooth muscle(TSM) to acetylcholine(ACh, 0.1-1000uM), KCl were measured. The results were as follows ; 1. Contractile responses of TSM to ACh significantly increased in C group at Ach 0.3, 1, 3, 10, 30, 100, 300, 1000uM(P<0.05, P<0.01) and increased in D at 0.1, 0.3, 3, 30, 30, 100, 300, 1000uM. 2. The sensitivity of TSM to Ach increased more in A, B group, but it was not significant. 3. The maximal contractile response of TSM to ACh decreased more significantly in C group(P<0.01) and D group(P<0.05) the control group. 4. The maximal contractile response of TSM to KCI decreased more significantly in B group and C group(P<0.001) than in the control group. 5. The counts of lymphocytes in BALF decreased more significantly in B group and D group(P<0.05) than in the control group. 6. The counts of macrophages in BALF decreased more significantly in B group, C(P<0.05) than in the control group. 8. Serum IgE level increased more significantly in B group and C group(P<0.05) than the control group. 9. The counts of WBC, RBC, HGB in blood increased more significantly in A group than the control group. The above results support a role for BYJ orally administered in treatment of deficiency allergic Asthma.