Cardiovascular Effects of Glucagon-Like Peptide-1 Receptor Agonists

강유미,정창희 대한내분비학회 2016 Endocrinology and metabolism Vol.31 No.2

Glucagon-like peptide-1 (GLP-1) is a member of the proglucagon incretin family, and GLP-1 receptor agonists (RAs) have beenintroduced as a new class of antidiabetic medications in the past decade. The benefits of GLP-1 RAs are derived from their pleiotropiceffects, which include glucose-dependent insulin secretion, suppressed glucagon secretion, and reduced appetite. Moreover,GLP-1 RAs also exert beneficial roles on multiple organ systems in which the GLP-1 receptors exist, including the cardiovascularsystem. Cardiovascular effects of GLP-1 RAs have been of great interest since the burden from cardiovascular diseases(CVD) has been unbearably increasing in a diabetic population worldwide, despite strict glycemic control and advanced therapeutictechniques to treat CVD. Preclinical studies have already demonstrated the beneficial effects of GLP-1 on myocardiumand vascular endothelium, and many clinical studies evaluating changes in surrogate markers of CVD have suggested potentialbenefits from the use of GLP-1 RAs. Data from numerous clinical trials primarily evaluating the antihyperglycemic effects ofmultiple GLP-1 RAs have also revealed that changes in most CVD risk markers reported as secondary outcomes have been in favorof GLP-1 RAs treatment. However, to date, there is only one randomized clinical trial of GLP-1 RAs (the ELIXA study)evaluating major cardiovascular events as their primary outcomes, and in this study, a neutral cardiovascular effect of lixisenatidewas observed in high-risk diabetic subjects. Therefore, the results of ongoing CVD outcome trials with the use of GLP-1 RAsshould be awaited to elucidate the translation of benefits previously seen in CVD risk marker studies into large clinical trials withprimary cardiovascular outcomes.

GT rotary file을 이용한 근관성형법과 충전방법의 비교

강유미,진정희,유미경,이세준,이광원 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.5

The purpose of this study was to compare the shaping time of two shaping methods and the leakage of three different obturation techniques. Ninty three canaled human molar teeth were used. which were randomly divided into two groups of forty teeth each and ten control teeth. After working length determination. the one group was prepared crowndown technique using rotary root canal instruments of GT rotary files .12/20, .10/20, .08/20 and .06/20 taper(Maillefer Instrument SA. Switzerland). The other group was instrumented with Gates Gildden burs(#1, #2 and #3) to coronal preparation and GT rotary files .08/20 and .06/20 taper to apical preparation. Shaping time was measured. After root canals were instrumented, they were divided to three subgroups and obturated as follows: Subgroup 1, obturated with single cone method : Subgroup 2, obturated with lateral condensation : Subgroup 3, obturated with continuous wave technique. Three subgroups were obturated using non-standardized gutta-percha cone(Diadent, Korea, 06 or .08 taper) and AH-26(Dentsply DeTrey, Germany) as a root canal cement. Ten unobturated teeth served as positive and negative controls. After immersion in 2% methylene blue solution for 1 month, the teeth were washed during 24h. The teeth were determineralized in 10% nitric aciid and dehydrated by immersion in 80, 90 and 100% ethyl alcohol. The teeth were finally cleared and stored in 100% methylsalicylate, and apical dye penetration was evaluated under stereomicroscope(Leica M420, LC, U.S.A) at (×) 8.75 magnification. Liner measurement of dye penetration was assessed with the use of digitalized image analysing system (analySIS, GmbH, Germany), The data were analysed statistically using independent T-test and Two-way ANOVA and Tukey test. The result were as follows: 1. In canal prepared with GT^Trotary file, shaphing time taked more than the group of using Gates Gildden drill to coronal preparation without statistical significant (p>0.05). 2. The group of single cone obturation using canal preparation of GT^TM rotary files showed significantly more apical leakage than those of lateral condensation and continuous wave technique regardless of shaping method (p<0.05). 3. The group of single cone obturation using canal preparation of GT^TM rotary files and Gates Gildden drill showed significantly more apical leakage than those of continuous wave technique regardless of shaping method (p<0.05). 4. Regardless of shaping method. The group of continuous wave obturation showed less apical leakage than those of lateral condensation without statistical significance (p>0.05). 5. The group of single cone obturation using canal preparation of GT^TM rotary files and Gates Gildden drill showed more apical leakage than the group of lateral condensation using sane shaping method without statistical significance (p>0.05).

자율운항 선박에서 액체 위험화물의 위기 분석 방법 고찰

강유미,정재용,임정빈 해양환경안전학회 2018 해양환경안전학회 학술발표대회 논문집 Vol.2018 No.06

저선량 방사선의 면역활성 효과 연구 : 정맥 투여된 림프종세포의 신체내 암 발병과정에 미치는 영향

강유미,봉진종,양광희,김차순,김지영,남선영,이하은,유재영,진영우,이경미,김희선 대한방사선방어학회 2012 대한방사선방어학회 학술발표회 논문요약집 Vol.2012 No.11

붕괴중대재해의 사례분석을 통한 건설가설 안전관리 개선방안

강유미,박준모,김옥규,곽순섭,최병주,송길호 대한건축학회지회연합회 2011 대한건축학회지회연합회 학술발표대회논문집 Vol.2011 No.1

혼산에 의한 폭발사고의 화학반응 경로 분석 - 화학물질 운반 선박을 중심으로 -

강유미,임정빈 해양환경안전학회 2017 海洋環境安全學會誌 Vol.23 No.6

본 연구의 목적은 혼산 화물의 폭발사고에 대한 화학반응 경로를 분석하는데 있다. 분석에는 사건-가지분석기법을 적용한 구조 적인 시나리오를 이용하였다. 구조적인 시나리오는 재결서에 기록된 혼산 화물 사고의 내용에서 다양한 화학반응 경로를 추정하여 구축하 였다. 분석에는 화학 이론에 의거한 정성적 분석과 화학 반응식을 이용한 정량적 분석 및 설문조사를 통한 확률적 분석 등 세 가지 방법을 혼합 적용하였다. 분석결과, 사고 발생의 주요 경로는 진한 황산과 물이 반응하여 폭발하는 경로, 혼산과 금속이 반응하여 폭발하는 경로, 특수한 물질과 합성하여 폭발하는 경로 등 세 가지로 나타났다. 이 결과는 재결서에 기록된 경로와 유사함을 알았고, 이를 통해서 본 연구 에서 제안한 화학물질의 경로분석 기법이 타당함을 알았다. 본 연구에서 제안한 방법은 다양한 화학물질 사고의 화학반응 경로 추정에 적 용 가능할 것으로 기대된다. The purpose of this study is to analyze the chemical reaction pathway for explosion accident of mixed cargo. The analysis used a structural scenario using event-tree analysis. Structural scenarios were constructed by estimating various chemical reaction paths in the content of the mixed cargo accident recorded in the written verdict. The analytical method was applied to three kinds of analysis: chemical analysis based on chemical theory, quantitative analysis using chemical reaction formula, and probabilistic analysis through questionnaire. As a result of analysis, the main pathway of the accident occurred in three ways: the path of explosion due to the reaction of concentrated sulfuric acid with water, the path of explosion due to the reaction of metal and mixed acid, and the path of explosion by synthesizing with special substances. This result is similar to the path recorded in the validation, and it leads to thar the proposed path analysis method is valid. The proposed method is expected to be applicable to chemical reaction path estimation of various chemical accidents.

중장년층의 심리적 특성과 창업환경이 창업의도에 미치는 영향 및 개인자산의 조절효과에 관한 연구

강유미,김재호 한국창업학회 2015 한국창업학회지 Vol.10 No.3

CHANGES IN BODY AND ORGAN WEIGHTS, HEMATOLOGICAL PARAMETERS, AND FREQUENCY OF MICRONUCLEI IN THE PERIPHERAL BLOOD ERYTHROCYTES OF ICR MICE EXPOSED TO LOW-DOSE-RATE -RADIATION

강유미,신석철,진영우,김희선 대한방사선방어학회 2009 방사선방어학회지 Vol.34 No.3

We exposed ICR mice to low-dose (0.2 Gy) and low-dose-rate (0.7 mGy/h) -radiation (137Cs) in the Low-dose-rate Irradiation Facility at the Radiation Health Research Institute to evaluate systemic effects of low-dose radiation. We compared the body and organ weights, number of blood cells (white and red blood cells and platelets), levels of biochemical markers in serum, and frequency of micronuclei in polychromatic erythrocytes between low-dose irradiated and nonirradiated control mice. The ICR mice irradiated with total doses of 0.2 and 2 Gy showed no changes in body and organ weights, number of blood cells (white and red blood cells), or frequency of micronuclei in the polychromatic erythrocytes of peripheral blood. However, the number of platelets (P = 0.002) and the liver weight (P < 0.01) were significantly increased in mice exposed to 0.2 and 2 Gy, respectively. These results suggest that a low-dose-rate of 0.7 mGy/h does not induce systemic damage. This dose promotes hematopoiesis in the bone marrow microenvironment and the proliferation of liver cells. In the future, the molecular biological effects of lower doses and dose rates need to be evaluated.

Role of NO/VASP Signaling Pathway against Obesity- Related Inflammation and Insulin Resistance

강유미,Francis Kim,이우제 대한당뇨병학회 2017 Diabetes and Metabolism Journal Vol.41 No.2

Obesity has quickly become a worldwide pandemic, causing major adverse health outcomes such as dyslipidemia, type 2 diabetes mellitus, cardiovascular disease and cancers. Obesity-induced insulin resistance is the key for developing these metabolic disorders, and investigation to understand the molecular mechanisms involved has been vibrant for the past few decades. Of these, low-grade chronic inflammation is suggested as a critical concept in the development of obesity-induced insulin resistance, and the anti-inflammatory effect of nitric oxide (NO) signaling has been reported to be linked to improvement of insulin resistance in multiple organs involved in glucose metabolism. Recently, a body of evidence suggested that vasodilatory-stimulated phosphoprotein (VASP), a downstream mediator of NO signaling plays a crucial role in the anti-inflammatory effect and improvement of peripheral insulin resistance. These preclinical studies suggest that NO/VASP signaling could be an ideal therapeutic target in the treatment of obesity-related metabolic dysfunction. In this review, we introduce studies that investigated the protective role of NO/VASP signaling against obesity-related inflammation and insulin resistance in various tissues.

안와 연부조직에서 발생한 간엽성 연골육종-1증례 보고-

강유미,지미경,강석진,김병기,김선무 대한병리학회 1989 Journal of Pathology and Translational Medicine Vol.23 No.2