고요산혈증의 위험인자 : 아산시 지역 주민을 대상으로

김용배,장원기,황보영,김화성,안규동,이병국,이용진,이종은,이준숙,이찬구,이한정,이성수 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

Objective : Serum uric acid has now been identified as a marker for a number of metabolic and hemodynamic abnormalities. The aim of this study is to evaluate risk factors which influence hyperuricemia in the citizens of Asan. Method : The study design was cross-sectional and research subjects were 1086 citizens of Asan. General characteristics, cigarette smoking, alcohol consumption, and past history were obtained by interview using a structural questionnaire. Also, we measured height, weight and blood pressure, and serum uric acid of the subjects. Results : The mean serum uric acid level was 5.27 ㎎/㎗ in men and 4.01 ㎎/㎗, in women, In the multiple logistic regression analysis, statically significant risk factors of hyperuhcemia were gender, body mass index, blood lead concentration, and serum creatinine. Conclusion : Our results suggest that gender, body mass index, blood lead concentration, and serum creatinine might be the most important risk factors of hyperurcemia. Education program as well as routine check-up for serum uric acid was highly recommended for the effective prevention of hyperuricemia.

직업적 연폭로에서 혈중 연량 수준에 따른 선별검사로서의 혈중 ZPP 검사의 타당도

한구석,안현철,김용배,리갑수,김화성,황규윤,장봉기,이성수,안규동,이병국 순천향대학교 산업의학연구소 1999 순천향산업의학 Vol.5 No.1

In order to evaluate the validity of current screening criteria of lead exposure and to provide effective information for the better health management of lead workers, author investigated the interrelationship between blood lead and blood zinc protoporphyrin(ZPP) and evaluate the validity of blood zinc protoporphyrin as the screening test and blood lead as gold standard of diagnostic test. The total of 2245 lead workers (male workers: 1982, female workers : 263) from 12 lead using industries were studied. Blood lead, ZPP, hemoglobin and hematocrit were selected as lead exposure variables. Personal information on sex, age and work duration were also checked. Blood lead was measured with flameless atomic absorption spectrometry (model: Hitachi 8100) using standard addition method. Blood ZPP was measured with portable hematoflurometer (model: Aviv 206). The results obtained were as follows: 1. The mean blood lead of all lead workers were 0.7±14.3㎍/㎗(Male: 31.0±14.4㎍/㎗, Female: 28.2±12.9㎍/㎗), whereas the mean blood ZPP of those were 68.1±47.5㎍/㎗(Male: 63.9±43.7㎍/㎗, Female: 100.1±61.0㎍/㎗). The mean value of hemoglobin and hematocrit of all lead workers were 14.5±1.5g/㎗(Male: 14.7±1.3g/㎗, Female: 12.3±1.2g/㎗) and 45.4±3.6(Male: 46.2±2.8, Female: 39.5±3.1) respectively. 2. Validity of test using blood zinc protoporphyrin as screening test for blood lead levels of 30㎍/㎗ as gold standard of diagnostic test revealed that the highest validity value for male and female lead workers were 50 and 90 ㎍/㎗ of ZPP respectively, showing 50 and 60 ㎍/㎗ of ZPP for all lead workers. While those test for blood lead levels of 40㎍/㎗ as gold standard of diagnostic test revealed that the highest validity value for male and female lead workers were 60 and 90 ㎍/㎗ of ZPP respectively, showing 60 ㎍/㎗ of ZPP for all lead workers, those test for blood lead levels of 50 and 60㎍/㎗ as gold standard of diagnostic test revealed that the highest validity value for male and female lead workers were 60 or 70 and 100 ㎍/㎗ ZPP respectively, showing 60and 70 or 80 ㎍/㎗ of ZPP for all lead workers. 3. Predictive value of test using blood zinc protoporphyrin as the screening test for different blood lead levels of 30, 40, 50 and 60㎍/㎗ as gold standard of diagnostic test revealed that positive predictive value of screening test were decreased by the increase of blood lead level regardless of csreening criteria value ZPP and negative predictive value of screening test were increased accordingly regardless of screening criteria value of ZPP. On the other hand, within same blood lead level as a gold standard positive predictive values were inceased by the increase of screening criteria value of ZPP, whereas the negative predictive value were decreased accordingly by the the increase of screening criteria value of ZPP. 4. The correlation analysis of all lead workers among study variables revealed that CPbB and natural log transformation ZPP(LZPP) were better correlated with other variables and found to be better estimate than PbB and ZPP themselves. The age was correlated with all other variables, but the work duration was not. The correlation analysis of male and female workers among study variables revealed the same results with all lead workers. 5. The slope of simple linear regression of CPbB (independent variable) with ZPP in female workers(3.223)was steeper than in male workers(2.144). That of lead workers with work duration of less than 1 year was steeper than that of lead workers whose work duration was more than 1 year. But there was no slope difference between two groups divided by their work duration of 2 years less and more. The slope of simple linear regression of CPbB lead (independent variable)with ZPP in lead workers whose blood lead were higher than 30㎍/㎗and 40㎍/㎗ were steeper than those whose blood lead were less than 30㎍/㎗ and 40㎍/㎗. 6. The slope of simple linear regression of CPbB (independent variable) with ZPP in lead industries with low mean blood lead were less steeper than those with high mean blood lead. 7. The slope of simple linear regression of CPbB (independent variable) with LZPP in female workers(0.0308was steeper than in male workers(0.0253). That of lead workers with work duration of less than 1 year was steeper than that of lead workers whose work duration was more than 1 year. But where was no slope difference between two groups divided by their work duration of 2 years less and more. While the slope of simple linear regression of CPbB lead (independent variable) with LZPP in lead workers whose blood lead were hogher than 30㎍/㎗ was not steeper than those whose blood lead were less than 30㎍/㎗, there was no slope difference between two groups whose blood lead were less than 40㎍/㎗ and more than 40㎍/㎗. 8. The slope of simple linear regression of CPbB (independent variable) with LZPP in lead industries with low mean blood lead were less steeper than those with high mean blood lead, but the difference was not significant then that of CPbB and ZPP. With above results, it is recommended that the screening criteria value of ZPP should be down to 60-70㎍/㎗ from 100㎍/㎗ for male lead workers and screening criteria of ZPP for female lead workers was all right with current value of 100㎍/㎗. So it is recommended to make different screening criteria of ZPP for male and female workers like the hemoglobin and hematocrit screening criteria. It is also preferable to use CPbB and LZPP rather than uncorrected PbB and ZPP in the evaluation of lead exposure for lead workers.

대전시 노은 도매시장 채소류의 농약 잔류 실태 및 식이섭취량 추정

한국탁,이규승,이은경,이용재,고광용,원동준,이정원,권순덕 한국환경농학회 2003 한국환경농학회지 Vol.22 No.3

대전시 노은 도매시장에서 채취한 6종의 채소류 중 농약잔류량을 조사한 후 이에 대한 위해성 평가를 실시하였다. 전체 100건의 분석시료 중 농약이 검출된 시료의 비율은 46.0%이었고, 잔류허용기준 초과비율은 6.0% 이었다. 검출비율이 높은 시료는 상추(85.0%), 깻잎(80.0%), 오이(60.0%) 순이었고, 상추 3건, 깻잎 3건이 허용기준을 초과하였다. 살균제는 dicar-boximide계, 유기염소계, azole계 농약, 살충제는 유기인계, 합성 pyrethroid계 농약이 많이 검출되었다. 검출빈도가 높은 성분은 procymidone, chlorpyrifos, chlorothalonil, cypermethrin, EPN의 순이었다. 위해성을 평가하기 위해서 각 농작물에 대한 농약의 추정 섭취량과 ADI를 비교한 결과, 허용기준을 초과한 깻잎의 bitertanol, triflumizole, iprobenphos가 다른 성분에 비하여 높은 비율을 보였다. 그러나 각 농산물의 식이섭취량이 적어 ADI에 대한 추정섭취량의 비율이 0.46%이하로 나타나 그 영향이 매우 낮은 것으로 판단되었다. Pesticide residues in some vegetables collected at Noeun wholesale market in Daejeon were surveyed and assessed their risk In 100 samples, the detection rate of pesticide was 46.0% and the rate exceed MRL was 6.0%. Commodities showing high detection rate were lettuce(85.0%), perilla leaf(80.0%) and cucumber(60.0%). Dicarboximide, organochlorine, and azole fungicides and organophosphorus and pyrethroid insecticides were detected. Detection frequency of pesticide was in the order of procymidone, chlorpyrifos, chlerothalonil, cypermethrin and EPN. When the estimated intake amount of the pesticides were compared with ADI to assess their risk, bitertanol, triflumizole and iprobenphos in perilla leaf were higher rate than the other vegetables. However the total amounts of intake of pesticides were estimated to less than 0.46% of ADI.

한 · 아프리카 포럼의 의미와 이명박 정부의 대아프리카 정책에 대한 소고

이한규(Lee Han-kyu) 한국아프리카학회 2011 한국아프리카학회지 Vol.33 No.-

The foreign relations in the current international society is putting the authentic mutual dependence and understanding between the nations above others unlike the cold war system, so such circumstances require the medium & long term approach that could reinforce Soft Power in various fields. Such an approach is an advisable means in that it can actualize the international realism aiming for national interest with more appropriateness and also actualize the international idealism more reinforcing the approach to world peace and international issues at the same time. Especially the diplomatic strategy toward Africa employed by the countries in the West is changing into the strategy putting emphasis on Soft Power by linking the practicality of the so-called resource diplomacy and market expansion to sustainable economic development. With the coming of the 21st century, a nation’s diplomacy is confronted with endless changes and challenges due to a countless number of mutually influencing complex factors, and moreover, a nation is facing the situation where it cannot seek for only practical interests any more owing to the emergence and roles of diverse international performers. Especially in case of Korea, the capacity reinforcement of Soft Power is an imperative strategy in the medium & long term not only for the resource diplomacy toward Africa but also building peace in the Korean Peninsula. Further, it’s necessary to give a top priority to capacity reinforcement through the development of Soft Power uniquely applicable to Africa in case of Korea which is acquainted with the western culture in that Africa still has a cultural pattern different from the West. Accordingly, as a responsible stakeholder in international society, as a late-starting nation whose launching into Africa is late, and ,as someone argues, as a model of African economic development, Korea in the 21st century is required to reestablish the basic guideline for the policy toward Africa through the more comprehensive and consultative method led by the private-public-academic sectors, and to put forth the Korean paradigm of Soft Power to debate from the medium & long-range view. On its basis, there need to be the expansion of cultural exchange, and ‘intelligence gathering the strength’ of domestic resources that could expand the base of cultural exchange more than anything else.

재발 또는 불응성 비호즈킨 림프종 환자에서 CDME 구제항암화학요법 후 고용량 항암화학요법 및 자가말초혈액 조혈모세포이식의 효과

김세형,한강원,배상병,김찬규,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Background and objectives : The long-term survival in patients with non-Hodgkin's lymphoma (NHL) after conventional dose chemotherapy is about 35% and the rest of the patients tend to have relapse. So, in relapsed or refractory NHL, we compared the outcome of patients undergoing high-dose chemotherapy with autologous peripheral blood stem cell transplantation(APBSCT) with only salvage chemotherapy of cisplatin, dexamethasone, mitoxantrone, and etoposide(CDME). Materials and methods : From June 1993 to December 1999, 25 patients with relapsed or resistant NHL were treated with CDME regimen as salvage chemotherapy. Twelve patients were received four cycles of CDME chemotherapy, and 13 patients were received high-dose chemotherapy with APBSCT following two cycles of CDME chemotherapy. Results : The median follow-up duration was 12.8 months(range:4-68). The overall response rate was 41.7% (complete response rate 25%, partial response rate 16.7%) in 12 patients with CDME only. Thirteen patients who were treated with high-dose chemotherapy with APBSCT achieved 61.5% complete response rate and 15.4% partial response rate, with an overall response rate of 76.9%. The estimated 3-year progression-free survival rate was significantly higher among patients who received high-dose therapy than patients who received CDME only(41.5% vs 20.0%, p<0.05). And, 3-year overall survival rate was significantly higher among patients who received high-dose therapy(51.3% vs 25.0%, p <0.05). Conclusions : In relapsed or refractory NHL, CDME chemotherapy is an effective salvage chemotherapy and allow peripheral blood stem cell collection. Also, high-dose chemotherapy with APBSCT following CDME is superior to CDME salvage chemotherapy only.

횡문근융해증과 급성 신부전 및 범발성 혈관내 응고장애를 동반한 열사병 1예

최대은,박수진,권오경,이한규,이영모,이상주,나기량,이강욱,신영태 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Heat stroke is a life-threatening illness characterized by an elevated core body temperature that rises above 40% and central nervous system dysfunctions that results in delirium, convulsions, or coma. Heat stroke is subdivided into two forms, classic and exertional. Since strenuous exercise is one of the major exacerbating and precipitating factors, the incidence of exertional heat stroke is high among young adult, especially military personnel undergoing military training. Exertional heat stroke commonly causes rhabdomyolysis, lactic acidosis, acute renal failure, shock and pulmonary edema. We report a case of heat stroke with rhabdomyolysis, acute renal failure, disseminated intravascular coagulopathy(DIC) after strenuous exercise. A 18 year old man was admitted to the hospital because of loss of consciousness. He was a wrestler and he had tried to lose 6kg in weight by jogging and strenuous exercise on that summer day with hot temperature. The development of this illness was favoured by much clothes inappropriate for that environmental condition with a purpose to enhance sweating, and by restricted intake of water and food. On admission, the blood pressure was 80/50mmHg, and body temperature was 39.4℃ with stuporous mentality. Laboratory finding were as follows : in complete blood cell count, hemoglobin was 16.7g/dL and platelet count was 158,000/ mm³. In blood chemistry, AST 1061U/L, ALT 201U/L, BUN 30mg/dL, Cr 2.2mg/dL, LDH 941IU/L, CK 696IU/L were resulted. In arterial blood gas analysis, pH 7.39, pCO₂ 30mmHg pO₂ 86mmHg, HCO₃ 18.4mEq/L, O₂ saturation 96.7% were resulted. In urinalysis, specific gravity 1.025, protein 3+, erythrocyte 2+ were resulted. In brain imaging study, brain CT finding was normal. After appropriate treatments with rapid cooling, hydration and supportive care, he improved with alert mental status. On 2nd hospital day, in laboratory result, thrombocytopenia and coagulopathy were appeared and renal insufficiency was aggravated. So he was treated with platelet concentrate and fresh frosen plasma for DIC, and enough hydration for appropriate urine volume preservation. After all, On 22nd hospital day, he fully recovered and discharged. Nowadays, with followed for some duration, he is wellbeing with no complications.

초등학생들의 과외 스트레스 분석

이한규 인제대학교 1998 仁濟論叢 Vol.14 No.1

This study was designed to examine whether extra-curricular activities(ECA) become stressors for young elementary school students, and to investigate whether stress responses depend on personality traits. The subjects of this study were one hundred second and third grade students, fifty per each grade. The children were divided into two groups: one group consisted of fifty eight children who participated in ECA on their parents' demand, and the other consisted of forty two children who participated in ECA on their own interests or who did not involve in ECA. The stress responses of the children were evaluated with three test materials that measured physical symptoms, depression, and anxiety of the children. The children were also administered the Eysenck Personality Questionnaire that examined their personality in four dimensions: toughmindedness, extraversion-introversion, emotional, and lie dimensions. The results of this study showed that there were no significant differences in the stress responses between two groups, which suggested that ECA were not stressful activities for these children. This can be explained in three ways. First, the children of this study mostly involved in music, art, or athletic activities which could have been very amusing. Second, the instructors of ECA these days teach children interestingly. Third, some children are very proud of their participating in ECA, which, therefore, are far from stressful. The srtess responses, however, had strong correlations with personality traits, especially with extraversion-introversion, emotional, and lie dimensions. Those who were high in emotional dimension, and low in extraversion-introversion and lie dimensions tended to show strong stress responses. This suggests that parents and ECA instructors must be very careful with the children who are introvert, highly emotional, and who are less willing to follow the social customs.

참쑥 정유의 항세균 및 항진균 효과

이현옥,한규용,한동민 한국식품영양학회 1999 韓國食品營養學會誌 Vol.12 No.6

참쑥의 정유성분을 추출하여 수종의 병원성 세균과 곰팡이를 대상으로 항세균 및 항진균 효과를 실험하여 다음과 같은 결과를 얻었다 그람 양성균인 S.epidermidis와 S. aureus는 200ppm의 농도에서, S. mutans는 1,000ppm의 농도에서 세균성장 억제효과가 나타났으며, 통계학적으로 유의성이 인정되었다.(P<0.05). 그람 음성균인 Z.mobilis와 En. faecalis는 200ppm의 농도에서. Ps. putida는 400ppm 농도에서 세포성장 억제효과가 나타났다(P<0.05) V. parahaemolyticus는 800ppm의 농도에서 Ps. aeruginosa는 1,000ppm의 농도에서 세포성장 억제효과가 나타났다. (P<0.05) 효모형 곰팡이인 C. albicans와 Cr. neoformans는 200ppm의 농도에서 세포성장 억제효과가 나타났다(P<0.05) 사상형 곰팡이인 Al. mali는 600ppm의 농도에서,A. nidulans는 400ppm의 농도에서, F. oxysporum은 100ppm의 농도에서 세포성장 억제 효과가 관찰되었으며. 이들 중 A nidulans에 대한 효과가 가장 높게 나타났다. Essential oil of Artemis a lavandulaefolia, the chrysanthemum family plant used in the chinese medicine. was extracted and antibacterial and antifungal activity with many kinds of the pathogenic bacterium and fungi was experimented by it. Staphylococcus epidermidis, and Streptococcus aureus, gram positive bacterium, at the concentration of 200ppm and Streptococcus mutans at the concentration of 1,000ppm showed the growth inhibition effect of the cell. These showed statistically significant difference(p<0.05). Zymomonas mobilis, Entrecoccus faecalis, gram negative bacterium, at the concentration of 200ppm and Pseudomonas putida at the concentration of 400ppm showed the growth inhibition effect of the cell (p<0,05), V. parahaemolyticus at the concentration of 800ppm and Pseudomonas aeruginosa at the concentration of 1,000ppm showed the growth inhibition effect of the cell(p<0,05). Candida albicans and Cryptococcus neoformans, yeast-type fungi, showed the gorwth inhibition effect of the cell at the concentration of 200ppm(p < 0.05). Altenaria mall, Aspergillus nidulans and Fusarium oxysporum, filamentous fungi, took the growth inhibition effect of the cell at the concentration of 600ppm, 400ppm and 100ppm respectively.

일정경사 수심단면에서 평균수위의 상승/저하 효과를 고려한 해빈류의 예측

이철응,김영중,최한규 江原大學校 産業技術硏究所 1997 産業技術硏究 Vol.17 No.-

The numerical model for prediction of longshore current with set-up/down effect on a plane beach is developed using the longshore component of the depth-integrated momentum balance equation. To predict the longshore current, the wave height model should first be formulated because the longshore current depends on the wave height directly. Two wave model, regular wave model and random wave model, are developed based on the energy flux balance equation. Also, the numerical model estimating the set-up inside the shoreline is developed using both the on-offshoremomentum equation and the moving boundary technique. The numerical models are verified by the analytical solution, and compared with laboratory data. It is found from the comparison that developed models may be predicted accurately the longshore current with set-up/down effect on a plane beach.

防波堤의 任意 配置에 對한 波浪 廻折

李한배,李庸揆,吳世汎,片宗根 명지대학교 공학기술연구소 1988 공학기술연구소 논문집 Vol.3 No.-

In harbor design, it is a necessary condition to retain calmness inside a harbor. For this purpose, breakwaters are disposed as exterior structures against incident waves. There are cases that necessitate main and auxiliary breakwaters according to frequent directions of incident waves. In these cases, harbor entrances have various geometric shapes in horizontal plane. In the program developed here, harbor entrances are classified into six different cases by the disposition of breakwaters and the attack angle of incident waves. For each case, the diffraction phenomena inside and around harbor entrance are analysed by superposing the solutions of Sommerfeld's. The method gives fairly good results compared with those reported before, and also is proved to be computationally very efficient. Therefore, the method may be applicable to the preliminary design of breakwater dispositions, and also the program can be used as the basic subroutine in the calculation of wave height distributions inside a harbor with reflected waves.