Methylation Status and Expression of E-cadherin in Oral Squamous Cell Carcinomas Compared to Benign Oral Epithelial Lesions

Son, Hyun-Jin,Chu, Jung-Youb,Cho, Eui-Sic,Lee, Dong-Geun,Min, Myung-Gee,Lee, Suk-Keun,Cho, Nam-Pyo The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Expression of invasion/metastasis suppressor, E-cadherin, is reduced in many types of human carcinomas. Although somatic and germline utations in the CDH1, which encodes the human E-cadherin, have frequently been reported in cases with diffuse gastric and lobular breast ancers, irreversible genetic inactivations are rare in other human carcinomas. Recently, it has been well documented that some genes in human cancers may be inactivated by altered CpG methylation. Herein, we determined the expression and methylation status of E-cadherin in oral squamous cell carcinoma (SCC) by immunohistochemistry and methylation-specific PCR. The expression of E-cadherin was significantly higher in the well-differentiated oral SCCs than the moderately or poorly differentiated ones. None of eight tested benign pithelial hyperplasias showed aberrant methylation, whereas five of 12 oral squamous cell carcinomas showed aberrant methylation. When we compared E-cadherin expression with methylation status, oral SCCs with normal methylation showed a higher expression of E-cadherin than those with methylation. These findings suggest that aberrant CpG methylation of CDH1 promoter region is closely associated with transcriptional inactivation and might be involved in tumor progression of the oral mucosa.

公共土地開發事業 地方化問題와 代案에 관한 小考

조길환,황의진,김영곤 여수대학교 1998 論文集 Vol.13 No.2

Since 1980 the Korea Land Development Coporation has played a major role in land development by means of a Public Initiated Land Development Scheme. This strategy has attempted to correct the market failure of the generation of large sum of windfall profits. In accordance with reimplementation of the local autonomous ruling system since 1991, the demend for local government initiated land development have increased rapidly as local governments attempt to math the influence of national local development policy. In this regards, it is very useful for urban planners to analyze the merits and dismerits of the local government initiated land development schemes in view of national agency's development. This paper recommends several mitigation measures to improve the settlement of the local government initiated land development scheme.

都市公營開發事業에 對한 考察

조길환,황의진,김영곤 여수대학교 1998 論文集 Vol.13 No.2

This Paper studied the background and characteristics of the adopted public development among the system of housing land development that is executing in our country nowadays And it defined the reasons of problems that is caused by a social change in the Project of public development at the level of city public development toward a service that the public development effects to the City planning. So it would like to propose reform methods in develo-ping housing area to give basic data in establishing system of city public development by the local selfgoverning body as the methods for a construction of effective city space and smooth supply of housing area is presented as follows. First : In order to ensure a legitimacy of an exercise of government power for the business of public development, the gualification of a practical system of public development is to be strengthened. According to the guideline of the policy of city development or nation's housing or land, the condition of Yelated areas, the characteristics of business subject, the system of public development is to be selected. The object of the public development such as the developing business of residential land for the low-incomed class, the suitable business that is developed by the pu-blic, the developing business of land in national basic industries is to be realized and objectified more. Second : A differtial application of distribution price of the residential land according to not only the distribution of residential land related with housing construction business and its use or object but also the storage of public land and reformation of system and distribution object of public development land through an activation of the system of land selling in advance. Third : The idleness one of planning developed land such as a rational management for restriction of privaty ownership of developing profit, the establishment of effective restoration system of the developed profit, and establishment of land developing fund is to be controlled. Fourth : To ensure a reinvestment resources for continuous propulsion of the city developing business, its effective propulsion of developing business by a preaying distribution and induction of land demand and distribution acceleration ncouragement of purchase interest) is to be drived. So the distribution acceleration and fund revulsion is to be smooth with a rational reform of a distribution method by a minimization of dependency degree of outer fund in an early period of development and establishment of inverstment resources by a restoring profit of the public development. Fifth : A method of activation in city developing business is to be considered by a diversity of the developing subject. Sixth : The search for distribution method of space for city environment and the enlargement method of equipment space is to be considered.

사이클1㎞獨走競技 選手의 無酸素性 運動能力 測定方法

김기진,김상수,안의수,조현철 龍仁大學校 體育科學硏究所 1992 體育科學硏究論叢 Vol.2 No.1

To try optimal test for the anaerobic performance of 1㎞ time trial cyclists, this study was performed by the analysis of results with the repeated test of exiting method. Seven elite male 1㎞ time trial cyclists with between 4 and 10 years of competitive riding experience participated in the study. 1. Only increasing value of CPK activity after Supramaximal exercise test was negative correlated to the 1㎞ time trial performance in variables related to the anaerobic performance, and there are on variables could estimate the 1㎞ time trial performance. 2. In general, variables related to the anaerobic performance of Supramaximal exercise test showed a significant correlation with variables of the Wingate anaerobic test, and mean power output and peak power output of the Wingate anaerobic test,and mean power output and peak power output of the Wingate anaerobic test showed a significant correlation with isokinetic power of knee joint. 3. Exercise intensity of pretest on the basis of lactate threshold has problems in the anaerobic glycolysis power test. this finding the consideration to upgrade a exercise intensity of pretest. 4. In comparison of peak value of blood lactate concentration, peak value of Supramaximal exercise test showed the highest value, but peak value of anaerobic glycolysis power test showed the lowest value. On the basis of the results obtained in this study, it is a difficult that existing anaerobic tests have a direct application to the estimation of 1㎞ time trial cycling performance. but we can find that apply these tests to the assessment of a potential capacity of 1㎞ time trial cycling performance. The exercise intensity and duration of these existing tests must be reconsiderated for a suggestion of accurate anaerobic performance test.

유도 '되치기 본'의 개선 방안에 관한 연구

김의환,김도준,김규수,김관현,김종달,최종삼,조용철,박순진,윤익선,안병근,정 훈,김미정,한성철 龍仁大學校 武道硏究所 1999 武道硏究所誌 Vol.10 No.1

The purpose of this study was to reform practically a Korean Judo's Doechigi-Bon(Forms of Counterattack, judo's Gaeshi no Kata, Judo's Uradori no Kata, Judo's Gonosen no Kata) that was established in 1955 Korea, according to changing of techniques by Judo's modernization, in order to have Judo's carefulness and systematic diffusion. Reform procedure of Judo's Doechigi-Bon was 1st stage, Questionnaire survey 303 judokas, 2nd stage, Technical seminar by judo experts(12 judo professor) 4 times, 3rd stage, wording report for reform, 4rd stage, Discussion and judgement of Teaching and Judgement commission of Korean judo Association(KJA), 5th stage, Public hearing for reform in KJA, 6th stage, Report and decision of board of directors in KJA, 7th stage, public publication of Judo News(No.53) in KJA. Basic principle of reform of Judo's Doechigi-Bon were as table 1. Table 1. Basic principle of reform of Judo's Doechigi-Bon ------------------------------------------------------------------------------- Items Reformed Key Points of Judo's Doechigi-Bon ------------------------------------------------------------------------------- 1. Structure 1) Grand classification : Classified by 3 parts(1,2,3Gyo) 2)Medium classification : Te waza, Goshi waza, Ashi waza devided per each part(Gyo) 3)Sub-classification : Classified five techniques per each part(Gyo) 2. Contents 1) Selected established techniques as possible 2) Considered rationalty and overlapping of counterattack techniques 3. Decision of Conterattack techniques 1) Refered to results of Basic Questionnaire survey 2) Priority to decisions of Judo expert technical seminar -------------------------------------------------------------------------------- Reformed Korean Judo's Doechigi-Bon(Forms of Counterattack techniques-KJA, 1999) are as follows: 1. Gyo; ① Uki otoshi -> Uchi mata ② Harai goshi -> Harai goshi gaeshi ③ O soto gari -> O soto gake ④ Ko uchi gari -> Sasae tsurikomi ashi ⑤ O uchi gari -> Ko soto gari 2. Gyo; ① Ippon seoi nage -> Okuri eri jime ② Tsuri domi goshi -> Uki waza ③ Okuri ashi harai -> Okuri ashi harai ④ Ko soto gari -> Tai otoshi ⑤ Hiza guruma -> Hiza guruma 3. Gyo; ① Kata guruma -> Sumi gaeshi ② Tai otoshi -> Ko soto gari ③ Hane goshi -> Harai tsurikomi ashi ④ Uchi mata -> Tai otoshi ⑤ Tomoe nage -> O uchi gari

슬관절에 히야루론산 주입후 발생한 활막성 연골종증 : 증례 보고

최의성,김용민,김동수,손현철,박경진,조병기,배승환 충북대학교 의과대학 충북대학교 의학연구소 2009 忠北醫大學術誌 Vol.18 No.2

활막성 연골종증은 비교적 드문 양성 종양으로 관절내 활액막 결체조직의 양성 반응성 이형성에 의해 여러 개의 연골성 결절을 형성하고 이것이 관절내로 유리되어 유리체를 형성하는 질환으로 주로 슬관절에 발생한다. 활막성 연골종증의 정확한 발생 기전은 아직 밝혀지지 않았으나 외상, 감염 등이 원인으로 제시되고 있다. 저자들은 슬관절 내 히야루론산 주입후 발생한 슬관절내 활막성 연골종증을 1 례 경험하였으며, 관절경적 제거술을 통해 만족스런 결과를 얻었다. As a relatively rare benign tumor, synovial chondromatosis forms several cartilaginous nodules by the benign reactive metaplasia of synovial connective tissues within joints, which are loosed into the joints and cause a disease forming loose body mainly in knee joint. Accurate mechanism of synovial chondromatosis has not been clarified yet; however, trauma, infections and others have been suggested as its possible causes. The authors of this study experienced an example of a patient with synovial chondromatosis in knee joint occurred after the injection of hyaluronic acid in the joints and had a satisfactory outcome through the arthroscopic resection.

고정 좌표축상에서의 전압 보상 기능을 가진 능동전력필터 제어기설계 및 시뮬레이션

송의호,조진호 국립7개대학공동논문집간행위원회 2001 공업기술연구 Vol.1 No.-

This paper deals with a simple control algorithm of shunt active power filter (SAPF) to reduce the source current total harmonic distortion (THD) and compensate the point of common coupling (PCC) voltage distortion caused by the interaction current harmonic components with system impedance. The proposed SAPF is implemented with three-phase IGBT based voltage source inverter (VSI) with a dc bus capacitor. The proposed simple control algorithm is based on not the synchronous reference frame but the stationary reference frame. Therefore, compared to the conventional SAPF, the proposed SAPF provides reduction of computation. To prove the validity of the proposed control algorithm, computer simulation is executed.

스포츠센터 소비자의 고객충성도에 영향을 미치는 요인에 관한 연구 : 서비스 품질과 서비스 가치를 중심으로 Centered on the quality and value of services

정의권,최영진,조현철 중앙대학교 스포츠과학연구소 2002 體育硏究 Vol.- No.17

This study centers on the quality and value of services perceived by consumers regarding factors that affect customer loyalties of sport center consumers. Study has been administered by a questionnaire survey of 200 male and female adult members of four sport centers in Seoul area. Following is the results: 1. Analyzing the relationship between demographic characteristics of sport center consumers and factors of their selection of those sport centers, there is significant difference in consumers' schooling and their family income. 2. Service quality perceived by sport center consumers appears to have a positive influence on service value. 3. Service value of sport center consumers appears to have a positive influence on customer loyalties. 4. Service quality perceived by sport center consumers appears to have a direct influence on customer loyalties. 5. Assessing the causal relationship between the service quality and value perceived by sport center consumers and customer loyalties, direct influence that the perceived service quality has on customer loyalties is stronger than indirect influence that mediated by service value.

한국 · 대만 유도국가대표선수들의 한팔 업어치기 동작 시근 활성도 비교 분석

김의환(Eui-Hwan Kim),안병근(Byung-Keun Ahn),김성섭(Sung-Sup Kim),조준명(Joon-Myoung Cho),지준안(Chun-An Chi),진종현(Jong-Hyun Jin),김지태(Ji-Tae Kim) 한국생활환경학회 2011 한국생활환경학회지 Vol.18 No.2

The purpose of this study was to compare and analyze the electromyograpic activity between Korean and Taiwanese of Ippon-Seoinage (one-armed shoulder throw) as Tokuinage (favorite and major technique) in Judo. The subject (Tori, attacker), who was 4 Korean and Taiwanese representative judoists from 2007 to 2009 years, respectively, Uke (defender) was a Judo-doll made by Kim, Eui-hwan etc. (2007), whole body of judo-doll was fixed, upper body was flexible 35 degree forward and backward, lower was 15 degree, was used to muscles activities measured by surface-electrode & electromyography. Subject performed 5 successful trials respectively, with parter (Uke) was resistance (R-0%) of judo-doll. Muscle activities were obtained from the electromyography analysis. Muscle activities in all phase, Taiwanese were lower than Korean, right Bicep, Trapezius, Tibialis muscles in Kuzushi phase, right Bicep, right Trapezius, left Rectus abdominus in Tsukuri and Kake phase, different between Taiwanese and Korean were signify (p < .5).

국내 다기관에서 조사한 지역사회획득 메티실린내성 황색포도알균의 빈도와 임상적 특성

송진수,최평균,송경호,조재현,김성한,방지환,이창섭,박경화,박경운,신수,최희정,김의석,김동민,이미숙,박완범,김남중,오명돈,김의종,김홍빈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

목적 : 최근 전세계적으로 지역사회획득 메티실린내성 황색포도알균(community-associated methicillin-resistant Staphylococcus aureus, CA-MRSA)의 보고가 증가하고 있다. 하지만, 우리나라에서는 CA-MRSA 감염증에 대한 증례보고만 있을 뿐 아직까지 체계적인 연구결과가 없는 실정이다. 저자들은 국내에서 CA-MRSA의 빈도, 감염증의 임상적 양상, 분리된 균주의 항균제내성 양상을 조사하였다. 재료 및 방법 : 2005년 1월부터 2005년 6월까지 7개 병원에서 MRSA가 분리된 환자의 명단을 파악한 후 의무기록지와 건강보험심사평가원의 자료를 검토하였다. 외래나 응급실에서 혹은 입원 후 72시간 이내에 균주가 분리되고 MRSA 획득과 관련된 위험인자가 없는 경우 CA-MRSA로 정의하였으며, 분리된 균주의 임상적 의미에 따라 원인병원체(pathogen), 집락화(colonizer), 미결정(undetermined)으로 분류하였다. Penicillin과 oxacillin을 제외하고 3개 이상의 다른 계열 항균제에 내성이면 다제내성으로 정의하였다. 결과 : 연구기간동안 총 3,251주의 황색포도알균이 분리되었으며, 이 중 MRSA는 1,900주(58.4%)였다. MRSA 가운데 CA-MRSA는 114주(6.0%) 였으며, 이들이 분리된 부위는 귀(62주), 비뇨기계(14주), 피부 및 연부조직(11주), 호흡기계(10주), 혈액(3주) 등이었다. CA-MRSA 균주 가운데 집락균은 22주, 원인병원체는 22주였으며, 나머지 균주에 대해서는 그 임상적 의미를 결정할 수 없었다. 항균제 감수성 검사를 시행한 73균주 중 47주(64.4%)는 다제내성이었다. CA-MRSA 감염증 22예 중 피부 및 연부조직 감염(9예)과 중이염/외이도염(9예)이 가장 흔하였다. 침습적 감염증(invasive infection)은 4명(원발성 균혈증 3예, 감염성 관절염 1예)에서 확인되었지만, CA-MRSA 감염증으로 사망한 환자는 없었다. 결론 : 병원내 감염증에서는 MRSA가 심각한 문제이지만, 아직까지 지역사회 감염증에서 CA-MRSA는 흔하지 않았다. Background : Methicillin-resistant Staphylococcus aureus (MRSA) infection has emerged in patients who do not have the established risk factors. In Korea, little is known about the epidemiology and clinical features of community-associated MRSA (CA-MRSA). Material and Methods : Clinical microbiology laboratory databases of 7 hospitals were reviewed to identify the patients from whom MRSA was isolated during the period of January to July 2005. Only one isolate per patient was enrolled. In order to identify the risk factors of MRSA acquisition, the medical records and the Health Insurance Review Agency databases were reviewed. CA-MRSA was defined as MRSA isolated from patient without established risk factors. We analyzed patient demographics, underlying medical conditions, characteristics of infection, and antimicrobial susceptibility profiles. Results : Of total 3,251 S. aureus isolates, 1900 (58.4%) were MRSAs. Of the MRSA isolates, 114 (6.0%) were CA-MRSA. Of 114 CA-MRSA isolates, 22 (19.3%) were colonizers, 22 (19.3%) were pathogens, and the clinical significance of remaining 70 (61.4%) could not be determined. Median age of the 22 patients with CA-MRSA disease was 47 years. Nine patients had skin and soft tissue infections, 9 ear infections, 3 bacteremia, 1 septic arthritis. Seven patients had underlying medical disease. None died of the CA-MRSA infections. Of the 73 isolates of CA-MRSA, 47 (64.4%) were resistant to more than 3 classes of antibiotics besides β-lactams. Conclusion : Although MRSA is highly prevalent among hospital-associated S. aureus infection, CA-MRSA infections are not common.