C형 간염바이러스 항체 면역블롯검사에서 불확정판정을 받은 헌혈자의 HCV 양성 확인

조연정,서동희,황병갑,김동집,정남현 大韓輸血學會 2001 大韓輸血學會誌 Vol.12 No.2

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

도시지역 보건사업에서 컴퓨터의 활용방안에 관한 연구

염용태,이명숙,조병희,송동빈 고려대학교 의과대학 1990 고려대 의대 잡지 Vol.27 No.2

Nacessity of new communication media in information society is repidly increasing in many fields of Korea. It includes the field of primary helath care in the courses of collecting informations on demographic feature, social characteristics and health behavior of peoples. In light of above reasons, the authors attempted to utilize personal computers for the primary health services to promote health of unban people as a pilot study in Guro-6- Dong, Seoul. Five nurses working in Guro-6-Dong Health Subcenter completed family health records of 3,930 households among the total of 4,270. A total of 3,904 family health records among 3,930 were computerized and sorted out in categories of population characteristics, population dymanics, characteristics of householders, housing, family planning, maternal and child health(M.C.H), health status of residents and of others. Names of risky category in M.C.H, and family planning were listed and the lists were handed to the nurses concerned in order to practice proper cares in time. Sorted data were compared with ones of City of Seoul, average of other cities, and ones of nationwide. With the results of above practice, in terms of utilization of computer in uban primary health sevices, the following strategy was proposed. In order to provide proper health services the unban people demanded, efficient devices of information collection, processing and interpretation systems on health were urgently needed in every dong unit(health subcenter) of health centers. Recommended was personal computer network as a new communication media. Additional advantages of the devices were continuity and efficiency in services, and utilization in evaluation of health services and analysis of cost -effectiveness.

재생골재 혼합율에 따른 콘크리트 압축강도 변화에 관한 연구

조동영,유희중 호남대학교 2003 호남대학교 학술논문집 Vol.24 No.2

시중 판매중인 Fresh-Cut 채소 제품의 품질평가

조순덕,박주연,김은정,김동만,김건희 덕성여자대학교 대학원 2007 덕성여자대학교 대학원 논문집 Vol.9 No.-

Fresh-cut 채소 제품이 소비자에 의해 선택되어 소비되려면 이의 친환경적 원료생산과 가공, 포장, 서빙에 이르는 전 과정에서 체계적인 품질관리가 이루어져야 하며 갈변제어, 연화제어 및 미생물적 제어 등 관련 기술의 연구개발이 요구된다. 본 연구에서는 시중 유통 · 판매되고 있는 fresh-cut 채소제품의 품질을 비교평가하기 위해 현재 유통되고 있는 9개사 제품을 선정하였으며, 관능검사를 포함하여 vitamin C, 무기질, 중금속 함량, 잔류농약 및 미생물오염 정도를 조사하였다. 관능평가에서는 갈변 등 품질변화로 인해 전반적인 기호도가 그다지 높지 않았다. 채소류에서 중요 영양성분인 vitamin C 함량은 9개사 모든 제품의 주재료인 양상추에서 거의 검출되지 않았고 다른 채소류의 vatimin C 함량 역시 식품성분표보다 소량이었다. 무기질 함량 역시 극히 소량이었는데, 이는 박피, 절단 등의 최소 가공 공정을 거치면서 파괴되기 쉬운 vitamin C와 무기질이 대부분 손실되었기 때문으로 사료된다. 안전성측면에서 평가한 잔류 중금속 함량의 경우 몇 개의 제품에서 구리와 납이 소량 검출되었으며 잔류농약은 검출되지 않았다. Most fresh-cut agri-food products are less stable than the unprocessed materials from which they are made. The objective of this study was the development of a quality control system for fresh-cut agri-food products. In this study, the vitamin C, mineral, residual heavy metal contents and pesticides of various fresh-cut agri-food products were analysed. Through the sensory evaluation, the reason for the lower than expected overall acceptability in most products is that cut products are likely to cause browning and easily lose their freshness. Therefore, the postharvest technology that can maintain the quality, freshness and appearance must be supplied. Vitamin C contents did not exist in all salad products of the selected 9 companies, although vitamin C and mineral contents that are main nutrients that can be supplied mainly in salads. The results showed that vitamin C and mineral contents were very small and extremely small in other vegetables compared with the standard of a food ingredient, It is possible that vitamin C and most minerals are easily destroyed were lost through the minimal process like peeling and cutting. In safety side, the remaining heavy metal contents of fresh-cut agri-food were investigated and the results showed that copper and lead existed in some products because cadmium in agricultural produce is only controlled by the minimum standard of heavy metal contents in Korea. No residual pesticides were detected in all products.

한국 주요정신장애의 유병률 및 관련요인 : 2006 전국정신질환역학조사

조맹제,장성만,함봉진,정인원,배안,이영문,안준호,원승희,손정우,홍진표,배재남,이동우,조성진,박종익,이준영,김진영,전홍진,이해우 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.3

Objectives The aims of this study are to estimate the prevalence of the DSM-IV psychiatric disorders in the Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI), and to compare those with previous studies. Methods The Korean Epidemiologic Catchment Area study Replication (KECA-R) was Conducted between August 2006 and April 2007. The sampling of the subjects was carried out across 12 catchment areas. A multistage, cluster sampling design was adopted. The target Population included all eligible residents aged 181o 64 years. Face-to-face interviews were conducted with the Korean version of Composite International Diagnostic Interview (K-CIDI) based on the DSM-IV (N=6,510, response rate=81.7%). Results A total of 6,510 participants completed the interview. The lifetime and 12-month prevalence rates for all types of DSM-IV disorders were 30.0% and 17.3%, respectively. Those of Specific disorders were as follows : 1) alcohol use disorder, 16.2% and 5.6% ; 2) nicotine use disorder, 9.0% and 6.0% ; 3) specific phobia, 3.8% and 3.4% ; 4) major depressive disorder, 5.6% and 2.5% ; and 5) generalized anxiety disorder, 1.6% and 0.8%. Data relating to nicotine and alcohol use disorder revealed a very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among females than males. Conclusion The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in the distribution of psychiatric disorders across the country and times were observed.

原料乳의 貯藏中 滴定酸度 및 總生菌數의 變化에 關한 硏究 : Ⅰ. 貯藏時間 및 溫度差에 의한 變化 Ⅰ. Studies on the Time of Storage and Difference Temperature

趙永來,尹東根,李乙熙 진주산업대학교 1980 論文集 Vol.18 No.-

機械搾乳한 原料乳를 5℃,15℃ 및 30℃에서 保存하여 5時間 간격을 두고 經視的으로 酸度測定, 總生菌數檢査 및 大腸菌群檢査를 한 結果는 다음과 같다. 1. 搾乳卽時의 滴定酸度는 0.1455%였다. 2. 搾乳卽時의 總生菌數는 4.5×10exp(4)/㎖이었다. 3. 滴定酸度는 5℃에서는 25時間이상 20℃에서는 5∼10時間 사이에 30℃에서는 5時間에서 기준치 이하였다. 4. 총생균수는 5℃에서는 20시간 이상 20℃에서는 10시간 30℃에서는 5시간 保存까지 基準(2×10exp(6)/㎖)이하로 나타났다. 5. 搾乳卽時 大腸菌群은 4.0×10exp(2)/㎖이었으나 15時間까지는 增加하였고 그 率은 점차 감소되었다. This study was conducted to fine out the titratable acidity and microbiological change during storage raw maik. It were taken from the mixed milk by Holstein cows in Jinju Agriculture & Forestry Junier Technical College under temperature of 30℃, 20℃ and 5℃ each for 25 hours in the laboratory. The results obtained were as follows; 1. The titratable acidity was 0.1455% in right after the milking. 2. The total bacterial counts of right after the milking was 4.5×10exp(4)/㎖. 3. The titratable acidity did not increase up to the inedible level of goverment standard until more than 25, between 5 and 10. and before 5 hours at 5, 20 and 30℃ conditions, respectively. 4. The total bacterial counts of raw milk did not increase up to inedible level of goverment standard until more than 20, 10 and 5 hours at 5, 20, and 30℃ conditions, respectively. 5. The colforms count of raw milk of right after the milking was 4.0×10exp(2)㎖ and there after it were incressed a space of 15 hours. But as the time passed it were decreased every temperature conditions.

水紅花子의 抗癌活性 및 抗轉移 效果에 關한 硏究

曺永周,金聖勳,金東熙 대전대학교 한의학연구소 2002 혜화의학회지 Vol.10 No.2

To evaluate the antitumor activity and antimetastatic effects of Polygoni Orientalis Fructus(POF), studies were done experimentally. The results were obtained as follows: 1. In cytotoxicity against A549, and XF498 cell concentration inhibiting cell growth up to below 30% of control was recognized at 200㎍/㎖ of POF. Also POF inhibited cell growth up to below 30% of control against SK-OV-3, SK-MEL-2, HCT15 and MCF-7 cell at 100㎍/㎖. 2. The concentration inhibiting adhesion of A549 and SK-OV-3 to complex extracellular matrix up to below 70% of control was recognized at 100㎍/㎖ of POF. 3. In pumonary colonizatin assay, a number of colonies in the lungs were decreased signiicantly in POF treated group as compared with control group. These results suggested that POF extracts might be usefully applied for prevention and treatment of cancer.

강릉 연안에서 어획한 오징어의 간장 중 일반성분 및 지질 조성의 계절변화

조순영,전미정,주동식,전중균,이미희,정인학 강릉대학교동해안지역연구소 1999 東海岸硏究 Vol.10 No.2

연간 어획량으로 볼 때 오징어는 다른 어종 못지않게 중요한 종류이다. 오징어는 몸통뿐 아니라 내장과 간장 또한 이용가치가 매우 뛰어남에도 불구하고 그동안에는 사료용으로만 약간 사용되고 나머지는 대부분 폐기하였다. 본 연구에서는 이들 간장의 이용도를 넓힐수 있는 기초자료를 확보하고자 간장 중 일반성분과 지질 클래스의 변화를 월별로 조사하였다. 우선, 주문진항에서 4월에서 10월까지의 매월 한차례씩 살아있는 오징어를 구입하여 이들의 체중과 체장, 그리고 내장과 간장의 무게를 재고, 간장은 일반성분과 지질분석을 하였는데, 월별 체중 및 체장은 7월을 기점으로 여름철에 증가하며 체중도 같은 경향을 나타내었다. 그리고 간장의 무게도 체중의 증가와 비례하여 증가하였다. 비만도는 체장의 증가율에 비해 체중의 증가율이 높은 5월이 비만도가 가장 높았다. 같은 기간 중 일반성분의 변화를 보면, 수분은 대체로 감소하는 경향이고 단백질은 7월에서 9월 사이에 증가하는 경향을 보였다. 지질은 단백질과는 반대로 7월에서 9월 사이에 감소하는 경향을 보였으며, 회분은 매월 일정한 값을 나타내었다. 이러한 결과로 어체의 성장이 활발한 여름철에 단백질의 양이 증가하고 반면에 지질의 함량은 감소하는 것으로 나타났다. 한편, 지질 클래스에서 단순지질의 경우 NL은 봄철에서 가을로 가면서 점차 증가하는 경향을 보였고, 반면 S, PL은 감소하는 경향을 보였다. PL에서는 대부분 PC만이 검출되었으며, 계절적으로는 봄에서 가을로 갈수록 감소하는 경향을 보였다. Squid is one of the most popular species over the East coast of Korea and sold as raw or processed one at the market. However, the liver and intestine occupied more than 20% of whole body are discarded wastefully at present. At this point of view, we analyzed lipid classes and fatty acid composition of liver, and tried to develop the utilities on the useful components of liver and intestine of squid. Alive squids were collected at the port of Jumunjin, Kangwon-Do, Korea, from April to Oct., 1988, and measured the body length, body weight and liver weight. Chemical composition of liver was analyzed by general method. Moreover, lipid class of total lipid was analysed using Iatroscan. As a results of this study, body weight, body length and liver weight increased after July, and hepatosomatic index(HSI) increased after May. Moreover, condition factor was maintained at moderate level after May. Among chemical components, water content had negative correlation with lipid and concentrations of protein and ash were not changed remarkly. In analysis of lipid class, it was proved that neutral lipid(NL) fraction of total lipid(TL) contained triacylglyceride(TG), sterol ester(SE) and free fatty acid(FFA) while polar lipid (PL) fraction of TL contained phosphatidylcholine(PC) dominantly.

전기자극이 후지체공 흰쥐의 체중과 후지둘레에 미치는 영향

조성채,김동희 木浦海洋大學校 1998 論文集 Vol.6 No.1

본 연구는 활동저하모형인 후지체공 방법에 의해 근위축이 흰쥐의 체중과 추지둘레에 미치는 영향을 알아보는데 그 목적이 있으며, 이를 규명하기 위하여 간헐적 전기자극이 후지체공에 이해 항중력근이 위축반응에 미치는 효과를 분석하였다. 연구의 처치수단으로는 후지체공, 후지체공과 병행한 두 가지 전기자극(20Hz, 40Hz) 방법과 후지체공 후에 전기자극하는 방법을 실시하였으며, 실험대상은 Sprague-DawleyrP 230-250g의 흰쥐를 각 진단별로 10마리씩 홍 70마리를 사용하였다. 처치기간은 후지체공 7일과 매일 총 120분의 전기자극을 7일간 실시하였다. 연구의 관찰 변이은 후지체공에 의한 골격근 위축의 유발과정과 위축을 유발시킨 후 7일간의 회복기간에 전기자극하여 체중과 후지 둘레를 측정하여 후지체공과 전기자극이 미치는 효과를 규명하였다. 본 연구를 통하여 관찰된 변인들이 측정치를 비교 분서간 결과는 다음과 같다. 첫째, 7일간의 후지체공 후 근위축에 의하여 체중과 후지 둘레의 감소가 현저하게 나타났으나 전기자극군의 감소가 후지체공군에 비해 적게 나타나서 근위축 예방의 효과가 있음을 알 수 있었다. 둘째, 후지체공을 제거한 7일간의 회복과정에서도 전기자극군이나 자연회복군 모두 후지체공전의 체중이나 후지 둘레로 회복되지 않았지만 전기자극을 추가하는 회복집단이 위축의 회복이 빠름을 알 수 있었다. 이상의 요약에서 후지체공 후 체중과 후지둘레가 대조군에 비하여 감소하였으나 위축과정과 병행한 전기자극과 회복기의 추가 전기자극이 근위축의 예방과 회복에 효과적인 도움을 주는 것으로 나타났다. 이러한 실험성적은 간헐적 전기자극이 근위축을 효과적으로 예방할 수 있을 것으로 생각되며, 특히 근위축 발생 후 회복기의 전기자극이 매우 효과적인 것으로 나타났다.