Polymorphism of Cefotaxime sodium

Sohn, Young-Taek,Park, Sun-Hee 덕성여자대학교 약학연구소 2005 藥學論文誌 Vol.16 No.1

Three crystal forms of cefotaxime sodium have been isolated by recrystallization and characterized by powder X-ray diffractometry, differential scanning calorimetry, and thermogravimetric analysis. The dissolution patterns of three crystal forms of cefotaxime sodium were studied in water at 37±0.5℃, 90rpm for 180 minutes. Three crystal forms of cefotaxime sodium showed difference in dissolution rate and solubility. After storage of two months at 52% RH (saturated solution of Na_(2)Cr_(2)O_(2).2H_(2)O / 20℃), all crystal forms showed no transformation.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

일차성 식도이완불능증의 풍선확장술후 치료효과의 객관적 평가지표

손영해,나호영,조성범,주영은,김현수,최성규,유종선,김세종 全南大醫大 2001 전남의대학술지 Vol.37 No.2

진행된 자궁경부암 및 재발암에서 vincristine, bleomycin, mitomycin-C 및 cisplatin의 치료성적에 관한 연구

손영선,강길전,남상륜 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1

Seventeen patients with advanced or recurrent cervical cancer were treated with vincristine, bleomycin, mitomyicin-C and cisplatin between February, 1986 and January, 1989. 1. Among evaluable patients, response rate was 55.6%(patial responses in all). Response rates of advanced and recurrent group were 71% and 0%, respectively. 2. Medium survival for responders and nonresponders were 26 months and 25 months: there was no statistically significant difference(p>0.05) 3. Median survival for preoperative or preradiational chemotherapy and postoperative chemotherapy were 26 months and 23 months (p>0.05). 4. Nausea and vomiting were observed in most patients (88%), but easily controlled, and were followed in frequency by ferer, alopecia, leukopenia, stomatitis, diarrhea, but there was no serious toxicities. In addition, combination chemotherapy with vincristine, bleomycin, mitomycin-C and cisplatin in patients with advanced cervical vancer seemed to be relatively effective and well tolerable, but more cases need to be evaluated in patients with recurrent cervical cancer.

Job shop에서 지체작업수 성과를 고려한 작업배정 규칙

손영진,우종선,문석환 한국의사결정학회 2001 경영과학연구 Vol.10 No.-

Scheduling techniques and dispatching rules are widely studied because of their simulation-based analysis of dispatching rules for scheduling in dynamic job shops taking into account of utilization on the shop floor and due-date tightness. This research proposed new dispatching rules for a job shop that are expected to minimizes the proportion of tardy jobs. With respect to the proportion of tardy jobs objectives, the relative performance of the proposed dispatching rules were evaluated against that of the well-known ones.

우유와 두유를 혼합한 이유보충음료의 개발

손경희,윤선,이민준,김순영,김용태,장동훈,강석필 연세대학교 생활과학연구소 2001 生活科學論集 Vol.10 No.1

The purpose of this study is to develop an infant supplement composed of cow and soy milk which has acceptable taste and digestability and meets nutritional needs of the infants. Even though soy milk is and excellent source of protein for infants who are allergic to dairy products, its protein quality is still lower than that of regular milk. Therefore in the present study the development of sow-soy milk infant formula was attempted. To make the formula equal amount of cow and soy milk were mixed and supplemented with vitamins and minerals to meet the nutritional standards of breast milk, CODEX and recommended dietary allowances for Korean infants. In animal experimental study, the weight gain rate of weaning rats was highest in the order of 100% milk, cow-soy milk, control, soy milk, commercial soy infant milk group. Feed efficiency ratio(FER) were not significantly different among control, 100% milk and cow-soy milk groups. However, commercialized soy infant milk group showed significantly lower FER than other groups. When the cow-soy milk formula was fed to infant in the age of 5 month to 25 months, it did not show any unsatisfactory results in acceptability and bowel movements of the subjects. Since the cow-soy milk formula has not only all the nutrients for the physical growth of infants but also contains valuable physiological functional ingredients, it is expected to be a good choice of supplements for infants.

일측 시상경색 후 발생한 기억장애 2예

순은희,이애영,김선국 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.1

Lesions of the anterior and medial parts of the thalamus are often accompanied by memory dysfunction Bilateral lesions may produce major memory deficits that have sometimes been reported to last for several years Unilateral lesion may also be associated with memory dysfunction which is usually less severe and persistent and may be linked to a selective field of memory We report two amnesic patients with isolated infarct in the polar territory of the left thalamus. This cases demonstrate that unilateral left thalamic infarction in the polar territory can be presented with isolated verbal amnesia with relatively preserved visuospatial memory function and lateralization of memory dysfunction after thalamic infarction which is not always present.

5-FU 투여후 백서 가슴샘에서 일어나는 형태학적 및 생화학적 변화

손영탁,김선,정옥,한승로,김수일,이영호,김원식 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.2

Thymus is a lymphoid organ forming T-cells from hematogenous stem cells. Apoptosis of thymocytes in the cortex of thymus is so rapid that cannot find easily with routine histological techniques. In this experiment, TUNEL immunohistochemistry and TEM were used to detect apoptotic changes after 5-fluorouracil treatment in the thymus of the rat. In addition, SDS-PAGE was carried to reveal protein changes along the apoptotic changes. The results were as follows ; 1. Thymocytes in the cortex were decreased markedly and many apoptotic cells were found in the cortex on DAT 3. 2. Relatively small-sized apoptotic bodies induced by 5-FU were detected on DAT 3 at the cortex, and clustered in partly. 3. On DAT 6, new germinal centers formed in the peripheral cortex, and many apoptotic bodies of various size and shapes were detected in the germinal center. 4. In SDS-PAGE, a protein with molecular weight of 123kDa was increased on DAT 6. According to the above results, it could be concluded that 5-FU acted directly on the thymocytes and induced apoptotic changes on DAT 3. But, on DAT 6, the period of recovery, new germinal centers were formed in the cortex, in which active B cell production to compensate the loss of thymocytes was noticed. To make new T-cells from B-cells and to eliminate unnecessary B-cells, vigorous apoptosis in the germinal centers should occur, and 123kDa proteins which considered as integrins should act as transmembrane signaling molecules in this process.

페오니플로린 연구의 최신 동향

손영선 水原大學校 2018 論文集 Vol.32 No.-

Paeoniflorin is a mono-terpene glycoside extracted from the roots of Paeonia lactiflora Pall. Paeonia lactiflora Pall has so many ingredients such as albiflorin, paeoniflorin, tannins, phytosterols, casuariin and β-sitosterol[15]. In the analysis of peony petals, glycosides such as quercetin, glucopyranosides, methyl-gallate, paeonioflolol and kaemperol glucopyranosides were identified[11]. Traditionally, peonies have been prescribed for inflammatory and gynecological diseases and have been shown to reduce the inflammatory response through TLR2/4 activation[28]. The pain control pathway also regulates glutamate excitatory amino acid (EAA) and high-dose morphine-induced pain relief via N-methyl-D-aspartate (NMDA) signaling [1]. Recently, the most well-known applications of peoniflorin have been the neuroprotective effect of neurological damage mitigation in the aortic occlusion animal model in autoimmune encephalomyelitis [18], clinical improvement through reduction of the central nervous system (CNS) and spleen-infiltrated Th17 cells [7], the effect of inhibiting cell proliferation in breast and bladder cancer [24,29], the effect of regulating the blood glucose level, which significantly reduces serum insulin and glucagon levels, and the effect of high fat diet on cholesterol and blood lipid profiles [15]. In addition, there are various applications, and well-known effects include antioxidant and whitening effects including modulation of immune activity, control of hypertension, regulation of myocardial infarction, improvement of perioperative adhesion after surgery, and expression of proteins that can resist environmental stress.1)

THI에 의한 서울시 지하철 역사 근로자의 신체 및 심리적 증상에 관한 연구

손종렬,김선철,변상훈,문경환,김영환 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.2

This paper reports an investigaion for the health status of subway workers in the 67 subway stations in the Seoul area during from September 15th to Nobimber 15th, 2002 . Prevalence of subuective complaints was surveyed of 400 subway workers applied by a general health questionnaire-the Todai Health index(THI). The basic tool employed in this present study was the THI which is modified Comell Medical Index(CMI) and was developed by Tokyo University Research Team in Japan, and had been used to evaluate manufacturing workers, iron workers and other workers by Kim(1979), Chung(1982), Lym(1987), Lee(1996) in Korea. The results were summarized as follows; 1. The physical and psychological complaints were much higher in the 20~29 age group than other age groups. 2. The physical and psychological complaints showed a high tendency of increased incidence in all items as length of service decreased, and the 3~5 years group was higher than less 1 year group with regard to the symptoms of Digestive(C), Aggressiveness(F), Nervousness(E). 3. The physical and psychological complaints showed much higher tendency in the station staff(S?S) group than other groups. 4. The physical and psychological complaints showed much higher tendency in the under station(Un.S) and upper station (Un.S) groups than other groups. 5. The responses of physical and psychological complaints by monthly pay showed much higher tendency in he income of 10.1~1.50 millions won group than other groups. 6. The responses of physical and psychological complaints by smoker or non-smoker showed much higher tendency in the smoker group than non-smoker group. Therefore, it can be concluded that the worker of subway studied was perceived as acceptable the importance of health status, and suggested that the goverment of related subway need to be effort to control the health of subway workers in environment of indoor.