영남문집해제 : 우천집 (牛川集) ( 정옥 )

정옥 영남대학교 민족문화연구소 1988 민족문화연구소 자료총서 Vol.4 No.-

『牛川集』

鄭玉 안동대학교 퇴계학연구소 2004 退溪學 Vol.14 No.-

방울토마토(Lycopersicon escylentnm mill ssp.)를 添加한 Yogurt의 製造에 관한 연구

鄭玉,金鍾禹 충남대학교 농업과학연구소 1998 농업과학연구 Vol.25 No.2

In order to determine the effect of tomato(Lycopersicon escylentnm mill ssp.) on the yogurt quality, skim milk powders were added with tomato juice of 0%, 1%, 3%, 5% and fermented by mixed culture(Streptococcus salivarius subsp. thermophilus and Lactobacillus delbrueckii subsp. bulgaricus. The results were summarized as follows: 1. Addition of tomato juice in skim milk decreased pH(4.3) and increased acidity(0.93%) more than control did(pH 4.6, titratable acidity 0.85%). By the addition of tomato juice, acid production was increased and pH was decreased in proportion to concentrations of tomato juices added to skim milk. 2. The number of lactic acid bacteria in yogurts added with tomato juice (4.59×10^12cfu/ml) more increased than those in control yogurt(8.96×10^11cfu/ml). By the addition of tomato juice, the number of lactic acid bacteria counts increased in proportion to concentration of tomato juices added to skim milk. 3. As fermentation time goes by, the Brix degree sugar content in skim milk were decreased more rapidly than control. 4. The pH, titratable acidity, Brix degree and lactic acid bacteria were not significantly changed for all yogurts for the storing at 5℃ for 14 days. 5. In yogurt fermentation, addition of tomato juice with glucose (1% tomato juice + 4% glucose, 3% tomato juice + 2% glucose, 5% tomato juice + 0% glucose) decreased pH and increased acidity than control(5%glucose) did. In addition of tomato juice, acidity was increased and pH was decreased in proportion to concentration of tomato juices added to skim milk. 6. In yogurt fermentation, the number of lactic acid bacteria of yogurt added with tomato juice(1% tomato juice+4% glucose, 3% tomato juice+2% glucose, 5% tomato juice+0% glucose) increased than control(5% glucose). In addition of tomato juice, the number of lactic acid bacteria increased in proportion to concentration of tomato juices added to skim milk. 7. As fermentation time goes by, the Brix degree were decreased more rapidly than control(5% glucose). By the change of pH, titratable acidity, Brix degree and lactic acid bacteria, in yogurt fermentation, we definited that the promotive effect of tomato(Lycopersicon escylentnm mill ssp.) on the yogurt.

생기액(生肌液)의 세포독성 및 자궁경부암 바이러스 (HPV 16 type) 암 유발인자 E6와 E7의 작용에 미치는 효과

정옥(Ok Joung),조영식(Young Sik Cho),조정원(Cheong Weon Cho),이경애(Kyung Ae Lee),심정현(Jung Hyun Shim),조민철(Min Chul Cho),이홍수(Hong Soo Lee),염영일(Young Il Yeom),김상범(Sang Bom Kim),박순희(Sue Nie Park),윤도영(Do Young Yoon) 대한약학회 2000 약학회지 Vol.44 No.4

Cervical cancer is one of the leading causes of female death from cancer worldwide with about 500,000 deaths per year. A strong association between certain human papilloma viruses (HPV types 16 and 18) and cervical cancer has been well known. An extract of natural products, named as Somatid, has been used to investigate whether this agent has the ability of inhibiting the oncogenes E6 and E7 of HPV type 16. This Somatid inhibited the proliferation of human cervical cancer cell lines (C-33A, SiHa, CaSki) and HaCaT keratinocytes in a dose response manner. In vitro binding assay and ELISA showed that Somatid inhibited the in vitro biding of E6 and E6AP which are essential for the binding and degradation of the tumor suppressor p53. In addition, Somatid inhibited the in vitro binding of E7 and Rb which is essential tumor suppressor for the control of cell cycle. The levels of mRNA for E6 and E7 were also decreased by Somatid. Our data suggested that Somatid inhibited the oncogenecity of E6 and E7 of HPV 16 type, thus can be used as a putative anti-HPV agent for the treatment of cervical carcinomas caused by HPV.

블록 코딩을 활용한 동역학 수업에서 나타나는 물체의 운동 개념 변화 과정

정옥(Ok Jeong),오원근(Wonkun Oh) 한국물리학회 2022 새물리 Vol.72 No.11

본 연구는 블록 코딩을 활용한 수업을 통해 동역학의 기초라고 할 수 있는 위치와 변위, 속도, 가속도의 개념이 학생에게 어떤 형태로 형성되어 있고 어떻게 변화되어 가는지, 이 과정에서 어떠한 메타인지적 과정이 이루어지고 있는지 알아보는 데 목적이 있다. 이를 위해 5명의 학생들과 1:1로 수업을 진행하면서 학생들에게 형성되어 있는 개념을 확인할 수 있도록 코딩을 유도하는 질적 연구를 진행하였다. 그 결과 학생들에게 형성되어 있는 동역학 관련 오개념이나 개념적 어려움을 확인하였으며, 학생 스스로 경험하는 인지적 갈등과 갈등 해소 과정에서 나타나는 메타인지적 과정을 확인할 수 있었다. This study examines how students concepts of position, displacement, speed, and acceleration, which can be said to be the basis of dynamics, are formed and changed through the teaching of dynamics by using block coding and how metacognitive processes are enhanced in this process. A qualitative study was conducted on five students who engaged in a teaching class that introduced the block coding method to enable the students to check their own concepts. As a result, it was possible to discover misconceptions or conceptual difficulties related to dynamics that were formed in students, and to observe the cognitive conflicts experienced by the students themselves and the metacognitive process that appeared in the conflict resolution process.

음성합성을 위한 C-ToBI기반의 중국어 운율 경계와 F0 contour 생성

김병창,정옥,이근배,김승원 대한음성학회 2005 말소리 Vol.53 No.-

음성합성을 위한 C-ToBI기반의 중국어 운율 경계와 F0 contour 생성

김승원,정옥,이근배,김병창,Kim, Seung-Won,Zheng, Yu,Lee, Gary-Geunbae,Kim, Byeong-Chang 대한음성학회 2005 말소리 Vol.53 No.-

Prosody Generation Based on C-ToBI Representation for Text-to-SpeechSeungwon Kim, Yu Zheng, Gary Geunbae Lee, Byeongchang KimProsody modeling is critical in developing text-to-speech (TTS) systems where speech synthesis is used to automatically generate natural speech. In this paper, we present a prosody generation architecture based on Chinese Tone and Break Index (C-ToBI) representation. ToBI is a multi-tier representation system based on linguistic knowledge to transcribe events in an utterance. The TTS system which adopts ToBI as an intermediate representation is known to exhibit higher flexibility, modularity and domain/task portability compared with the direct prosody generation TTS systems. However, the cost of corpus preparation is very expensive for practical-level performance because the ToBI labeled corpus has been manually constructed by many prosody experts and normally requires a large amount of data for accurate statistical prosody modeling. This paper proposes a new method which transcribes the C-ToBI labels automatically in Chinese speech. We model Chinese prosody generation as a classification problem and apply conditional Maximum Entropy (ME) classification to this problem. We empirically verify the usefulness of various natural language and phonology features to make well-integrated features for ME framework.

5-FU로 백서 가슴샘에서 유도된 세포고사의 Comet Assay에 의한 분석

김수원,한승로,정옥,조근자,김선,김원식 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

Thymus is a lymphoid organ forming T-cells from hematogenous stem cells. Apoptosis of thymocytes in the cortex of thymus is so rapid that cannot find easily with routine histological techniques. In this experiment, Comet assay and SDS-PAGE were used to detect apoptotic changes and protein changes after 5-fluorouracil(5-FU) treatment in the thymus of the rat. The results were as follows. 1. The number of thymocytes in the cortex was markedly decreased, and many apoptotic cells with various size and shapes were found on DAT 5 in 5-FU treated group. 2. On DAT 5, new nodules with germinal centers began to appear in the peripheral cortex, and in the germinal center, there was many apoptotic bodies of various size and shapes. 3. In SDS-PAGE, a protein with molecular weight of 123kDa was increased on DAT 5 which was considered as integrins subfamily.

5-FU 투여후 백서 가슴샘에서 일어나는 형태학적 및 생화학적 변화

손영탁,김선,정옥,한승로,김수일,이영호,김원식 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.2

Thymus is a lymphoid organ forming T-cells from hematogenous stem cells. Apoptosis of thymocytes in the cortex of thymus is so rapid that cannot find easily with routine histological techniques. In this experiment, TUNEL immunohistochemistry and TEM were used to detect apoptotic changes after 5-fluorouracil treatment in the thymus of the rat. In addition, SDS-PAGE was carried to reveal protein changes along the apoptotic changes. The results were as follows ; 1. Thymocytes in the cortex were decreased markedly and many apoptotic cells were found in the cortex on DAT 3. 2. Relatively small-sized apoptotic bodies induced by 5-FU were detected on DAT 3 at the cortex, and clustered in partly. 3. On DAT 6, new germinal centers formed in the peripheral cortex, and many apoptotic bodies of various size and shapes were detected in the germinal center. 4. In SDS-PAGE, a protein with molecular weight of 123kDa was increased on DAT 6. According to the above results, it could be concluded that 5-FU acted directly on the thymocytes and induced apoptotic changes on DAT 3. But, on DAT 6, the period of recovery, new germinal centers were formed in the cortex, in which active B cell production to compensate the loss of thymocytes was noticed. To make new T-cells from B-cells and to eliminate unnecessary B-cells, vigorous apoptosis in the germinal centers should occur, and 123kDa proteins which considered as integrins should act as transmembrane signaling molecules in this process.

카드뮴에 의해 유발된 흰쥐 고환의 미세구조 및 단백질 변화

황일면,한승로,정옥,김수일,이영호,김원식 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.2

Although cadmium is a well known heavy metal which attacks testis and results male infertility, the mechanism of action in the testis is'nt still fully known. In the previous experiment, authors observed morphological changes in the testis, and found cadmium-induced death of all the spermatogenic cells and hemorrhagic necrosis within the seminiferous tubules, and apoptosis and death of interstitial cells and fibroblasts in the interstitial tissue of the testis. In this experiment, cadmium chloride (4 mg/kg of body weight) administered to the adult male rats(Sprague-Dawlcy) intraperitoneally and sacrificed 1 week after treatment. And electrophoresis, immunoprecipitation and Western blotting, and N-terminal analysis were performed to find the proteins changed after cadmium treatment in the testis. And the results were as follows; 1. Two proteins of molecular weight 42kDa and 21kDa disappeared after cadmium treatment. 2. The protein of 2lkDa was rat collagen type I alpha 2. According to the above results, it was considered that cadmium degraded the collagen fibers within the wall of small blood vessels in seminiferous tubules and interstitial tissues and disrupted vascular walls, which resulted hemorrhagic necrosis, death of all the spermatogenic cells, and the death of interstitial cells and fibroblastic cells.