Assessment of Alcohol Level in Inebriated Victims of Sexual Assault using Ethyl Glucuronide

Young?Hoon Jo,Mia Kwon,Joon-Bae Lee,Jeong A Ko 한국분석과학회 2022 학술대회논문집 Vol.2022 No.5

남성화를 보이는 여성에서 발견된 난소의 Steroid Cell Tumor 1예

조인호,정대훈,박영미,서영진,손영실,정철회,강영미,정수전,김영남,이경복,성문수,김기태 인제대학교 2006 仁濟醫學 Vol.27 No.-

Steroid cell tumor is a rare ovarian sex cord-stromal tumor which accounts for 0.1% of all ovarian tumors. Until now, only 4 cases have been reported in domestic literatures. Steroid cell tumor often secrets testosterone and presents virilization in adult women or precocious puberty in children. Treatment is often performed by surgical removal, adjuvant chemotherapy and radiation, but completely accepted treatment was not existed. We experienced a case of steroid cell tumor, which was manifested by typical virilization in a 43-year old patient, who was previously performed hysterectomy and unilateral oophorectomy. So, we present with a brief review of the literatures.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

자극특성 고분자 수화젤에 고정화된 효소의 촉매특성과 온도에 의한 효소활성의 조절에 관한 연구

김기훈,신영조 부산대학교 1994 生産技術硏究所論文集 Vol.47 No.

Poly(N-isopropylacrylamide) hydrogel is thermo-responsible which swells and shrinks reversibly as temperature changed through its phase transition temperature. When an enzyme is immobilized within this hydrogel, the catalytic activity of the immobilized enzyme can be switched on and off in accordance with the swelling and shrinking of hydrogel, respectively. In this work, invertase, sucrose hydrolase, was immobilized within poly(N-isopropylacrylamide) hydrogel and its catalytic activity as a function of temperature was studied. At 30℃, which is above the phase transition temperature of hydrogel, enzyme showed its activity. At 40℃ which is above the phase transition temperature, enzyme did not show its activity. Phase transition temperature of N-isopropylacrylamide hydrogel can be controlled by copolymerization with acrylamide. Poly(N-isopropylacrylamide) hydrogels which have different content of acrylamide were prepared and invertase was immobilized within those copolymer hydrogel. Enzyme activity of immobilized invertase within poly(N-isopropylacrylamide) hydrogel by temeprature was studied. In all the cases, immobilized invertase which is in below respective phase transition temperature showed its catalytic activity. Above phase transition temperature, immobilized invertase did not show its catalytic activity. Poly(N-isopropylacrylamide) 수화젤은 온도의 변화에 따라 가역적으로 수축과 팽윤을 하는 열응답성 고분자 수화젤이다. 이러한 온도에 민감한 수화젤에 효소를 고정화시키면 수화젤의 팽윤과 수축에 따라 효소가 그의 활성을 나타내던가 혹은 그의 활성을 나타낼 수 없는 이른바 온도에 따른 촉매로서의 효소활성의 "switch on-off" 기능을 기대할 수 있다. Poly(N-isopropylacrylamide)수화젤에 sucrose 분해효소인 invertase를 고정화시키고 sucrose hydrolysis의 반응온도를 조절하여 고정화된 invertase의 반응촉매로서의 온도에 따른 효소활성 조절에 대한 연구 및 고정화된 효소의 재사용에 관하여 고찰하였다. Poly(N-isopropylacrylamide)수화젤에 고정화된 효소를 사용하여 수화젤의 상전이 온도 이하인 30℃에서 sucrose를 분해반응시켰을 경우에는 glucose가 생성되었으나 수화젤의 상전이 온도 이상인 40℃에서 반응을 시켰을 경우에는 glucose의 생성이 정지되었다. 30℃와 40℃에서의 반복적인 반응온도의 변화에서도 효소는 그의 활성을 유지하였으며 반응 후 회수된 고정화효소는 재사용이 가능한 것을 관찰하였다. 여러 조성의 N-isopropylacrylamide와 acrylamide를 공중합시켜 Poly(N-isopropylacrylamide) 공중합 수화젤을 만들었으며, 공중합체의 조성에 따라 수화젤의 상전이온도가 변화되었다. 이 공중합체 수화젤에 invertase를 고정화하여 상전이온도의 변화에 따른 invertase의 효소활성에 대하여 연구하였다. 각 수화젤에 고정화된 invertase는 상전이온도 이하에서는 효소의 활성을 나타내지만 상전이온도 이상에서는 효소의 활성이 나타나지 않았다.

Zone refining에 의한 고순도 Cu 제조에 관한 연구

윤영옥,조형호,조훈,김세광,김영직 대한금속재료학회 2005 대한금속·재료학회지 Vol.43 No.3

The refining efficiency of high-purity Cu was investigated prepared by zone refining, with respect to travel rate, distribution coefficient, number of pass and zone length. Especially, to investigate refining efficiency with respect to zone length, experimental and computer simulation results were compared. The composition of the refined high-purity Cu was analyzed by GDOS (Glow Discharge Optical Spectroscopy) and GDMS (Glow Discharge Mass Spectrometer). The composition profiles of each segment at the given condition were compared with the results of micro hardness profiles. The results showed that the refining efficiency was inversely proportional to the travel rate, while it was proportional to the number of pass. The travel rate was more effective than the number of pass to enhance the refining efficiency in zone refining process. Impurities whose distribution coefficients are below 0.5 were removed efficiently. The effectively refined region increased with decreasing the zone length from 45 mm to 30 mm. Especially, the element S, which is known to be hardly removed by zone refining, could be removed to a level of under 0.1 ppm over the 60% region at 1 mm/min. (Received July 22, 2004)

비선형 음향효과에 의한 고온 재료의 파괴인성 열화도 평가

정현조,남승훈,장경영,남영현 한국비파괴검사학회 2000 한국비파괴검사학회지 Vol.20 No.5

고온 장시간 사용재의 열화로 인한 파괴인성의 저하를 초음파 방법으로 평가하기 위하여 Cr-Mo-V 강을 실험실에서 인공 열화처리하여 열화로 인한 손상 기구를 규명하고, 열화도에 따른 초음파 파라미터의 변화를 체계적으로 관찰하였다. 초음파 파라미터로서 속도, 감쇠와 보다 최근에 개발된 비선형 음향 파라미터를 사용하였는데, 비선형 음향 파라미터가 가장 민감한 변화를 보였다. 또한 전기비저항 측정 결과와 비교할 때 두 방법 모두 전체적으로 유사한 거동을 보였다. Charpy V-notch 충격시험으로부터 구한 파면양상 천이온도(FATT)와 비선형 파라미터 사이에는 비교적 좋은 상관관계가 성립하였으며, FATT와 파괴인성(KIC) 사이의 관계식에 근거하여 열화된 발전설비 재료의 파괴인성을 초음파 비선형 파라미터의 측정을 통하여 간접적으로 구할 수 있음을 보였다. In order to develop an ultrasonic evaluation method for properties degradation of high temperature materials, a number of Cr-Mo-V steel samples were heat-treated, and their damage mechanism was examined. Ultrasonic parameters such as velocity, attenuation, and more recently developed nonlinear acoustic parameter were measured. The nonlinear acoustic parameter was found to be most sensitive to material degradation mainly attributed to the precipitation of impurities in grain boundaries. When compared to the electrical resistivity results, the nonlinear parameters showed similar behavior. There existed a relatively good correlation between the nonlinear parameter and the fracture appearance transition temperature (FATT) obtained by Charpy V-notch impact test. Based on the relationship between the FATT and the fracture toughness (KIC), correlation between the nonlinear parameter and KIC was established.

국제스포츠 정보 시스템의 현황 분석

육조영,윤찬호,김범수,노덕선,이무연,배진희,이승훈 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

Information has become a strategic tool with progress of sports science and sports technology. Demand on sports information is spreading to leisure, recreation, sociology, science of nutrition, psychology, sports medicine, sports therapy, prophylactic medicine, alternative medicine, sports industry and sports nature etc. if on line data base can be manipulated freely then acceleration and quality improvement of the study in this field can be effected and it is possible to gain new insight for receiving latest information But next problem is cost for use. For this reason this author summarized quick and effective on lline search points as follows: 1. Data base should be chosen with clear purpose for its use. Conduct prior investigation on contents and fee system of data base. With the same data base fee system may be differed depending on distributor therefore it is necessary to try different distributors at first as much as possible. 2. Prior to starting on line search prepare search method. If on line is started and then search method is checked than quickly telephone charge will go up. Search method should be prepared in advance by thinking sufficiently of what theme is to be searched. 3. Look for good advisor: lf there is no advisor nearby then the best thing is counselling with the person in charge for the distributor. If the result of search is stored at floppy disk by "downloading" then even after communication line is cut off it will be possible to print out anytime. 4. In this study the author explained about on-line search of lterature data line but recently it is possible to search overseas sports news or information on rate of victory or defeat of prfessional footbali etc. in real time. In Japan it is possible to search feature articles of Nihon Kesai or Asahi (except culture and sports column) by on-line. However in our country there are not many data bases in the field of sports and physical education which can be on-line searched. Our country belongs to up per level in the world in terms of study of sports science and technology and we are attracting attention from countries in Asia and from different parts of the world and the task facing us now is developing independent and unique data base for our country.

국제 스포츠 정보 시스템의 동향 분석

육조영,임정일,윤찬호,이무연,노덕선,배진희,이승훈 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

As Follow suggested : The purpose of this study was to consider tendency of modern sports information. today Modernst information system had four areas such as collection, clearance, communication and application So, most literuture of America and Europe was collected, cleared, communicated and apilcated in international sports data base. If we utillited communication circuit properly, we could use sports information beneficently at the laboratory and office. In the future and now, one was that special sports institution needed to obtain Education about sports imformation such as information of specialization, and information of knowledge on both soft phase and hard phase of new media. Although korea used date base of foriegn country efficiently, korea had to make effort to create its own information system and wish to avoid friction of economy and fiction of information.

사후분해 시체에 대한 법의학적 접근

최영식,이상용,김유훈,조갑래,이봉우,양경무,정낙은,서중석,이한영,이원태,강현욱 大韓法醫學會 2000 대한법의학회지 Vol.24 No.2

Disposal of a homicide victim by dismemberment is rare, but individual cases are on record in most major medicolegal departments. Recognition of postmortem mutilation may be of importance in the interpretation of certain murders committed by sexual perverts and other mentally deranged individuals and sometimes performed for the sole reason of easier disposal of the body. Postmortem dismemberment is usually readily recognizable as such; The edges of the injuries are dry and lack evidence of bleeding. The joints may be disarticulated without fracture, or the use of an axe or saw may be evident from examination of bones. Parallel horizontal or oblique furrows in the bone surface are caused by skipping of the saw prior to establishing depth. Such patterns on the bone may assist in identifying the particular saw involved. So we report 25 dismembered corpses that autopsied in National Institute of Scientific Investigation. This paper can help in attempting to establish not only the first criminal investigation steps but also the medicolegal approach methods in unidentified and dismembered deaths.

A7003 합금의 환경친화적 압출공정을 위한 Mg조성 및 공정비교 연구

조훈,조형호,한명근,김영직 한국전과정평가학회 2002 한국전과정평가학회지 Vol.4 No.1

최근 수송기계 경량화 추세에 부응하여 door impact beam, seat side rail 및 hood support와 같은 자동차 부품등에 Al-Mg-Zn계 중경질 A7003 합금소재의 적용이 검토되고 있는 실정이다. 그러나 이들 합금소재의 적용을 위해서는 제품의 용도와 특성을 만족함과 동시에 압출성이 높은 합금소재의 개발이 선행되어야 한다. 본 연구에서는 A7003 합금소재의 압출성을 향상시키기 위하여 합금원소 첨가량이 미세조직, 압출성 및 기계적 특성에 미치는 영향을 조사하였다. Mg조성 제어에 의해 기계적 강도의 저하없이 A7003 합금의 압출성을 향상시킬 수 있었다. 또한 MLCA 기법을 적용하여 A7003 합금중의 Mg 첨가량 및 빌렛가열공정 변화에 따른 에너지 소비량 및 환경오염부하물질 배출량을 산정하였다. A7003 합금중 Mg의 첨가량을 제어하여도 압출재 생산에 소요되는 에너지의 소비량은 거의 같음을 확인하였으며 CO₂와 같은 대기오염물질을 저감시키기 위해서는 유도가열에 의한 빌렛가열공정의 적용이 가장 효과적임을 알 수 있었다. A7003 alloy has characteristics of their excellent weldability, high corrosion resistance and superior plastic working however the broadening of application for the alloy has been hampered by the lower extrudability associated by Mg content. For improvement of extrudability and enhanced recovery efficiency during Al scrap recycling, it has been generally practiced to reduce Mg content in A7003 alloy. Therefore, it is necessary to investigate the influence of Mg content on mechanical strength and extrudability of A7003 alloy. For efficient material processing which has small amounts, material life cycle assessment(MLCA) is evaluated. The quantitative analysis of energy requirements and CO₂ emission for production of A7003 extruded bar are estimated with different Mg content and billet pre-heating process (heating source by light oil or LPG). In particular, the estimation of energy requirements was performed within shipping and gating range (except the mining and extraction stages) to investigate the influence of the variables on energy requirements and CO₂ emission in detail. As Mg content increased, the flow stress and the extrusion pressure for A7003 alloy increased. It has been thought that an increment in extrusion pressure with increasing Mg content is caused by the solid solution hardening of Mg atoms in the matrix and increment in volume fraction of intermetallic compound, Mg2Si. The extrudability and the tensile strength are equal to, or above that of conventional A7003 alloy even the content of Mg varied from 1.1wt.% to 0.5wt.%.alloy. This means that minimizing the content of Mg in A7003 alloy can enhance recovery efficiency during Al scrap recycling. It can be quoted that rather than Mg content energy source for billet heating is a prime factor to determine the atmospheric CO₂ emission.