정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

수종의 구강 함수제가 치은 섬유아세포에 미치는 영향

서조영,박준봉 慶北大學校 齒科大學 1990 慶北齒大論文集 Vol.7 No.1

세균성 치태의 축적을 경감시키는 목적으로 구강함수제로 사용되는 0.1%와 1% Chlorhexidine, Cetylpyridinium Chloride과 Listerine이 치은 섬유아세포에 미치는 영향을 규명하여 이들 약제들의 생물학적 평가를 도모하고자 시험관적 실험을 실시하였다. 위 약제성분들이 함유된 구강함수제를 구입하여 소독후 100배 희석액을 만들었다. 치은 조직으로부터 분리 배양한 섬유아세포를 60mm 배양접시에 넣어 24시간 전 배양후 상충액을 제거한 다음 준비된 배양액을 재 주입히킨후 24, 48, 72시간동안 37℃ 100 습도 5% Co^2공기 혼합 배양기에서 배양하였다. 배양접시 기저부에 부착된 세포를 trypsin으로 분리하여 그 수를 측정하여 다음과 같은 결과를 얻었다. 시간이 경과함에 따라 세포수의 변화는 Listerine에서는 약간의 감소를 보였으며, 0.1% CHX, CPC, 1% CHX에서는 현저히 감소하였다. 치은 섬유아세포에 대한 독성은 Listerine, 0.1% CHX, CPC, 1% CHX 순으로 강하게 나타났다. 순수 배양액만으로 배양한 경우 24시간까지는 세포가 증식하지 않았으며, 72시간까지는 약2배의 세포 증식을 보였다. The purpose of this study was to evaluate the effect of the four gargling solutions-Listerine, Cetylpyridium chloride(CPC), 0.1% % 1% Chlorhexidine(CHX)-on the human gingival fibroblasts in vitro. The 3×10 exp (5) cells of human gingival fibrobalsts were seeded in each 60mm Petri dish with Dulbecco's Modified Eagle's Medium containing 100u/ml penicillin, 100㎍. ml streptomycin, 1㎍/ml amphotericin-B and 10% fetal bovine serum and incubated for 24 hours. After discard of the supernatant of old medium, those cells cultured with fresh prepared medium at 37℃ 5% Co2/air incubator. The number of cells in the each dish were counted on the hemocytometer after 24, 48, 72 hours incubation. The results were as follows; 1. In the course of time, Listerine was the weak decrease of cell counts and 0.1% CHX, CPC & 1%CHX were the most significant decrease of cell counts in comparision to control cultures. 2. To the cytotoxic effect on the human gingival fibroblast, Listerine, 0.1%CHX, CPC, 1%CHX in order showed more cytotoxic. 3. In the case of culture medium only used, the number of cells were increased two times at 72 hours after seeding. J. Kyungpook Univ. Sch. Dent. Vol. 7, No. 1, 1∼8, 1990.

2000學年度 新入生 實態調査

서영대,박주신,원준대 인하대학교 학생생활연구소 2001 學生生活硏究 Vol.21 No.-

北韓政治體制分析을 위한 接近 모델에 關한 考察 : 세가지 模型을 中心으로 its Validity and Availability

徐陽重,宋永俊 慶尙大學校 1981 論文集 Vol.20 No.2

The purpose of this article is to study various approaches for analyzing the political systems in the western countries. Their validity and availability are particularly considered in this article. There is not any integrated models to fully explain communist systems. The existed models can only explain the specific facet of the communist system. Several problems are arisen from applying these proposed models to the various communist systems. The totalitarian model overlooks the system changes. The formulation of the development and the modernization models can not be validated practically. The approaches to analyse the advanced communist systems such as the Soviet Union can not apply to the North Korea. Each country has her own historical practices, and has different ways of establishing a communist society, and thereby of taking communist government. In the case of North Korea, the organized ideology with the pseudo charismatic authority and the systematic terrorism are still predominant. From the analyzed result of these models, it is concluded that the nature of the political system in North Korea should be investigated by introducing the sequential analysis based on the comparison with comparison with synchronic and diachronic approaches.

APEC 회원국의 경제통합에 따른 한국의 무역효과 분석

서청석,장영준 慶熙大學校 1997 論文集 Vol.26 No.-

The purpose of this paper is to analyze the APEC establishment effects on Korea's trade. This paper hypothesizes the two cases of Korea's economic status as an industrialized nation and as a developing nation, and establishes the six scenarios for the two cases by the year 2000, 2010, and 2020. Based on these scenarios, the trade changes between Korea and APEC member nations were estimated. The results can be summarized as follows. First, if Korea is classified as a developing nation in 2000, the first year of APEC trade liberalization, it shows that the trade between Korea and APEC member nations yields the trade surplus and export and import increase Second, if Korea is classified as a developing nation in 2010, the first stage of establishment of APEC trade liberalization, Korea will experience the surplus of trade balance and export-import will increase more. Third, in the year 2020, when economic integration between industrialized nations and developing nations is achieved, the scenario shows the rapid increase in Korea's export and import caused by the integration and equilibrium of trade balance. Based on the results of above analysis, we can forecast that the participation to APEC economic integration will be advantageous to Korea. It will be more desirable for Korea to participate the APEC economic integration as a developing nation in order to maximize positive effects. In reality, Korea should head toward the participation to APEC economic integration after evaluating advantages and disadvantages because the perspective that Korea should be classified into industrialized nations is increasing in international economic environment. Second, as a result of the analysis on the APEC economic integration effects, Korea's trade balance against industrialized nations is aggravated whereas its trade balance against developing nations is improved. It represents that the current situation of Korea's international competitiveness is in between industrial nations and developing nations. Korea should, therefore, prepare for enhancing international competitiveness on the government level as well as local firm level against APEC economic integration. Third, it is expected that APEC economic integration would be beneficial to industrialized nations but unfavorable to developing nations who might complain about the disadvantage, and would try to compensate it by requesting the complementary measures. Accordingly, Korea should play a crucial role as a bridge which will alleviate dispute between Korea and APEC member countries.

1999學年度 新入生 實態調査

서영대,박주신,원준재 인하대학교 학생생활연구소 2000 學生生活硏究 Vol.20 No.-

皮膚科 外來 癩患者의 動態

宋浚榮,朴義守,徐舜鳳,徐基錫,河龍馬,孫在卿,金基洪,金蘭姬 大韓癩學會 1981 癩學 會誌 Vol.14 No.1

치은 섬유아세포에 미치는 치주포대 추출물의 영향

이덕혜,서조영,박준봉 慶北大學校 齒科大學 1990 慶北齒大論文集 Vol.7 No.1

The purpose of this study was to evaluate the effect of soluble extracts form four peridontal dressings, two of which were eugenol and the others were non-eugenol, upon human gingival fibroblasts in vitro. Each of mixed dressing which added to medium was incubated in the 35mm petri dish for 24hrs. After discard of the supernatant of old medium, those cells were cultured with fresh prepared medium in the 5% CO2 incubator at the state of 37℃, for 24, 48, & 72 hours. Author counted the number of cells by hemocytometer at each designed time and observed the change of morphology of cells stained with Hematoxylin-Eosin on the inverted phase contrast microscope The results were as follows. 1. In the course of time, K.P pack was the most significant decrease of cell counts in comparison to control cultures with Wondrpak, Coe-pak Cellopack following in that order at original extracts and there were somewhat decrease at 1/10 & 1/100 diluted solutions in all samples. 2. Throughout the present study, the eugenol containing periodontal dressings, K.P pack & Wondrpak, showed more cytotoxic effects on fibroblasts than non-eugenol dressings, Cellopack & Coe-pak. 3. In microscopic apearance of four dressings, the degenerative changes with pyknotic nuclei, lysis of cytoplasm and marked vacuolizaion were evident at orignal extracts. 4. At 1/10 & 1/100 diluted solutions, there was nothing remarkable morphological change in all kinds of periodontal dressings as time goes by. J. Kyungpook Univ. Sch. Dent. Vol. 7, No. 1, 9∼21, 1990

당뇨병환자에서 뇨증 Fibronectin농도의 증가에 관한 연구

한승범,조준승,손건영,서성문,박근용,조성래,박규영,박정모,이인규,여준기 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Plasma fibronectin is an α₂-glyoprotein, which is produced by vascular endothelial cells. Raised level of plasma fibronectin has been observed in diabetic patients particularly in the presence of microvascular complications. However, no available data exist about urine level of this glycoprotein in diabetic patients. We measured urine fibronectin level by ELISA methods in 54 diabetic patients who have microvascular comlications or not. The following results were obtained. 1) Urine fibronectin level(㎍/g creatinine) in diabetic group(1740.0±678.0) is increased compaired with those in normal control group(471.0±59.0). but this results were not significantly different among two groups(P>0.05). 2) Urine fibronectin level(㎍/g creatinine) was significantly increased in patients with nephropathy (6188.0±3144.0) compared with those in normal control group(471.0±59.0) and patients without nephropathy(645.0±251.0)(P<0.001). 3) There were a significant correlation between BUN, creatinine, creatinine clearance, 24hr urine total protein and urine fibronectin level in diabetic patients. Our data suggest that urine fibronectin excretion level might be used as a sensitive guide for diabectic nephropathy.

합병증이 동반된 Meckel씨 게실 2례 보고

정병욱,박동일,이준희,서정욱,원유홍,김웅,신현종,권영무 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

합병증이 동반된 Meckel씨 게실을 가진 환자의 치료에 대한 필요성은 과정이 문제이다. 하지만 우연히 만나는 게실의 처치는 논란 중이다. 부수적인 게실 절제술(incidental diverticulectomy)의 제안자는 증상이 있는 게실의 외과적 처치는 중요한 이환 및 사망률은 지적한다. 이를 반대하는 사람들은 전 생애를 통해 합병증의 위험성이 낮게 나타나므로 필요가 없다고한다. 게실의 예방적 제거는 개복술시 우연히 발견 될 때 시행한다. 이는 남아있는 게실이 나중에 합병증을 일으키는 것보다 술후 합병증의 위험성이 매우 적음을 알 수 있다. 저자들은 합병증이 동반된 Meckel씨 게실 2예를 경험하였기에 문헌 고찰과 더불어 보고하는 바이다. The necessity for therapy with complicated Meckel's diverticular is a matter of course.However, management of the incidentally encountered diverticulum is controversial. Proponents of incidental diverticulectomy point to the significant morbidity and mortality rates of surgical treatment of symptomatic divenicular. Other authors base their opposition to incidental diveniculectomy on the low risk of complications developing during lifetime. Prophyillctic removal of the diveniculum is indicated when it is found incidentally at laparotomy, because there are few postoperative complications and the risk exists that the remaining diverticulum may be the cause of later complication. The 2 cases of complicated Meckel's diverticulum are reported with a brief review of literature.