Poster Session : PS 0831 ; Upper GI Tract : Clinical Factors to Predict Angiographically Detectable Non-Variceal Upper Gastrointestinal Bleeding in Patients Refractory to Endoscopic Treatment

( Tae Hwan Ha ),( Tae Hoon Oh ),( Sung In Yu ),( Min Kim ),( Jong Wook Kim ),( Won Ki Bae ),( Jae Hyung Kim ),( Seung Suk Baek ),( Mi Jin Ryu ),( Ye Na Choi ),( Ji Young Park ),( Eileen L Yoon ),( Tae 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Non-variceal upper GI bleeding (NVUGIB) is a common medical problem that has signifi cant association with morbidity and mortality. Angiographic detection and subsequent transarterial embolization (TAE) is a primary treatment option when medical and endoscopic treatments fail. We investigated clinical factors that could affect the success of the angiographic detection and prognosis after TAE in patients with NVUGIB refractory to endoscopic therapy. Methods: A retrospective analysis of the clinical data was done in patients with failed endoscopic treatment who underwent angiography for the treatment of acute NVUGIB between May 2002 and May 2013. Patients were divided into detection or non-detection groups according to the presence of bleeding stigmata in angiographic fi nding. Rebleeding defi ned as subsequent bleeding event within 7 days and mortality within 30days were analyzed as outcome parameters after TAE following detection in angiography. Results: A total 45 patients 37 (male, mean age, 65.9±14.9 years) were analyzed and classifi ed as a detection group (n=25, 55.5%) and non-detection group (n=20, 44.6%). Peptic ulcers were the most common cause of refractory NVUGIB. Larger transfusion amount (5.7±3.9 unit vs. 3.5±2.8 unit; P=0.03), prolonged aPTT level (34.2±17.3 sec vs. 21.8±13.8 sec; P=0.01) and short time interval between last endoscopy and angiography (17.5±25.9 hours vs. 34.3±59.5 hours; P=0.04) were found to be signifi cant factors for predicting angiographic detection. TAE was performed in all patients detected in angiography. Rebleeding (44%) was significantly associated with higher Rockall score (8.3±1.5 vs. 6.6±2.4; P=0.046) and mortality (12%) was signifi cantly associated with higher Rockall score (9.3±0.6 vs. 7.1±2.2; P=0.002) and higher level of BUN (55.3±47.4 vs. 27.6±17.4; P=0.01). Conclusions: Clinical characteristics associated with angiographic detection in patients with NVUGIB refractory to endoscopic therapy were severe bleeding, bleeding tendency and early angiographic intervention. The Rockall score is useful parameter for predicting rebleeding and mortality after TAE.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

인터넷 포르노그라피 연구 : 그 내용과 사회적 담론 It's Contents and Social Discourses

윤태진 연세대학교 언론연구소 2000 언론 사회 문화 Vol.- No.8

관개수심에 따른 벼의 생육 및 수량

윤성탁,전태웅,이동진 한국국제농업개발학회 2002 韓國國際農業開發學會誌 Vol.14 No.1

논토양에 있어서 관개수심에 따른 온도분포를 파악하고, 벼 재배에서 관개수심을 달리했을 때 수온과 지온의 온도환경변화와 이에 따른 수도의 생육 및 수량반응을 구명코자 실시한 시험결과는 다음과 같다. 우리나라 수원지방에서 수도재배기간 중 평균기온범위는 23.4∼29.1℃의 분포를 보였으며, 평균기온은 25.3℃이었다. 평균수온은 21.4∼26.7℃의 범위를, 지온은 21.7∼25.7℃의 범위를 보였으며, 수온 및 지온은 평균기온의 상승ㆍ하강에 따라 상승ㆍ하강하였다. 관개수심에 다른 생육특성을 보면 초장, 엽면적, 건물중 등은 처리간 차이가 없었다. 그러나 유수형성기는 12cm관개구에서 이앙 후 87일, 4cm구에서 83.3일이 각각 소요되어 관개수심이 깊을수록 유수형성기는 늦어지는 경향이었다. 수량 및 관련형질은 ㎡당 수수는 4cm관개구에서 413.3개/㎡로 가장 많았으나, 수당립수 및 ㎡당 입수는 오히려 8cm관개구가 각각 99.0개. 38,808개/㎡로 가장 많았으나, 관개수심별 정조수량은 대차 없었다. This experiments were carried out to evaluate the characteristics of temperature and the response of growth and yield characteristics under different irrigation depth in paddy rice field. Range of mean air temperature showed from 23.4℃ to 29.1℃ and mean of these air temperature was 25.3℃, while range of water temperature was from 21.4℃ to 26.7℃ and mean water temperature was 24.7℃. Range of soil temperature also was shown from 21.7℃ to 25.7℃ and mean temperature was 24.4℃ during growing periods of rice in Suwon. Plant height, leaf area index and dry matter were not shown difference among different irrigation depth, but date of panicle formation between irrigation depth showed difference such as that 12cm irrigation depth required 87.0 days while 4cm irrigation depth 83.3 days from transplanting showing that the deeper the irrigation depth, the later the panicle formation delayed. Number of panicles per ㎡ was shown highest in 4cm irrigation depth with 413.3/㎡, but 8cm irrigation depth showed higher number of grain per panicle and number of grain per ㎡ with 99.0, 2560.0/㎡ respectively. Unhulled rice yield among different irrigation depth showed no difference statistically.

한국어 단음 인식을 위한 자기구조화 신경망의 확장

진광식,윤태성 國立 昌原大學校 産業技術硏究所 1995 産技硏論文集 Vol.9 No.-

In this study, speech recognition experiments for 10 Korean digits(from 0 to 9) are performed using nelcepstrum and SOFM(Self-Organized Feature Map). Especially, the feature map for each digit was composed of 4 parts. 3 parts are for the initial, medial and final phonemes, and 1 part is for the whole phone. We did not do the exact segmentation for each phoneme extraction. But, with the proposed feature map, the patterns for 10 digits are classified well. In the recognition experiment, 10(digits)3??(speakers)??10(utterances)=300 data were tested and 150 data of them are used as training data. In case of training data, the recognition rate is 98.6% and for other test data, 92.6%. These results are much better than those of the conventional SOFM(training data:82.29%, other test data:85.95%).

通話量 管理시스템의 電算化에 관한 硏究

윤형로,박규태,김진호 연세대학교 산업기술연구소 1981 논문집 Vol.13 No.2

In the telecommunication network traffic information is used for improving present utilization by means of efficient operation of switching facilities and for designing economical telephone network by means of forecasting the future trends. Various kinds of software developed and added to the AUTRAX System, which is designed for automatic measurement, to accomplish a complete traffic information systems. For the use of traffic information to design the future telephone network, some mathematical models, which are derived for calculation of point to point traffic estimation and forecasting of future traffic distribution, were studied. Some computer programs for several models were developed and implemented.

Simulated Moving Bed를 이용한 Bupivacaine 키랄분리 : (1) Preparative Chromatography를 이용한 기본조건 결정 (1) Optical Separation Conditions for Preparative Chromatography

윤지연,이중기,서성섭,최민호,박태진 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.6

Racemate Bupivacaine의 키랄분리를 위한 크로마토그래피의 최적분리조건을 조사하였다. Kromasii^(�) 키랄고정상에서 최적이동상조성 성분은 n-hexane/2-propanol/acetic acid/triethylamine, 99/1/0.3/0.05(vol.%)이였다. 이동상 조성성분인 2-propanol의 부피비가 증가할수록 체류시간과 분리도가 동시에 감소되었다. 이동상 성분 중에서 미량으로 존재하는 triethylamine이 증가할수록 피크의 sharpness가 증가하고 체류시간 역시 감소하였다. 또한, acetic acid가 없으면, 크로마토그래피 광학분할이 불가능하였으며 부피 0.3%에서 분리도가 가장 높음을 확인할 수 있었다. 한편, 키랄의약품의 대량분리방법중의 하나인 SMB(simulated moving bed)크로마토그래피 시스템(직경 1.0cm×10cm×8개 칼럼으로 구성)의 최적분리조건을 전산모사에 의해 구하였으며, 이를 실험으로 확인하였다. 그 결과 switching time 15분, feed의 유량 0.1 ml/min, desorbent 0.86 ml/min, raffinate 0.3 ml/min, extract 0.66 ml/min, recycle 1.0 ml/min일 때 100% 순도의 R-form과 S-form을 얻을 수 있었으며, 실험치와 전산모사치간의 오차는 ??2%이내였다. The chiral separation of racemate Bupivacaine was carried out to find the optimum condition for chromatographic system. The optimum species and composition for mobile phase were n-hexane/2-propanol/acetic acid/triethylamine, 99/1/0.3/0.05(vol.%) in case Kromasil� chiral stationary phase was employed. The retention time and resolution decreased with the increase in the ratio of 2-propanol in the mobile phase. The sharpness of peak and retention time decreased, as the content of triethylamine increased. Without the existence of acetic acid, the chromatographic separation didn't occur, and the resolution was the highest at the acetic acid volume ratio of 0.3%. The optimum condition of SMB (simulated moving bed) was determined by simulation and its results was compared with exprimental data from lab-scale SMB (10 mm 1D×8 ea). Rased on the SMB simulation and experimental results, 100% purity of R and S Bupivacaine were obtained and the error between the calculated and experimental value was within ±2%.

BLDC 모터의 속도 제어를 위한 퍼지 가변 구조제어에 관한 연구

진광식,윤태성,박종락 國立 昌原大學校 産業技術硏究所 1998 産技硏論文集 Vol.12 No.-

This paper shows the efficiency of fuzzy integral variable structure controller(FIVSC) with sliding mode which outperforms a traditional variable structure controller(VSC). This approach of the FIVSC solves the chattering problem which has been occurred in VSC and is applied to brushless D.C. motor. The simulation results verify the efficiency of the FIVSC.

장기간의 트레이닝이 체격 및 체력에 미치는 영향

윤규태,이승준,이승준 순천향대학교 기초과학연구소 2000 순천향자연과학연구 논문집 Vol.6 No.1

The purpose of this study is to investigate how a long-term training affect a physique and a physical strength on two groups of being trained and untrained. There are 11 items divided under as a factor of the physique and 12 items as a factor of the physical strength to be measured and compared the relationship between two factors. The results of this study are as follows: 1.The most significant differences statistically among factors of the physique in this study appears in chest, lower limb length and upper arm girth. 2.In case of the physical strength, there are significant differences in vertical jump, side step, sit-up, chinning bar, toe touching and mobility tests Like above the results showing, it causes that trainees have been more grown up than untrainees in the development of Staying power, muscular power and promptitude. In addition, there are a lot of benefit to keep the continuant exercises for the development of the body and the physical strength