당뇨병환자에서 뇨증 Fibronectin농도의 증가에 관한 연구

한승범,조준승,손건영,서성문,박근용,조성래,박규영,박정모,이인규,여준기 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Plasma fibronectin is an α₂-glyoprotein, which is produced by vascular endothelial cells. Raised level of plasma fibronectin has been observed in diabetic patients particularly in the presence of microvascular complications. However, no available data exist about urine level of this glycoprotein in diabetic patients. We measured urine fibronectin level by ELISA methods in 54 diabetic patients who have microvascular comlications or not. The following results were obtained. 1) Urine fibronectin level(㎍/g creatinine) in diabetic group(1740.0±678.0) is increased compaired with those in normal control group(471.0±59.0). but this results were not significantly different among two groups(P>0.05). 2) Urine fibronectin level(㎍/g creatinine) was significantly increased in patients with nephropathy (6188.0±3144.0) compared with those in normal control group(471.0±59.0) and patients without nephropathy(645.0±251.0)(P<0.001). 3) There were a significant correlation between BUN, creatinine, creatinine clearance, 24hr urine total protein and urine fibronectin level in diabetic patients. Our data suggest that urine fibronectin excretion level might be used as a sensitive guide for diabectic nephropathy.

태안해안국립공원 지역특화자원을 활용한 탐방프로그램 개발 연구

배준호(Joon-ho Bae),남승민(Seung-min Nam),허학영(Hak-young Heo),송창룡(Chang-ryong Song),박현숙(Hyun-suk Park) 국립공원연구원 2021 국립공원연구지 Vol.12 No.1

본 연구를 위해 먼저 국내·외 해상·해안국립공원의 운영프로그램 현황에 대한 조사를 시행하였으며, 조사된 일부 사례의 경우 기후 및 지형적 요인, 그에 따른 생태환경의 차이, 그리고 관련 법령 차이 등의 이유로 즉시 국립공원에 도입하기 보다는 중·장기적 운영계획과 인프라의 확충, 전문성 확보 등 체계적인 준비가 필요한 것으로 나타났다. 보다 적합한 탐방프로그램의 개발을 위해 사업대상지 현장방문을 실시하였으며, 기존 운영프로그램 현황, 각종 시설, 인력현황 파악, 주변 환경 분석, 담당자 인터뷰 등을 통해 맞춤형 탐방프로그램을 구성하였다. 태안해안국립공원의 경우, 연구원 협업 철새 가락지 부착체험, 태안 해변길 - 솔모랫길 탐방, 태안해변 드론 탐방, 마음의 의자, 연날리기, 새와 예술 그리고 … 등의 체험형 프로그램과 한서대학교와 함께하는 해양 안전 교육 프로그램, 유류 오염 교육 프로그램 등의 교육형 프로그램 등 모두 8가지 해양국립공원 운영프로그램이 도출되었다. 제안된 탐방프로그램을 운영하기 위해서는 별도의 장소 및 운영시설의 확충, 예산편성, 운영을 위한 타당성 검토 등이 우선되어야 할 것이다. 특히 탐방프로그램을 효율적으로 운영하기 위해서는 프로그램 지도자의 역량개발이 필요하며, 현재 운영되고 있는 프로그램을 보완하고 새로운 프로그램을 시행하기 위한 추가적 논의가 필요할 것으로 사료된다. For this study, we first examined the currently operating programs of domestic and overseas maritime and costal national parks. It was found that some of the programs require systematic preparations such as mid- and long-term operation plans, infrastructure expansion, and maintenance of professionalism rather than immediately introducing them into national parks due to the differences in climatic and geographic factors, ecological environment, and relevant regulations. To develop more suitable programs, on-site visits were made and the customized programs were suggested by closely examining the status quo and interviewing people in charge of running the currently offered programs. For Taean Coastal National Park, eight programs were recommended as feasible ones, including the experiential programs such as Bird Ringing, Taean Beach Trail - Sol Sand Trail Walking, Travel Taean Beach with Drone, Thinking Chair, Kite Flying, and Culture & Arts Program (Birds, Arts, and …), and the educational programs such as Marine Safety Training and Oil Pollution Awareness Program. For the suggested programs to be realized, the expansion of separate places and operating facilities for each program, budgeting, and feasibility study should be preceded. To operate the programs effectively and efficiently, in particular, it is necessary to develop the competency of program leaders, and additional discussion for supplement the currently operated programs and implement new programs.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

유통경로에 있어서 공정성과 상호관계의 질에 관한 고찰

박준승 경복대학 2000 京福論叢 Vol.4 No.-

본 연구에서는 유통경로에 있어서 상호관계의 질이 장기적인 협력관계를 증진시키는 데 중요한 역할을 한다는 관점에 기초하여, 이전의 연구들의 한계점을 극복할 수 있는 이론적 토대를 제시하기 위해, 상호관계의 질과 공정성 사이의 포괄적인 관계뿐만 아니라, 상호관계의 하위구성개념들(예, 신뢰-신용성과 우호성, 결속-단기와 장기, 만족, 갈등)과 공정성의 하위구성개념들(예, 절차 및 분배 공정성) 사이의 개별적 관계에 초점을 맞추어 그 영향의 방향과 정도에 대한 이론적 토대를 제시하였다. On the basis of the concept that the relationship quality in marketing channel plays an important role in improving long-term cooperative relationship, this study have tried to provided theoretical basis to overcome the limitation of the previous research. That is, this study focused on the comprehensive relationship between relationship quality and fairness as well as the individual relationship between subconstructs of relationship quality(e.g., trust<credibility and benevolence>, commitment<short-term and long-term>, satisfaction, and conflict) and subconstructs of fairness (e.g., distributive fairness and procedural fairness). As well as this study provided theoretical basis of the direction and degree.

완전뇌허혈후 재관류시에 국소뇌혈류, 체성감각유발전위 및 신경학적 회복에 대한 Mannitol과 Thiopental의 효과

박춘근,이상원,박영섭,최승진,허필우,정동섭,강준기,최창락 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.2

The cardiopulmonary bypass or cerebral circulation arrest is often used in the treatment of complex aneurysm or of arteriovenous malformation to decrease the risk of intraoperative aneurysm rupture. Although experimental studies have suggested that some drugs may protect the brain from ischemic injury, there are limitations in maintaining cerebral perfusion arrest without incurring neurologic deficits due to the initiation of detrimental processes including excitotoxic neuronal injury, activation of phospholipases, influx of calcium, and generation of damaging free radicals. The purpose of this study is to determine wheter mannitol or thiopental has any favorable effects on the recovery of neurologic deficits and on the regional cerebral blood flow(rCBF), somatosensory evoked potential(SEP) and electroencephalogram(EEG) in cats which underwent 15 minutes-complete global ishcemia-reperfusion. The complete global ischemia was produced in 38 cats by temporary intrathoracic occlusion of the innominate artery and the subclavian artery following ligation of bilateral mammary arteries and simultaneous induction of hypotension. The cats were allocated randomly to one of 4 treatment groups : (1) control group, 8 cats received equal volume of saline solution : (2) thiopental group, 10 cats received 45㎎/㎏ thiopental intravenously, (3) mannitol group, 10 cats received 2g/㎏ mannitol intravenously, (4) combined mannitol and thiopental group, 10 cats received equal dose of mannitol and thiopental intravenously. The drugs were administrated in a equally divided dosage before and after the ischemic episode. The results were as follos : 1) Eight animals which received saline showed the severe postischemic hypoperfusion and poor recovery of SEP and EEG, and 6 of them died within 6 hours after the ischemia. 2) Ten thiopental-treated animals also showed the severe postischemic hypoperfusion and poor recovery of SEP and EEG, and 6 of them died within 6 hours the ischemia. 3) Both mannitol-and combined treated groups showed early recovery of EEG, good recovery of SEP and EEG without the severe postischemic hypoperfusion, and 7 of 10 mannitol-treated animals and 8 of 10 combined treated animals were significantly recovered in all parameters. There were not significant differences in all parameters between the mannitol-and combined treated groups. 4) Thirty-four of 38 animals involved in this 15 minutes-ischemia resulted in the severe neurologic deficits inspite of treatment with mannitol, thiopental or both of them. These results suggest that, in cats, mannitol treatment is effective but not thiopental in preventing severe neurologic injury following complete global ischemia and the duration of complete ischemia should be far less than 15 minutes.

檀君神話 硏究

朴勝俊 배화여자대학 1984 培花論叢 Vol.3 No.-

The Dangun myth consists of three motives: Hwanung's descent from the heaven, the transformation of the bear, the hierosgamos of Ungnyeo and Hwanung. There can be found the structure of death and rebirth in each motive. The second motive, again, can be analyses into four mythemes. First, the coexistence of a tiger and a bear in the same cave is the symbol of uroboros, a primodial chaos before the creation of the world. Second, the desire of a bear to become a man means a self-consciousness as a bestial entity, and desire of renewal and rebirth. Third, dietary taboo and the prohibition of light is the painful process for self-realization and is corresponding to the dragon fight found in hero myth. Fourth, the transformation of the bear into a woman, abandoning her bestiality, represents the motive of death and rebirth. The transformation is the process of initiation toward the center, Sindansu as the World Tree. This study can be summarized into the following four items. (1) Dangun-myth contains the archetype of human collective unconsciousness for self-realization. (2) It expresses the ancient Korean viewpoint of man to become a full-fledged man from the state of ignorance through pains. (3) It is a symbolic myth of creation which illustrates the cosmogony from chaos. (4) It demonstrates the creation not by God's wil but by a positive self-will.

박목월 시에 나타난 기독교적 시의식

박승준 배화여자대학 1999 培花論叢 Vol.18 No.-

This study aims at examining the major aspects of christianity in Park Mokwol's Poetry including the characteristics. Mokwol's poetic element of, Christianity first appears in his work orchid and others. Deeply rooted in the diverse aspccts of Christianity in this work is his simple religious wish to lead a natural life of selflessness. It was also one of his living strategics to effectively cope with the heartless world of reality and the worldly greed to accumulate riches. In his work Clearness and Cloud we also find some important aspects of Christianity, particularly when we notice that he matures into a Christian gladly accepting the pains of life in this world patiently as well as with an attitude of willing obedience to the law of nature. In his work Kyungsangdo Fallen Leaves, which was written in his sixties, we notice that his life is colored with a sense of futility and loneliness. He then pursues a life of eternity through God and His help,and in due course his religio us sentiments turn to a transcendental will. A totality of Mokwol's devout religiosity is most clearly revealed in his work A Big and Soft Hand. Mokwol is surely a creative poet of a new mental world. In this work, howe ver, he realizes the futility of the poet's attempt to interpret and praise the world with the limits of human perspectives. He then gets to overcome the worldly self who could never be free from the fundamental limitations of mortality (such as death, old age, etc.), and he is born again as a man of faith who has the ability to see through man and the world, and eventually he finds a way of his own salvation.

총단관결찰로 인한 血淸蛋白分劃像의 變化

朴東烈,曺準承 慶北大學校 醫科大學 1980 慶北醫大誌 Vol.21 No.1

총단관결찰후에 血淸蛋白分劃像이 어떻게 變動하는가를 보기 위하여 一定한 其間 같은 條件下에서 동육한 쥐를 使用해서 手術前 正常 血淸과 단관결찰 24, 48 및 72時間째의 血淸을 分離하여 cellulose acetate膜을 利用한 電氣泳勳을 實施해 서 그蛋白分劃像을 調査해 보았다. 正常 쥐血淸의 總蛋白濃度는 7.12 g/dl, albumin 3.11 g/dl (43.6%), α_1-globulin 0.15g/dl(2.1%), α_2-globulin 0.79 g/dl(11.1%), β-globulin 1.71g/dl(24.1%), γ-globulin 1.36 g/dl(19.1%)이었으며 이의 A/G 比는 0.77이었다. 쥐 血淸의 蛋白分劃은 사람血淸의 그것과 比較해서 A/G 比와 albumin및 α_1-globulin의 濃度가 낮고 β-globulin의 濃度는 높았다. 총단관을 結紮한 後의 血淸蛋白의 電氣泳動像은 變動을 나타내었다. 卽 단관결찰 72時間뒤에는 γ-globulin이 約半으로 減少되고 β-globulin은 增加 되었으며 其他의 蛋白分劃에는 別다른 變動이 없었다. Change in eletrophoretic patterns of serum protein after ligation of the common bile duct was investigated in albino rats weighing approximately 200g. Sham operated rats were used as control. Rats were sacrificed 24, 48 and 72 hours after the operation. Serum samples of each group were analyzed for determinations of total protein and its eletrophoretic patterns using a cellulose acetate membrane. In comparison with human, normal rat serum showed lower levels of albumin and alpha 1-globulin, lower A/G ratio and higher level of beta-globulin. The ligation of the common bile duct produced an alteration of electrophoretic patterns of serum protein. In 72 hours after the ligation, beta-globulin level increased apparently, but gamma-globulin level decreased to approximately half of the control.

특성 길이를 이용한 평직 복합재 볼트 체결부의 강도 예측

박승범,변준형,안국찬 한국안전학회 2003 한국안전학회지 Vol.18 No.4

A study on predicting the joint strength of mechanically fastened woven glass/epoxy composite has been performed. An experimental and numerical study were carried out to determine the characteristic length and joint strength of composite joint. The characteristic lengths for tension and compression were determined from the tensile and compressive test with a hole respectively. The characteristic lengths were evaluated by applying the point stress failure criterion to a specimen containing a hole at the center subjected to tensile loading and a specimen containing a half circular notch at the center subjected to compressive load. The joint strength was evaluated by the Tsai-Wu and Yamada-Sun failure criterion on the characteristic curve. The predicted results of the joint strength were compared with experimental results.

神門穴 鍼刺戟이 母性分離 스트레스로 야기된 攝食 障碍와 시상하부 neuropeptide Y 발현에 미치는 영향

박히준,류연희,홍미숙,김승태,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective : The purpose of this study is to find out the effect of acupuncture at HT7(Shinmun) on the feeding behavior and hypothalamic neuropeptide Y(NPY) expression in the maternally separated rat pups. Methods : To show the effect of acupuncture, we performed maternal separation(MS) for 7 days beginning on postnatal day 14, and observed body weight, food intake, and NPY immunoreactivity in the paraventricular nucleus(PVN) of hypothalamus after acupuncturing at HT7, the end of the transverse crease of the ulnar wrist of the forepaw. Results : MS induced a significant decreases in body weight and food intake, while acupuncture treatment at acupoint HT7 showed much more improvement in those evaluations. NPY-immunoreactivity in area PVN were decreased in the MS group, but significantly increased in the HT7 group. Conclusions : These findings suggest that acupuncture has an effect on the feeding disorders caused by MS, possibly by modulating NPY expression in the PVN.