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이유선,정진옥,박용규,박형서,노상필,정승현,김정희,이재환,최시완,성인환 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2
급성 심근염환자에서 발행한 완전 방실차단을 영구 심장박동 조율기로 치료한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Myocarditis, an inflammatory process involving the myocardal wall, may be caused by most infectious agents. Irrespective of its etiology, it presents commonly with evidence of heart failure, hypotension, and various electrocardiographic abnormalities. Patient with myocarditis may be asymptomatic or may have a rapidly progressive fatal disease. Medical management of patients with myocarditis includes specific therapy for underlying infection and control of the complication of myocarditis such as congestive heart failure and arrhythmia. Recently we had experienced myocarditis with complete atrioventricular block in 37-year-old man. Although he had shown complete recovery of heart failure, he had shown complete atrioventricular block, so we inserted permanent pacemaker. We report it with review of the literature.
서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)
김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2
Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.
박배근,染谷梓,류시윤,김현수,조성환,전무형,손화영 충남대학교 수의과대학 동물의과학연구소 2001 動物醫科學硏究誌 Vol.9 No.-
Ozone is very effective in acute and chronic viral disease as a virucidal agent and in improving the general health of the animals. The effects of ozonized water supply against Cryptosporidium baileyi was studied in 2-day-old chicken. After oral inoculation of chicken with 1×10^6 oocysts, ozonized water(0.5ppm) and tap water were supplied to experimental and control group, respectively. The prepatent period of both group was 6 days postinoculation(PI). The patent period of experimental group was shorter(6-18 days) than that of control group(6-22 days). The number of oocysts in the feces were maximum on days 11 PI, indicating 1.99×10^6 oocysts/experimental chicken and 6.00×10^6 oocysts/control chicken. The number of discharged oocysts during experimental period was higher in control group than that of experimental group. In the view of febric bursa sections on 7 days PI, the number of endogenous development of C baileyi was smaller in experimental group that in control group. This results indicate that the autoinfected sporozoite were damaged by ozone. The ozonized water supply to chickens is alleviation cryptosporidiosis.
박성환 聖潔敎神學大學校 社會科學硏究所 1998 社會科學硏究 Vol.5 No.1
AbstractThis study focused on the function of the career management, or the process of career management for the company.In the stage of planning, employees should set the career process, crystallizing the completion of the above mentioned, a company should support the backing of career plan, the career counselling, and the setting of career process.In the stage of career development, a company should help the career development and advancement for the employees to enhance their careers through the placement and transfer, the education training, and promotion.In the stage of career control, a company should do the career evaluation and feedback its result to the employees. To complete these processes of career management, the building up the databases, the establishment of promotion path and qualification system, and the evaluation of result and potentiality should be well supported.
朴尙煥 弘益大學校 1989 弘大論叢 Vol.21 No.1
Giroso, which was activated and established by the Taejo's joining carried out the policy of taking care of the national aged as a government organ. The events of respecting the aged such as Sayun (giving a banquet for the aged), Dosang (be-stowing the pictures for the aged), Samul (Royal grant ) etc. were managed by Gi-roso. As a results, the appeasement of the aged made it possible to centerize the political authority and also contributed to establishment of the social molars of respecting the aged and filial piety.
급성기 주요우울장애 환자에서 Natural Killer T 세포
박이진,이제훈,이권행,한상익,전양환 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.3
Objectives : To evaluate an association between depression and altered immunity, we examined peripheral T lymphocyte or natural killer (NK) cell measures plasma ACTH and cortisol using the flow cytometry in acute and unmedicated patients with major depressive disorder (MDD). Methods : Forty-two patients with MDD from the outpatient clinic and forty normal controls from the hospital staff were recruited. We applied Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A) for depressed subjects. Peripheral T lymphocyte or NK cell measures (CD3, CD4, CD8, or CD56) and plasma hormones (ACTH and cortisol) were obtained from all subjects. Results : There were no statistical differences in CD3, CD4, CD8, or CD56 between the two subjects. The number of CD56 cells negatively correlated with HAM-D scores (r= -0.42, P<0.01), but did not correlate with HAM-A scores in patients with MDD. The number of CD56 cells showed strong negative correlation with CD4/CD8 (r= -0.47, P<0.01) in the control group, but not in the depressed group. Patients with MDD had higher cortisol level than controls within the normal range. Conclusion : The trait of immunological imbalance and HPA axis abnormality were shown in patients with MDD. Especially, the severity of depression, but not the anxiety, could be reflected as decreased number of CD56 (NK T) cells in acute and Unmedicated state.
Aspergillus sp. ISR 균주를 통한 콜레스테롤 합성저해제 lovastain의 생산
박상은,조미현,신동화,황승환,박천석 경희대학교식량자원개발연구소 2005 硏究論文集 Vol.24 No.-
본 연구에서 한국 토양에서 분리된 lovastatin 생산 균주인 Aspergillus sp. ISR 균주를 이용하여 여러 배지 조성 성분이 lovastatin의 생산에 미치는 영향을 관찰하였다. 탄소원으로는 lactose보다 glycerol 5%가 가장 효과적이었으며 질소원과 인산염의 경우는 기본 RPM배지 조성과 농도에서 보다 효과적인 것을 발견하지 못하였다. 복합영양원으로 rapeseed meal 보다는 대두박이 보다 효과적이어서 저렴한 배지원으로 사용이 가능할 것으로 사료된다. 최종적으로 최적화된 배지를 사용하여 52 mg·L^(-1)의 lovastatin을 생산할 수 있었고 이는 기존의 RPM 배지보다 수율이 4.5배 증가한 것이다. 좀 더 효과적인 lovastatin의 생산을 위하여 회분식 발효에 대한 연구와 분자유전학적인 연구를 통한 고생산 균주의 제조에 대한 연구가 진행중이다. Effects of various nutritional components on the production of lovastatin were investigated in the Aspergillus sp. ISR. Among various carbon (C) sources, glycerol was determined to be the most effective C source at the concentration of 5% (v/v). In case of nitrogen sources, 0.2% (w/v) KNO_(3) efficiently induced the lovastatin production in Aspergillus sp. ISR. Interestingly, the addition of soybean meal into the production medium enhanced the lovastatin production compared to the rapeseed meal. Conclusively, Aspergillus sp. ISR produced 52 mg·L^(-1) of lovastatin in the optimized medium containing 5% (v/v) glycerol, 0.2% (w/v) KNO_(3), 0.3% (w/v) KH_(2)PO_(4), and 0.3% (w/v) soybean meal, which was 4.5 times higher than the amount produced using the standard RPM (rapeseedmeal production medium).