정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

혈압 및 혈관손상에 대한 Candesartan과 Cilnidipine의 병용투여 효능 평가

정상혁,한주희,명창선 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-

This study was designed to evaluate the effect of candesartan combined with cilnidipine on high blood pressure in spontaneous hypertensive rats (SHRs) and vascular injury induced by cuff-placed neointimal hyperplasia model. To measure blood pressure, low and high doses of candesartan (0.765 and 1.53 mg/kg/day) and cilnidipine (0.96 and 1.92 mg/kg/day) alone or in combination were orally administered in telemetered-SHRs for 2 weeks. To examine the protective action of vascular injury, high doses of candesartan (1.53 mg/kg/day) and cilnidipine (1.92 mg/kg/day) alone or in combination was orally administered for 2 weeks in cuff-induced neointimal hyperplasia model of C56BL/6 mice. As a result, high doses of candesartan and cilnidipine in combination decreased in systolic blood pressure (SBP) and mean arterial pressure (MAP) as compared with monotherapy of high dose of each drug, but not statistically significant. In vascular injury model, candesartan and cilnidipine in combination decreased BrdU-positive cells in neointima and vascular smooth muscle cell proliferation as compared with monotheray of each drug. Thus, these results indicate that the combination of candesartan with cilnidipine is effective for the protection of vascular injury, suggesting this combination to be a valuable tool for the management of vascular remodelling such as restenosis.

우리나라 일부 여고생과 여대생의 건강 위험 행태 분석

한성현,최민자,이선희,이명선,이혜진 한국모자보건학회 2000 한국모자보건학회지 Vol.4 No.1

조선업 근로자의 누적외상성질환 실태와 누적외상성질환 범용 작업위험도 평가도구를 이용한 작업분석

한상환,백남종,박동현,장기언,이명학,박종태,김대성,이연숙,백경자,신용수,송동빈 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.4

Cumulative trauma disorders were surveyed in a cross-sectional study of 100 male shipyard workers an 43 male office workers. And baseline checklist for risk assessment of cumulative trauma disorders was applicated in a ship making process. Cases of cumulative trauma disorders were defined using physical examinations and electronic diagnostic mathods. Data on demographics, individual factors(medical condition), work organization and psychosocial aspects of work were obtained by questionnaire. Association between the above factors and cumulative trauma disorders were assessed by multiple logistic regression models. 29(29%) participants of male shipyard workers and 4(9.2%) study subjects of male office workers met our case definitions for cumulative trauma disorders. The myofascial pain syndrome of neck muscles(12% of participants) and carpal tunnel syndrome(5% of participants) were the major two medical conditions in shipyard workers. The odds of male shipyard workers for cumulative trauma disorders to male office workers was 3.15 after adjustment of age(95% C. I. : 2.25-5.44). And the variables such as duration of present job, HIVD condition, and surges in workload were associated at least one of the cumulative trauma disorders in the final models(p<0.05). This study indicates that workrelated upper extremity musculoskeletal disorders are relatively common among shipyard workers, and shows that the psychosocial factors is not likely to be related to the occurrences of these disorders in heavy workers. Also we developed baseline checklist for risk assessment of cumulative trauma disorders. The checklist was unique in that its expected users were industrial hygienists and occupational healthing nurses who did not have much ergonomic background and in that it was targeted to Korean workers in various types. As the first application of the checklist, shipyard workers were evaluated.

채용시 건강진단이 근로자 채용에 미치는 영향과 작업전 적정배치검사 도입의 필요성

한상환,정성철,이명학,송동빈 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.1

In Korea, every worker should undergo a preemployment medical examination according to Law for Occupational Safety and Health. But evaluation of it has not been previously carried out. Thus a telephone survey of 213 establishments of Inchon area for evaluation of preemployment medical examination in Korea was conducted. One hundred and fourteen companies(46.5% of all the subjects) were examined medically on preemployment, 47 establishments(41.2% of this study subjects) reevaluated workers by each establishment's medical criteria, and only less than half of diseased workers(DM 38.6% ; hypertension 42.1% ; HBV carrier 28.0% ; active pulmonary tuberculosis 7.9% ; back pain 12.3% ; and noise induced hearing loss 18.4%)were employed. Employee's fees for preemployment medical examination were covered by 53.5% of all the subjects. From our survey, it is clear that preemployment medical examination plays discriminating role on the employment of workers based on health status. We thus proposed to change over from preemployment medical examination were covered by 53.5% of all the subjects. From our survey, it is clear that preemployment medical examination plays discriminating role on the employment of workers based on health status. We thus proposed to change over from preemployment medical examination to preplacement examination based on the evaluation of essential job functions and reasonable accommodation.

렉테나 설계를 위한 이중대역 정합회로 설계

박명윤,최진형,조승호,이원준,한상민 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

Wireless Power Transfer(WPT) is very popular because it can wirelessly supply energy to the sensor. The Dual-Band rectenna with ISM matching(2.4-2.48GHz/5.72-5.82GHz) is presented. The dual-band rectenna system consists of harmonics rejection filter, dual-band impedance matching circuit, voltage multiplier rectifier. Especially, for system efficiency, it is important to perform dual-band matching to transfer maximum power to the rectifier. Dual-Band Rectenna can harvest more power than single-band rectenna and be high performance in communication environment using ISM band such as Wi-Fi, Bluetooth existing several-tone signal.

평판하 연기선단의 가시화

한용식,김명배,오광철,유상필 한국화재소방학회 2001 한국화재소방학회논문지 Vol.15 No.1

수평 평판과 충돌하는 제트에 의해 생성되는 연기유동을 관찰하기 위해 질소가스에 kerosene연기입자를 뛰워 유동장을 가시화하였다. 광원으로는 아르곤-이온 레이져 평면광이 사용되었다. Kerosene smoke의 산란 광에 의한 수직평면 상(image)과 수평평면 상을 고속 CCD 카메라와 비디오 카메라로 녹화하였으며, 얻어진 영상으로부터 연기 선단의 순간속도 및 평균속도를 측정하였다. The flow induced by a vertically impinging circular jet under a horizontal plate is investigated by visualization technique, using kerosene smoke in nitrogen gas to visualize the vortex flow and impinging flow. The light source was the sheet beam of Ar-Ion laser. The vertical and horizontal images scattering of kerosene smoke were recorded by the high speed CCD camera and the video camera. The instantaneous velocity of the smoke front were measured from the acquisited images.

초정밀 공작기계용 스핀들의 설계제작 및 특성 평가

한복수,박성환,명태식,권경우 大田産業大學校 2001 한밭대학교 논문집 Vol.18 No.-

Precision machining widely bases on the technology connected with machine tools, machining and others. The prototype was designed in the base of the analysis of the precision air bearing spindle which have greate influence upon the machining accuracy of the precision machine. The contents in this study are as follows. 1) Design and manufacture of the spindle system, 2) Performance test of the system. The spindle system is made of aero-static, which has the excellent rotation accuracy was designed and manufactured. As a result of the test (static vibration, dynamic vibration, spindle rotation), the air spindle system was stability. We think that this system can apply to the ultra-precision machine tools.

生態親和的 飼育環境 制御方式 確立을 위한 누에 核多角體病 發生要因 分析

韓明世,林鐘聲 慶北大學校農業科學技術硏究所 1997 慶北大農學誌 Vol.15 No.-

世界的으로 養蠶地域에서 큰 피해를 주는 核多角體病은 養蠶現場에서 蠶室 蠶具類의 철저한 포르말린 소독에도 불구하고 예방효과가 疑問視되는 경우가 발생하며, 이는 병원체의 存否 만으로 본 疾病의 蔓延이 설명될 수 없기 때문이라는 사실을 實驗病理學的으로 立證하였다. 核多角體病의 發生을 助長하는 不良 環境要因을 파악하기 위하여 1979년부터 1993년 까지 15년간 한국 일본 필리핀 등지에서 57건의 사육사례를 조사하였다. 環境狀態와 發病事例의 연관성을 분석하므로써 發病生理와 관련된 環境要因을 해명한 결과, 고름병 發生頻度는 상엽육과 인공사료육 간에 비슷한 경향을 나타내었고, 잠실 잠구류의 消毒방법에서는 포르말린 消毒 與否에 따른 차이가 인정되지 않았다. 交雜種은 原種보다 核多角體病 발생율이 다소 높은 수준이었으며, 특히 애누에때 부터 장기간 通氣不良인 사육환경에서는 發病率이 현저하게 높았다. 또한, 1993년부터 1997년 까지 5년간의 實證試驗에서는 蠶室 및 蠶具類의 청소와 사육실의 强制循環式 換氣로 사육환경을 개선하므로써 人體에 有害한 농약을 사용하지 않고도 누에 核多角體病 발생을 효율적으로 제어할 수 있음을 立證하였다. For the prevention of worldwide prevalent disease of nuclear polyhedrosis virus (NPV), environmental conditions and their incidence of grasserie was investigated through 57 cases of silkworm rearing from the year of 1979 to 1993 in the countries of Korea, Japan, and Philippines. Relationship between the occurrence of NPV and environmental factors were also analysed from the aspect of causal pathogenesis. Unfavorable foactors related to the prevalence of NPV disease was reconfirmed by the assay of experimental rearing. Silkworms reared on mulberry leaves or artificial diet appeared similar result on the occurrence of grasserie. Disinfection by formalin and simple sweeping or washing was not significantly different on the occurrence of NPV disease. Following insufficient ventilation on the younger larvae, from the 1st to 3rd instar, the disease by NPV at the later stage was remarkably emphasized those insidence. An experimental rearing from 1993 to 1996 demonstrated the prevention of NPV disease by simple cleaning of sweeping under the condition of air forced ventilation, the customal practice of disinfection with formalin or any other chemical agents could be omissible.

효율적인 원격교육을 위한 웹 메일시스템의 설계 및 구현

한명성,이완주 용인대학교 학생생활연구소 2000 학생생활연구 Vol.8 No.-

In this thesis, I implement a wed-based mail system using PHP language and IMAP protocol. The web-based mail system will be useful not only as the effective mail system in the environment such as school with many students but little computers, but also as the assistance of the distance education program spread in our educational circumstance. The web-based mail system do not adopts POP protocol but IMAP protocol appropriate to use in "line"essage processing. IMAP protocol designed for "online" application thus, shows better performance in the circumstance of "online" such as the web-based mail system then POP protocol Therefore, 1 can guarantee that the web mail system based on IMAP protocol has the better capacity then based on IMAP protocol. Also, using the script language PHP, highlighted as a wed programming language for the next generation with the fast speed and security, it is designed to be able to respond quickly over a number of user. The web-based mail system provides various functions for user's conveniences such as controling mailbox of producing, deleting and changing, various functions for MIME message decoding controling addresses, registrating spam mail beside the basic functions like reading, sending, replying and deleting. The personal informations such as password and text informations registrating in spam mail and address control became more stabilized and secure through the database. This system is implemented in Solaris circumstance using Apache web server, but it can be used in all the circumstances of Unix, NT and Linux because most of web sever provides PHP 1anguage.