당뇨병환자에서 뇨증 Fibronectin농도의 증가에 관한 연구

한승범,조준승,손건영,서성문,박근용,조성래,박규영,박정모,이인규,여준기 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Plasma fibronectin is an α₂-glyoprotein, which is produced by vascular endothelial cells. Raised level of plasma fibronectin has been observed in diabetic patients particularly in the presence of microvascular complications. However, no available data exist about urine level of this glycoprotein in diabetic patients. We measured urine fibronectin level by ELISA methods in 54 diabetic patients who have microvascular comlications or not. The following results were obtained. 1) Urine fibronectin level(㎍/g creatinine) in diabetic group(1740.0±678.0) is increased compaired with those in normal control group(471.0±59.0). but this results were not significantly different among two groups(P>0.05). 2) Urine fibronectin level(㎍/g creatinine) was significantly increased in patients with nephropathy (6188.0±3144.0) compared with those in normal control group(471.0±59.0) and patients without nephropathy(645.0±251.0)(P<0.001). 3) There were a significant correlation between BUN, creatinine, creatinine clearance, 24hr urine total protein and urine fibronectin level in diabetic patients. Our data suggest that urine fibronectin excretion level might be used as a sensitive guide for diabectic nephropathy.

Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

産卵鷄에 대한 練炭灰添加給與 效果에 關한 硏究

朴成振,文勝式,鄭場龍 진주산업대학교 1982 論文集 Vol.20 No.-

This experiment was conducted to investigate the effect of Briquette ash treatment on egg production rate, egg weight, feed conversion and egg quality with date obtained from 100 pieces egg type fowls Babcock (B 380, 230days-age) fed and allotted 5 treatments at the rate of 0%(C), 0.5%(T_1) 1.0%(T_2), 1.5%(T_3)AND 2.0%(T_4) during the experiment period of 119 days from May 21, 1982 to September 20, the same year ar Department of Animal science, Jin Ju Agricultural and Forestry Junior Technical College. The results obtained are summarized as follows; 1. Average egg weight at each experiment plot was 62.21g(T_2) 61.62g(T_3), 60.88g(T_4), 60.42(T_1) and 60.04g(C), but the difference was not significant. Feed conversion at each experiment plot was 2.52(T_2) 2.60(T_3), 2.65(C) and 2.67(T_4). 2. Average egg production rate at each experiment plot was 82.02%(T_2) 81.85%(C) 81.43%(C), 79.41%(T_3) and 78.23(T_4), but the difference was not significant. 3. Weight of egg yolk and albumen were higher at fed with the treated Briquette ash plot than that without Briquette ash plot, and weight of egg shell and thickness were not significant.

維新벼에 나타난 生育後期의 萎週

朴鍾聲,金文圭,禹基大,劉勝憲 충남대학교 농업과학연구소 1977 農業技術硏究報告 Vol.4 No.1

1. Chemical properties of soils and inorganic compositions of rice plants were analysed to explain the acute wilting occurred in the late stage of rice variety, Yusin. The results obtained were summarized as follows. 1) The amount of K and S_iO_2 of soils where severe rice wilting occurred was lower than that of soils where rice wilting didn't occurred. 2) The amount of N and FeO of wilted rice plants was higher than that of normal rice plants while the amount of K_2O and SiO_2 and the ratio of K_2O/N of former were lower than that of letter. 2. Severe wilting was occurred only in the rice variety, Yusin, when three varieties… Yusin, Milyang #15, Milyang #23……were interplanted. The amount of organic and inorganic compositions of three varieties and chemical properties of rhizosphere soils were analysed. 1) The rice variety, Yusin, was the lowest and that of the rice variety, Milyang #15, was the highest in the level of total carbohydrate and hemicellulose. 2) Comparatively higher levels of K were observed in rhizosphere soil where Yusin was planted, while the level of the K in the plant of Yusin was the lowest.

여성의 사회교육 참여에 따른 생활만족도와 만족도에 미치는 요인 분석

문태영,박승환 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1

The purpose of this study was to examine how much women's life satisfaction was affected by social education and what factors impacted on that. The subjects in this study were 300 women who had participated in social-education programs provided by two women's centers for one year or longer period of time. A survey was conducted in August and September 2003 with self-administrated questionnaires on their life satisfaction and to what extent they received social education, and the responses from 286 women were selected for analysis, except for incomplete answer sheets. For data handling, statistical data on frequency and percentage were obtained, and t-test was implemented. Besides, regression analysis was carried out to identify what factors affected their satisfaction with social education. The findings of this study were as follows: First, among demographic variables, which were background variables, the health status of the respondents was significantly different according to age, education, family income and subjective health. By age, the older women were more contented with their lives and participated in more social-education programs. The older women preferred music and sports programs, and those who stopped at high school and school of lower grade favored music classes. The college graduates preferred art programs, and monthly mean income and subjective health made no significant differences. Second, their participation in social-education programs made a significant difference to their life satisfaction. Those who learned Samulnoli and singing found their lives most satisfactory, and the women who took computer classes were less pleased with their lives than those who took the other classes. The gap between them was significant.

측두엽에 발생된 Gliosarcoma

박양화,권익승,홍승관,문명선,신미경 대한신경외과학회 1989 Journal of Korean neurosurgical society Vol.18 No.1

저자들은 근래 좌측 측두엽에 발생된 Gliosarcoma 1예를 수술적 부분적출 및 수술후 방사선 조사로 치료한 후 일시적 증상 호전을 보이다가 수개월 내에 급속한 임상적 악화 및 종양 재증식을 치험하고 희귀한 증례이기에 보고하고저 한다. Gliosarcoma는 악성 뇌교종과 섬유육종이 혼합된 뇌종양으로써, 문헌 고찰 결과 악성 뇌교종 내의 혈관내피세포 과증식이 어떠한 알려지지 않은 기전에 의하여 악성 변화를 일으켜 섬유육종이 발생되는 경우가 대부분으로 사료된다. A case of left temporal gliosarcoma is reported. The patient was a 40-year old man who had headache, behavior change, dysphasia, and mental confusion for about 2 months duration. On brain CT, a large partially cystic mass with homogeneous enhancement was located at left temporal lobe and associated with remarkable pentumoral edema and mass effect. Angiographic tumor vascularity was faintly visualized. Surgical subtotal resection of the tumor and post-operative radiotherapy offered transient symptomatic improvement, being followed within several months by clinical deterioration and regrowth of the tumor on brain CT. Light microscopic studies of the H & E and special stained specimens showed two different components within the tumor in a mixed fashion, i.e. intermingled glioblastoma multiforme and fibrosarcoma. Electron microscopic study of the sarcomatous cells disclosed intracytoplasmic Weibel-Palade-like bodies, a specific marker of endothelial cells. The fibrosarcomatous component of gliosarcoma is believed to be originated from malignant transformation of the hyperplastic endothelial cells within the anaplastic glioma. Literature concerned with gliosarcoma is reviewed.

통상정보학의 실용성 제고를 위한 연구방향

박승락,박문서 한국통상정보학회 1999 통상정보연구 Vol.1 No.2

연구방법론의 관점에서 통상정보학은 매우 다양한 방법으로 접근이 가능하며, 특히 정보통신기술을 적극적으로 활용할 수 있기 때문에 항상 새로운 접근 방법이 출현할 수 있다. 또한, 정보기술의 급격한 발전으로 국제전자상거래가 급격히 확산되고 있는 현 시점에서 수출기업의 단순한 무역자동화 수준을 벗어난 국제간 B to B 전자상거래의 전략적 활용방안에 대한 연구가 필요한 때이다. 이에 본 연구에서는 통상정보학의 실용성 제고를 위한 구체적인 연구방향으로써 전략 정보시스템과 조직이론을 가미한 조직간 정보시스템 이론을 제시함으로써, 조직간의 전략적 연계를 통한 전략적 통합정보시스템 구축전략을 제시하고자 하였다. 이를 통하여 정보화의 이점을 통상학 분야에 도입하고, 전략적으로 활용 가치가 있는 정보를 생산, 저장, 유통 및 활용함으로써 학술적 비용발생을 최소화하며, 기업의 이윤발생을 촉진함으로써 국가경쟁력의 확보에 기여할 수 있도록 하는 것이 통상정보학의 궁극적인 지향 목표이다.

한국 초파리집단의 선택불리에 관한 지구 자기장의 5배인 자기장의 영향

박은규,정승문,김중현,최오목 圓光大學校 1995 論文集 Vol.29 No.2

본 연구에서는 한국 선유도의 자연집단 야생형 초파리와 가시돌연변이형 황색체-소시 초파리를 Helmholtz coils 장치를 이용해서 유도한 지구 자기장의 5배인 자기장내의 집단과 비교 집단인 지구 자기장내의 집단에서 발생율 변동과 성적 선택빈도를 조사하여, 선택불리에 관한 유전적 행동을 관찰해서 다음과 같은 결과를 얻었다. 1.야생형 유전자(+)를 운반하는 염색체의 선택빈도는 15세대까지 평균 빈도가 지구 자기장의 5배인 자기장내의 초파리 집단, 지구 자기장내의 초파리 집단이 각각 0.6489, 0.6553으로 관찰되었다. 이 결과는 지구 자기장의 5배인 초파리 집단에서 더 강한 선택불리 행동을 보여 주었다. 2.초파리 집단의 발생율 변동은 지구 자기장의 5배인 자기장내의 초파리 집단 3세대(13.60%), 지구 자기장내의 초파리 집단 6세대(22.35%), 8세대(22.30%)에서 아주 낮은 발생율의 변동을 보여주었으며, 2개의 상이한 자기장내 초파리 집단의 전체 평균 발생율은 지구 자기장의 5배인 자기장내의 초파리 집단, 지구 자기장내의 초파리 집단에서 각각 58.07%, 41.93%로 관찰되었으며, 후자보다 전자에서 발생율이 증가함을 보여 주었다. 3.돌연변이형 황색체-소시 유전자(ym)를 운반한 염색체의 선택빈도는 각각의 자기장내의 초파리 집단에서 0.0542, 0.0646으로 관찰되었다. 이 결과는 지구 자기장의 5배인 자기장내의 초파리 집단에서 0.0542로 상대적으로 강하게 선택불리 행동을 보여 주었다. 4.돌연변이형 황색체 유전자(y)를 운반한 염색체의 선택빈도는 각각의 초파리 집단에서 0.0185, 0.0144로 관찰되었다. 이 결과는 비교 집단인 지구 자기장내의 초파리 집단에서 0.0144로 더 강한 선택불리 행동을 보여 주었다. 5.돌연변이형 소시 유전자(m)을 운반한 염색체의 선택빈도는 각각의 조절된 자기장내의 초파리 집단에서 0.0328, 0.0190으로 관찰되었다. 이 결과도 지구 자기장내의 초파리 집단에서 0.0190으로 상대적인 강한 선택불리 행동을 보여 주었다. 6.수컷이 가지고 있는 Y-염색체의 선택빈도는 각각의 초파리 집단에서 0.2457, 0.2467로 관찰되었다. 이 결과는 지구 자기장의 5배인 초파리 집단에서 0.2457로 더 높은 선택불리 행동을 보여 주었다. 7.Duncan's multiple range test의 LSD값으로 유의 차이 유무 검정을 하였던 바 야생형 유전자의 A 그룹과 돌연변이형 유전자들의 B 그룹사이에서 고도의 유의 차이가 있음이 밝혀졌다. To elucidate the genetic behavior of selective disadvantage among visible mutants of Drosophila melanogaster bred and kept by the genetic study laboratory room. Wonkwang University and the wild type collected at Sunyoudo island in Korea, and reared under the influence of two different strength of magnetic fields, i.e. the quintuple and the ambient magnetic field, this study was carried out at the above indicated laboratory room. 1.The mean selective frequencies of wild gene(+)-carry chromosome up to 15th generation, affected by two different magnetic fields, showed 0.6489 and 0.6553 with the magnetic field strength as mentioned order before. The data explains that the population of Drosophila melanogaster reared in the quintuple magnetic field showed higher selective disadvantage. 2.The variations of emergence rates of the populations of Drosophila melanogaster altering by generation showed the drastic lowest values at the specified generation, for example, 13.60% under the quintuple magnetic field at the third generation and 22.35% and 22.30% under the ambient magnetic field at the 6th and 8th generation. The over-all mean emergence rates of the populations of Drosophila melanogaster reared in controlled magnetic fields, i.e. the quintuple and the ambient magnetic fields using Helmholtz coils, showed 58.07% and 41.93% respectively. Referring to these data, the population of flies raised in the quintuple magnetic field showed a relatively higher emergence rate than the ambient magnetic field. 3.The mean selective frequencies of the individual of ym gene-bearing chromosomes showed 0.0542 and 0.0646 by the same order of magnetic field strength indicated above. It was shown that the population of flies reared in the quintuple strength generated by Helmholtz coils cleared the relatively strong selective disadvantage being 0.0542. 4.The mean selective frequencies of the mutant that carries y gene-bearing chromosome showed 0.0185 and 0.0144 from the two different magnetic fields in the same magnetic order. The results indicated that the population of flies from the ambient magnetic field showed higher selective disadvantage frequency, 0.0144. 5.The mean selective frequencies for the mutant carrying m gene-bearing chromosome were calculated as to be 0.0328 and 0.0190 for the same order of magnetic field strength. The found from this results is that the selective disadvantage behavior for the mutant rearing m gene chromosome in the ambient magnetic field was stronger than the one, being 0.0190. 6.The mean selective frequencies of the male flies which carries Y-chromosome showed 0.2457 and 0.2467 respectively. The results indicated that the male flies from the quintuple magnetic field showed higher selective disadvantage being 0.2457. 7.Through Duncan's multiple range test and LSD value, the highly significant differences between A group of the wild type and B group of the other three mutants were calculated.

마약길항제의 방출 제어형 제제 (제2보) : 나록손 이식제제의 생체적합성 및 약물속도론적 평가 Biocompatibility and Pharmacokinetics of Naloxone Implant

문미란,박주애,이승진,김형국,김길수 梨花女子大學校 藥學硏究所 1995 藥學硏究論文集 Vol.- No.5

For the effective administration of narcotic antagonist, the application of sustained release implantable systems with biodegradable polyphosphazene was examined. Using poly[(diethyl glutamate)-co-(ethyl glycinate) phosphazene]. the implantable devices containing naloxone hydrochloride were prepared and in vivo implantation studies were carried out subcutaneously in rat and rabbit with this preparation for the biocompatibility and pharmacokinetics. The histological finding in rats at initial time period was the inflammation that occurred focally around the implants, but they were showed subsequent mild and limited chronic inflammations and the irreversible changes such as necrosis and degeneration of the muscle or connective tissues were not observed. Therefore the placebo and naloxone implants are considered to be biocompatible formulations histologically. In pharmacokinetic studies, the release of naloxone from the naloxone implants into blood plasma was maintained in 192 hours, but the initial burst effect was observed. If this problem was solved, the application for the narcotic antagonist sustained release systems can be expected.