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梨花女子大學校 生藥 分科 委員會 梨花女子大學校 藥學硏究所 1964 梨花藥學硏究 Vol.- No.5
본대학 생약 분과회에서는 1964년 8월 2일로부터 8월 7일까지 설악산을 중심으로 한 식물채집을 통해서 여러 종류의 식물과 특히 약용식물을 조사해 보았다. 설악산은 강원도 양양군과 인제군 사이에 있는 높이 1708m의 고산으로서 태백산맥 위에 솟아 있고 주봉은 청봉이라 하며 1년중 5~6개월은 눈에 덮혀 있다 한다. 이 산은 커다란 석산 덩어리로서 웅대한 산세, 빽빽한 숲, 거울같이 맑은 시내, 길고 급하게 내려쏟는 폭토 이들 모두가 변화있고 조화있게 비치되어 마치 금강산을 상상케 한다. 그러므로 봄, 가을을 통해서 많은 관광객, 등산객, 특히 고산식물이 풍부하므로 해마다 식물 채집을 위한 많은 사람들이 오는 곳이다. 이 산의 식물에 대한 많은 조사서들이 발표되었지만 이번 본 생약회에서는 처음으로 설악산을 중심으로 분포되어 있는 일반 식물 및 약용 식물을 조사해 본 것이다. 본 분과회는 가급적이면 완전한 식물 표본을 얻는데에 목적을 두었으나 완전치 못하여 유감스럽다.
梨化女子大學校 衛生化學敎室 梨花女子大學校 藥學硏究所 1960 梨花藥學硏究 Vol.- No.2
食品添加物이라함은 食品의 調味, 着香, 保存, 漂白 또는 蟛脹 其他 食品의 加工의 目的으로 食品에 添加, 混和, 浸潤等에 依하여 使用하는것을 말한다. 이것은 大別하여보면 合成甘味科, 合成糊科, 膨脹劑, 漂白劑, 合成殺菌劑, 合成着色科, 防腐劑, 合成着香科같은 것이있다.
梨花女子大學校 生藥分科委員會 梨花女子大學校 藥學硏究所 1963 梨花藥學硏究 Vol.- No.4
1963년 7월 22일부터 7월 26일까지 본대학 생약반은 충청남도 일대의 식물을 德嵩山을 중심으로 채집하고 약용으로 쓰이는 식물을 조사해 보았다. 덕숭산은 충남 예산군에 위치해서 북위 약 36˚31', 동경 126˚40'의 지점으로 태안반도와 영일만을 이으는 즉 식물분포경계선에 위치하는 곳으로 기추는 중부지방의 기후대에 속하고 7월에는 평균기온 25˚7' 강우량은 7월 350mm 정도이다.
Lee, Ki-Seon,Khil, Lee-Yong,Chae, Sang-Ho,Kim, Deukjoon,Lee, Byung-Hoon,Hwang, Gwi-Seo,Moon, Chang-Hyun,Chang, Tong-Shin,Moon, Chang-Kiu 이화여자대학교 약학연구소 2008 藥學硏究論文集 Vol.- No.17
In the present study, the mechanism of antiplatelet activity of DK.-002, a synthesized (6aS,cis)-9.10-Dimethoxy-7,11b-dihydro-indeno|2,1-c ]chroniene-3.6a-diol, was investigated. DK-002 inhibited the thrombin, collagen, and ADP-induced rat platelet aggregation in a concentration- dependent manner, with 1C_(50) values of 120. 27, and 47 μM, respectively. DK-002 also inhibited thrombin-induced dense granule secretion, thromboxane A_(2) synthesis, and [Ca^(2+)], elevation in platelets. DK-002 did not show any significant effect on ADP-induced inhibition of cyclic AMP elevation by prostaglandin E_(1). but DK-002 was confirmed to inhibit ADP-induced [Ca^(2+)] elevation and shape change. DK-002 inhibited 4- bronw-A23187-induced [Ca^(2+)], elevation in the presence of creatine phosphate/creatine phosphokinase (CP/CPK, a ADP scavenging system) and indomethacin (a specific inhibitor of cyclooxygenase). DK-002 also inhibited Ca^(2+) mobilization in thrombin- or 4-bromo-A23187-stimulated platelets through its inhibitory effects on both Ca^(2+) release from intracellular stores and Ca^(2+) influx, in the presence of CP/CPK and indomethacin. Taken together, the present study shows that DK-002 has inhibitory effects on stimulation of platelets, and suggests that its antiplatelet activity might be related to the inhibitory mechanism on Ca^(2+) mobilization in stimulated platelets. ⓒ 2005 Elsevier Inc. All rights reserved.
Cytotoxic Phenylpropanoids from the Rhizomes of Alpinia galanga
Nam, Joo-Won,Kim, Sun-Jack,Han, Ah-Reum,Lee, Sang-Kook,Seo, Eun-Kyoung 이화여자대학교 약학연구소 2005 藥學硏究論文集 Vol.- No.15
A bioassay-guided fractionation of the n-hexane and chloroform extracts of the rhizomes of Alpinia galanga led to the isolation of two active compounds, l'S-l-acetoxychavicol acetate (1) and p-coumaryl alcohol τ-O-methyl ehter (2). 1'S'-1-acetoxychavicol acetate (1) exhibited significant cytotoxicity against all human cancer cell lines tested (A549; 8.14, SNU638; 1.27, HCT16; 1.77, HT1080; 1.2, HL60; IC50 2.39 μg/ml), whereas p-coumaryl alcohol τ-O0methyl ether (2) showed selective cytotoxicity against the SNU638 cell (IC_(50) value of 1.62μg/ml).
Noh, Hyun-Jin,Ha, Hun-Joo,Yu, Mi-Ra,Kim, Young-Ok,Kim, Ji-Hye,Lee, Hi-Bahl 이화여자대학교 약학연구소 2004 藥學硏究論文集 Vol.- No.14
Objective: To demonstrate the presence of an independent renin-angiotensin system (RAS) in the peritoneum and to determine the role of locally produced angiotensin (Ang) Ⅱ in high glucose-induced upregulation of transforming growth factor (TGF)-β1 and fibronectin by human peritoneal mesothelial cells (HPMC). Methods: In cultured HPMC, the expression of mRNAs for angiotensinogen, angiotensin-converting enzyme (ACE), Ang Ⅱ type 1 receptor (AT1), and TGF-β1 was evaluated by real-time polymerase chain reaction; ACE, AT1, and fibronectin proteins by Western blot analysis; and Ang Ⅰ, Ang Ⅱ, and TGF-β1 proteins by ELISA. Dichlorofluorescein (DCF) -sensitive cellular reactive oxygen species (ROS) were measured by fluorometry. Results: HPMC constitutively expressed all the components of RAS, and 50 mmol/LD-glucose (high glucose) significantly increased angiotensinogen, ACE, and AT1 mRNAs and ACE, AT1, and Ang Ⅱ proteins. Ang Ⅱ increased TGF-β1 and fibronectin protein expression and DCF-sensitive cellular ROS. Losartan prevented Ang Ⅱ-induced increase in cellular ROS. Both losartan and captopril inhibited high glucose-induced upregulation of TGF-β1 and fibronectin expression in HPMC in a dose-dependent manner. Antioxidant catalase and NADPH oxidase inhibitor diphenyleneiodinium effectively inhibited Ang Ⅱ-induced TGF-β1 and fibronectin protein expression. Conclusions: The present data demonstrate that H PMC constitutively express RAS, that AngⅡI produced by HPMC mediates high glucose-induced upregulation of TGF-β1 and fibronectin expression, and that Ang Ⅱ-induced TGF-β1 and fibronectin expression in HPMC is medicted by NADPH oxidase-dependent ROS. These data suggest that locally produced Ang Ⅱ and ROS in the peritoneum may be potential therapeutic targets in peritoneal fibrosis during long-term peritoneal dialysis.
박소민,최명신,한규원,김길수 이화여자대학교 약학연구소 2005 藥學硏究論文集 Vol.- No.15
PGE₁is an endogenous substance of potent vasodialator as well as inhibitor of platelet aggregation. It has been used therapeutically in peripheral arterial occlusive disease and impotence. Intracavernous injection of PGE₁ for erectile dysfunction has been established for several years as a treatment option for erectile dysfunction of diverse etiologies, but this mode of administration is limited by penile discomfort, pain at the injection site, inconvenience and noncompliance. As the matter of worse, the β-hydroxy moiety of PGE₁is extremely susceptile to dehydration in solution to give inactive PGA₁ and PGB₁. For the improvement of stability, rapid absorption at action site and the convenience of application, PGE₁was formulated as urethral suppositories of three types of formulations, such as PEG, witepsol, and the mixture of PEG and witepsol. The stability test of PGE₁and the release test in urinary suppositories were performed. Futhermore, the effect fo enhancers and vehicle composition on the penetration of PGE₁through excised rat skin was evaluated by permeability coefficient and enhancement ratio.
Jung, Jae-Hoon,Kim, Moon-Hee,Kim, Min-Jeong,Kim, Jin-Young,Moon, Ji-Ae,Lim, Jae-Su,Kim, Mi-Young,Lee, Kyung-Lim 이화여자대학교 약학연구소 2004 藥學硏究論文集 Vol.- No.14
Translationally controlled tumor protein (TCTP) is a growth-related protein under transcriptional as well as translational control. We screened a rat skeletal muscle cDNA library using yeast two-hybrid system and found that TCTP interacts with the third large cytoplasmic domain of α1 as well as α2 isoforms of Na,K-ATPase, believed involved in the regulation of Na,K-ATPase activity. Interaction between TCTP and Na,K-ATPase was confirmed by coimmunoprecipitation in yeast and mammalian cells. We also showed, using ^(86)Rb^(+) uptake assay, that overexpression of TCTP inhibited Na,K-ATPase activity in HeLa cells. Northern and Western blotting studies of HeLa cells transiently transfected with GFP-tagged TCTP showed that overexpression of TCTP did not change mRNA and protein purified from an Escherichia coli expression system inhibited purified HeLa cell plasma membrane Na,K-ARTase in a dose-dependent manner. Using deletion analysis, we also found that the C-terminal 102-172-amino-acid region of rat TCTP that contains the TCTP homology region 2 is essential for its association with, and inhibition of, Na,K-ATPase.