서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)

김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1

Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

동일한 혈관 내에 발생한 이식형 약제 주입기 카테터의 위치이상

오대석,김영재,김명훈,조광래,임세훈,이정한,이근무,정순호,신치만 仁濟大學校 白病院 2010 仁濟醫學 Vol.31 No.-

저자들은 56세 여성 환자의 왼쪽 쇄골 하 정맥에 시행한 이식형 약제주입기 카테터의 삽입 후 발생한 비정상 위치에 대한 증례를 보고하고자 한다. 카테터의 끝은 환자의 늘 어진 가슴, 체위, 신체의 움직임, 카테터의 유동성 등의 영향으로 천자된 정맥 내에서 견인되고 뒤쪽으로 이동하였다. 환자는 어떠한 증상도 호소하지 않았지만 비정상 위치의 카테터는 심각한 합병증을 유발할 수 있기 때문에 제거되었다. 따라서 시술자는 약제주입기 삽입 전에 환자의 신체 상태와 단순 흉부 촬영상을 확인하고 카테터의 비정상 위치가 발생할 수 있는 위험 징후를 알아차려야 하겠다.

북한이탈주민의 복지욕구와 지원방안

오영훈,박미은 한남대학교 사회과학연구소 2011 사회과학연구 Vol.20 No.1

북한이탈주민에 대한 사회복지의 관심은 관련 정치적 이슈나 국제관계적 이슈 보다는 다양한 사회적 맥락과 관계 속에서 이들이 어떻게 효과적으로 적응하고 통합될 수 있는지에 초점이 있다. 이런 측면에서 본 글은 일차적으로 기존의 관련 연구들을 참조하여, 북한이탈주민이 경험하는 다양한 생활문제 가운데 남한 사회로의 적응과 관련한 몇 가지 문제들을 인간의 기본적인 복지욕구와 연관시켜 살펴보았다. 남한 사회에서 북한이탈주민들은 여러 측면에서 복지욕구의 좌절을 경험한다. 즉 이들이 평소 경험하는 자신에 대한 정체성 혼란은 생존의 필수적인 욕구인 존재감의 욕구를 억압하게 되고, 주변의 편견과 부정적인 반응에 기인한 자신에 대한 이미지 혼란도 내면의 자존감 욕구를 좌절시킨다. 같은 동포이지만 사회적 소수자로서의 열등하게 처우 받는 상황은 남한 사회에 뿌리 내리고 싶은 소속감의 욕구를 방해한다. 그리고 새로운 환경에서 경험하는 다양한 생활상의 스트레스는 정서적 안정의 욕구를 방해하는 요인이 된다. 특히 생사의 고비를 뛰어넘는 탈북과정과 낯선 남한사회에서의 적응 기간에 나타나는 심리적 충격과 외상은 우리 사회에서 건강한 시민으로 성장하는데 커다란 걸림돌이 된다. 그 밖에 이산의 아픔과 대인적 갈등으로 인한 취약한 가족관계는 친밀한 관계욕구의 상실로 이어지며, 자본주의 사회에서 구직과 취업의 어려움은 생계와 생활안정의 욕구를 위협한다. 따라서 향후 이들을 위한 지원방안은 이러한 복지욕구를 충분히 고려하여 접근되어야 한다. 무엇보다 사회복지를 비롯한 다양한 지원주체들이 이들의 불안정한 정체성과 취약한 존재감을 재확립하고, 사회구성원으로서 살아가는데 필요한 소속과 안정, 그리고 관계 및 참여의 욕구를 충분히 다루어주어야 한다. 부정적인 인식과 편견을 뛰어 넘어 이들의 장점과 가능성을 적극 열어주고, 사회적 자원으로서 우리 사회에 생산적으로 기여할 수 있는 구체적인 방안을 보여줄 필요가 있다. 또한 사회적 책임과 역할을 다할 수 있도록 다양한 교육의 기회를 제공하고, 성숙한 민주시민으로 성장하도록 꾸준히 격려해야 한다. 이러한 과제는 사회복지를 비롯한 다양한 민간단체들이 정부와 파트너십을 형성하여 사회적 책임을 분담하려는 노력을 통해 보다 효과적으로 성취될 수 있다. Concern of social service for North Korean defectors is basically related to their daily adaptation and social integration in South Korea. In this context, this study deals with the social service needs of North Korean defectors and policies to support them. North Korean defectors are severely suffering from such adjusting problems as confusion of self identity and image, maltreatment as a minority group, traumatic experience, low employment, daily life stress, family conflicts, loneliness, anxiety, hopelessness. These difficulties distort their basic needs for resettlement in a totally different environment. In order to meet the frustrated needs of North Korean defectors, we should begin with an effort to understand and empathize their deep trauma and survival drive. More specifically, needs-based alternatives should be widely explored to work out the above problems and to help them successfully adapt to our society.

콩 β-Conglycinin의 대장균 발현과 정제

오문헌,노영희 한국식품영양학회 1999 韓國食品營養學會誌 Vol.12 No.2

콩 단백질은 글리시닌과 β-콘글리시닌을 주요 성분으로 하며, 콩 β-콘글리시닌이 나타내는 알레르기 원인과 콜레스테롤 저하 작용을 밝히고저 유전자 공학적인 방법을 시도하였다. 즉 β-콘글리시닌의 α-subunit를 유전자 클로닝하고 대장균에서의 발현시스템을 구축하였다. 발현벡터는 pET21d이며 플라스미드를 구축하여 E. coli BL21(DE3)에 형질전환시켰고 발현된 단백질은 균체전체 단백질의 15%이며 90%이상이 가용화 상태로 축적되었다. 축적된 발현 단백질은 천연의 β-콘글리시닌과 동일한 트리머로 확인되었다. 발현 단백질은 20∼40% 황산암모늄 분별침전과 Q-Sepharose 이온교환크로마토그래피, Butyltoyopearl 소수성 컬럼크로마토그래피로 정제하였다. 이것은 콩단백질의 기능특성을 규명하는데 필요한 대장균 대량 발현계를 확립하고 발현 단백질의 정제방법을 확립한 결과이다. Soybean protein consists of two major components β-conglycinin and glycinin, which together constitute 70% of the total seed storage protein at maturity. β-Conglycinin is a trimeric glycoprotein and formed by the assembly of various combinations of three subunits, α,α´and β, which have molecular weights of 69,000, 72,000 and 42,000, respectively. Recently, β-conglycinin was identified as powerful LDL lipoprotein receptor activation, hypercholesterolemia and major allergenic proteins. To investigate these reasons, we constructed an expression system of cDNA encoding α-subunit of β-conglycinin in Escherichia coli and purified the expressed protein. The pro-β-conglycinin sythesized in Escherichia coli BL 21 (DE3) comprised approximately 15% of the total bacterial proteins and the expressed protein are formed soluble and trimer such as native protein in Escherichia coli cells. The highly expressed protein was purified to homogeneity by salt precipitation with 20∼40% ammonium sulfate, ion-exchange chromatography with Q-sepharose and hydrophobic column chromatography with Butyltoyopearl.

하악골에 발생한 원발성 결핵성 골수염의 치험례

김영수,김철훈,오수진 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.1

This is an extermely rare disease and a case of tuberculous osteomyelitis of mandible in a 45-year-old woman was reported. The patient was visited for complaining slight facial swelling on left side and purulent discharge from extracted socket. Roentgenograhic examination of the mandible revealed bone destruction on left side of mandibular body. Destructive lesion was removed with saucerization and specimen from the involved soft tissue and bone were sent for microscopic examination. This case proved to be primary tuberculous osteomyelitis caused by the absence of primary focus. After 3 months follow-up check, we noticed good prognosis of bone and soft tissue healing.

해외컨벤션센터의 설계특성에 관한 연구

高永勳,吳德成 충남대학교 지역개발연구소 2000 地域開發論叢 Vol.12 No.-

'Convention Center' that was reflected its requirement is a institution which try to attract Conference and Exhibition, Meeting of variety international scale. Generally, Convention Center is mix-used development for the attractive international Conference and Exhibition. Mixture functions get the Conference room, Exhibition, Lodging of International scale. And it must mixture planning that is each functions effectively achieve in variety an event. This study aims to understand architectural characteristics of Convention Center which is attracted variety international events and to suggest fundamental data of mixture planning of Convention Center, to analyze, a case divide to the cluster and building type. This study consists of following three parts. The first part takes theoretical review and research of a case of Convention Center which was development and management in the inside and outside of the country. And the second take a theoretical review of in terms of mixture planning of Convention Center. The third makes analysis of architectural characteristics of mixture of Convention Center as case study which are analyzed in term of location, mixture of the functions, scale of facilities, main facilities. Until now I examined architectural characteristics of mixture planing of Convention Center by means of case study. I think that I should have examined location where development Convention Center, connect to facilities and environment in area. And induct to preposition mixture of functions, ratio of facilities, connect of the each facilities, receptive facilities considering the developing Convention Center characteristics. In present, The Convention Center of development and management in country, is almost Conference and Exhibition functions and its a little. Therefore, it will be fundamental data of Convention Center that developing in the future.

하악골 전돌증 수술 후 하악골 이동량에 따른 발음 양상에 관한 비교 연구

신기영,이동근,오승환,성헌모,이숙향 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.1

After performing mandibular setback surgery, we found some changes in patterns and organs of speech. This investigation was undertaken to investigate the aspect and degree of speech patterns according to the amount of surgical setback in mandibular prognathic patients. Thirteen patients with skeletal Class Ⅲ malocclusion were studied preoperative and postoperative over 6 months. They had undergone the mandible setback operation via bilateral sagittal split ramus osteotomy(BSSRO). We split the patients into two groups. Group 1 included patients whose degree of mandibular setback was 6mm or less, and Group 2 above 6mm. Control group was two adults wish normal speech patterns. A phonetician performed narrow phonetic transcriptions of tape-recorded words and sen- tences produced by each of the patients and the acoustic characteristics of the plosives, fricatives, and flaps were analyzed with a phonetic computer program (Computerized Speech Lab(CSL) Model 4300B(USA) ). The results are as fallows : 1. Genera1ly, Patients showed longer closure duration of plosives, shorter VOT(voice onset time) and higher ratio of closure duration against VOT 2. Patients showed more frequent diffuse distribution than the control group in frication noise energy of fricatives. 3. In fricatives, frequency of compact from were higher in group 1 than in group 2. 4. Generally, a short duraction of closure for /ㄹ/ was not realized in the patient's flaps. Instead, it was realized as fricatives, sonorant with a vowel-like formant structure, or trill type consonant. 5. Abnormality of the patient's articulation was reduced, but adaptation of their articulation after surgery was not perfect and the degree of adaptation was different according to the degree of surgical setback.

태권도장 운영의 활성화 전략에 관한 연구

김주훈,윤오남,서영환,이계행 조선대학교 스포츠과학연구소 2001 스포츠科學硏究 Vol.12 No.-

The purpose of this study was to analyze and determine the students' satisfaction with quality of Taekwondo teachers, the teachers' instruction and programs, facilities, and management. 500 subjects in Kwangju answered questionnaires and 442 of the questionnaires were used for this study. 1. In comparison of the students' general characteristics with satisfaction with quality of Taekwondo teachers, there was no significant difference between sex while significant differences were observed according to school years, age, Dan(Poom, Keub), and training periods. 2. In comparison of the students' ·general characteristics with the teachers' instruction and Programs, there was no significant difference between sex while significant differences were observed according to school years, age, Dan(Poom, Keub), and training periods. 3. Sex and training periods were not related to satisfaction with facilities while school years, age and Dan(Poom, Keub) were significantly related. 4. In comparison of the students' general characteristics with the teachers' management, there was no significant difference between sex while significant differences were observed according to school years, age, Dan(Poom, Keub), and training periods.

생쥐 위장관의 Interstitial cells of Cajal(ICC)에 대한 면역조직화학적 연구

김영철,차경훈,신무경,임건한,김주영,안병수,김장만,양경철,박도영,오재욱,장인엽 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

Background and Objectives : Interstitial cells of Cajal(ICC) are the pacemakers in gastrointestinal tract that modulates gastrointestinal motiliey and these cells also transmit neural input from enteric nerves to smooth muscles. Recent work on tissues from patients with motility disorders that suggest that loss or defect in ICC could be related to pathophysiology in human and animal models. Immunolabelling of ICC in intestinal wall is recently developed by using specific marker, anti-c-kit antibody. Immunohistochemistry was done for ICC network in attempt to provide a morphological basis for the mechanism regulating gastrointestinal motility Methods : Cryosection was done, and whole-mount preparations of mouse stomach, gastrointestinal tract were immunolabelled using the anti-c-Kit. Immunolabelled ICC networks were observed under a confocal laser scanning microscopy. Results : According to three dimensional reconstruction study, we found that the c-Kit-positive celluar networks were widely distributed in the gastrointestinal muscle (1) circular muscle layer(IC-IM), (2) myenteric plexus(IC-MY), (3) deep muscular plexus(IC-DMP) in ileum, (4) submucosal plexus(IC-SMP) and longitudinal muscle layer(IC-LM) in colon. Conclusion : The characteristic profiles of ICC celluar networks provide a morphological basis upon the mechanism regulating gastrointestinal motility. Additional studies for the enteric nerves-ICC interaction are need to evaluate the detailed roles of Icc in gastrointestinal tract.