Regulatory Effect of Matcha Green Tea on Fine Dust-Exposed Cytotoxicity in Respiratory System

Jong Min Kim,Jong Hyun Moon,Min Ji Kim,Hyo Lim Lee,Hye Rin Jeong,Min Ji Go,Tae Yoon Kim,Seung Gyum Joo,Jong Cheol Kim,Ho Jin Heo 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

This study was performed to evaluate the protective effect of matcha green tea on particulate matter (PM)2.5-indued nasal and pulmonary cytotoxicity. The matcha green tea increased the cell viability and inhibited the ROS production in PM2.5-induced cytotoxicity in nasal RPMI2650 and pulmonary A549 cells. The matcha green tea regulated the expression of apoptosis, such as p-Akt, BCl-2, caspase-3, caspase-1 and HO-1, and inflammation, such as TLR4, TLR4 and Nrf2, in PM2.5-indued RPMI2650 cells. In addition, the matcha green tea showed regulatory effect of the apoptosis and inflammatory effect by increasing the BCl-2 and suppressing the caspase-3, TLR4, TNF-α and COX-2 in A549 cells. In addition, the matcha green tea suppressed antioxidant deficits by regulating the reduced GSH contents, SOD activities and MDA levels, and ameliorated the mitochondrial dysfunction by regulating the mitochondrial ROS production, mitochondrial membrane potential and ATP contents in pulmonary tissue. Ultimately, consumption of matcha green tea down-regulated the inflammatory proteins such as TNF-α, p-JNK, p-IκB-α, p-NF-κB and COX-2 in lung tissue.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

微生物的 防除에 있어서 日光에 露出된 흰불나방 核多角體病 Virus의 病原性에 關한 硏究

林鍾聲,李虎雄 경북대학교 1982 새마을 硏究論叢 Vol.2 No.-

In order to clarify pathogencities of the nuclear polyhedrosis virus of the Fall Webworm, Hypantria cunea, exposed to sunlight bioassay had been experimented in various concentrations and periods with H. cunea NPV Smeared with egg albumin-charcoal mixture on the surface and back-side of foliage. The results were obtained as follows 1N-HCl or carnoy's fluid pretreatment improved Staining properties of inclusion bodies. The polyhedron were triangular and tetragonal in shape and about 2.0u in size, and virus particles consisting of 2∼12 rods in a bundle were rod-shaped of about 330×35mu in size. The site of infection were in the nucleus of the hypodrmis, fat body, muscle, blood cell, trachea, mid gut cell. Compared with pathogenecity in same concentration of H. Cunea NPV, exposed to sunlight from 1 to 7 days in two days interval, the longer the period sunlight exposure was, the lower pathogenecity. Inoculation of the H. Cunea NPV smeared with egg albumin-charocoal mixture on the back-side of foliage showed the highest pathogenecity in treatments. LD_50 Values were 8.3days in short period and 12.4days in long period.

자각성 이명 환자에서 Ginkgo biloba extracts(Ginexin-F)의 제 3상 임상 효과

임현호,정근,최종욱 釜算慶南耳鼻咽喉科學會 1996 임상이비인후과 Vol.7 No.2

남성유방에 발생한 지방육종

최종범,임성철,기근홍,전호종,서재홍 대한병리학회 1992 Journal of Pathology and Translational Medicine Vol.26 No.3

장기간의 지구력 훈련이 안정시 및 최대운동시 생리적 변인에 미치는 효과

임종호,박호윤 대전대학교 기초과학연구소 1995 自然科學 Vol.6 No.-

생리적 변인에 대한 장기간의 훈련 효과를 알아보았다. 대상은 15세부터 28세까지의 남성으로 지구력 훈련을 장기간 지속적으로 해온 운동 선수 집단(21)과 운동 프로그램에 참여한 경험이 없는 일반인 집단(18)으로 나누었으며, 각각 중학교, 고등학교 및 일반 성인집단으로 세분하였다. 모든 피보험자에 대해 안정시 생리적 변인들을 측정하였고, 최대 산소 섭취량을 측정하기 위해 점증적 탈진 운동에 의한 최대 대사 능력을 알아보았다. 자료의 처리를 위해 two-way ANOVA를 사용하였으며, 연구의 가설 검증에 대한 유의도 수준을 5%로 하였다. 결론적으로, 운동 선수 집단과 일반인 집단의 신체적 조건을 유사하게 고려하더라도 지속적인 장기간 지구력 훈련의 효과는 안정시와 최대 운동시의 생리적 변인에 큰 영향을 미친다고 하겠다. The purpose of this study was to investigate the effect of long-term athletic training on the physiological variables. The sample consists of 21 male athletes and 18 non-athletes. 7 male athletes and 6 non-athletes were selected in the following three respective categories : middle school, high school, and adult(aged 15 to 28 years). The athletes were long distance and marathon runners and non-athletes not participating in athletic program. Rest physiological variables were measured and maximal matabolic capacity by incremental exercise were used to assess maximal oxygen uptake in all subjects. Two-way ANOVA were conducted for the statistical analysis. The 5% level of significance was used as the critical level for acception of hypotheses for this study. On the basis of the results analyzed in the study, the conclusion could be drawn as follows: 1. Rest heart rate and rest systolic blood pressure were significantly lower in athletes than in non-athletes, and adults(marathon runners) lowest. 2. Maximal systolic blood pressure were significantly higher in athletes than in non-athletes, and adults(marathon runners) highest. 3. Maximal oxygen uptake in athletes was significantly higher compared to non-athletes.

노인의 게이트볼 활동 참여정도에 따른 자아개념인지에 관한 연구

임종호 대전대학교 기초과학연구소 2003 自然科學 Vol.14 No.1

본 연구는 노인의 게이트볼 활동 참여정도에 따른 자아개념 인지에 대해 알아보기 위하여 천안 지역의 게이트볼 활동 참여 노인 총 258명을 대상으로 하여 게이트볼 활동 참여정도(기간, 빈도, 강도)에 따라 자아개념이 어떻게 나타나는지를 분석하였는데 그 주요 결론은 다음과 같다. 첫째, 노인의 게이트볼 활동 참여기간에 따른 자아개념은 사회체육활동 참여기간에 따라 자아개념에 차이가 있었으며 참여 기간이 길면 자아개념이 높은 것으로 나타났다. 둘째, 노인의 게이트볼 활동 참여빈도에 따른 자아개념은 사회체육활동 참여빈도에 따라 자아개념에 차이가 있으며 참여빈도가 많아지면 자아개념이 높은 것으로 나타났다. 셋째, 노인의 게이트볼 활동의 참여강도에 따른 각 요인별 자아개념에 대한 평균과 표준편차를 살펴보면 요인별 별 차이가 없는 것으로 나타났으며 통계적으로도 유의한 차이를 보이지 않았다. 이러한 결과는 게이트볼 활동의 참여강도는 자아에 큰 영향을 미치고 있지 않음 나타내 준다. The study analyzed how the seniors to react in self-concept based on frequency of participation in the gateball activity. (period, frequency, strength) through the survey research of 258 seniors who participate in the gateball activity in Cheonahn area in order to find out how a gateball activity influence to seniors' self-concept. Hereunder are the major results in the research. 1. Seniors' self-concept based on the period of gateball activity shows differences by the period of participation in the social physical activity. The result shows that longer period of participation gives higher self-concept. 2. Seniors' self-concept based on the frequency of participation in gateball activity shows difference by the frequency of participation in the social physical activiy. The result shows that more frequent participation gives higher self-concept. 3. As the average and the standard deviation of seniors' self-concept based on each kind of cause from strength in playing the gateball activity were shown, the differences were scarcely found by the kinds of cause. And difference also could hardly be found in the statistical research. Thus, the result shows that strength in playing a gateball activity does not influence much to seniors' self-concept.

피치제어를 이용한 풍력발전시스템의 출력제어

임종환,최민호,허종철,김건훈 제주대학교 산업기술연구소 2000 尖端技術硏究所論文集 Vol.11 No.2

This paper derives a modeling of a wind turbine and generator, and presents a power control algorithm for a full pitch-controlled wind turbine system. The design of a controller, in general, is Performed by linearizing the torque in the vicinity of a operating point assuming the tip speed ratio is constant. For power control, however, the tip speed ratio is no longer a constant. In this study, a reference pitch model is derived in terms of a wind speed, angular velocity, and pitch angle, which makes it possible to design a controller without linearizing the non-linear torque model of the blade. The validity of the algorithm is demonstrated with the results produced through sets of simulation.

고교투기종목 코치의 리더십이 지도만족 및 지도 효율성에 미치는 영향

임종호,김진표,김윤태 대전대학교 기초과학연구소 2000 自然科學 Vol.11 No.2

이 연구는 투기종목 지도자의 변화적 리더십과 상통적 리더십이 지도만족 및 지도 효율성에 미치는 영향과 상대적 기여도를 규명하는데 목적이 있다. 연구대상은 투기종목(유도, 태권도, 레슬링, 복싱)의 고등학교 258명을 대상으로 리더십, 지도만족, 지도 효율성을 조사하였다. 수집된 자료는 윈도우용 SPSSV. 9.0을 사용하여 분석하였으며, 변환적 리더십 ? 상통적 리더십, 지도만족 및 지도 효율성의 하위척도에 대하여 다중회귀분석(maltiple regression)을 이용한 경로분석(path analysis)을 실시하였다. 그 결과 다음과 같은 결론을 도출하였다. 1. 변환적 리더십과 상통적 리더십이 내재적 만족을 설명하는 능력은 37.3%이고, 외재적 만족을 설명하는 능력은 57.8%이었다. 그리고 리더십과 지도만족이 지도효율성을 설명하는 능력은 42.5%이었다. 2. 경로도형에서 내재적 만족에 대하여는 카리스마, 개별적 배려, 조건적 보상, 예외적 관리가 유효하고, 외재적 만족에 대하여는 카리스마와 예외적 관리가 유효하며, 지도 효율성에 대하여는 카리스마, 개별적 배려, 조건적 보상, 내재적 만족이 유효하였다. The purpose of this study is to analyze the effects of coaches' leadership styles on players' satisfaction with leadershp and coaching effectiveness. To this end, 258 high school combat sports players were sampled to be surveyed. The collected data were analyzed using SPSS for Windows V 9.0 program to verify the differences of subcategories between schools with the independent determine the causes with the multiple regression analysis. The results of this study are as follows: Two leadership styles' explanatory power of student players' internal satisfaction with leadership was 37.3%, while that of external satisfaction with leadership was 57.8% And leadership styles and satisfaction with leadership explained 42.5% of the coaching effectiveness. On the other hand, as far as internal satisfaction was concerned, "charisma", "personal consideration", "conditional compensation" and "special management" were found significant. And as far as external satisfaction was concerned, such subcategories as "charisma", "personal considerationN, "intellectual stimulation" and "special management" were found significant For coaching effectiveness, such subcategories as "charisma", "personal consideration", "conditional compensation" and "external satisfaction" were found significant.

피치제어를 이용한 풍력발전시스템의 출력제어

임종환,최민호,허종철,김건훈 濟州大學校 産業技術硏究所 2000 산업기술연구소논문집 Vol.11 No.1

This paper derives a modeling of a wind turbine and generator. and presents a power control algorithm for a full pitch-controlled wind turbine system. The design of a controller. in general. is performed by linearizing the torque in the vicinity of a operating point assuming the tip speed ratio is constant. For power control. however. the tip speed ratio is no longer a constant. In this study. a reference pitch model is derived in terms of a wind speed. angular velocity. and pitch angle. which makes it possible to design a controller without linearizing the non-linear torque model of the blade. The validity of the algorithm is demonstrated with the results produced through sets of simulation.