정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

컴포넌트 기반의 건강관리 시스템 개발을 위한 UI 툴

정호진;주문일;박광호;박태향;김희철 인제대학교 2012 仁濟論叢 Vol.27 No.1

Component-based systems are generally known as useful for maintenance and extension. However, there are a number of difficult aspects in designing them, and skillful knowledge of component-based design is strongly requested. Against the problem, this paper presents a User Interface tool that helps to develop component-based healthcare systems more easily and effectively. This UI tool has been developed, aiming at enabling easier and faster development of such systems. Further it supports standardization and interoperability. We expect that use of the UI tool helps to add, delete, change medical contents, and maintain related systems with less effort and better performance.

군집분석과 다차원척도법으로 본 유치열의 우식패턴

정승열,이광희,라지영,안소연,김윤희 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.2

The purpose of this study was to identify patterns of caries in the dentition of preschool children using cluster analysis and multidimensional scaling. 815 preschool children aged 36-71 months old were examined for caries experience. The first four clusters in the cluster analysis were (1) molars, (2) upper incisors, (3) lower 1st molars, and (4) upper 1st molars in teeth, (1) occlusal surfaces of lower molars and upper 2nd molars, (2) mesial surfaces of upper central incisors, (3) occlusal surfaces of lower 1st molars, and (4) separation between occlusal surfaces of upper and lower 2nd molars in tooth surfaces, and (1) proximal surfaces of upper anterior teeth, (2) occlusal surfaces of lower molars, (3) buccolingual surfaces of upper anterior teeth and (4) buccolingual, proximal, and occlusal surfaces of upper molars and buccolingual and proximal surfaces of lower molars in tooth surfaces groups. In the multidimensional scaling analysis, teeth could be divided into lower 1st molars, upper 1st molars, upper central incisors, upper lateral incisors, lower 2nd molars, upper 2nd molars, and the rest(canines, lower incisors), tooth surfaces could be divided into occlusal surfaces of lower molars, mesial surfaces of upper central incisors, occlusal surfaces of upper molars, and the rest, and tooth surface groups could be divided into proximal surfaces of upper anterior teeth, buccolingual surfaces of upper anteiror teeth, occlusal surfaces of lower molars, and the rest in the order of the distance from others. In the cluster analysis and the multidimensional scaling analysis, caries patterns were different according to the age. 유치열에 존재하는 우식패턴을 연구하기 위하여 유치열을 가진 유아들을 대상으로 치면별 우식경험도 조사를 실시하고 군집분석과 다차원척도분석을 실시하였다. 연구대상은 367H 월 이상 71 개 월 이하의 어린이 815명 이 었다. 군집분석에서 먼저 분리된 네 개의 군집은, 유치는 (l) 유구치, (2) 상악 유절치, (3) 하악 제1유구치, (4) 상악 제1유구치, 유치면은 (1) 하악 유구치 교합면과 상악 제 2유구치 교합면, (2) 상악 유중절치 근심면, (3) 하악 제1유구치 교합면, (4) 상하악 제2유구치 교합면의 분리, 유치면군은 (l) 상악 유전치 인접면, (2) 하악 유구치 교합면, (3) 상악 유전치 협설면, (4) 상악 유구치 협설면, 인접면, 교합면 및 하악 유구치 협설면과 인접면이었다. 다차원척도분석에서 상호간에 가장 멀리 떨어진 순서로 보았을 때, 유치는 하악 제 1유구치 , 상악 제 1유구치 , 상악 유중절치, 상악 유측절치, 하악 제 2유구치, 상악 제 2유구치, 기타 유치(유견치, 하악 유절치)로 나눌 수 있었고, 유치면은 하악 유구치 교합면, 상악 유중절치 근심면, 상악 유구치 교합면, 기타 유치면으로 나눌 수 있었으며, 유치면군은 상악 유전치 인접면, 상악 유전치 협설면, 하악 유구치 교합면, 기타 유치면군으로 나눌 수 있었다.

Resazurin Disc 우식활성검사의 척도 세분에 따른 타당도 변화에 대한 연구

정영석,이광희,김대업 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.1

The purpose of study was to investigate the variation of validity of the Resazurin Disc Caries Activity Test by subdivision of the measuring scale of the test. The 3-level color scale of RD test was revised and 4- and 5-level scales were made. The subjects of study were preschool children, 227 for 3-level group, 238 for 4-level group, and 256 for 5-level group. The validity of the RD test using each scale was analyzed by using the caries experience as criteria. The results were as follows:

하악 제1대구치 이소맹출의 치험례

소정원,이광희,라지영,안소연,김윤희,반재혁 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.1

Ectopic eruption is caused by an abnormal direction of eruptive path, most common in maxillary first molar, mandibular lateral incisor, and maxillary canine, and sometimes mandibular first molar. Ectopic eruption of first molar leads to abnormal root resorption of second deciduous molar, which, if left untreated, could cause premature loss of second deciduous molar; mesial tilting and rotation of first permanent molar; lack of space for eruption of second premolar; and occlusal problems. Therefore early treatment is advised when diagnosed as ectopic eruption. Treatment of ectopic eruption in the first permanent molar involves providing proper guidance for the direction of eruption using interproximal wedging and distal tipping methods while preserving second deciduous molar. This case report shows satisfactory results of the ectopic eruption of mandibular first molars in young patients who were treated with Humphrey appliance and Halterman appliance. 이소맹출은 치아가 비정상적인 위치로 맹출하는 경우를 말하며, 주로 상악 제1대구치, 하악 측절치, 상악 견치에서 발생하며 하악 제1대구치에서는 드물게 발생한다. 제1대구치의 이소맹출은 흔히 제2유구치의 비정상적인 치근흡수를 야기하며, 이를 방치하게 되면 제2유구치의 조기상실, 제1대구치의 근심경사 및 회전, 제2소구치의 맹출 공간 부족 및 교합문제 등을 야기하게 되므로 이소맹출로 진단될 경우 조기 치료가 추천된다. 이소맹출은 대개 통상적인 방사선검사를 통해 발견되나, 간혹 제2유구치의 치근흡수가 심할 경우 치수가 감염되어 동통을 야기하는 경우도 있다. 이소맹출의 치료는 제2유구치를 보존하면서 제1대구치의 맹출 방향을 바로 잡아 주는 것으로 크게 치간이개(interproximal wedging)와 원심경사이동(distal tipping)을 이용한 방법을 사용한다. 본 증례들은 하악 제1대구치의 이소맹출을 보이는 환아들로, Humphrey appliance와 Halterman appliance를 이용하여 양호한 치료 결과를 얻었기에 보고하는 바이다.

내변형 폴리머 개질 아스팔트 혼합물의 개발

김광우,도영수,정규동,조희원,안경애,이상범 강원대학교 석재복합신소재제품연구센터 1997 석재연 논문집 Vol.2 No.-

본 연구에서는 국내산 LDPE 및 SBS 폴리머를 아스팔트 함량의 3%, 4%, 5%와 카본블랙을 10% 사용하여 AP-3 아스팔트를 개질한 화강암, 편마암, 석회암 혼합물을 제조하고 그 특성의 변화를 고찰하였다. 폴리머는 3가지 골재 혼합물 모두에 전반적으로 인장강도와 강성의 증가를 가져오는 것으로 나타났다. 그러나 그중 편마암에서는 그 효과가 비교적 적고 화강암과 석회암에 더 큰 것으로 나타났다. 또한 두 폴리머간 개질효과의 차이는 거의 없었으나 LDPE가 약간 높게 나타나 보였다. 카본 블랙의 사용은 폴리머 개질 혼합물의 경우에는 별로 효과적이지 못하였으나, 일반혼합물의 경우는 아스팔트의 강도특성에 영향을 미침임을 알 수 있었다. SBS and LDPE polymers with contents of 3%, 4%, 5% and a carbon black with content of 10% by wt. of asphalt were used in three aggregate mixtures, a gneiss, a granite and a limestone waste aggregates. Indirect tensile strength and stiffness index were evaluated for each mixture. The two polymers were effective on improving those strength characteristics for all three aggregate mixtures. Especially, limestone and granite aggregates were improved more than gneiss. Among two polymers, there were almost no difference in performance even though LDPE showed a little higher values. Carbon black improved the properties of plain asphalt mixtures, although it was not the case for the PMA mixtures.

어린이에게 사용되는 가철식 교정장치용 clasp의 유지력비교

한정재,김대업,이광희 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.2

본 연구의 목적은 어린이에게 사용되고 있는 가철식 교정장치를 위한 clasp에 대하여 각 디자인간 유지력의 차이를 평가하고자 함이다. 상악 유견치와 제 1, 2유구치 및 제 1 대구치를 단일 치아 모형과 두 개의 인접 치아 형태로 금속 주모형을 제작한 후 clasp를 종류에 따라 형성하여 각 모형에 대한 clasp의 유지력을 측정하였다. Clasp의 종류에 따른 유지력을 서로 비교하여 다음과 같은 결론을 얻었다. 1. 단일치아에서 유지력을 얻는 clasp중 Jackson clasp와 Adams clasp는 다른 clasp에 비하여 높은 유지력을 나타냈으며, C clasp는 가장 낮은 유지력을 나타냈다. (p<0.05) 2. 두 개이상 치아의 치간부 undercut을 이용하는 clasp중 eyelet clasp가 가장 큰 유지력을 보여주었고 triangular clasp, ball clasp순으로 낮은 유지력을 보여주었다. (p<0.05) The purpose of this study was to compare the retentive forces of various types of clasps for removable orthodontic appliances for primary and mixed dentition. Seven metal models of a single tooth and two teeth were made, including axillary left primary canine, first primary molar, second primary molar and first molar. Retentive forces of Adams clasp, circumferential clasp(C clasp), Jackson clasp, Duyzing clasp, arrowhead clasp, ball clasp, eyelet clasp, and triangular clasp were measured by Universal Testing Machine(Zwick Z020, Germany). The obtained results were as follows. 1. Jackson clasp and Adams clasp showed the highest retentive force among single tooth clasps. 2. C clasp showed the lowest retentive force, and there was no statistically significant difference in retentive force between mesial end C clasp and distal end C clasp. 3. Eyelet clasp showed the highest, and ball clasp showed the lowest retentive force among clasps for interdental undercut. 4. Triangular clasp showed higher retentive force than ball clasp.

유치원아동에서 고자당배지를 이용한 우식활성검사치와 우식경험유치면지수와의 상관성

이광희,김유정 大韓小兒齒科學會 1991 大韓小兒齒科學會誌 Vol.18 No.2

116 preschool-children were examined for caries activity and dmfs index.20% Sucrose-sulphasomidine-broth was used to cultivate plaque sample that was obtained from buccal side of maxillary posterior teeth. After incubation for 48 hours and 72 hours, acid production of Streptococcus mutans was evaluated by the color change of pH indicator(5% Bromcresol green) in the medium. 1.There was significant correlation between dmfs index and caries activity test scores(P<0.05). 2.Age and sex did not significantly affect caries activity test scores. 3.By cultivating plaque sample in 20% sucrose-sulphasomidine-broth over 72 hours caries-inactive children can be differentiated from caries-active children.

알칼리 처리에 의한 폴리에스테르 필름의 강도 및 염색성의 변화

오정숙,이광주,전정희 효성여자대학교 가정대학 학도호국단 1985 家政大論集 Vol.4 No.-

When polester fibers are hydrolyxed in alkaline solution, they dissolve successively from their surface and change their dyeability. We examined the weight loss ofpolyester films treated with NaOH solution under various conditions and the equilibrium.amount of disperse dyes absorbed in films. An uptake of dyes on films treated withan alkaline solution has beer discussed in relat'on to the changes of weight loss of films. The changes of weight loss increased linearly on hydrolyzing time because ofdissolving uniformly froml their surface of films. However. in high concentrations ofalkaline solution, the changes of weight loss increased drastically owing to OH-attackedto the inner regions of films. The tensile strength of hydrolysed films decreased a sodden drop when the weightloss were low. But it decreased gently when weight loss were high. The dye uptake of hydrolyzed films increased a very small amount below 20% ofweight loss. However, it increased remarkably above 20% of weight loss.

위암세포에 의한 종양침윤 림프구의 면역반응 억제기전에 관한 연구

박정규,송규상,서광선,최정목,배진선,장일성,윤완희,노승무,조은경,백태현 大韓免疫學會 1995 大韓免疫學會誌 Vol.17 No.3

Tumor-infiltrating lymphocytes ('1°ILs) interact most closely with tumor cells and thus are more likely to reflect tumor host interactions accurately. But it is unknown whether such T cells are nonspecific inflammatory cells or a subset of specific host immune responses. In this study, there was no clear correlation between the infiltration of T lymphocytes in stomach cancer and the overexpression of c-ErbB-2 or increasing class I MHC expression on tumor cells. A positive correlation was seen between the presence of TILs in the tumor and tumors with diploidy by flow cytometric DNA analysis. The proliferative responses of Ills stimulated with IL-2, anti-CD3 mAb, or both were examined. When compared to normal mucosal-associated lymphoid tissue lymphocytes, the proliferative response of TILs to high dose IL-2 was minimal. A similarly poor response to anti-CD3 mAb plus IL-2 was also observed. The freshly isolated TILs exhibit reduced ability to proliferate in response to IL-2, anti-CD3 mAb or both. The microenvironment of the tumor suppresses the proliferative capacity of the TILs. The mechanism of this suppression remains unknown. It could be mediated by suppressor cells, by soluble substances within the tumor, or both. To examine this question, supernatants of stomach cancer cells (SNSNU-1) were tested for the presence of immunosuppressive factors. Human peripheral blood T-cells and tumor-draining lymph node lymphocytes (TDLNL) were incubated for 3 days with SNSNU-1 and then assessed for proliferative responses to PMA, anti-CD28 mAb, or both and for the inducibility to express IFN- r or IL-4 mRNA to PMA. Peripheral blood T-cells pretreated with SNSNU-1 were unable to proliferate in response to PMA, anti-CD28 mAb or both. SNSNU-1 also produces inhibitory activities of TDLNL proliferative response to PMA or anti-CD28 mAb and PMA (49%, 52%, respectively). In contrast, culture supernatants obtained from HEp-2, K562 or Daudi showed normal proliferative responsiveness of peripheral blood T-cells and TDLNL by PMA, anti-CD28 mAb or both.