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가미강활산(加味羌活散)이 집먼지 진드기 추출물로 유도된 NC/Nga mouse의 아토피 피부염에 미치는 영향
김윤희,한재경,김윤희,Kim, Yun-Hee,Han, Jae-Kyung,Kim, Yun-Hee 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.1
Objectives The purpose of this study is to investigate the effect of KKHS on atopic dermatitis in an in-vivo experiment using an NC/Nga atopic dermatitis mouse, which has histological and clinical similarities to this condition in humans. Methods To investigate the effect of KKHS on atopic dermatitis (AD), we evaluated atopic dermatitis-like skin lesions by clinical skin index and analyzed immunological parameters in peripheral blood mononuclear cells(PBMCs), splenocytes, draining lymph node(DLN) and performed skin histology in ears and dorsal skin of atopic dermatitis of NC/Nga mouse in vivo. Results In vivo, clinical skin severity score was significantly lower in the KKHS group than in the control group. IgE, IL-6, TNF-${\alpha}$, IgM, IgG2a and IgG2b levels in serum decreased remarkably in the KKHS group than in the control group, and the level of IFN-${\gamma}$ production which is secreted from Th1 cell was increased by KKHS. After this experiment we analyzed immunological cells ($CD3^+$, $CD19^+$, $CD4^+$, $CD8^+$, $CD3^+CD69^+$, $CD4^+CD25^+$ and $CD49b^+$) by flow cytometry. It results that the total absolute number of $CD3^+$, $CD19^+$, $CD4^+$ and $CD8^+$ cells were recovered as much as normal state, and the level of $CD3^+CD69^+$ in isolated DLN and PBMCs were significantly decreased, and total absolute number of $Gr-1^+$, $CD11b^+$ and $CD3^+$ in dorsal skin of NC/Nga mouse were decreased by KKHS. We analyzed ear, DLN, and neck-back skin after biopsy and dyeing by hematoxyline/eosin(H&E), toluidine staining (mast cells marker). KKHS were very effective to the histological symptoms which are in dermal and epidermal thickening, hyperkeratosis and inflammatory cell infiltration. Ear thickness was significantly decreased compared with the control group and the size of inflammatory lymphocytes cells (ILC) and plasma cells (PC) in DLN were also decreased. Conclusions KKHS on atopic dermatitis in an in-vivo experiment using an NC/Nga atopic dermatitis mouse was very effectiveness to the atopy dermatitis treatment.
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원내검사 및 원외검사 결정을 위한 손익분기점 분석 경험
김윤희 대한진단검사의학회 2006 Annals of Laboratory Medicine Vol.26 No.6
배경 : 심화된 경쟁구도 의료시장에서는 의료서비스의 지속적품질개선을 통한 원가절감이 요구된다. 검사실에서는 정기적으로원내 또는 원외검사(make-or-buy) 결정을 위한 자료들을 검토하는 것이 요구되는 데, 이때 유용한 도구가 손익분기점(break-even point, BEP) 분석이다. 본 연구에서는 최근 본원 검사실에서 의뢰건수의 증가추세를 보인 면역측정 외부위탁검사들을 검사실 내부에서 시행(make)할 경우의 원가계산을 하여, BEP 분석을 시행하였다. 대 상 및 방 법 : AFP, CEA, PSA, ferritin, fT4, T3, TSH,CA 125, CA 19-9 및 HBeAb 의 10가지 검사를 Abbott Ax-SYM 장비로 검사실 내부에서 자체 시행할 경우의 고정비 및 변동비를 계산하였다. 손익분기건수(break-even volume)는 연간고정비를 단위당 외부위탁구매가와 단위당 변동비의 차로 나누어서, BEP 비율은 손익분기건수에서의 총 구매가를 현재의 연 검사건수에서의 총 구매가로 나누어서 구하였다.\\Test volumeLoss\6,149,000 \18,447,000 \30,745,000ProfitTotal purchasing costsTotal purchasing costsContribution margin rateBreak-even pointTotal costsBreak-even pointBreak-evenvolume: 155930,000,00025,000,00020,000,00015,000,00010,000,0005,000,000012,000,00010,000,0008,000,0006,000,0004,000,0002,000,0000-2,000,000-4,000,000-6,000,000-8,000,000-10,000,0000 500 1,000 1,500 2,000 2,500 3,000A B464 김윤희결과 : AFP, CEA, PSA, ferritin, fT4, T3, TSH, CA125,CA19-9 및 HBeAb의 연 고정비는 평균 8,279,187원, 단위 당 변동비는 평균 3,786원이었다. 손익분기건수는 평균 1,599건, BEP비율은 평균 852%이었다. 고정비에 질 관리 비용을 포함하지 않은 경우의 BEP 비율은 평균 74%이었다.
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CuZnSOD와 APX를 엽록체에 발현시킨 담배식물체의 Highlight와 Chilling 스트레스에 대한 광합성 효율
김윤희,권석윤,방재욱,곽상수,Kim, Yun-Hee,Kwon, Suk-Yoon,Bang, Jae-Wook,Kwak, Sang-Soo 한국식물생명공학회 2003 식물생명공학회지 Vol.30 No.4
환경스트레스에 대한 항산화효소의 보호효과를 이해하고 효과적인 스트레스내성 식물을 개발하기 위하여 CuZnSOD와 APX를 엽록체에 발현시킨 형질전환식물체 (CA식물체)에 강한 빛 (highlight, 1,100$\mu$mol m$^{-2}$ sec$^{-1}$)과 4$^{\circ}C$ chilling을 처리하였다. CA식물체 잎절편에서의 보호효과를 CuZnSOD을 도입한 SOD식물체, APX을 도입된 APX식물체 및 비형질전환식물체 (NT식물체)의 것과 비교하였다. CA식물체의 광계2에서의 광합성 효율 (Fv/Fm)은 highlight와 4$^{\circ}C$ chilling복합처리 1시간째에서 NT식물체에 비해 약 15%의 보호효과를 나타내었고, 광계1에서의 P700 redox state는 처리 후 3시간째에 약 23%의 보호효과를 나타내었다. SOD식물체와 APX식물체의 복합처리에 대한 보호효과는 CA식물체와 NT식물체의 중간 효과를 나타내었다. 이러한 결과는 엽록체에서 CuZnSOD와 APX의 동시발현이 highlight와 chilling에 의한 산화스트레스를 극복하는 데 매우 중요하게 관여함을 직접적으로 제시하는 것이다. In order to understand the protection effects of antioxidant enzymes against oxidative stress caused by various environmental stresses, transgenic tobacco (Nicotiana tabacum cv, Xanthi) plants expressing both copper/zinc superoxide dismutase (CuZnSOD) and ascorbate peroxidase (APX) in chloroplasts (referred to as CA plants) were subjected to highlight (1,100$\mu$mol m$^{-2}$ sec$^{-1}$) and chilling at 4$^{\circ}C$. The protection effects of CA plants using leaf discs were compared with those of transgenic plants expressing either CuZnSOD or APX in chloroplasts (SOD plants or APX plants, respectively) and non-transgenic (NT) plants. CA plants showed about 15% protection in the photosynthetic efficiency (Fv/Fm) of photosystem II relative to NT plants 1 hr after treatment of both highlight and chilling, whereas they showed about 23% protection in the redox state of P700 in photosystem I at 3 hr after treatment. SOD plants or APX plants showed an intermediate protection effect between CA plants and NT plants. These results demonstrated that the coexpression of CuZnSOD and APX in chloroplasts importantly involves in the protection effects against oxidative stress caused by various environmental stresses.
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산림치유 프로그램 개발을 위한 숲 방문 빈도에 따른 요구분석
김윤희 한국인간·식물·환경학회 2016 인간식물환경학회지 Vol.19 No.2
Forest visiting frequency level is likely to indirectly affect the preferences and needs of the program. The forest visiting frequency degree is an important factor which can affect the development and conduct of the program. Therefore, forest needs analysis was conducted for the development of forest therapy program in accordance with the frequency of visits. First, after examining the frequency of forest visits degree according to demographic characteristics, the group of 217 people visiting the forest at least once a week or a month was classified as a high-frequency group. The group of 403 people visiting the forest at least once a quarter or a year and almost no visit was classified as a low-frequency group. The need difference according to the frequency of visits was analyzed through descriptive statistics analysis, frequency analysis, crosstabs by use of SPSS 21.0 program. The most important factors of Implementation period, season, paid the participation fee made differences depending on the frequency of visit. This study, as an exploratory research, making us understand the needs related to forest healing program for the forest visit groups of high and low frequencies, will be an important basis for the development and operation of forest therapy program.
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김윤희,김정숙 대한간호학회정신간호학회 1998 정신간호학회지 Vol.7 No.2
암환자 집단이 인지하고 있는 최근 5년간 생활스트레스, 사회적지지 및 대응방법를 조사하고 변수들과의 상관관계를 파악하여 정상인과 비교해봄으로써 암의 발병과의 관계를 파악하고자 1996년 10월1일부터 1997년 2월15일까지 암환자 81명과 일반적 특성이 유사한 정상인 87명을 대상으로 조사·분석하여 다음과 같은 결과를 얻었다. 1. 암환자가 인지하고 있는 생활스트레스 점수는 평균 172.54로서 2년내 질병발생 가능성 35%의 점수범위이었고, 정상인의 스트레스 점수 109.24보다 유의하게 높았다. 2. 암환자가 지각해온 사회적지지 점수는 평균 86.70으로서 정상인의 88.51보다 낮았으나 유의하지 못하였다. 3. 암환자의 과거 대응방법 이용점수는 평균 80.28로서 정상인의 대응방법 이용점수 88.09보다 대응방법 이용정도가 유의하게 낮았다. 4. 정상인은 생활스트레스와 대응방법, 사회적지지와 대응방법 점수간에 유의한 정상관계가 있었으나 암환자의 생활스트레스와 사회적지지 및 대응방법간에는 어떤 관계도 나타나지 않았다. This study was aimed to examine the role of public health office such as understanding the present situations of mentally disordered persons in the region of jurisdication requiring study, grasping highly possible group to be mentally disordered, investigation of the request of the residents for mental health service and mental health promotion of local residents as basic investigation study to examine the roles of public health office which should make management of chronic psychiatric patients and performs effectively the work of mental health promotion of local residents. This study has been conducted for 2 years from Jan. 1997 through Dec. and 118 psychiatric patients (48 mean and 70 women) registered with public health office, 100 residents who answered to the investigation requesting mental health service and 1,283 residents to find the highly dangerous group of mental disorder among 55,005 residents of K region (Kapyung-Gun contry), and total 1,501 residents have participated at the study, and the collected materials have been statistically managed by frequency degree and percentage according to the purpose of the study. The Result of the study First, Total number of psychiatric patients was 118 by 48 men(40.7%) and 70 women(59.3%), and they are classified by medical examination schizophrenia by 44(37.3%), mood disorder by 21(17.8%), eplepsy by 19(16.1%) and mental retardation by 11(9.3%). The age distribution showed that 28.8% was thirties, 23.7% fourties, 17.0% sixties and 16.1% tweenties. Second, They requested the health promotion of the aged by 35.0% most as the business required for mental health promotion of the residents while management of the aged who live alone showed 14.0%, steady mental health education 10.2%, stress management education 10.2%, education that drinking is dangerous 8.3%, psychiatric disease prevention education 7.3%, management of dementia patients 6.3% and chronic psychiatric patients 5.8%. This region showed that the business for health promotion for the aged who occy 10% of all the residents and health management has been highly requested. Third, They also required political consideration for transportation convenience in order to manage chronic psychiatric patients, professional manpower and financial support, development of rehabilitation program and the use of welfare facilities, and the effective ways and measures are required to developed for understanding the cause of stress and the management of stress to promote the health of the residents and positive propagation and education are required on no smoking and on drinking considering that smokers and drinkers occupy over 70% of the residents while 13.6% is alcoholic. Fourth, They requested the public health office to do the role of promoting mental health for all the residents, using the leading group in the region, securing professional mental manpower, full understanding and concerns about the chronic psychiatric patients and their family, finding, preventing treating and providing traffic convenience to the residents to reach the public health office. In conclusion, the public health office in K region where there is not nay mental doctor and clinic to contact should start preferentially the psychiatric health business for local community by settling it in existing primary health medical system.
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