저인산혈증성 구루병 환아의 증례 보고

박윤희,이종갑,최병재 大韓小兒齒科學會 2000 大韓小兒齒科學會誌 Vol.27 No.1

저인산혈증성 구루병은 구루병 중에서 보통 용량의 비타민 D 투약 치료에 반응하지 않는 형태로, 성염색체 우성 유전되며, 신세관에서 유기인의 재흡수가 감소되어 생기는 것으로 생각된다. 따라서, 저인산혈증이 특징적 소견이며, 혈청 내 알카리성 인산효소 활성이 증가되어 있고, 혈청 칼슘 농도는 보통 정상 범주에 속한다. 치과적 소견으로 특징적인 것은 임상적으로 건전한 치아에서 나타나는 다수의 자발적 치근단 농양과 농루이며, 치아의 맹출지연과 법랑질 저형성증도 관찰할 수 있다. 치과 방사선적으로는 치수각이 현저히 신장되어 있고, 때로는 상아법랑경계까지 연장되어 있으며, 치아주위 치조백선의 약화나 상실, 비정상적 치조골 소주 양상을 관찰할 수 있다. 본 환아는 저인산혈증성 구루병으로 진단되어 투약 치료 중이며, 구강검사 결과 특징적 치과소견인 다수의 자발적 치근단 농양과 농루, 치수각의 현저한 신장 및 치아 맹출 지연이 관찰되어 이의 구강 및 방사선 소견에 대해 보고하는 바이다. Hypophosphatemic rickets is lack of reponse to physiologic dose sof vitamin D, different from the vitamin D dependent rickets. It is inherited in an X-linked dominant fashion. The prime features of this disorder are lowered serum phosphate levels, elevated serum alkaline phosphatase and normal serum calcium levels. The dental manifestation often include apical radiolucencies, abscess and fistulas of clinically sound teeth. Dental radiographs show ricketic bone trabeculations, abscent or abnormal lamina dura and abnormal cementum. This case which was diagnosed to hypophosphatemic rickets, showed multiple spontaneous periapocal abscess and gingival fistula, enlarged pulp chambers, extension of the pulp horns into the cusp tips and delayed eruption.

김치가 노화촉진쥐 뇌의 유리기 생성 및 항산화효소 활성에 미치는 영향

김종현,류재두,이한기,박정희,문갑순,최홍식,송영옥 부산대학교 김치연구소 2002 김치의 과학과 기술 Vol.8 No.-

본 연구는 김치가 노화와 직접적인 관련이 있는 유리기 생성 및 항산화 효소활성에 미치는 영향을 살펴보기 위하여 배추김치, 배추갓김치 그리고 갓김치를 식이중량의 5% 첨가하여 실험식이를 제조하여 이를 노화촉진쥐인 SAMP8에게 1년간 섭취시켰다. 총유리기, OH radical, H_2O_2농도 그리고 TBARS 농도 모두 가령에 따라 증가하였으며, 김치섭취시 유의적으로 감소되었다(p<0.05), 김치군에 있어서 생성된 유리기를 제거하기 위해 항산화계 효소인 SOD, catalase, GSH-px 그리고 GSH/GSSG는 모든 김치군에서 유의적으로 증가 하였다(P<0.05). 따라서 김치섭취는 먼저 가령에 의해 생성되는 유리기의 생성은 억제시키면서, 둘째 이를 제거하기 위한 항산화계 효소 활성은 더욱 활성화시키므로써 항노화 기능을 발휘한다고 생각된다. 김치종류 중에서는 배추갓김치와 갓김치가 배추김치보다 유리기 생성을 억제하고, 항산화계 활성을 증진시킨 것으로 보아 이들의 항노화 효과가 클것으로 생각된다. This study was performed to investigate the effect of kimchi intake on antiaging characteristics in the brain of senescence-accelerated mouse (SAM) in terms of free radical production and anti-oxidative enzymes. Two hundreds twenty SAM (20 mice) were divided into four groups and fed kimchi diet for 12 months. Experimental groups were kimchi free AIN-76 diet (control) group, Korean cabbage kimchi diet (KCK)group, 30% mustard leaf added Korean cabbage kimchi diet (MKCK) group, and mustard leaf kimchi diet (MLK) group. Concentrations of total free radical, OH radical and H_2O_2 of control group increased up to 123%, 262% and 174% of initial value (p<0.05) after one year. Increase in free radical production in kimchi groups due to aging was decreased by kimchi feeding. Among kimchi groups. MKCK and MLK groups showed greater inhibiting effect against free radical production than KCK. The concentration of TBARS in the bruin of control group also significantly increased up to 362% of initial value as aged (p<0.05) and production of TBARS in kimchi groups were decreased. When the activities of Cu, Zn-SOD, Mn-SOD, GSH-px and catalase of kimchi groups were compared to those of control at the same experimental period, anti-oxidative enzyme activities of kimchi groups were lower than those of control (p<0.05). But GSH/GSSG in kimchi groups were higher compared to control. In conclusion, decrease in free radical production and increase in anti-oxidative enzyme activities were observed from kimchi groups suggesting that kimchi might have important role on retarding aging. Among kimchi variety tested in this experiment, MKCK and MLK seem to have greater effect on inhibiting free radical production and increasing anti-oxidative enzyme activities than KCK.

선인장 양심실 보조장치의 설계 및 임상적용을 위한 평가

민병구,박찬영,최재순,이혁수,황창모,김삼성,윤걸중,김종원,선경,이경갑,정종태,김원곤 제주대학교 인공심장이식연구소 2001 인공심장 연구 Vol.2 No.1

현재 개발되고 있는 맥동형 이식형 인공심장은 완전이식형 인공심장과 좌심실보조장치 뿐이다. 좌심실보조장치를 장착한 환자의 10~15%가 우심실의 보조를 필요로하고 완전이식형 인공심장의 장착을 위해서는 자연심장을 제거해야하는 상황에서 이식형 양심실보조장치에 대한 필요성이 대두되고 있다. 본 연구진은 완전이식형 인공심장으로 개발된 한국형 인공심장을 개선하여 양심 실 보조장치를 개발하였다. 양심실보조장치는 이동형 작동기식 미케니즘을 이용하고 있으며 에너지 변환장치와 감속기로 구성된 작동기와 혈액주머니, 그리고 내장형 제어기로 구성되어 있다. 선인장 펌프로 명명된 KAH350은 캐뉼라의 연결을 위한 커넥터를 포함하여 길이 177mm, 폭 164mm, 높이 67 이고 무게 780g이며 최대 심박출량은 5L/min 이다. 양심실보조장치로 개발된 선인장펌프는 좌심실보조장치로도 응용이 가능하다. 이식적합성과 생체적합성을 평가하기 위하여 좌심실보조장치로 5회, 양싱실보조장치로 6회의 동물실험을 수행하였다. 각각 최장 28일간 생존하였으며 11회의 동물실험중 장치의 결함에 의한 것이 3회 있었는데 이들은 모두 전자장치의 결함과 방수처리문제였다. 현재 이식적합성과 일박출량을 향상시킨 KAH400모델이 개발중이다. The types of pulsatile implantable artificial hearts that are on the way of development and have been developed are totally implantable artificial heart and implantable left ventricular assist device (LVAD). Approximately 10% to 15% of all patients Implanted with wearable VADs have required right heart support with another device. And it is reluctant to patient who should remove his or her own heart to be implanted with total artificial heart. These situations drive the development of implantable bi-ventricular assist device (BVAD). The Korean BVAD was develophed by modifying the moving actuator type Korean artificial heart. This electro-mechanical BVAD comprises actuator including energy converter and reduction gear train, blood sacs, and internal motor and energy controllers. The KAH350 which is named as 'Cactus Pump' is 177mm in length, 164mm in width, and 67mm in thickness including connectors and nuts. The weight and maximum cardiac output of Cactus Pump is 780g and 5L/min, respectively. The Cactus Pump that was developed as BVAD could be used as LVAD by attaching compliance caps on the 2 ports of one ventricle. The animal experiments were undergone 5 times for LVAD, and 6 times for BVAD. The best records were 28 days survival in both applications. There were 3 times of device failure and they were all associated with electrical connection and hermetic sealing. The KAH400 that has improved anatomical fitting characterisitcs and stroke volume is on development.

납 폭로 근로자에서 δ-aminolevulinic acid dehydratase 유전형질이 zinc protoporphyrin 및 δ-aminolevulinic acid에 미치는 영향

이병국,황규윤,장봉기,김용배,리갑수,안현철,김화성,이성수,안규동,박종범 순천향대학교 산업의학연구소 1999 순천향산업의학 Vol.5 No.1

The inhibition of δ-aminolevulinic acid dehydratase (ALAD) in the heme synthetic pathway results in increased protophoryphyrin (ZPP) and δ-aminolevulinic acid (ALA) and is responsible for some of toxicological effects of lead. This enzyme is coded by the ALAD gene containing 2 co-dominant alleles. The polymorphisms of ALAD gene may be related to differential effects of lead on ZPP and ALA, ALAD genotype was measured in 975 Korean male lead workers, of whom 897 were homozygous for ALAD1 (ALAD 1-1 genotype) and 96 were heterozygous for ALAD2 (ALAD 1-2 genotype). Blood lead in subjects with ALAD1 was significantly higher than those with ALAD2 (p = 0.01). No difference between ALAD genotypes was found for age, exposure duration, ZPP, ALA, hemoglobin, hematocrit, body mass index, tobacco and alcohol use. After adjustment for possible confounders, ALA and ZPP became significantly elevated in ALAD1 subjects (p = 0.004 and 0.055, respectively). This result suggests that ALAD1 subjects may be more susceptible to the hematotoxicologic effects of lead than ALAD2 subjects.

「조선문법(朝鮮文法)」문장론의 원사법(原詞法)과 은각(隱覺) 및 략생구어(掠省句語)

박종갑 ( Jong Gap Park ) 한민족어문학회 2015 韓民族語文學 Vol.0 No.69

국어 문법서의 몇몇 대표작들-김규식의 「朝鮮文法」(1912), 주시경의 「國語文法」(1910), 김두봉의 「조선말본」(1916), 최현배의 「우리말본」(1937) 등에는 문장의 기저구조와 관련돼 보이는 기술이 있다. 본고는 이에 대한 종합적인 검토와 대조 작업의 일환으로, 우선, 김규식의 「朝鮮文法」의 관련 부분을 집중적으로 검토하였다. 「朝鮮文法」은 ``原詞法``, ``隱覺``, ``掠省句語``, ``掠省``, ``拔去`` 등 여러 가지 용어로, 이 주제에 대해 가장 다양하게 기술하고 있다. 문장론에서의 原詞法은 통사구조적 기저구조와 의미해석적 기저구조 두 가지를 가리키고 있는 것으로 정리하였다. 본고에서는 隱覺을 생략의 개념이라고 정리하였다. 은각으로 기술하고 있는 경우는 크게 문장의 구성성분이 은각된 경우와 문장이 은각된 경우로 대별되는데, 隱覺은, 생략되기 전의 문장구조인 原詞法에서, 담화상황을 통하여 복원이 가능한 문장의 구성성분이나 담화의 한 부분인 문장이 생략되는 것이라고 정리된다. 은각되기 전의 구조는 통사구조적 기저구조에 상응하는 것이라할 수 있으므로, 은각은 기저구조와 표면구조를 연결하는 통사적 수단인 변형과 일맥상통하는 점이 있다. 「朝鮮文法」에서는 하나의 주어가 몇 개의 서술어와 연결되거나 몇개의 주어가 하나의 서술어와 연결되는 것이 있다고 하고 이를 掠省□ 連結句語[略省句語]라 하였다. 주어진 문맥을 이용하여 의미논리적으로 추론하여 설정한 중문 형식의 구조에서, 중복된 부분을 생략한 구조가략掠省한 連結句語인데, 이러한 경우의 생략을 拔去라는 용어로 기술하고 있다. 掠省이란 말을 쓰면서도 隱覺이란 용어는 사용하지 않고 拔去란 말로 설명하고 있다는 점에서, 은각으로 기술한 부분과 掠省句語에서의 기술을 서로 다른 관점에서 처리하고 있음을 짐작할 수 있다. The several representatives of Korean grammars-Kim Gyusik 「Joseon- munbeop」(1912), Ju Sigyeong 「Kugeomunbeop」(1910), Kim Dubong 「Joseon- malbon」(1916), Choe Hyeonbae 「Urimalbon」(1937) etc.-have the descriptions related to the underlying structures of sentences. As a bid for comprehensive examination and contrastive analysis for this, the paper intensively studied the related part of Kim Gyusik 「Joseonmunbeop」(1912) above all. 「Joseonmun- beop」 described so diversely this theme with the several terms such as ``weonsabeop``, ``eungak``, ``ryaksaenggueo``, ``ryaksaeng``, ``palgeo`` etc.. Weonsa- beop indicates both a sentence-structural underlying structure and semantic- logical interpretation. Eungak refers to the omission of ``the component of a sentence`` or ``a sentence`` restorable through a discourse situation in a sentence- structural underlying structure. Eungak has something in common with the transformation of syntactic equipment connecting an underlying structure with a surface structure. Ryaksaenggueo is the structure which omits an overlapped part in the structure of a compound sentence form established by means of semantic-logical inference employing a given context. This kind of omission is described as the term of palgeo in 「Joseonmunbeop」.

남북한 주민의 의사소통 장애 요인과 그 해소 방안에 대하여

박종갑 ( Jong Gap Park ) 한민족어문학회 2007 韓民族語文學 Vol.51 No.-

김규식 문법과 주시경 문법의 문장론 대조 연구

박종갑(Park, Jong-Gap) 한국어문학회 2015 語文學 Vol.0 No.127

The aim of the article is to illuminate the grammatical characteristics of Kim Gyusik’s 『Joseonmunbeop』 and Ju Sigyeong’s 『Kugeomunbeop』 by comparing underlying structures in their syntax. For this, to begin with, the article compared all exemplary sentences employed in these grammars. After that, by analysing and comparing the definitions of terms shown in two grammars, the article revealed the grammatical characteristics of them and, furthermore, worked to investigate the analytical methods of sentence structures in two grammars. In 『Joseonmunbeop』, employing a variety of types of examples and various terms, the author diversly described various phenomena related to so called underlying structures. In 『Kugeomunbeop』, employing restricted examples and terms, the author analysed them consistently and systematically. The author introduced the notion of ommission in the descriptions in 『Joseonmunbeop』 but this kind of notion does not exist in 『Kugeomunbeop』. So it seems that there is the notion corresponding to a syntactical underlying structure in 『Joseonmunbeop』, and, but not the notion in 『Kugeomunbeop』 and the author can be seen to give a semantic underlying structure instead in 「Kugeomunbeop」. A simple sentence and a conjunct sentence are classified in 『Joseonmunbeop』 but are not in 『Kugeomunbeop』. In 『Kugeomunbeop』, in the case of a conjunct sentence corresponding to phrase connection(gujeopssok), similar examples with the case of 『Joseonmunbeop』 are addressed but the descriptive methods are different.

한국의 발톱진균증 환자의 삶의 질에 관한 연구

조백기,박종갑,김형옥,김성욱,백승철,김진우,김시용,안규중,전재복,오지원,김낙인,이규석,오칠환,김수남,김상태,손숙자,신용우,김동석,이원우,권경술,서대헌,황규왕,이종석,고재경,강원형,정기양,최응호,김기홍,박석돈,강승주,함정희,명기범,김방순,구상완,김병수,원영호,김한욱,송은섭,정병수,노병인,홍창권,박장규,한지윤,김광중,구대원,김종민,김재홍,유희준,양경미 대한의진균학회 1998 대한의진균학회지 Vol.3 No.2

Background: Onychomycosis, especially toenail onychomycosis has become one of the common fungal infection and has historically been regarded as a cosmetic rather than medical problem by many patients, even by physicians. Recently, however, there are several reports that is a refractory disease which may cause a deleterious effect on patiets quality of life (QOL). Objective: The purpose of this study was to investigate the impact of toenail onychomycosis on QOL in Korea and to assess the chandes of QOL after treatment. Methods: Total 1004 patients with toenail onychomycosis which was confirmed by clinical findings and KOH preparation were were enrolled at 47 dermatologic centers in Korea, and interviewed with standardized QOL questionnaire before and after sytemic antifungal treatment. Responses to the questionnaire were scored by 5-point scale (1∼4) and averaged, and were analyzed for 5 dimensions of emotional impact, social impact, symptorn and functional impact, patients views concerning treatment, and relationship with doctor. Results: 1. Before and after treatment, the most serious impact was emotional dimension showing 1.90 and 1.30 in average score (AS), and social (AS: 1.14 and 0.83) and symptom and functional impact (AS: 1.05 and 0.92) was also affected. 2. In female rather than male, statistically more significant impact on patients QOL was observed in all dimensions. 3. After treatment, 3 of 5 dimensions were improved significantly - emotional dimension (AS : from 1.90 to 1.30), social dimension (AS: from 1.14 to 0.83), patients view concerning treatment (AS: from 1.34 to 1.02). 4. The drgree of patients satisfaction at the therapeutic effect was very high- 62.4% (immediately after treatment) and 65.8% (9 months affer initiation of treatment) of patients answered excellent or good. Conclusion: This study confirms that toenail onychomycosis has significant impact on the overall QOL of patients. Also the effect of antifungal therapy on patients QOL were watisfactory. Therefore, both doctor and patient should pay more attention to the treatment of onychomycosis. [Kor J Med Mycol 3(1): 115∼124]

原因不明熱後에 續發된 Secondary hypogonadism의 一例 : A case report

朴利甲,慶爛浩,朴鍾亮,李相玉,崔明子 醫藥係社 1965 綜合 醫學 Vol.10 No.9

The Role of Alcoholics' Insight in Abstinence from Alcohol in Male Korean Alcohol Dependents

Jong Sung Kim,Byoung Kang Park,Gap Jung Kim,Sung Soo Kim,Jin Gyu Jung,Mi Kyeong Oh,Jang Kyun Oh 대한의학회 2007 Journal of Korean medical science Vol.22 No.1